scholarly journals Multiparity as a risk factor for congenital toxoplasmosis: a cross-sectional study

Author(s):  
Priscilla Vilela dos Santos ◽  
Débora Nonato Miranda de Toledo ◽  
Bianca Alves Almeida Machado ◽  
Zolder Marinho Silva ◽  
Valter Ferreira de Andrade-Neto ◽  
...  
Author(s):  
Alessandro Borghi ◽  
Monica Corazza ◽  
Elisa Maietti ◽  
Cataldo Patruno ◽  
Maddalena Napolitano ◽  
...  

Background: Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel contained in make-ups remains controversial. Objective: The study aimed to assess the association between nickel allergy, the use of pigmented makeup products and self-reported eyelid dermatitis. Method: This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis. Among the patients, any co-sensitization to cosmetics or metals was recorded. Results: 87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and 52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences. The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products, both in general and considering each product separately. Age, atopy, or co-sensitization to other metals or cosmetics did not affect the occurrence of eyelid dermatitis. Conclusion: Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant action.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Abbas Alshami ◽  
Nasam Alfraji ◽  
Steven Douedi ◽  
Swapnil Patel ◽  
Mohammad Hossain ◽  
...  

An amendment to this paper has been published and can be accessed via the original article.


2020 ◽  
Author(s):  
Rajan Shrestha ◽  
Bijay Khatri ◽  
Madan P. Upadhyay ◽  
Janak R. Bhattarai ◽  
Manish Kayastha ◽  
...  

Abstract BackgroundObesity has become a global epidemic and an important risk factor for non-communicable diseases. Earlier thought to be a problem of developed world, it has now become a problem of low- and middle-income countries like Nepal. In absence of a routine surveillance or a registry system, the actual burden and trend of obesity in Nepal is unknown. Obesity and overweight are recognized risk factors for hypertension and associated with cardiovascular disease. The aim of the study was to find out burden of obesity, using three commonly employed metrics in hospital outpatient setting of a low-income country as predictors of hypertension, and compare ability of different anthropometric measurements through a non-inferiority study to predict hypertension.MethodsThis cross-sectional study was conducted among 40-69 years outpatients in a tertiary Eye and ENT hospital in a semi-urban area of Nepal among randomly selected 2,256 participants from 6,769 outpatients who were evaluated in Health Promotion and risk factor screening service. We did correlation analysis to determine the relationship between anthropometric measurement and blood pressure. The area under the Receiver Operating characteristic curve of Body Mass Index (BMI), Waist to Height Ratio (WHtR) and Waist Circumference (WC) was calculated and compared. ResultsThe prevalence of obesity and overweight by BMI was 16.09% and 42.20% respectively; by Waist-to-Height-Ratio was 32.76% which is two times higher than obesity measured by BMI. High waist circumference was observed among 66.76% participants. Female participants had greater prevalence of high WC (77.46%) than male (53.73%) (p<0.001). Prevalence of hypertension and pre-hypertension was 40.67% and 36.77% respectively. The areas under the curve were significantly higher than 0.5 for BMI (0.593), WHtR (0.602) and WC (0.610).ConclusionWaist circumference correlated well with obesity and hypertension. It also had higher predicting ability than WHtR and BMI to predict hypertension. Waist circumference thus proved to be non-inferior to two other commonly used metrics. It proved superior in detecting obesity in female. This simple and inexpensive tape measurement may play an important role in future diagnosis of obesity and prediction of HTN in resource constrained settings of developing countries.


PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10691
Author(s):  
Yimeng Hu ◽  
Qinge Li ◽  
Rui Min ◽  
Yingfeng Deng ◽  
Yancheng Xu ◽  
...  

Background The relationship between serum uric acid (SUA) and several diabetic complications or co-morbidities remains a matter of debate. The study aims to explore the association between SUA levels and the prevalence of non-alcoholic fatty liver disease (NAFLD), diabetic retinopathy (DR), diabetic nephropathy (DN) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 2,809 participants (1,784 males and 1,025 females) were included in this cross-sectional study. Clinical characteristics and the prevalence of each of the four diseases were analyzed based on gender-specific quartiles of SUA levels. The Pearson correlation analysis and linear-regression analysis were used to access the correlation between SUA levels and clinical characteristics. Furthermore, a binary logistic regression analysis was carried out to determine whether SUA was an independent risk factor for each of the four complications. Results SUA levels were positively correlated to BMI, BUN, Scr and TG, but negatively associated with eGFR, HDL, FBG, 2h-PG and HbA1c% for the patients with T2DM. The prevalence of NAFLD and DN, but not DR or DPN, were increased with SUA levels from the first to the fourth quartile. Binary logistic regression further disclosed that SUA was an independent risk factor for NAFLD (ORs Male = 1.002, ∗P = 0.0013; ORs Female = 1.002, ∗P = 0.015) and DN (ORs Male = 1.006, ∗P < 0.001; ORs Female = 1.005, ∗P < 0.001), but not for DR and DPN. After adjustment for the confounders, SUA levels were significantly associated with NAFLD within the 3rd (ORs = 1.829, P = 0.004) and 4th quartile (ORs = 2.064, P = 0.001) for women, but not independently associated with SUA for man. On the other hand, our results revealed increased prevalence of DN for SUA quartile 2 (ORs = 3.643, P = 0.039), quartile 3 (ORs = 3.967, P = 0.024) and quartile 4 (ORs = 9.133, P < 0.001) in men; however, SUA quartiles were significantly associated with DN only for quartile 4 (ORs = 4.083, P = 0.042) in women Conclusion For patients with T2DM, elevated SUA concentration is an independent risk factor for the prevalence of NAFLD and DN after adjustment for other indicators, but not DR or DPN.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Guihua Jian ◽  
Dongsheng Cheng ◽  
Zhi Wang ◽  
Junhui Li ◽  
Qi Yang ◽  
...  

Abstract Background and Aims Both constipation and chronic kidney disease (CKD) are common among seniors. However, the association between constipation and CKD remain unclear. This study investigates the correlation between the two to provide a new basis for clinical treatment. Method Data from Shanghai community elderly physical examination database (2010-2018) were used to conduct a cross-sectional study and a retrospective cohort to evaluate the relationship between constipation and the prevalence of CKD and rapid renal function decline in the elderly community. Results The cross-sectional study covered 16,177 participants, with an average age of 71.3. Comparing to no constipation group, seniors with constipation have a higher proportion of suffering from CKD stage 3. Constipation is an independent risk factor contributing to the high prevalence of CKD stage 3 (OR:1.238,95% CI,1.045-1.466). This finding was further tested through a retrospective cohort study that included 4,203 participants with a medium following time of 6.1 years. As a result, 9.5% (n=401) reported to have rapid progression of renal function. After adjustment of confounding factors, the logistic regression analysis indicates that, constipation is an independent predictive variable of rapid renal function decline among aged population. Conclusion Constipation is an independent risk factor for the prevalence of CKD and an independent predictor of rapid renal function decline among seniors in the community. Prevention and treatment for constipation should be taken at an early stage, which may reduce the incidence of CKD and delay the progression of CKD.


2020 ◽  
Vol 52 (11) ◽  
pp. 2205-2212
Author(s):  
Petrini Plytzanopoulou ◽  
Marios Papasotiriou ◽  
Panayiotis Politis ◽  
Christophoros Parissis ◽  
Pinelopi Paraskevopoulou ◽  
...  

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