scholarly journals Reproductive Hormone in Transfusion dependent βeta thalassemia major patients.

2019 ◽  
Vol 26 (12) ◽  
pp. 2179-2183
Author(s):  
Sana Fatima Baloch ◽  
Ikram Din Ujjan ◽  
Sadia Shahmeer ◽  
Nazia Hafeez ◽  
Kiran Amir ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
P Value ◽  
Transfusion Rate ◽  
Cross Sectional ◽  
Endocrine Profile ◽  
History Of ◽  
Study Setting

Objective: To evaluate endocrine profile in transfusion dependent beta-thalassemia major patients. Study Design: Descriptive cross sectional study. Setting: Department of Pathology Liaquat University of Medical and Health Sciences, Jamshoro /Hyderabad and Thalassemia Centre Hyderabad. Period: 6 months from January 2018 to June 2018. Material & Methods: Cases already diagnosed with β- thalassemia major with recurrent blood transfusions (>20 transfusions or transfusion period over 2 years) both genders were included. All the patients went through routine laboratory checkups including Testosterone hormone, Luteinizing Hormone, and Follicle Stimulating Hormone. Data was recorded in preplanned proforma. Results: Overall 114 subjects were studied and their mean age was found to be 12.38+5.71 years. Females remained in majority as 56.1%. Mean of follicle stimulate hormone (FSH) and luteinizing hormone (LH) level were 4.60+4.88 and 5.39+8.39 respectively. Most of the patients, 35.1% had >300 of transfusion rate. Ferritin levels were significantly correlated with patients with history of transfusion rate >300; p-value 0.003. Testosterone level’s mean was considerably high among patients presented with transfusion rate of 201 to 300 and >300 transfusions; p-value 0.006. Likewise, mean of FSH and LH level was as well significantly high among the female subjects with history of transfusion rate of 201 to 300 and >300 transfusions; P-Values 0.019 and 0.026 respectively. Conclusion: Frequent hypogonadism was noted among thalassemia patients. Very low level average of FSH, LH and testosterone was seen.

Investigation of Pancreatic Sonography Findings in Patients With Beta-Thalassemia Major

2021 ◽  
pp. 875647932198966
Author(s):  
Razieh Behzadmehr ◽  
Iraj Shahramian ◽  
Pouya Ostad Rahimi ◽  
Mahboobeh Sheikh ◽  
Soosan keikha ◽  
...  
Keyword(s):  
Statistical Tests ◽  
Pancreatic Head ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Cross Sectional ◽  
Beta Thalassemia Major

Objective: Some structural abnormalities have been reported on sonography of pancreas in patients with beta-thalassemia which can indicate that the patient is developing diabetes. In this study, the aim was to investigate the findings of pancreatic sonography in patients, with beta-thalassemia major. Methods: This cross-sectional study included information extracted from the medical record and entered into an information form. A cohort of 190 people were split into case and control groups, retrospectively. The required data were extracted from patient’s documents. Data were analyzed with SPSS software, version 22; with the chi-square statistical tests. A P value of < .05 was considered statistically significant. Results: This study consisted of 33 males and 61 females in the case group and 32 males and 64 females in the control group. The most common echogenicity observed during pancreatic sonography, in the control group, was an isoechoic feature (72.3%), followed by hyper and hypoechogenicity (18.1% and 9.6%, respectively). The prevalence of an isoechoic texture in the patient case group was 58.3%, while hyper and hypoechogenicity were seen in 26% and 2.1%, respectively ( P = .070). There was a poor negative correlation between diabetes and pancreatic echogenicity ( P = .002 and r = −.226). Also, there was a poor positive correlation between fasting serum glucose levels and pancreatic echogenicity ( P = .034, n = 96 and r = .217). Conclusion: This study demonstrates, in this patient group, that there was a poor relationship between pancreatic head size with serum ferritin levels and pancreatic echogenicity with diabetes. These results may suggest using sonography to diagnose early stages of diabetes in patients with thalassemia.

scholarly journals PATIENTS WITH SUICIDE ATTEMPT

2015 ◽  
Vol 22 (10) ◽  
pp. 1321-1326
Author(s):  
Jamil Junejo ◽  
Badaruddin Junejo ◽  
Inayatullah Awan ◽  
Asma Perveen
Keyword(s):  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Family Issues ◽  
Younger Age ◽  
History Of ◽  
Age Range ◽  
Study Setting ◽  
Status Level

Objective: To determine the demographic details (gender, age, marital status,level of education, and occupation) of suicide attempters attending the tertiary care hospitalservices at Hyderabad, Pakistan. Study Design: Cross sectional study. Setting: Liaquat universityhospital Hyderabad and Sir Cowasjee Jahangir Institute of psychiatry (CIJP) Hyderabad.Period: Twelve months from the 1st January 2011 to 31st December 2011. Methodology:The aim of the study was. Patients with a history of attempted suicide. Two hundred (200)consecutive cases were recruited and selected according to the inclusion criteria. An informedconsent was obtained from patients for being included in the study. A specially designed semistructuredProforma was used to record demographic details of the patients. Data were enteredinto and analyzed through statistical software SPSS version 20. Results: Total 200 hundredcases were included in the study. Males 78.5 % (N=157) outnumbered female patients 21.5% (N= 43). The age range of study subjects was between 15 -59 years. Mean age of the totalcases was 22.6 years. Majority of the patients presenting with suicide were single comprising61 % (N= 122) of study cases with a P value < 0.001. Total cases of married subjects were 27.5% (N= 55) with a P value < 0.001. While 5.5% subjects were separated and 6 % were divorced.Unskilled labors made the largest group comprising of 24.5 % (N=49) of all the cases. Otheroccupations included farmers (15.5 %), skilled labor (15%), jobless (11.5%), house wives (8.5%), students (7 %), and shopkeepers (6%). Out of the total 200 patients with attempted suicide32% were illiterate, 33.5 % were educated up to primary level, 19.5% were matriculate, 09 %were intermediate passed, and only 6 % were graduate. (Table-II). Conclusion: In Pakistan stillSuicide attacks are reported. Our results suggest that suicidal thoughts can be entirely predictby common reported in male and younger age due to very sensitive to family issues, lowereducation level and major depression due to unemployment or low level earning of unskilledlabor occupation in the Pakistan population.

scholarly journals A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

2008 ◽  
Vol 28 (5) ◽  
pp. 361 ◽  
Author(s):  
Farzad Najafipour ◽  
Akbar Aliasgarzadeh ◽  
Naser Aghamohamadzadeh ◽  
Amir Bahrami ◽  
Majid Mobasri ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Endocrine Complications

scholarly journals Diagnostic, therapeutic and prognostic aspects of uterine synechiae managed by hysteroscopy in the gyanecological endoscopic surgery and human reproductive teaching hospital

2017 ◽  
Vol 7 (1) ◽  
pp. 56
Author(s):  
Etienne Belinga ◽  
Isidore Tompeen ◽  
Claude Cyrille Noa Ndoua ◽  
Junie Metogo Ntsama ◽  
Sandrine Mendibi ◽  
...  
Keyword(s):  
Past History ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Qualitative Variables ◽  
Preoperative Diagnostic ◽  
Chi Square Test ◽  
Human Reproductive ◽  
History Of

Background: Uterine synechiae refers to a total or partial union of the inner walls of the uterus resulting from endometrial trauma. It is a cause of reproductive failure. Until now, synechia was not optimally treated and has remained understudied in Cameroon. Objective of present study was to Evaluate the diagnostic, therapeutic and prognostic aspects of uterine synechiae treated by hysteroscopy.Methods: We conducted a descriptive cross-sectional study with an analytical component from January 1st 2015 to July 31st 2017 at Yaounde. All patients diagnosed with uterine synechiae and treated with hysteroscopy were our sample. Sampling was consecutive. The chi-square test was used for the comparison of qualitative variables and Fisher's test for ANOVA variance analysis. The comparison of the averages was made by the Student's test. P-value less than 0.05 was considered as statistically significant.Results: Hysteroscopies were indicated for uterine synechiae in 14.50%. Nulliparous were 56.67%. A history of curettage/aspiration was present in 66.66%. All of the patients had a form of infertility and 83.33% had menstrual disorders. Hysterosalpingography showed a better sensitivity (88%). After hysteroscopic treatment, 63.30% had a complete anatomical restitution. There is a significant correlation between the stage of severity of synechia and anatomical restitution (p=0.008; Spearman correlation coefficient=-0.477).Conclusions: Uterine synechiae represent one-sixth of all indications for hysteroscopy and present clinically as menstrual disorder associated with infertility. A past history of uterine curettage is common. Hysterosalpingography has a better preoperative diagnostic sensitivity. Hysteroscopy allows optimal treatment.

scholarly journals Recurrent Miscarriage and Consanguinity among Omani Women– A Cross Sectional Study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Fatma Al Hoqani ◽  
Wadha Al Ghafri ◽  
Saneya El tayeb ◽  
Yahya Al Farsi ◽  
Vaidyanathan Gowri
Keyword(s):  
Recurrent Miscarriage ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Recurrent Miscarriages ◽  
Sultan Qaboos University ◽  
Chi Squared ◽  
History Of

Objective: to determine the prevalence of explained and unexplained recurrent miscarriages (RM) and to find out if there is a significant relationship between recurrent miscarriages and consanguinity. Methods: A cross sectional in which the cases group included all women with RM attending the outpatient clinic at Sultan Qaboos University Hospital from July 2006 to April 2012 and the controls group included women with no history of RM after matching them with cases for age (case to control ratio was 1:1). The main outcome measures were the prevalence of consanguinity in women with or without recurrent miscarriages. Results: During study period a total of 290 women with RM were seen. Of which, 150 (51.7%) women had unexplained RM. Control group with no history of RM were 300 women. Consanguinity rate among cases (49.5%) %) was less than the controls (52.7 %%). Both first cousin and second cousin marriages were more common in the controls than the cases and it was not statistically significant (p value 0.476, chi squared test). Conclusion: In this study we found that more than half of RM cases were unexplained and there was no significant association between RM and consanguinity.

scholarly journals OVARIAN MALIGNANCY

2018 ◽  
Vol 25 (02) ◽  
pp. 237-241
Author(s):  
Shabana Rafiq ◽  
Razia Bibi ◽  
Samina Ashraf
Keyword(s):  
Cross Sectional Study ◽  
Reproductive Age ◽  
Ovarian Malignancy ◽  
Ovarian Mass ◽  
Sectional Study ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of ◽  
Study Setting

Objectives: To determine the frequency of ovarian malignancy in women ofreproductive age presenting with ovarian mass and to determine frequency of factors leadingto ovarian malignancy. Study Design: Cross sectional study. Setting: Department of Obstetrics& Gynaecology, Lady Wallington Hospital, Lahore. Period with Dates: From 05.11.11 to26.06.12. Results: The result of our study reveals majority of the patients between 21-30 yearsi.e. 45.88%(n=39), common age was 24.21+3.76 years, 43.53%(n=37) were nulliparous (inmajority), while frequency of ovarian malignancy in women of reproductive age presenting withovarian mass was recorded in 14.11%(n=12) while frequency of factors leading to ovarianmalignancy was 91.67%(n=11) patients were nulliparous while family history of ovarianmalignancy was in 8.33%(n=1) patients. Conclusions: The frequency of ovarian malignancy ishigher among reproductive age females with increased risk of nulliparity.

scholarly journals Serum IGF-1 and short stature in adolescents with beta-thalassemia major

2018 ◽  
Vol 58 (4) ◽  
pp. 151-8 ◽  
Author(s):  
Monalisa Elizabeth ◽  
Eddy Fadlyana ◽  
Lelani Reniarti ◽  
Faisal Faisal ◽  
Hadyana Sukandar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Short Stature ◽  
Family Income ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Growth Chart ◽  
Chi Square ◽  
Cross Sectional ◽  
Beta Thalassemia Major

Background The  prevalence  of  short  stature  in  thalassemia  patients ranges from 39.3 to 65%.  The  cause  of short stature is complex  and  still up for debate.  In  Indonesia, data on the  prevalence  and risk  factors  of  short  stature  in  adolescents  with  thalassemia  have been limited. Objective To assess for the prevalence and risk factors of short stature in adolescents with beta-thalassemia major. Methods This cross-sectional study was done from February to March 2017 at the Thalassemia Clinic at Dr. Hasan Sadikin General Hospital, Bandung. The baseline characteristics data of 80 adolescents with thalassemia aged 10-14 years were recorded. Short stature was assessed by height-for-age, (Z-score <-2SD) based on the 2007 WHO Reference Growth Chart. Mid-upper arm circumference was scored according to age and sex and serum IGF-1 was measured by ELISA method. Data analyses used were Chi-square, Fisher’s, and Mann-Whitney tests. Logistic regression model was used to further analyze for risk factors of short stature. Results Subjects were 40 males and 40 females, 81.2% of whom had short stature. The mean serum IGF-1 level was 32.2 (SD 26.38) ng/mL. The IGF-1 cut-off point by ROC curve was £38.51 ng/mL, with sensitivity of 64.4% and specificity of 86.7%. The risk factors of short stature were IGF-1 level £38.51 ng/mL (PR 40.66; 95%CI 4.37 to 377.58; P<0.001) and low family income (PR 19.76; 95%CI: 1.152 to 256.08; P=0.022). Conclusion IGF-1 level may be useful as a predictor of short stature in adolescent beta-thalassemia major patients.

scholarly journals Hemoglobin profiles of siblings of thalassemia patients

2015 ◽  
Vol 55 (2) ◽  
pp. 70
Author(s):  
Muhammad Riza ◽  
Septin Widiretnani
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Mean Corpuscular Hemoglobin ◽  
Carrier Status ◽  
Corpuscular Hemoglobin ◽  
Inherited Disorders ◽  
Cross Sectional ◽  
Hemoglobin E ◽  
History Of ◽  
Complete Blood Counts

Background Thalassemia and hemoglobinopathies are themost common inherited disorders in many areas of the world,including South East Asia. The siblings of thalassemia major is agroup of high risk to carry the gene of thalassemia. Determiningthe carrier is useful for early treatment planning and preventionto the next child.Objective To determine carrier status among siblings ofthalassemia patients using a capillary electrophoresis system.Methods A cross-sectional study on the siblings of thalassemiamajor patients was performed from January 2011 to February2012 at Dr. Moewardi Hospital. Complete blood counts wereperformed in the siblings. Subjects with mean corpuscular volume(MCV) <80 fl and mean corpuscular hemoglobin (MCH) <27pg were subjected to analize hemoglobin fraction by capillaryelectrophoresis.Results Of the 26 subjects, there were 12 males and 14 females.The mean age was 9.38 (SD 6.8) years (range 1 to 29 years). Fromthe siblings, 10 were identified as normal, 5 were identified as ßthalassemia carriers and 5 were hemoglobin E (HbE) carriers. Sixsiblings were diagnosed with ß thalassemia/ HbE.Conclusion There are high occurrence of the two common typesof thalassemia carriers (ß and HbE) in our small group of subjectswho had a family history of thalassemia. Most of the siblingsof thalassemia had low MCV and MCH. 

scholarly journals Renal damages in patients with major β-thalassemia

2019 ◽  
Vol 9 (1) ◽  
pp. e02-e02
Author(s):  
Malihe Najafpour ◽  
Majid Farshdousti-Hagh ◽  
Ali Akbar Movasagpoor-Akbari ◽  
Abbas-Ali Hosein-Pour Feyzi ◽  
Majid Malaki
Keyword(s):  
Renal Function ◽  
Renal Dysfunction ◽  
Urine Analysis ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Iron Chelators ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthy Control

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

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