scholarly journals MASTALGIA

2009 ◽  
Vol 16 (02) ◽  
pp. 239-246
Author(s):  
NAUMAN ANWAR RANA ◽  
AHMED WAQAS ◽  
RANA HASSAN JAVAID ◽  
Intisar-UI- Haq
Keyword(s):  
Side Effects ◽  
P Value ◽  
Evening Primrose Oil ◽  
Evening Primrose ◽  
Quasi Experimental ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Randomised Controlled ◽  
Group 1

Mastalgia is a common clinical symptom experienced by up to 70% of women at some stage of their life. A wide varietyof therapeutic agents are available for the treatment of mastalgia. Both evening primrose oil and non steroidal anti-inflammatory drugs havebeen assessed in randomised controlled trials and demonstrated to be effective. The objective of this Quasi experimental study was tocompare the efficacy and safety of topical nonsteroidal anti-inflammatory drugs with evening primrose oil in the treatment of mastalgia. Westudied 90 female patients presenting with breast pain from 25 July 2006 to 25 July 2007 at the surgical outpatient department of CMHKharian. The patients were divided into three groups. Group-1 was given capsule Effamol (evening primrose oil), group-2 topical brufen geland group-3 topical Vaseline for two months. Patients were followed every two weeks for two months. Response was assessed using Cardiffbreast pain score. Side effects of drugs were recorded at each follow up. Out of 30 patients of group-1,14 (46.6%) had clinically significantresponse at the end of 8 weeks treatment as compared to 27 (90%) in group-2.5 (16.6%) patients of group-1 showed mild side effects whilenone in group-2 had any side effect, p- value was < 0.0001 showing highly significant statistical difference between 2 groups. Topicalnonsteroidal anti-inflammatory drugs are safe and effective as compared to evening primrose oil in the treatment of mastalgia.

scholarly journals Comparison between use of combination of mifepristone and misoprostol versus misoprostol alone in the management of intrauterine fetal death

2018 ◽  
Vol 7 (7) ◽  
pp. 2778
Author(s):  
Sreeveena Talasani ◽  
Pran Hitha Venkamolla ◽  
Kalpana Betha
Keyword(s):  
Side Effects ◽  
Fetal Death ◽  
Intrauterine Fetal Death ◽  
P Value ◽  
Ultrasound Scan ◽  
Efficacy And Safety ◽  
Medical Sciences ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Background: Intrauterine fetal death (IUFD) is estimated to occur in 1% of all pregnancies. The advent of prostaglandins has revolutionized the management of IUFD. There are limited studies using a combined regimen of mifepristone and misoprost for induction of labor in IUFD. Hence this study was undertaken to assess the efficacy and safety of combined regimen with misoprostol alone, in the management of IUFD.Methods: This hospital based prospective study included 60 pregnant women with IUFD admitted at Mediciti Institute of Medical Sciences, during the period January 2015 to July 2016. An ultrasound scan was performed to confirm IUFD and localize the placenta. Women were divided alternatively into 2 groups with 30 in each group (group 1- women received 200 mg mifepristone orally followed by misoprostol after 24 hours & in group 2, 100 µg misoprostol  every 6 hourly for a maximum of 4 doses between gestational age  24-26 weeks, 25-50 µg 4 hourly for a maximum of 6 doses beyond 26 weeks).Results: The mean induction to delivery interval was 10 hours in group 1 and 16.3 hours in group 2 (p value 0.007). Mean dose of misoprostol required in group 1 was 1.87 and 2.67 in group 2 (p value 0.008). With respect to side effects, the two groups did not differ significantly.Conclusions: The combined regimen was more effective than misoprostol for the induction of labour in IUFD, in terms of higher rate of successful delivery and shorter induction to delivery interval. 

scholarly journals Nonsteroidal anti-inflammatory drugs, muscle relaxants, and B-group vitamins in the treatment of lumbar ischialgia

2020 ◽  
Vol 12 (6) ◽  
pp. 71-76
Author(s):  
V. A. Shirokov ◽  
A. V. Potaturko ◽  
N. L. Terekhov
Keyword(s):  
Trigger Points ◽  
Pain Reduction ◽  
Muscle Relaxants ◽  
Mcgill Pain Questionnaire ◽  
Vitamin B ◽  
Patient Groups ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Group 1

Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants are used orally or intramuscularly (IM) to treat lumbar ischialgia caused by musculoskeletal disorders or radiculopathy. A comparative study has been conducted to investigate the efficacy and safety of the NSAID meloxicam (Amelotex®) injected intramuscularly and into the trigger points in combination with tolperisone and B-group vitamins for lumbar ischialgia.Patients and methods. The investigation enrolled 62 patients aged 30–60 years with lumbar ischialgia, who were randomized into three equal groups. Group 1 patients were injected with meloxicam 1.5 ml (15 mg of its active ingredient) into the trigger points daily for 3 days, followed by one 15-mg tablet daily for 14 days; Group 2 received IM meloxicam 15 mg daily for 3 days, followed by one 15-mg tablet daily for 14 days; Group 3 had IM meloxicam 15 mg daily for 3 days, followed by one 15-mg tablet daily for 14 days in combination with tolperisone (Calmirex®) as tablets: 150 mg (Day 1 of therapy), 300 mg (Day 2), and 450 mg daily (Day 3 until the end of therapy). All the patients received IM Vitamin B complex (Compligam B®) 2 ml for 5 days. The treatment efficiency was evaluated using the pain visual analogue scale (VAS), the Oswestry disability questionnaire, and the McGill pain questionnaire, the range of motion, and the severity of neurodystrophic syndrome.Results and discussion. All the patient groups showed a rapid and substantial pain reduction on the VAS and a functional activity improvement according to the Oswestry scale, which made it possible to complete the treatment within an average of 9.6 days. Groups 3 and 1 exhibited a faster improvement and, as a result, a shorter therapy duration on 8.6±1.2 and 9.2±0.9 days than did Group 2 (8.6±1.2 days). On day 2 of treatment, there was a more considerable pain reduction on the VAS in Group 1 that received meloxicam injections into the trigger zones. The administration of meloxicam intramuscularly and into the trigger zones in combination with tolperisone and vitamin B complex was noted to be safe and well tolerated.Conclusion. The injection of Amelotex into the trigger zones is highly effective and safe in treating lumbar ischialgia. An NSAID (meloxicam) in combination with a muscle relaxant (tolperisone) speeds up recovery and shortens the duration of NSAID intake.

scholarly journals Comparative study of efficacy of drotaverine hydrochloride and valethamate bromide with control in first stage of labour

2013 ◽  
Vol 11 (1) ◽  
pp. 38-42 ◽  
Author(s):  
P Dahal ◽  
B Banerjee ◽  
DK Uprety ◽  
BP Das ◽  
A Thakur ◽  
...  
Keyword(s):  
Side Effects ◽  
Mode Of Delivery ◽  
Active Phase ◽  
Fetal Outcome ◽  
Control Group ◽  
P Value ◽  
Drotaverine Hydrochloride ◽  
Group 2 ◽  
And Control ◽  
Group 1

Background: Labour is the most perilous journey a woman has to undertake. Painless and short labour is desired by every woman and is a constant aim for obstetrician.Objective: To analyze and compare the efficacy and safety of drotaverine and valethamate with control group on improving cervical dilatation and promoting progress of labour. Method: Three hundred demographically similar women, both primigravida and multigravida with a term pregnancy in established labour were randomly divided into three groups. One hundred women (group 1) were given injection valethamate intramuscularly,100 women (group 2) were given drotaverine and the rest 100 (group 3) were not given any drug. Comparative analysis was carried out as regards to duration of first stage of labour, mode of delivery, maternal side effects and fetal outcome. Results: The mean duration of active phase of labour in group 1, 2 and 3 was 254.29±96.621 min, 178.31±73.412 min and 346.31±123.351 min respectively. The duration of injection to end of first stage of labour in valethamate and Drotaverine group was 228.12±84.626min and 168.89±69.576min respectively (p value<0.0001). The duration of injection to delivery in Valethamate was 249.13± 88.321 min and in Drotaverine was 192.56±75.479min (p value<0.0001). There were no serious maternal and fetal adverse effects in any group but minor side effects were more common in valethamate group. Conclusion: The reduction of the duration of the first stage of labour was apparently more in drotaverine group as compared to valethamate and control group. Drotaverine was found to be safe with minimal or no adverse effect on the mother and the fetus. Health Renaissance, January-April 2013; Vol. 11 No.1; 38-42 DOI: http://dx.doi.org/10.3126/hren.v11i1.7600

scholarly journals Side Effects of Daily versus Weekly Iron Supplementation in Pregnant Women

2019 ◽  
pp. 17-22
Keyword(s):  
Side Effects ◽  
Pregnant Women ◽  
Iron Supplementation ◽  
Numerical Data ◽  
P Value ◽  
Chi Square ◽  
Gastrointestinal Side Effects ◽  
Chi Square Test ◽  
Group 2 ◽  
Group 1

Background & Objective: Iron supplementation in pregnant women is highly recommended, however there is reduced compliance due to the common gastrointestinal side effects. This study aimed to compare the clinical side effects between pregnant women with daily and weekly iron supplementation. Methods: Seventy-nine pregnant women who met the inclusion and exclusion criteria were given iron supplements every day (group 1, n=37) and twice a week (group 2, n=42). All numerical data were assessed by independent t-test. Side effects were assessed after one month of administration using a questionnaire containing complaints felt by pregnant women and were evaluated by chi-square test using SPSS 25. A P value <0.05 was considered as statistically significant. Results: The most common side effects of iron supplementation in both groups were black feces (35.4%) and nausea (31.6%). Nausea (45.9% vs. 19.0%; P<0.05) and constipation (35.1% vs. 11.9%; P<0.05) were more frequent in group 1 than in group 2, respectively. Other side effects, such as heartburn, flatulence, vomiting, black feces, and urine discoloration did not differ significantly between the two groups (P>0.05). Conclusion: The daily iron supplementation elevated the episodes of nausea and constipation during pregnancy than the weekly supplementation. The daily iron supplementation in pregnant women increases the risk of side effects, potentially reducing compliance.

Ivermectin may Not be a Miraculous Drug to Improve PF Ratio and Virus Clearance in COVID-19 Patient

2021 ◽  
Vol 15 (5) ◽  
pp. 999-1001
Author(s):  
Abid Mushtaq ◽  
Saba Zartash ◽  
Muhammad Javed ◽  
M Asim Rana ◽  
M A Qayyum ◽  
...  
Keyword(s):  
Standard Treatment ◽  
Symptomatic Improvement ◽  
P Value ◽  
Medical Sciences ◽  
Virus Clearance ◽  
Therapeutic Anticoagulation ◽  
Treatment Centre ◽  
Quasi Experimental ◽  
Group 2 ◽  
Group 1

Aim: To evaluate the effectiveness of Ivermectin in COVID 19 infection in terms of virus clearance and symptomatic improvement. Study design: Prospective Quasi experimental study Place and duration of study: Study was carried out in COVID treatment units of Services Institute of Medical Sciences and Bahria International Hospital COVID treatment centre from April 15, 2020 to November 30, 2020 Methodology: One hundred COVID19 confirmed patients for this study and divided into 2 groups. Both groups were given standard treatment including Oxygen, therapeutic anticoagulation and hydroxychloroquine therapies. Group-1 was given Ivermectin for 6 days and group 2 didn’t receive Ivermectin. Results: The significance value represented as p value (p=.825) was greater than the table value at 0.05 in all aspects, which shows that Ivermectin has no effect in improving PF ratio in COVID19 patients. Out of 50 only 4 patients who received Ivermectin got COVID19 PCR negative after 6 days but on the other hand 3 patients who did not receive Ivermectin also got their PCR negative after 6 days of treatment. Conclusion: Ivermectin does not seem to be effective in improvement of PF ratio and virus clearance in COVID19 patients. Keywords: SARS-CoV-2, COVID-19, PF ratio, Ivermectin, Virus clearance, Anti-viral treatment, Viral clearance

scholarly journals Comparison of High Intensity Accelerated Corneal Cross Linking Protocols in Treatment of Progressive Keratoconus;

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Bushra Akbar ◽  
Imran Basit ◽  
Amjad Akram ◽  
Maham Zahid
Keyword(s):  
Armed Forces ◽  
Comparable Efficacy ◽  
Cross Linking ◽  
P Value ◽  
Quasi Experimental ◽  
Final Time Point ◽  
Spss Software ◽  
Group 2 ◽  
Group 1

Purpose:  To compare the safety and efficacy of Accelerated Corneal Cross Linking (AXL) protocols ,9mW/cm2 for 10 min with 18mW/cm2 for 5 min in terms of refractive and topographic keratometric indices in patients with progressive keratoconus over 3, 6, 12 and 18 months follow-up. Study Design:  Quasi experimental study. Place and Duration of Study:  Armed Forces Institute of Ophthalmology Rawalpindi Pakistan, from Nov 2016 to Jun 2018. Material and Methods:  Sixty eyes, 30 in each group, of 55 consecutive patients diagnosed with progressive keratoconus were enrolled through convenience sampling and were subjected to AXL with irradiance protocols of 18 watt/cm2 for 5 minutes in group 1 and 9mwatt/cm2 for 10 minutes in group 2. All patients underwent a comprehensive ophthalmic examination at baseline and postoperative follow up visits at 3, 6, 12 and 18 months. Primary outcome parameter was disease stability defined as increase in maximum keratometry over baseline K max of no more than 1 diopter at 1 year after AXL. Statistical analysis of data was performed with IBM SPSS software (version 20.0 SPSS). P value of < 0.05 was considered as statistically significant. Results:  Disease stability was 96 % in each group. At the final time point of 18 months, group 2 (AXL 9mmwatt/cm2 for 10 min) was superior as compared to group 1 (AXL 18mmwatt/cm2 for 5 min) in terms of flattening of steep and sim K (p = 0.007, 0.023 respectively). Conclusion:  The two AXL protocols are safe and appear to show comparable efficacy in disease stability. They can be used alternatively in the treatment of progressive keratoconus.

P1689COMPARISON OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS(NSAIDS) AND/OR PAINKILLERS USE BY KIDNEY (KTRS) AND HEART TRANSPLANT RECIPIENTS (HTRS)

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Anna Jędrzejczak ◽  
Wioletta Szczurek ◽  
Michał Zakliczyńśki ◽  
Bartosz Foroncewicz ◽  
Rafał Staros ◽  
...  
Keyword(s):  
Side Effects ◽  
Heart Transplant ◽  
Solid Organ Transplantation ◽  
P Value ◽  
Solid Organ ◽  
Transplant Recipients ◽  
First Choice ◽  
Inflammatory Drugs ◽  
Heart Transplant Recipients ◽  
Anti Inflammatory

Abstract Background and Aims Solid organ transplantation (SOT) has become the therapy of choice for the treatment of end-stage organ failure. The non-steroidal anti-inflammatory drugs (NSAIDs) and over-the- counter (OTC) painkillers are ofenly used. In a group of SOT recipients, co-morbidities and immunosuppression interactions significantly increase the risk of side effects. The aim of the study was to analyze the frequency and reasons of the NSAIDs and/or painkillers use by renal (RTRs) and heart transplant recipients (HTRs). Method This cross-sectional study was perfomed in randomly selected 388 RTRs and 286 HTRs aged from 18 to 82 years. The original annonymus questionnaire consisting of 32 questions related to health status and NSAIDs and/or analgesics use was applied. Questionnaire was distributed in paper-form and completed with the participation of medical worker either in transplant cardiosurgical or renal transplantation center. “R” v. 3.6.1. was used for statistical analysis and p-value &lt;0.05 was considered significant. Results 674 patients were surveyed. All patients: 34,3% (n=231) women and 65,7% (n=443) men in the mean age of 62.27 years completed the questionnaire. 70% (n=451) of respondents declared using NSAIDs and/or analgesics. Furthermore, 87% of participants declared using OTC painkillers. The most frequent causes for using analgesics are listed in Table 1. 68,5% of our SOT recipients declared that they were informed by their doctor about consequences of other drugs used with immunosuppression. 69,9% of HTRs comparing to 54,3% of RTRs ask their doctor before taking analgesics. Nevertheless, the survey also showed that every third patient (31,5%) was not sufficiently informed. Acetaminophen was the first-choice drug taken by 67,6% of patients (Fig. 1). Only 20% of patients declared not using NSAIDs and/or analgesics at all. Conclusion The result of our study indicates high frequency of NSAID and painkillers usage by RTRs and HTRs. Considering potentially harmful influence on transplanted organs, the costs of transplantation and post-trasplant care, the awareness of drug- related side effects or interactions and patients compliance need to be highlighted.

scholarly journals PENGARUH PENAMBAHAN TRAKSI OSCILASI PADA TRANSCUTANEUS ELECTRICAL NERVE STIMULATION TERHADAP INTENSITAS NYERI PADA PENDERITA OSTEOARTHRITIS GENU

2018 ◽  
Vol 1 (1) ◽  
pp. 20-25
Author(s):  
Isidorus Jehaman ◽  
Redi Tantangan
Keyword(s):  
Treatment Group ◽  
Pain Intensity ◽  
T Test ◽  
Verbal Description ◽  
P Value ◽  
Degenerative Diseases ◽  
Before And After ◽  
Quasi Experimental ◽  
Group 2 ◽  
Group 1

Degenerative diseases are chronic chronic diseases that affect a person's quality of life and productivity. One of the most common degenerative diseases and which has a high mortality rate is osteoarthritis in the knee. The purpose of this study was to determine the differences in the administration of TENS with Oscillation Traction on pain intensity in patients with genital osteoarthritis in Grandmed Lubuk Pakam Hospital. Research Method: this is research is quasi-experimental while the research design uses pre-test and post-test. The sample of this study used 2 treatment groups, namely treatment group 1 using TENS and treatment group 2 using oscillation traction. Both sample groups measured pain scales using the verbal description scale. The results of the analysis of the influence test with Independent t-test in treatment group 1 and treatment group 2. Test paired sample t-test obtained p value = 0.001 (p 5 0.05), which means that there is a difference in pain intensity before and after being given TENS. Whereas in the treatment group 2 oscillation traction obtained results of p = 0.001 (.050.05) which means that there is a difference in pain intensity before and after being given oxyylation traction. From the results of the independent t-test in getting results with p = 0.000 (α<0.05) it can be concluded that there is a difference in the administration of TENS with oscillation traction against pain intensity in Genu Osteoarthtritis sufferers. Conclusion There is a Difference in Giving TENS with Oscillation Traction Against Pain Intensity in Genu Osteoarthtritis Patients. Suggestion: minimize activity overload the knee joint, squat up and down stairs or lift excessive weight.

scholarly journals Efficacy and safety of two “Carmolis” forms for combined local therapy of knee osteoarthritis: results of a multicenter clinical trial

The Clinician ◽  
2020 ◽  
Vol 14 (1-2) ◽  
pp. 100-106
Author(s):  
L. N. Denisov ◽  
V. N. Sorotskaya ◽  
E. A. Leonova ◽  
L. V. Меn’shykova ◽  
M. L. Sukhareva ◽  
...  
Keyword(s):  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Disease Duration ◽  
Main Group ◽  
Control Group ◽  
Efficacy And Safety ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Group 1

Objective – to evaluate efficacy and safety of “Carmolis” fluid and gel in patients with knee osteoarthritis, as well as the gel efficacy combined with ultraphonophoresis.Materials and methods. The study included 200 patients, who were divided into 2 groups depending on the way of application of “Carmolis” forms. Group 1 included 165 patients with knee osteoarthritis (the main group included 90 patients, the control group – 75 patients), who underwent complex local treatment with 2 “Carmolis” forms. Group 2 included 35 patients (20 people in the main group and 15 in the control one). The main group received phonophoresis with “Carmolis” gel, and the control group received “Carmolis” gel locally on the affected knee joint. Patients’ average age in group 1 was 62,7 ± 8,5 years, the average age in the control group was 61.4 ± 8.7 years, the disease duration was 10.1 ± 4.7 and 9.2 ± 6, 0 years, respectively. In group 2 the average age and disease duration were 60.1 ± 12.8 and 5.7 ± 5.4 years, respectively.At the initial stage 90 patients of the main group 1 were rubbed “Carmolis” fluid locally in the joint followed by massage. After the fluid absorbed completely, “Carmolis” gel was applied, followed by massage. In the comparison group (75 patients), standard therapy was combined only with “Carmolis” fluid applied on the II knee joint.Twenty patients of the main group 2 were treated with phonophoresis combined with “Carmolis” gel. Clinical efficacy was assessed by pain dynamics.Results. Treatment with two “Carmolis” local forms significantly decreased average on moving from 61.8 ± 14.2 to 30.7 ± 14.2 (р <0,001), at rest – from 49 ± 19, 9 to 20.4 ± 8.5 (р <0,001), on palpation – from 38.7 ± 10.4 to 18.4 ± 5.7 (р <0,001). A similar dynamics was also revealed during WOMAC assessment (Western Ontario McMaster Universities OA Index). Before the treatment start the average WOMAC pain level in the main group was 240.5 ± 39.8, after the treatment – 114.8 ± 30.4 (р <0,001). The control group also showed pain decrease, but to a much lesser extent than in the main one. At the end of the treatment course, patients of both groups demonstrated a pronounced decrease of synovitis sings, but there were no differences between the groups. The dose of non-steroidal anti-inflammatory drugs in the main group was reduced in 70 (77.8 %) patients, in the control group – in 50 (66.7 %). The tolerability of both forms was very good and good. No adverse events were registered. Data on the effectiveness and safety of “Carmolis” gel combined with ultraphonophoresis are presented in the article.Conclusion. According to the results, combined therapy using “Carmolis” liquid and gel significantly reduces joint pain and synovitis severity, increases joints» functional ability and improves patients» general condition, which allows reducing the dose of non-steroidal anti-inflammatory drugs. Both “Carmolis” forms had excellent and good tolerability.

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