scholarly journals NASAL POLYPS

2018 ◽  
Vol 25 (09) ◽  
pp. 1417-1420
Author(s):  
Waseem Ahmad ◽  
Muhammad Iqbal ◽  
Gohar Amin
Keyword(s):  
Aspergillus Flavus ◽  
Potassium Hydroxide ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Fungal Culture ◽  
Aspergillus Fumigates ◽  
Reactive Hyperplasia ◽  
Taste Sense ◽  
Study Setting

Background: Nasal polyposis is a provocative situation of indefinite etiology thatinvolve nasal as well as sinus mucous membrane. Quality of life of a person can damage by nasalimpediment due to these nasal polyps. Further, it can cause of persistent postnasal drainage,hyposmia, sinusitis, taste sense change even bony demolition. It shows that inflammationreason a reactive hyperplasia of intra-nasal mucosal membrane resulted in the polyp formation.Objectives: To discover the kind of fungus concerned in nasal polyps fungal. Study Design:Descriptive study. Setting: ENT department of Sir Ganga Ram Hospital Lahore. Period: 1stJanuary 2017 to 30th June 2017. Materials and Methods: In microbiology department, thesecollected samples were processed to check the involvement of fungal. Out of all, 118 caseswere included in this study which culture was positive. Increase for microscopic assessment,mycological culture to determine the involvement of fungal and fungus kind, these sampleswere processed for diagnosis by potassium hydroxide (KOH). By using seaboard dextroseagar at 25ºC and 37ºC the fungal culture was done. Periodically it was identified through culturecharacteristics & microscopy if growth was present. Results: In this study, 118 culture positivesamples were included. In 82 cases Aspergillus Spp. was observed among positive specimens;In 32 samples Aspergillus flavus was observed while in 10 samples Aspergillus fumigates wasfound and species was not cleared in 40 samples. The fungal element was isolated in 36samples but genus was not determined. Conclusion: In fungal nasal polyposis, AspergillusSpp. is very general pathogen and we observed in our study that Aspergillus flavus is verycommon agent.

scholarly journals Prevalence and risk factors of Fungal Nasal Polyposis in Tertiary Care Hospital.

2020 ◽  
Vol 27 (02) ◽  
pp. 289-292
Author(s):  
Ayub Musani ◽  
Qaisar Sajjad ◽  
Faheem Ahmed Khan ◽  
Itrat Jawaid ◽  
Hina Iqbal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Tertiary Care ◽  
Total Duration ◽  
Care Hospital ◽  
Female Ratio ◽  
Male Female Ratio ◽  
History Of ◽  
Study Setting

Objectives: To determine the prevalence of fungal rhinosinusitis in nasal polyps’ patients and to determine the risk factors of fungal rhino sinusitis. Study Design: Prospective study. Setting: Out patients and in patients department of Abbasi Shaheed Hospital and Karachi Medical and Dental College. Period: October 2014 to April 2017. Total duration of study was two and a half years. Material & Methods: In this study 221 cases were included who diagnosed nasal polyposis on clinical ground. Both sexes were included in this study. After informed consent complete history were taken and noted in pre designed Performa. Complete ENT and physical examination was done. Relevant investigations were advised as per requirement. Results: Total numbers of patients selected for this study were 221. The overall prevalence of fungal rhino-sinusitis was found in 90 patients (40.70%). Mostly patients belong to poor socio-economical status i.e. 59 (65.55%) followed by middle class 18 (20%) patients. Mean age was 30.16 +/_ 12.33. Male were 55 (61%) and female were 35 (38.8%) with male female ratio was 1:1.57. In risk factors, 36 (40%) patients were farmers while history of allergy was found in 35 patients (38.88%). Conclusions: Patients with nasal polyps should be properly evaluated for the early treatment of fungal rhino-sinusitis and also remove the risk factors to prevent the recurrence and unnecessary complications.

scholarly journals Evaluation of the quality of life before and after functional endoscopic sinus surgery among patients with nasal polyps by means of SF-36 questionnaire

2020 ◽  
Vol 6 (10) ◽  
pp. 1827
Author(s):  
Farah Deeba ◽  
Syed Waseem Abbas ◽  
Ihsan Ali
Keyword(s):  
Quality Of Life ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Medical College ◽  
Sf 36 ◽  
Before And After

<p><strong>Background: </strong>Aim of the study was to evaluate the quality of life before and after FESS among patients with nasal polyps.</p><p><strong>Material and Method</strong>: This study was done in Government Medical College Srinagar from January 2019 to December 2019 for a period of 12 months.  A total of 69 patients with nasal polyposis who underwent FESS were included in the study. They were given a questionnaire SF-36 to be fulfilled preoperatively, 3 months and at 6 months after surgery.</p><p><strong>Result</strong>: The preoperative SF-36 score was 79.35 and postoperative score was 83.62 at 3 months, 86.88 at 6 months.</p><p><strong>Conclusion</strong>: SF-36 questionnaire values showed improvement at 3 months and then at 6 months of follow up.</p>

scholarly journals A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the USA from 2016 to 2019

2021 ◽  
pp. 1-22
Author(s):  
Sebastian Jugl ◽  
Aimalohi Okpeku ◽  
Brianna Costales ◽  
Earl J. Morris ◽  
Golnoosh Alipour-Haris ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
The Body ◽  
Medical Cannabis ◽  
High Quality ◽  
Chronic Noncancer Pain ◽  
High Quality Evidence ◽  
Improved Outcomes ◽  
Noncancer Pain ◽  
Study Setting

In 2017, a National Academies of Sciences, Engineering, and Medicine (NASEM) report comprehensively evaluated the body of evidence regarding cannabis health effects through the year 2016. The objectives of this study are to identify and map the most recently (2016–2019) published literature across approved conditions for medical cannabis and to evaluate the quality of identified recent systematic reviews, published following the NASEM report. Following the literature search from 5 databases and consultation with experts, 11 conditions were identified for evidence compilation and evaluation: amyotrophic lateral sclerosis, autism, cancer, chronic noncancer pain, Crohn’s disease, epilepsy, glaucoma, human immunodeficiency virus/AIDS, multiple sclerosis (MS), Parkinson’s disease, and posttraumatic stress disorder. A total of 198 studies were included after screening for condition-specific relevance and after imposing the following exclusion criteria: preclinical focus, non-English language, abstracts only, editorials/commentary, case studies/series, and non-U.S. study setting. Data extracted from studies included: study design type, outcome definition, intervention definition, sample size, study setting, and reported effect size. Few completed randomized controlled trials (RCTs) were identified. Studies classified as systematic reviews were graded using the Assessing the Methodological Quality of Systematic Reviews-2 tool to evaluate the quality of evidence. Few high-quality systematic reviews were available for most conditions, with the exceptions of MS (9 of 9 graded moderate/high quality; evidence for 2/9 indicating cannabis improved outcomes; evidence for 7/9 indicating cannabis inconclusive), epilepsy (3 of 4 graded moderate/high quality; 3 indicating cannabis improved outcomes; 1 indicating cannabis inconclusive), and chronic noncancer pain (12 of 13 graded moderate/high quality; evidence for 7/13 indicating cannabis improved outcomes; evidence from 6/7 indicating cannabis inconclusive). Among RCTs, we identified few studies of substantial rigor and quality to contribute to the evidence base. However, there are some conditions for which significant evidence suggests that select dosage forms and routes of administration likely have favorable risk-benefit ratios (i.e., epilepsy and chronic noncancer pain). The body of evidence for medical cannabis requires more rigorous evaluation before consideration as a treatment option for many conditions, and evidence necessary to inform policy and treatment guidelines is currently insufficient for many conditions.

scholarly journals Health-Related Quality of Life Impairment Among Patients With Severe Chronic Rhinosinusitis With Nasal Polyps in the SINUS-24 Trial

2021 ◽  
Vol 147 (2) ◽  
pp. AB133
Author(s):  
Jorge Maspero ◽  
Carl Philpott ◽  
Peter Hellings ◽  
Claire Hopkins ◽  
Martin Wagenmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Mucosal Eosinophilia and Neutrophilia Are Not Associated With QOL or Olfactory Function in Chronic Rhinosinusitis

2021 ◽  
pp. 194589242098743
Author(s):  
Nyssa F. Farrell ◽  
Jess C. Mace ◽  
David A. Sauer ◽  
Andrew J. Thomas ◽  
Mathew Geltzeiler ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis ◽  
Cross Sectional Study ◽  
Olfactory Function ◽  
Sinus Surgery ◽  
Small Subset ◽  
Cross Sectional ◽  
Snot 22

Background Chronic rhinosinusitis (CRS) is often differentiated by histopathologic phenotypes (eosinophilic versus neutrophilic), which may impact disease severity measures and outcomes. As such, it has been suggested that counts of cellular elements be included as part of a standard pathological report following endoscopic sinus surgery (ESS). Objectives This cross-sectional study evaluated associations of mucosal eosinophilia and neutrophilia with measures of quality-of-life (QoL) and olfactory function. Methods Patients with medically refractory CRS completed the SNOT-22 survey and Brief Smell Identification Test (BSIT) at enrollment. In addition, baseline Lund-Mackay computed tomography (CT) and Lund-Kennedy endoscopy scores were collected. Ethmoid mucosa was biopsied during ESS and reviewed using microscopy to quantify densest infiltrate of eosinophils or neutrophils per high-powered-field (HPF). Eosinophilic CRS (eCRS) and neutrophilic CRS (nCRS), both with and without nasal polyposis (NP), were compared across SNOT-22 and BSIT scores. Results 77/168 patients demonstrated mucosal eosinophilia (eCRS) while a total of 42/168 patients demonstrated mucosal neutrophilia (nCRS). After adjusting for polyp status, 35/168 had eCRSsNP, 42/168 eCRSwNP, 75/168 non-eCRSsNP, 16/168 non-eCRSwNP. Additionally, 22/161 were noted to have nCRSsNP, 20/161 nCRSwNP, 84/161 non-nCRSwNP, and 35/161 non-nCRSsNP. A small subset of patients demonstrated both eosinophilia and neutrophilia: 14 CRSwNP and 7 CRSsNP. When evaluating average Lund-Mackay Scores (LMS), significant differences existed between non-eCRSsNP and eCRSsNP (p = 0.006). However, after controlling for nasal polyps, eosinophilia did not significantly associate with differences in the Lund-Kennedy Score. Neutrophilia did not significantly associate with any changes in LMS or LKS after controlling for NP. Eosinophilic and neutrophilic histopathologic subtypes did not significantly associate with differences in baseline SNOT-22 or BSIT measures after controlling for NP. Conclusion Neither the presence of mucosal eosinophilia nor mucosal neutrophilia demonstrated significant associations with SNOT-22 quality-of-life or BSIT olfactory function scores when controlling for comorbid nasal polyposis.

scholarly journals CD133, a Progenitor Cell Marker, is Reduced in Nasal Polyposis and Showed Significant Correlations with TGF-β1 and IL-8

2021 ◽  
Author(s):  
Wagner Vargas Souza Lino ◽  
André Luis Lacerda Bachi ◽  
José Arruda Mendes Neto ◽  
Gabriel Caetani ◽  
Jônatas Bussador do Amaral ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Transforming Growth Factor ◽  
Middle Turbinate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Histologic Analysis ◽  
Aspirin Intolerance ◽  
Tgf Β1

Abstract Introduction Combination of chronic inflammation and an altered tissue remodeling process are involved in the development of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Studies demonstrated that mesenchymal stem cells expressing the progenitor gene CD133 were involved in a significant reduction of the chronic inflammatory process in the polypoid tissue. Objective To evaluate the levels of CD133 (Prominin-1) in nasal polypoid tissue and its correlation with interleukin-8 (IL-8) and transforming growth factor β1 (TGF-β1). Methods A total of 74 subjects were divided in the following groups: control group (n = 35); chronic rhinosinusitis with nasal polyps nonpresenting comorbid asthma and aspirin intolerance (CRSwNPnonAI) group (n = 27); and chronic rhinosinusitis with nasal polyps presenting comorbid asthma and aspirin intolerance (CRSwNPAI) group (n = 12). Histologic analysis and also evaluation of the concentration of CD133, IL-8, and TGF-β1 by enzyme-linked immunosorbent assay (ELISA) kits were performed in nasal tissue obtained from nasal polypectomy or from middle turbinate tissue. Results Higher eosinophilic infiltration was found in both CRSwNP groups by histologic analysis. Lower levels of TGF-β1 and IL-8 were observed in both CRSwNP groups when compared with the control group, whereas the CD133 levels were significantly reduced only in the CRSwNPnonAI group compared with the control group. Conclusion It was demonstrated that the nasal mucosa presenting polyposis showed a significant reduction of CD133 levels, and also that this reduction was significantly correlated with the reduction of TGF-β1 levels, but not with IL-8 levels. Therefore, these findings may be involved in the altered inflammatory and remodeling processes observed in the nasal polyposis.

scholarly journals 551 The Impact of Nasal Polyposis on Quality of Life Using the Eq-5d Health Profile

2012 ◽  
Vol 5 ◽  
pp. S175
Author(s):  
Isam Alobid ◽  
Liza Viscovich ◽  
Joan Ramon Montserrat ◽  
Jose Maria Guilemany ◽  
Manuel Bernal-Sprekelsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nasal Polyposis ◽  
Health Profile ◽  
The Impact

Assessment of quality-of-life outcomes after surgery for nasal polyposis with the DyNaChron questionnaire

2014 ◽  
Vol 272 (2) ◽  
pp. 367-375 ◽  
Author(s):  
Duc Trung Nguyen ◽  
Francis Guillemin ◽  
Fabien Arous ◽  
Roger Jankowski
Keyword(s):  
Quality Of Life ◽  
Nasal Polyposis ◽  
Life Outcomes ◽  
Quality Of Life Outcomes

scholarly journals Attributes of a Magnetic work environment, and its relation to work stress among nursing staff at Children’s Cancer Hospital Egypt (CCHE 57357)

2017 ◽  
Vol 6 (1) ◽  
pp. 35
Author(s):  
Sanaa Abdel-Azeem Ibrahem ◽  
Rasha Ibrahim El-Sayed Aly
Keyword(s):  
Work Environment ◽  
Work Stress ◽  
Nursing Staff ◽  
Magnet Hospital ◽  
Organizational Attributes ◽  
Correlational Design ◽  
Cancer Hospital ◽  
The Status ◽  
Study Setting

Background: The Magnet hospital is the hospital that implements specific organizational attributes in order to achieve a high quality of care through well-qualified and committed nursing staff.Aim of the study: The study was aimed at studying attributes of the Magnetic work environment, and its relation to work stress among nursing staff.Methods: Setting: It was carried out in the children’s cancer hospital, Egypt. Design: Using a descriptive correlational design. Subjects: Consisted of 172 nursing staff. Tools and procedure: two different self-administered tools were utilized (Magnet attributes questionnaire, and stress questionnaire). The fieldwork lasted from April to July 2016.Results: The study revealed that the highest percentage of nursing staff aged between 20 and 30 years. Nearly two thirds (64%) were having a bachelor degree in nursing. Total attributes of work environment were available with strength. 96.6% of nursing staff recorded low scores of stress.Conclusions: The nursing staff in the study setting considered “total attributes of Magnet work environment” as an area of strength. The total scores of stress were generally low. Statistically significant negative correlations were revealed between the scores of total Magnet attributes and stress.Recommendations: It is a matter of priority for Egyptian children’s cancer hospital to enhance and promote the development and maintenance of Magnetism and taking the lead in promoting the status of Magnetism in Egypt.

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