scholarly journals Hubungan Antara Kontrol Glikemik (HBA1C), Durasi Penyakit, dan Profil Lipid Pada Pasien Diabetes Melitus Tipe II Dengan Kejadian Neuropati Diabetik: Scoping Review

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Salma Kautsar Rachman ◽  
Eka Hendryanny ◽  
Tryando Bhatara
Keyword(s):  
Glycemic Control ◽  
Diabetic Neuropathy ◽  
Lipid Profile ◽  
Scoping Review ◽  
Lipid Profiles ◽  
Duration Of Diabetes ◽  
High Prevalence ◽  
Hba1c Control ◽  
Review Systematic ◽  
Diabetes Melitus

Diabetes melitus merupakan penyakit gangguan metabolik kronik yang menjadi salah satu penyakit dengan prevalensi dan insidensi tinggi setiap tahun di seluruh dunia, termasuk di Indonesia. Penyakit ini menjadi masalah yang lebih serius ketika terjadi komplikasi mikroangiopati dan makroangiopati, salah satunya neuropati diabetik. Neuropati diabetik dapat terjadi karena berbagai faktor, antara lain kontrol glikemik yang buruk, durasi penyakit, dan kadar profil lipid yang abnormal. Penelitian bertujuan mengetahui hubungan kontrol HbA1c, durasi menderita diabetes, dan profil lipid dengan kejadian neuropati diabetik. Pencarian sistematis scoping review menggunakan 12 laporan penelitian yang diperoleh dari beberapa database jurnal, yaitu PubMed dan Science Direct yang dilakukan pada bulan Oktober — Desember 2020. Hasil yang didapatkan adalah dari 6 laporan penelitian yang melaporkan hubungan antara HbA1c dan kejadian neuropati diabetik. Didapatkan 5 laporan penelitian yang melaporkan hubungan antara durasi menderita diabetes dan kejadian neuropati diabetik. Didapatkan 4 laporan penelitian yang melaporkan hubungan antara profil lipid dan kejadian neuropati diabetik. Simpulan dari 12 laporan penelitian tersebut adalah terdapat hubungan kontrol glikemik, durasi menderita diabetes, dan profil lipid dengan kejadian neuropati diabetik. Relationship Between Glycemic Control (HBA1C),Disease Duration, and Lipid Profile and Diabetic Neuropathy of Type II Type Diabetes Mellitus Patients: Scoping ReviewDiabetes is a chronic metabolic disorder which is a disease with a high prevalence and incidence every year throughout the world, including in Indonesia. This disease becomes a more serious problem when there are complications, one of which is diabetic neuropathy. Diabetic neuropathy can occur due to various factors, including poor glycemic control, duration of diabetes, and abnormal levels of lipid profiles. This study aims to determine the relationship between HbA1c control, duration of diabetes, and lipid profile with the incidence of diabetic neuropathy. The scoping review systematic search used 12 research reports obtained from several journal databases, such PubMed and Science Direct lasts from October to November 2020. The results of the articles is there were 6 research reports that reported an association between glycemic control and the incidence of diabetic neuropathy. There were 5 research reports that reported an association between the duration of suffering from diabetes and the incidence of diabetic neuropathy. There were 4 research reports that reported an association between lipid profiles and the incidence of diabetic neuropathy. The conclusions of the 12 research reports are there is an association of glycemic control, duration of diabetes, and lipid profile with the incidence of diabetic neuropathy.

scholarly journals Evaluation of Microalbuminuria and Glycosylated Hemoglobin in the Assessment of Diabetes Control in Children with Type 1 Diabetes Mellitus Hospitalized with Diabetic Ketoacidosis

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Saiprasad Onkareshwar Kavthekar ◽  
Vijay Tukaram Mali ◽  
Sachin Verma ◽  
Anil Bapurao Kurane ◽  
Nivedita Balasaheb Patil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
Duration Of Diabetes ◽  
Hba1c Control

Background: Microalbuminuria is thought to be an early predictor of impending diabetic nephropathy, while glycosylated hemoglobin (HbA1c) is a biochemical marker of long-term glycemic control in children with type 1 diabetes mellitus (T1DM). Objectives: The study aimed to evaluate the prevalence of microalbuminuria and its association with HbA1c on admission and duration of diabetes. Also, changes in HbA1c level on admission and three months after admission were studied to assess diabetes control in children with T1DM. Methods: This prospective study was conducted among 38 children (< 18 years) diagnosed with TIDM presenting with clinical signs, symptoms, and biochemical parameters of DKA. The presence of microalbuminuria, HbA1c level, and the number of past episodes of DKA were recorded. HbA1c level was again estimated after three months. The resultant data was tabulated and analyzed statistically (P < 0.05). Results: Microalbuminuria and poor HbA1c control were observed in 18% and 60% of the sample population, respectively. A significant association was found between HbA1c > 9% (P = 0.032) and the duration of diabetes > 4 years (P = 0.032) and microalbuminuria. Significant improvement in glycemic control was noted from the time of admission to three months after admission (9.76 ± 2.77 vs. 7.75 ± 1.28; P = 0.00012). A significant difference was observed between past DKA episodes according to HbA1c control (P < 0.001). Conclusions: Microalbuminuria assessment is needed in T1DM children, especially those with HbA1c > 9% and duration of diabetes > four years, to evaluate diabetic nephropathy. Good glycemic control can be achieved with effective insulin therapy accompanied by appropriate counseling and regular follow-up.

scholarly journals Lipid Profile, Blood Glucose Level and Body Mass Index (BMI) in Second Trimester of Pregnancy: Screening with Gestational Diabetes

1970 ◽  
pp. 34-43
Author(s):  
Donny S. Winardo ◽  
John J. E. Wantania ◽  
Suzanna P. Mongan
Keyword(s):  
Body Mass Index ◽  
Gestational Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Body Mass ◽  
Lipid Profiles ◽  
Fasting Blood Sugar ◽  
Second Trimester ◽  
Diabetes Melitus

Abstract Objective: To find out lipid profile data, blood sugar and Body Mass Index in trimester II pregnancy to the incidence of pregnancy with diabetes mellitus. Methods: This study is a cross sectional study. The number of samples obtained was 42 samples where all were taken in the second trimester. Samples taken from RSUP Prof. Dr. R. D. Kandou Manado and networking hospitals around Manado that meet the inclusion and exclusion criteria. All patient patients were explained about the research procedure and the signing of consent information. Blood samples were taken for examination of blood sugar (fasting blood sugar and 2 hours post-prandial blood sugar) and lipid profiles (total cholesterol, HDL, LDL, triglycerides). After the data is collected, it is included in the SPSS version 22.0 program for data analysis. Results: Found 2 subjects (4.76%) who had abnormal fasting blood sugar and found 4 subjects (9.53%) who had abnormal 2-prandial 2-hour blood sugar. For lipid profiles, it was found 16 subjects (38.1%) who had abnormal total cholesterol levels, for LDL there were 13 subjects (30.96%) who had abnormal levels, for HDL there were 4 subjects (11.9%) who had abnormal levels and for triglycerides there were 23 subjects (54.76%) who had abnormal levels. There was a significant negative correlation between LDL cholesterol and fasting blood sugar (p = 0.002; r = - 0.455), and so did total cholesterol with fasting blood sugar (p = 0.047; r = - 0.302). There was a significant correlation between BMI and total cholesterol (p = 0.013; r = 0.371). There was 1 subject (2.38%) diagnosed with gestational diabetes melt and fasting blood sugar at 190 mg / dL, for prandial 2 hours post blood sugar at 309 mg / dL and for triglycerides at 617 mg / dL. Conclusions: Based on this study found the incidence of gestational diabetes mellitus 2.38% of all trimester II pregnancies. There is a positive but not significant correlation between blood sugar and triglycerides, whereas there is no significant relationship between blood sugar and other lipid profiles. There is a positive but not significant correlation of BMI in trimester pregnancy with total cholesterol. Keywords: Blood sugar, Body Mass Index (BMI), lipid profile Abstrak Tujuan: Untuk mengetahui data profil lipid, gula darah dan Indeks Massa Tubuh pada kehamilan trimester II terhadap kejadian kehamilan dengan diabetes melitus. Metode: Studi ini merupakan studi potong lintang. Jumlah sampel yang didapatkan sebesar 42 sampel di mana seluruhnya diambil pada trimester II. Sampel diambil dari RSUP Prof. Dr. R. D. Kandou Manado dan rumah sakit jejaring sekitar Manado yang memenuhi kriteria inklusi dan eksklusi. Semua pasien-pasien dijelaskan mengenai prosedur penelitian dan penandatanganan inform consent baru dilakukan pengambilan sampel darah untuk pemeriksaan gula darah (gula darah puasa dan gula darah 2 jam postprandial) dan profil lipid (Kolesterol total, HDL, LDL, Trigliserida). Setelah data dikumpulkan, maka dimasukkan ke dalam program SPSS versi 22.0 untuk data analisis. Hasil: Ditemukan 2 subjek (4,76%) yang memiliki gula darah puasa abnormal dan ditemukan 4 subjek (9.,53%) yang memiliki gula darah 2 jam postprandial yang abnormal. Untuk profil lipid, ditemukan 16 subjek (38,1%) yang memiliki kadar kolesterol total abnormal, untuk LDL ditemukan sebanyak 13 subjek (30,96%) yang memiliki kadar abnormal, untuk HDL ditemukan 4 subjek (11,9%) yang memiliki kadar abnormal dan untuk trigliserida ditemukan 23 subjek (54,76%) yang memiliki kadar abnormal. Terdapat korelasi negatif signifikan antara kolesterol LDL dengan gula darah puasa (p = 0,002 ; r = – 0,455), dan begitu juga dengan kolestrol total terhadap gula darah puasa (p = 0,047 ; r = – 0,302). Terdapat korelasi signifikan antara IMT dengan kolesterol total (p = 0,013 ;r = 0,371). Terdapat 1 subjek (2,38%) yang terdiagnosis diabetes melitus gestasional di mana gula darah puasa sebesar 190 mg/dL, untuk gula darah 2 jam postprandial sebesar 309 mg/dL dan untuk trigliserida sebesar 617 mg/dL. Kesimpulan: Berdasarkan penelitian ini ditemukan kejadian diabetes melitus gestasional 2,38% dari seluruh kehamilan trimester II. Terdapat korelasi positif tetapi tidak bermakna antara gula darah dengan trigliserida, sedangkan tidak terdapat hubungan bermakna antara gula darah dengan profil lipid lainnya. Terdapat korelasi positif tetapi tidak bermakna IMT pada kehamilan trimester dengan kolestrol total. Kata kunci: gula darah, Indeks Massa Tubuh (IMT), profil lipid

1514-P: Suboptimal Glycemic Control and High Prevalence of Diabetes Complications in Adults with Type 1 Diabetes (T1D) in the SAGE Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1514-P ◽  
Author(s):  
ERIC RENARD ◽  
ZSOLT BOSNYAK ◽  
FELIPE LAUAND ◽  
PAOLO POZZILLI ◽  
HIROSHI IKEGAMI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Diabetes Complications ◽  
High Prevalence

The Effects of Coenzyme Q10 Supplementation on Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials

2018 ◽  
Vol 24 (23) ◽  
pp. 2729-2742 ◽  
Author(s):  
Nasrin Sharifi ◽  
Reza Tabrizi ◽  
Mahmood Moosazadeh ◽  
Naghmeh Mirhosseini ◽  
Kamran B. Lankarani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lipid Profile ◽  
Coenzyme Q10 ◽  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Meta Analysis ◽  
Lipid Profiles ◽  
Controlled Trials ◽  
Serum Triglycerides ◽  
Coq10 Supplementation

Background and objective: Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though findings are controversial. The aim of this systematic review and meta-analysis was to determine the effects of CoQ10 supplementation on lipid profile in patients with metabolic disorders. Methods: We searched PubMed, EMBASE, Web of Science and Cochrane Library databases until July 2017. Prospective clinical trials were selected assessing the effect of CoQ10 supplementation on different biomarkers. Two reviewers independently assessed the eligibility of studies, extracted data, and evaluated the risk of bias of included studies. A fixed- or random-effects model was used to pool the data, which expressed as a standardized mean difference with 95% confidence interval. Heterogeneity was measured using a Q-test and with I2 statistics. Results: A total of twenty-one controlled trials (514 patients and 525 controls) were included. The meta-analysis indicated a significant reduction in serum triglycerides levels (SMD -0.28; 95% CI, -0.56, -0.005). CoQ10 supplementation also decreased total-cholesterol (SMD -0.07; 95% CI, -0.45, 0.31), increased LDL- (SMD 0.04; 95% CI, -0.27, 0.36), and HDL-cholesterol levels (SMD 0.10; 95% CI, -0.32, 0.51), not statistically significant. Conclusion: CoQ10 supplementation may significantly reduce serum triglycerides levels, and help to improve lipid profiles in patients with metabolic disorders. Additional prospective studies are recommended using higher supplementation doses and longer intervention period.

Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics

2019 ◽  
Vol 15 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Eric Francelino Andrade ◽  
Víviam de Oliveira Silva ◽  
Débora Ribeiro Orlando ◽  
Luciano José Pereira
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Skeletal Muscle ◽  
Glycemic Control ◽  
Sedentary Lifestyle ◽  
World Population ◽  
Pharmacological Interventions ◽  
High Prevalence ◽  
The World ◽  
Main Factors

Introduction: Diabetes mellitus is a metabolic disease characterized by high glycemic levels for long periods. This disease has a high prevalence in the world population, being currently observed an increase in its incidence. This fact is mainly due to the sedentary lifestyle and hypercaloric diets. Non-pharmacological interventions for glycemic control include exercise, which promotes changes in skeletal muscle and adipocytes. Thus, increased glucose uptake by skeletal muscle and decreased insulin resistance through modulating adipocytes are the main factors that improve glycemic control against diabetes. Conclusion: It was sought to elucidate mechanisms involved in the improvement of glycemic control in diabetics in front of the exercise.

scholarly journals Correlation Between Lipid Profile with Type 2 Diabetes Mellitus Progression

2020 ◽  
Vol 8 (2) ◽  
pp. 66-72
Author(s):  
Angiesta Pinakesty ◽  
Restu Noor Azizah
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Cholesterol Levels ◽  
Type 2 Dm ◽  
Hba1c Levels

Introduction: Diabetes mellitus (DM) is a non-communicable disease that has increased from year to year. Type 2 diabetes mellitus is not caused by lack of insulin secretion, but is caused by the failure of the body's cells to respond to the hormone insulin (insulin resistance). Insulin resistance was found to be a major contributor to atherogenic dyslipidemia. Dyslipidemia in DM risks 2 to 4 times higher than non-DM. Although dyslipidemia has a great risk for people with type 2 diabetes mellitus, this conventional risk factor only explains a portion (25%) of excess cardiovascular risk in type 2 DM. Discussion: In uncontrolled type 2 DM patients, LDL oxidation occurs faster which results from an increase in chronic blood glucose levels. Glycemic control as a determinant of DM progressivity is determined through HbA1c examination. HbA1c levels are associated with blood triglyceride levels. Meanwhile, triglyceride levels are associated with total cholesterol and HDL cholesterol levels. HbA1c levels are also associated with LDL cholesterol levels. Conclusion: There is a relationship between lipid profile and the progression of type 2 diabetes mellitus.   Keywords: type 2 diabetes mellitus, dyslipidemia, HbA1c, glycemic control, lipid profile

scholarly journals Efektivitas Mobile Health Intervention Terhadap Manajemen Diri Dan Kontrol Glikemik Pada Pasien Dengan Diabtes Melitus Tipe 2: A Systematic Review

2020 ◽  
Vol 11 (4) ◽  
pp. 342
Author(s):  
Wahyu Sukma Samudera ◽  
Novita Fajriyah ◽  
Ida Trisnawati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Mobile Health ◽  
Controlled Trial ◽  
Health Intervention ◽  
Self Management ◽  
Diabetes Melitus

Background: Type 2 diabetes mellitus was one of non-communicable diseases that increased of prevalence in word wide, included in Indonesia. Utilization of technology as an effort of increase of diabetes treatment is important for achieving of optimum glycemic control and to prevent of complication of diabetes mellitus. However, intervention for self management in patients with diabetes mellitus at this time still not using technology based mobile health intervention. Purpose: This study aims to verify of effectiveness of mobile health intervention on self management and glycemic control in patient with type 2 diabetes mellitus. Method: Design of this studies was used systematic review of randomized controlled trial with PRISMA approach. Article search was carried out through databases: Scopus, Science Direct, and ProQuest with randomized controlled trial design within last 10 years. Results: The finding showed 407 articles have been obtained. Articles selection process were through few steps: topic selection, full text selection, design of studies and obtained 10 articles have been as appropriate of inclusion criteria. Based on results of finding of 10 articles were showed that mobile health intervention was effective in improving of glycemic control by decreasing hbA1c, fasting blood glucose, 2 hours post pandrial. Furthermore, mobile health intervention was effective in increasing of self management in patient with type 2 diabetes mellitus and increased adherence of diabetes medication. Moreover, mobile health intervention can also improve of insulin level and lipid profile in patient with type 2 diabetes mellitus. Conclusion: Mobile health intervention was effective in improving of glycemic control and self management, and giving of facilitate communication between patient and health providers Keywords: mobile health application; self management; glycemic control; diabetes mellitus ABSTRAK Latar belakang: diabetes melitus (DM) tipe 2 merupakan salah satu penyakit tidak menular yang mengalami peningkatan angka kejadian di dunia, termasuk di Indonesia. Penggunaan teknologi sebagai upaya meningkatkan manajemen diabetes melitus sangatlah penting untuk dilakukan guna mencapai kontrol glikemik optimal dan mencegah komplikasi dari Diabetes Melitus. Namun, manajemen diri pada sebagian besar pasien Diabetes Melitus saat ini masih belum menggunakan bantuan teknologi berbasis mobile health. Tujuan: Penelitian ini bertujuan untuk memverifikasi efektivitas dari penggunaan mobile health intervention terhadap manajemen diri dan kontrol glikemik pasien dengan diabetes melitus tipe 2. Metode: desain dalam penelitian ini adalah systematic review dengan menggunakan pendekatan PRISMA. Pencarian artikel dilakukan pada beberapa database yang meliputi: Scopus, Science Direct dan ProQuest dengan desain Randomized controlled trial dalam 10 tahun terakhir. Hasil: hasil temuan didapatkan sejumlah 407 artikel penelitian. Proses seleksi artikel dilakukan beberapa tahap meliputi: seleksi topik, fullteks, desain artikel penelitian dan didapatkan 10 artikel penelitian yang sesuai dengan kriteria inklusi. Berdasarkan hasil temuan dari 10 artikel penelitian yang digunakan, menunjukkan bahwa mobile health intervention efektif dalam memperbaiki kontrol glikemik pasien diabetes melalui penurunan kadar hbA1c, gula darah puasa, 2 jam post pandrial. Selanjutnya, mobile health intervention efektif dalam meningkatkan manajemen diri pasien diabetes dan meningkatkan kepatuhan pengobatan. Selain itu, mobile health intervention juga dapat memperbaiki level insulin dan profil lipid pasien diabetes melitus tipe 2. Kesimpulan: Mobile health intervention efektif dalam memperbaiki kontrol glikemik dan meningkatkan manajemen diri pasien diabetes melitus serta memudahkan komunikasi antara pasien dengan tenaga kesehatan Kata kunci: mobile health application; manajemen diri; kontrol glikemik; diabetes melitus

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