scholarly journals Effects of alpha-lipoic acid on the biomechanical properties of the skin

2021 ◽  
Vol 10 (2) ◽  
pp. 057-070
Author(s):  
Silvia Haydée Pérez Damonte ◽  
María Alejandra Moyano ◽  
Myriam Nuñez ◽  
Adriana Inés Segall
Keyword(s):  
Statistical Analysis ◽  
Lipoic Acid ◽  
Biomechanical Properties ◽  
Alpha Lipoic Acid ◽  
Skin Elasticity ◽  
In Vivo Measurements ◽  
Methods Of Measurement

Background: The Cutometer MPA 580® (Courage and Khazaka, Germany) is a well-established instrument for the accurate and reproducible measurement of the biomechanical properties of the skin. The purpose of this study was to assess the effect of 4 formulations containing 2.5% and 5.0% of α-lipoic acid and ascorbic palmitate or butylhydroxytoluene on skin elasticity and firmness and to assess the equivalence between alternative parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, R5, R6, all determined with the same cutometer. Methods: Measure of in vivo firmness and elasticity of the skin was performed using R and Q parameters measured in the same device. Results: Different statistical analysis were applied to the results obtained from the parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, of the in vivo measurements after the application of the four formulations during 28 days. A correlation between both types of measurements was demonstrate. Conclusion: A four-week treatment with a cream containing 5% α-lipoic acid improves the biomechanical characteristics of the skin, thus contributing to the protection against photo-aging. Both methods of measurement proved to be equivalent.

scholarly journals Chemopreventive Effects of Alpha Lipoic Acid on Obesity-Related Cancers

2016 ◽  
Vol 68 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Hyun-Seuk Moon
Keyword(s):  
Risk Factor ◽  
Lipoic Acid ◽  
Octanoic Acid ◽  
Scattered Data ◽  
Alpha Lipoic Acid ◽  
Chemopreventive Agent ◽  
Anti Cancer ◽  
In Vivo Animal Models

Background: It has been generally accepted that being overweight or obese is a risk factor for several types of cancers, including breast, thyroid, colon, pancreatic and liver. In fact, people who are obese have more fat tissues that can produce hormones, such as insulin or estrogen, which may cause cancer cells to grow. Alpha lipoic acid (ALA) is anorganosulfur compound derived from octanoic acid, which is produced in animals normally, and is essential for aerobic metabolism. Summary: Studies in both in vitro cells and in vivo animal models have shown that ALA inhibits the initiation and promotion stages of carcinogenesis, suggesting that ALA has considerable attention as a chemopreventive agent. This brief review collects the scattered data available in the literature concerning ALA and highlights its anti-cancer properties, intermediary metabolism and exploratory implications. Key Messages: Based on scientific evidences so far, ALA might be useful agents in the management or chemoprevention of obesity-related cancers.

Evaluation of alpha-lipoic acid anti-inflammatory properties using zebrafish as in vivo model

2019 ◽  
Vol 91 ◽  
pp. 389-390
Author(s):  
G. Camiolo ◽  
L. Rodríguez-Ruiz ◽  
Irene Pardo-Sanchez ◽  
G. Li Volti ◽  
R. Avola ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
In Vivo Model ◽  
Alpha Lipoic Acid ◽  
Anti Inflammatory

scholarly journals In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans

2020 ◽  
Vol 61 (3) ◽  
pp. 27
Author(s):  
Liang Zhang ◽  
Meghna R. Beotra ◽  
Mani Baskaran ◽  
Tin A. Tun ◽  
Xiaofei Wang ◽  
...  
Keyword(s):  
Biomechanical Properties ◽  
Lamina Cribrosa ◽  
In Vivo Measurements

scholarly journals Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 181 ◽  
Author(s):  
Anmar M. Abdulrazzaq ◽  
Mujtaba Badr ◽  
Omar Gammoh ◽  
Asad A. Abu Khalil ◽  
Bayan Y. Ghanim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Liver Function ◽  
Lipoic Acid ◽  
Rat Hepatocytes ◽  
Serum Levels ◽  
Liver Function Tests ◽  
Alpha Lipoic Acid

Background and objectives: Ascorbic acid, alpha lipoic acid (ALA) and silymarin are well-known antioxidants that have hepatoprotective effects. This study aims to investigate the effects of these three compounds combined with attenuating drug-induced oxidative stress and cellular damage, taking acetaminophen (APAP)-induced toxicity in rats as a model both in vivo and in vitro. Materials and Methods: Freshly cultured primary rat hepatocytes were treated with ascorbic acid, ALA, silymarin and their combination, both with and without the addition of APAP to evaluate their in vitro impact on cell proliferation and mitochondrial activity. In vivo study was performed on rats supplemented with the test compounds or their combination for one week followed by two toxic doses of APAP. Results: Selected liver function tests and oxidative stress markers including superoxide dismutase (SOD), malondialdehyde (MDA) and oxidized glutathione (GSSG) were detected. The in vivo results showed that all three pretreatment compounds and their combination prevented elevation of SOD and GSSG serum levels indicating a diminished burden of oxidative stress. Moreover, ascorbic acid, ALA and silymarin in combination reduced serum levels of liver enzymes; however, silymarin markedly maintained levels of all parameters to normal ranges. Silymarin either alone or combined with ascorbic acid and ALA protected cultured rat hepatocytes and increased cellular metabolic activity. The subjected agents were capable of significantly inhibiting the presence of oxidative stress induced by APAP toxicity and the best result for protection was seen with the use of silymarin. Conclusions: The measured liver function tests may suggest an augmented hepatoprotection of the combination preparation than when compared individually.

scholarly journals The Combination of N-Acetyl Cysteine, Alpha-Lipoic Acid, and Bromelain Shows High Anti-Inflammatory Properties in NovelIn VivoandIn VitroModels of Endometriosis

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
C. Agostinis ◽  
S. Zorzet ◽  
R. De Leo ◽  
G. Zauli ◽  
F. De Seta ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lipoic Acid ◽  
Inflammatory Diseases ◽  
Inflammatory Marker ◽  
The Novel ◽  
Alpha Lipoic Acid ◽  
Therapeutic Uses ◽  
Anti Inflammatory ◽  
Set Up

To evaluate the efficacy of an association of N-acetyl cystein, alpha-lipoic acid, and bromelain (NAC/LA/Br) in the treatment of endometriosis we set up a newin vivomurine model. We explored the anti-inflammatory and proapoptotic effect of this combination on human endometriotic endothelial cells (EECs) and on endothelial cells isolated from normal uterus (UtMECs). We implanted fragments of human endometriotic cysts intraperitoneally into SCID mice to evaluate the efficacy of NAC/LA/Br treatment. UtMECs and EECs, untreated or treated with NAC/LA/Br, were activated with the proinflammatory stimulus TNF-αand their response in terms of VCAM1 expression was evaluated. The proapoptotic effect of higher doses of NAC/LA/Br on UtMECs and EECs was measured with a fluorogenic substrate for activated caspases 3 and 7. The preincubation of EECs with NAC/LA/Br prior to cell stimulation with TNF-αprevents the upregulation of the expression of the inflammatory “marker” VCAM1. Furthermore NAC/LA/Br were able to induce EEC, but not UtMEC, apoptosis. Finally, the novel mouse model allowed us to demonstrate that mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size, compared to untreated mice. Our findings suggest that these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis.

scholarly journals THE EFFECT OF ALPHA LIPOIC ACID ON BLASTOCYST EMBRYO DEVELOPMENT IN VIVO IN MICE (Mus musculus) EXPOSED CIGARETTE SMOKE

2017 ◽  
Vol 41 (4) ◽  
pp. 385
Author(s):  
Syahruddin Said ◽  
Adi Setyawan Prianto ◽  
Senri Utama Pramadipta
Keyword(s):  
Cigarette Smoke ◽  
Lipoic Acid ◽  
Mus Musculus ◽  
Blastocyst Stage ◽  
Negative Control ◽  
Alpha Lipoic Acid ◽  
Blastocyst Development ◽  
Randomized Design ◽  
Negative Effect

This study was conducted to find out effect of alpha lipoic acid (ALA) on the development of in vivo blastocyst embryo in mice (Mus musculus) exposed in cigarettes smoke. This study used 30 mice divided into 6 treatment groups factorial 2x3. Factor A is treatment of ALA (0; 16.5 μM; 49.5 μM) per orally. Factor B is the treatment of cigarette smoke (with and without cigarette smoke). Giving cigarette smoke was done by covering the cage with plastic having two holes for cigarette smoke and airflow. The data obtained were analyzed using a complete randomized design (RAL) 2x3, followed by parametric Analysis of Variance (ANOVA) and independent sample T-Test, and Post Hoc Duncan test. The development of embryo of mice reaching blastocyst stage at ALA with dose 16,5 μM (16.00±7.12) were significantly higher (p<0.05) than negative control (13.50±1.73), but no significant effect with ALA dose 49.5 μM (19.25±4.03). The development of mice blastocyst embryos exposed to cigarette smoke (7.25±2.99) were significantly lower (p<0.05) compared with negative control. When the mice exposed to cigarette smoke were given ALA, the development of the blastocyst embryo returned to normal as in control, where the doses of 16.5 μM and 49.5 μM were not significantly different. It can be concluded that (1) ALA dose 16.5 μM and 49.5 μM have positive effect on blastocyst development in vivo, (2) cigarette smoke have negative effect on blastocyst development, (3) ALA 16.5 μM and 49.5 μM per orally capable counteract the oxidative stress caused by exposure to cigarette smoke.

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