Functional state of the brain bioelectric activity in treatment of diaphyseal lesions of the radius using the transosseous osteosynthesis of the wire and rod arrangement

Radial fracture is the most common trauma to the musculoskeletal system and accounts for 50 % of traumatic injuries to the bones of the upper limb. Disability in patients with fractures of the forearm bones ranges from 6 to 8 months, so the choice of the most effective method of treatment is very relevant. Currently, an important point is the tendency of optimizing the transosseous method by eliminating the disadvantages and looking for new advantages of external fixation. Bone fracture and associated surgical intervention are always accompanied by varying degrees of changes in the links of the central nervous system, hemodynamics and metabolism. In order to study the bioelectrical activity of the brain in 47 patients with a fracture of the radial diaphysis treated in the Traumatology Department of the Irkutsk Scientific Centre of Surgery and Traumatology, in the pre- and postoperative period we compared EEG indicators of two variants of the layout of the external fixation apparatus (EF): wire and rod. Analysis of the rhythms of bioelectrical activity of the brain in both groups in the preoperative period revealed a normal zonal distribution with the dominance of the alpha rhythm on the EEG, which generally reflects a rather high degree of organization of neuroactivity and indicates the stability of cerebral homeostasis. At the same time, in the group of patients with a wire-mounted EF device in the postoperative period, EEG indices significantly differed from the values of the norm and ndicators in the group with a rod-shaped arrangement. A decrease in the amplitude of alpha and beta rhythms was noted, as well as a shift in the frequency of bioelectric activity towards slow waves, which is a sign characteristic of discirculatory encephalopathy. An EEG study using the method of transosseous osteosynthesis with EF devise of a rod assembly showed its greater efficiency compared to the use of an EF device of a wire assembly during treatment and rehabilitation. Thus, the study of the bioelectric activity of the brain is a reliable method for assessing its functional state after an injury, as well as the effectiveness of the treatment.

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ДИНАМИКА ИЗМЕНЕНИЙ БИОЭЛЕКТРИЧЕСКОЙ АКТИВНОСТИ ГОЛОВНОГО МОЗГА У ПАЦИЕНТОВ, КОТОРЫМ ПРОВОДИТСЯ ХИРУРГИЧЕСКОЕ ВМЕШАТЕЛЬСТВО С ИСПОЛЬЗОВАНИЕМ ОБЩЕЙ АНЕСТЕЗИИ

World Science ◽

10.31435/rsglobal_ws/28022019/6355 ◽

2019 ◽

Vol 2 (2(42)) ◽

pp. 15-18

Author(s):

Дубовская С. С. ◽

Товажнянская Е. Л. ◽

Григоров Ю. Б. ◽

Соловйова Е. Т. ◽

Долженко М. А.

Keyword(s):

Comparative Analysis ◽

General Anesthesia ◽

Functional State ◽

Postoperative Period ◽

Bioelectrical Activity ◽

Emergency Medical Care ◽

Bioelectric Activity ◽

Regulatory Changes ◽

Two Stages ◽

The Brain

The purpose of this work is to determine the functional state of the brain of patients on the basis of the EEG, who underwent surgery under general anesthesia.The study was conducted in the surgical departments of various profiles on the basis of the Kharkov City Clinical Hospital of Emergency and Emergency Medical Care. prof. A. I. Meshchaninov.The study of the functional state of the brain by determining the bioelectrical activity of the brain, by conducting an EEG, was determined in two stages: before surgery and 3-5 days after surgery with general anesthesia.In a comparative analysis of the results obtained, a strong direct correlation is determined between the degree of regulatory changes in the bioelectric activity of the brain in the postoperative period and the age of the patients. Also, in a comparative analysis of the results, a strong direct correlation is determined between the degree of regulatory changes in the bioelectric activity of the brain in the postoperative period and the duration of anesthesia support. Given the above, we can recommend an EEG to assess the functional state of the brain of patients undergoing surgery under general anesthesia.

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ENCEPHALOMYELITIS OF MICE

Journal of Experimental Medicine ◽

10.1084/jem.72.1.49 ◽

1940 ◽

Vol 72 (1) ◽

pp. 49-67 ◽

Cited By ~ 104

Author(s):

Max Theiler ◽

Sven Gard

Keyword(s):

Virulent Strain ◽

Flaccid Paralysis ◽

Intracerebral Inoculation ◽

Cent Concentration ◽

The Central Nervous System ◽

The Stability ◽

High Degree ◽

Cardinal Symptom ◽

The Brain ◽

Intraperitoneal Inoculation

1. The two strains of virus named GD VII and FA, respectively, accidentally discovered during experiments with yellow fever, have been shown to be immunologically related to each other, as well as to the virus of mouse encephalomyelitis. 2. Infection of the central nervous system can be produced with both strains by intracerebral, intranasal, or intraperitoneal inoculations. The cardinal symptom produced by the GD VII strain of virus by all three methods of inoculation is a flaccid paralysis of the limbs. The symptoms produced by the FA strain are referable to lesions of the brain when infection is produced by intracerebral and intranasal inoculation. Following intraperitoneal inoculation of the FA strain of virus, however, a flaccid paralysis is usually produced. 3. By the use of graded collodion membranes the particle size of the virus of mouse encephalomyelitis has been shown to be from 9 to 13 mµ 4. The stability of the virus at different hydrogen ion concentrations has been tested. It has been found that there are two optima of stability, one at about pH 8.0 and the other at pH 3.3. 5. The virus is readily inactivated at 37°C. by 1 per cent hydrogen peroxide. 6. Of organic solvents tested, ether had no action, whereas ethyl alcohol in 20 per cent concentration almost completely inactivated the virus after 45 minutes in the cold. 7. The virus can be precipitated by means of ammonium sulfate. 8. With increasing age mice acquire a relative resistance to the virus. 9. Immunity to a subsequent intracerebral inoculation can be produced by intraperitoneal, as well as intranasal, administrations of relatively large amounts of virus. 10. Mice infected by the intracerebral inoculation of a relatively avirulent virus acquire a high degree of immunity to a subsequent inoculation of a highly virulent strain. 11. The course of infection in mice following intracerebral, intranasal, and intraperitoneal inoculation of the FA strain of virus has been studied.

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THE STATE OF CHANGES IN THE BIOELECTRICAL ACTIVITY OF THE BRAIN IN PATIENTS UNDERGOING SURGERY USING GENERAL ANESTHESIA WITH STANDART MANAGEMENT OF THE POSTOPERATIVE PERIOD

PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse ◽

10.21802/10.21802/2304-7437-2019-5(57)-95-101 ◽

2019 ◽

pp. 95-101

Author(s):

O. L. Tovazhyanskaya ◽

S. S. Dubivska ◽

Yu. B. Grigorov ◽

E. T. Solovyova

Keyword(s):

General Anesthesia ◽

Functional State ◽

Postoperative Period ◽

Surgical Stress ◽

Bioelectrical Activity ◽

Emergency Medical Care ◽

Standard Management ◽

Number Of Patients ◽

Two Stages ◽

The Brain

The purpose of this work is to determine the functional state of the brain of patients on the basis of the electroencephalogram, which were operated under general anesthesia against the background of the standard management of the postoperative period. The study was conducted in the surgical departments of various profiles on the basis of the Kharkov City Clinical Hospital of Emergency and Emergency Medical Care. prof. A.I. Meshchaninov. The study was conducted with the total number of patients in 86 young, middle-aged and elderly patients with surgical pathology who underwent surgery under general anesthesia. The study of the functional state of the brain by determining the bioelectrical activity of the brain, by conducting an electroencephalogram, was determined in two stages: before surgery and 3-5 days after surgery with general anesthesia. Based on the data obtained, it is possible to recommend an electroencephalogram to assess the functional state of the brain of patients undergoing surgery under general anesthesia. Marked electroencephalographic changes in the period after the operation indicate a deterioration in the functional state of the brain, which are a consequence of the effects of anesthesia, surgical stress, and effects on cognitive function.

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THE STATE OF CHANGES IN THE BIOELECTRICAL ACTIVITY OF THE BRAIN IN PATIENTS UNDERGOING SURGERY USING GENERAL ANESTHESIA WITH STANDART MANAGEMENT OF THE POSTOPERATIVE PERIOD

PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse ◽

10.21802/2304-7437-2019-5(57)-95-101 ◽

2019 ◽

pp. 95-101

Author(s):

O. L. Tovazhyanskaya ◽

S. S. Dubivska ◽

Yu. B. Grigorov ◽

E. T. Solovyova

Keyword(s):

General Anesthesia ◽

Functional State ◽

Postoperative Period ◽

Surgical Stress ◽

Bioelectrical Activity ◽

Emergency Medical Care ◽

Standard Management ◽

Number Of Patients ◽

Two Stages ◽

The Brain

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Statе of bioelectric activity of the brain in persons who received acoustic trauma in area of combat actions with a different stage of disorders in the auditory system

OTORHINOLARYNGOLOGY 2-3(2) 2019 - OTORHINOLARYNGOLOGY ◽

10.37219/2528-8253-2018-1-17 ◽

2018 ◽

pp. 17-25

Author(s):

Tetiana Shidlovskaya ◽

Tamara Shidlovskaya ◽

Nikolay Kozak ◽

Lyubov Petruk

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Functional State ◽

Acoustic Trauma ◽

Control Group ◽

Auditory Function ◽

Bioelectric Activity ◽

The Central Nervous System ◽

Quantitative Indicators ◽

The Brain

Topicality: Providing medical care to patients with combat acoustic trauma remains a topical issue of military medicine. There are works in the literature that show changes in the central nervous system under the influence of intense noise and at acoustic trauma, however, only in individual studies this objective assessment of the functional state of the central nervous system in patients with sensorineural hearing loss is shown as well as the promising use of them. Aim: is to determine the most significant indicators of bioelectric activity of the brain according to the EEG in terms of prediction of the course and ways of co-rejection of sensorineural hearing disorders in persons who have received an acute trauma in the area of fighting. Materials and methods: A group of servicemen with acoustic trauma was examined with the most characteristic, typical forms of audiometric curves – with a downward, precipitous type of the curve, which were divided into three groups depending on the degree of severity of sensorineural deafness. Group 1 – patients with initial non-expressed violations of the function of sound perception in the basal part of the cochlea, group 2 – with a more significant SDP accompanied by violations of speech and supra-vocal audiometry, the 3 groups included patients with severe violations of auditory function, lesions of the mediobasal part of the cochlea, often – with a "break" of perception of tones in the conventional range. A total of 205 patients with acoustic trauma were examined. As a control group, 15 healthy normal people were examined. The EEG study was carried out using the computer electroencephalometry of the firm "DX-System" (Ukraine) according to the generally accepted methodology according to the scheme of electrodes "10-20" Results: In qualitative analysis of electroencephalograms, servicemen with combat acoustic trauma revealed deviations from the norm in the functional state of the central nervous system, expressed in varying degrees, with the most characteristic decreasing of the bioelectric activity of the brain, irritative changes, disorganization and desynchronization of rhythms, more often in the temporal and frontal leads. The most significant changes were in patients with more severe hearing impairment (group 3). These changes indicate signs of severe cortex irritation and deep brain structures in servicemen with acoustic trauma from the combat zone. The analysis of EEG quantitative indicators showed that changes in the bioelectric activity of the cerebral brain in patients with acoustic trauma were manifested by deformation of the basic rhythm with modulation and weakened response to functional loads, especially in the anterior leads. Patients had the significantly (P<0,05) decreased percentage of alfa rhythm in the normal picture of the EEG and the increased representation of beta and delta rhythm, both in the background recording and in the functional loading of photostimulations and hyperventilation . The most significant (P<0,05) changes in bioelectric activity, in comparison with the control group, were observed in individuals 2 and, personally, in 3 groups, with more significant violations of auditory function. We also conducted a comparative analysis of EEG quantitative indicators among the study groups. The results of the research indicate a reliable (P<0,05) difference in the indices in the groups, from the first to the third group there was an increase in the representation of delta, theta and beta rhythm, most in the forward projections, and the decrease in the proportion of alpha rhythm. Moreover, these tendencies were maintained both during the background recording and at the functional loads. Conclusions: Thus, the servicemen with an acoustic trauma revealed objective signs of functional disorders in the cortical and deep structures of the brain. As the auditory function decreases in patients with acoustic trauma and redistribution of the main EEG rhythms in the direction of the growth of manifestations of slow-wave activity on a disorganized background occurs, especially in the frontal and temporal infections. In the subjects we surveyed with severe violations of auditory function, there are significantly more significant changes in the central nervous system than in patients with an initial SDE, which should be taken into account when carrying out treatment and preventive measures aimed at rehabilitation of the victims of combat operations with acoustic trauma.

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Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.698036 ◽

2021 ◽

Vol 13 ◽

Author(s):

Xiangyue Zhou ◽

Youwei Li ◽

Cameron Lenahan ◽

Yibo Ou ◽

Minghuan Wang ◽

...

Keyword(s):

Brain Edema ◽

Brain Tissue ◽

Molecular Mechanisms ◽

Glymphatic System ◽

System A ◽

Function Recovery ◽

The Central Nervous System ◽

The Stability ◽

The Brain

Stroke is the destruction of brain function and structure, and is caused by either cerebrovascular obstruction or rupture. It is a disease associated with high mortality and disability worldwide. Brain edema after stroke is an important factor affecting neurologic function recovery. The glymphatic system is a recently discovered cerebrospinal fluid (CSF) transport system. Through the perivascular space and aquaporin 4 (AQP4) on astrocytes, it promotes the exchange of CSF and interstitial fluid (ISF), clears brain metabolic waste, and maintains the stability of the internal environment within the brain. Excessive accumulation of fluid in the brain tissue causes cerebral edema, but the glymphatic system plays an important role in the process of both intake and removal of fluid within the brain. The changes in the glymphatic system after stroke may be an important contributor to brain edema. Understanding and targeting the molecular mechanisms and the role of the glymphatic system in the formation and regression of brain edema after stroke could promote the exclusion of fluids in the brain tissue and promote the recovery of neurological function in stroke patients. In this review, we will discuss the physiology of the glymphatic system, as well as the related mechanisms and therapeutic targets involved in the formation of brain edema after stroke, which could provide a new direction for research against brain edema after stroke.

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Analysis of electrogenesis’ changes in mental retardation persons by using computer electroencephalography

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.11.025 ◽

2021 ◽

Vol 11 (11) ◽

pp. 249-265

Author(s):

B. Lobasyuk ◽

L. Bartsevich ◽

A. Zamkovaya

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Mental Retardation ◽

Theta Rhythm ◽

Cognitive Activity ◽

Control Group ◽

Bioelectrical Activity ◽

The Central Nervous System ◽

Beta Rhythms ◽

The Brain

Justification. Mental retardation is a persistent decrease in human cognitive activity against the background of organic damage to the central nervous system. Neurophysiological diagnostics, in particular electroencephalography (EEG), most adequately reflects the morpho-functional state of the central nervous system, which is the basis of the mechanisms of mental activity, and the originality of the bioelectrical activity of the brain can be considered as the main indicator that determines a decrease in the level of intellectual development and, thereby, characterizes this state. This provision actualizes the search for highly informative indicators of the originality of the bioelectrical activity of the brain in children with intellectual disabilities. Purspose. With the use of periodometric analysis investigate EEG’s indicators and interhemispheric asymmetry of rhythms amplitudes in MR patients. Materials and methods. The EEG was recorded in a state of calm wakefulness with closed eyes with Neuron-Spectrum-2 electroencephalograph. Differences in indicators were tracked using the calculation of the coefficient of compliance (CC), EEG functional asymmetry coefficients in amplitude were determined, too. Results. It was revealed that in MR patients the amplitudes of the rhythms were greater than in healthy subjects. The greatest increase was determined in theta rhythm in the anterior temporal and posterior temporal leads in the left hemispheres. Duration indices in the delta, theta and alpha ranges of the EEG in mental retardation compared with the control group were increased, and the indices of the duration of beta rhythms - decreased. When analyzing FMPA in MR persons it turned out that in right-handers the negativeness of FMPA indices increased, and in left-handers there was an increase in the positivity of FMPA indices. Conclusions 1. With mental retardation, the amplitudes of the rhythms were greater than in healthy people. The greatest increase was determined in theta rhythm in the anterior temporal and posterior temporal leads in the left hemispheres. 2. The indices of duration in the delta, theta and alpha ranges of the EEG of MR subjects were increased, and the indices of the duration of beta rhythms – decreased. 3. When analyzing FMPA in MR persons, it turned out that in right-handers the negativeness of FMPA indices increased, and in left-handers there was an increase in the positivity of FMPA indices.

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The Influence of Somatic Pathology on the Health Status of Children With Attention Deficit Disorder and Hyperreactivity

Bulletin of Science and Practice ◽

10.33619/2414-2948/54/16 ◽

2020 ◽

Vol 6 (5) ◽

pp. 128-136

Author(s):

A. Matkeeva ◽

E. Kondratieva

Keyword(s):

Immune System ◽

Attention Deficit ◽

Attention Deficit Disorder ◽

Control Group ◽

Bioelectrical Activity ◽

High Morbidity ◽

The Central Nervous System ◽

Delayed Maturation ◽

Somatic Diseases ◽

The Brain

The article studies the mechanisms of various types of formation of somatic diseases that underwent perinatal lesions of the central nervous system. And also, the study included 30 children with attention deficit disorder with hyperreactivity in combination with various somatic diseases aged 6 to 8 years and a control group of 30 children (children’s health). The study concluded that the severity of disorders depends on the level of neuropsychic development. Children showed high morbidity, delayed maturation of bioelectrical activity of the brain, impaired autoregulation of cerebral circulation, tension and overstrain of autonomic regulation, imbalance of the immune system, reflecting immaturity of the central, autonomic nervous, immune system.

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An unusual headache: CSF negative APML relapse in the brain

Oxford Medical Case Reports ◽

10.1093/omcr/omaa075 ◽

2020 ◽

Vol 2020 (9) ◽

Author(s):

Thomas Quinn ◽

Manish Jain ◽

Ming-Te Lee

Keyword(s):

Diagnostic Delay ◽

Diagnostic Challenge ◽

Cerebrospinal Fluid Analysis ◽

Fluid Analysis ◽

Diagnostic Difficulties ◽

The Central Nervous System ◽

High Degree ◽

The Brain ◽

Post Therapy

ABSTRACT Acute Promyelocytic Leukaemia (APML) is a subtype of Acute Myeloid Leukaemia (AML), responsible for around 10% of cases of the disease in adults. Extra medullary disease (EMD) occurs infrequently in APML, but where EMD does occur, the central nervous system is one of the most commonly infiltrated sites. Our case describes a man in his 40s undergoing post-therapy surveillance for APML who presented to follow-up clinic with a headache, which was ultimately found to be caused by a tumour comprised of APML cells. His case presented a diagnostic challenge due to the benign appearances of the lesion on initial computed tomography brain imaging and the non-diagnostic cerebrospinal fluid analysis. The diagnostic difficulties described in our case emphasizes that clinicians working with APML patients must approach new neurological symptoms with a high degree of suspicion to prevent diagnostic delay.

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Bioelectric Activity of the Brain in the Operational Personnel of the Russian Nuclear Power Plant with a Low Level of Psychophysiological Adaptation

Medical Radiology and radiation safety ◽

10.12737/1024-6177-2021-66-2-29-35 ◽

2021 ◽

Vol 66 (2) ◽

pp. 29-35

Author(s):

F. Torubarov ◽

Z Zvereva ◽

S. Luk'yanova

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Cardiovascular System ◽

Functional Activity ◽

Main Role ◽

Central Regulation ◽

Bioelectric Activity ◽

Low Level ◽

The Central Nervous System ◽

The Brain

Purpose: The aim is to study the bioelectric activity of the brain in the operational workers of the Novovoronezh and Beloyarsk nuclear power plants with a low level of psychophysiological adaptation. Material and methods: An EEG study of 101 operational employees of the NPP was conducted, visual and spectral analyses were used. EEG indicators of individuals with a low level of psychophysiological adaptation and low functional activity of structural and functional formations of the central nervous system were compared with those of individuals with a high level of adaptation, high functional activity of structural and functional formations of the central nervous system. Results: Visual analysis of individuals with a low level of psychophysiological adaptation revealed abnormal EEG indicators, indicating functional disorders of the central nervous system. The greatest violations were revealed in the structural and functional formation responsible for the central regulation of the cardiovascular system. A comparative assessment of the spectral power of the EEG at different levels of psychophysiological adaptation revealed a state of tension (tense adaptation) observed in individuals with both low and high levels of adaptation. The similarity between the structural and functional formation "central regulation of the cardiovascular system" with low functional activity and a low level of psychophysiological adaptation in terms of the number of abnormal EEG indicators can be considered as evidence of its greatest contribution to the formation of a low level of adaptation.The evaluation of interhemispheric interactions in structural and functional formations at their low and high activity, as well as at low and high levels of adaptation, suggested that the formation of a high level of psychophysiological adaptation as an integral characteristic of the main role played by the formation of the "Cortex" and "central regulation of the cardiovascular system". In the formation of a low level of psychophysiological adaptation as an integral characteristic, the main role is played by the formations "cortex" and "cortical-subcortical interaction". Conclusion: A violation of the bioelectric activity of the brain may be one of the pathogenetic mechanisms of reduced adaptation. The presence of statistically significant differences in EEG indicators in individuals with low and high levels of adaptation, revealed by visual and spectral analysis, allows us to consider these indicators as informative not only in terms of identifying deviations in the diagnosis of functional disorders, but also in assessing the effectiveness of rehabilitation and health measures.

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