scholarly journals The Observation of Fast, Long Term, and Stable Performance of Toxic Absorption in Herbal Blessing Product Based on Galoba Maluku (Zingiberaceae Fruits)

2019 ◽  
Vol 2 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Ido F Seay ◽  
Hendry Izaac Elim
Keyword(s):  
Physical Chemistry ◽  
Herbal Medicine ◽  
Nitrogen Gas ◽  
Toxic Response ◽  
Healing System ◽  
Hiv Virus ◽  
Excellent Health ◽  
Stable Performance ◽  
Systematic Explanation

The search for the best herbal medicine products for multitasking healing system associated with Galoba (Maluku language) or Golobe (North Maluku language) or zingiberaceae fruits are presented with a very systematic explanation after an intensive research in the last 3 years (~2016-2019) vary from its antioxidant content of flavonoid, chemical bonding organization, HIV virus medicine test, and toxic inhibition status. We obtained that the best herbal medicine produced in this paper called as Herbal Blessing products preparing with different system of Love herbal made by STIKES Halmahera, North Maliuku, Indonesia can provide fast, long term, and stable performance of toxic absorption. Such fast toxic response is an instantaneous process with no longer than 1 minute as well as a stable toxic binding for up to 4 months and 10 days so far. The obvious observation indicated few interesting physical chemistry processes during toxic absorption such as the nitrogen gas released during the sample preparation of Herbal Blessing, and the oxygen vanished in different sample processes of the same source of Murnaten Amomum sp. observed in a protected bottle consisted of the sample interaction with toxic in water. These amazing findings suggest that Herbal Blessing products are very promising for future multitasking healing system for human excellent health.   

scholarly journals Multitasking Herbal Nanomedicine

2019 ◽  
Vol 2 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Hendry Izaac El
Keyword(s):  
Optical Property ◽  
Herbal Medicine ◽  
Natural Product ◽  
Herbal Medicines ◽  
Theoretical Physics ◽  
Healing System ◽  
Creative Research ◽  
Synthetic Drug ◽  
In The Beginning ◽  
Systematic Explanation

A frontier review from creative research works on nanotechnology and nanomedicine is presented in a systematic explanation. Based on multitasking healing system of herbal medicine identified in the beginning using a simple theoretical physics works, and the natural product of herbal medicine, the step by step guidance to develop important herbal nanomedicine is then enlightened. Such important herbal medicines with their unique and multitasking healing system were studied by implementing five point behavior parameters: (1). Optical property (OP), (2). Electronics and magnetics character (EMC), (3). Mechanical behavior (MB), (4). Chemical possessions (CP), and (5). Quantum movables (QM). Finally, the detail of output herbal nanomedicine is briefly elucidated. Our findings show that herbal nanomedicine are very promising for multitasking healing system which is absolutely different from normal synthetic drug which heals one target with one medicine.

Musikalisasi Syi’ir Aqoid Kiai Zaini Mun’im dan Budidaya Tanaman Obat Keluarga (Toga) di Pesantren Nurul Jadid Probolinggo

2020 ◽  
Vol 1 (1) ◽  
pp. 47-58
Author(s):  
Khodijatul Qodriyah
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
Successful Implementation ◽  
Short Term ◽  
Middle Term

The lack of students’ knowledge of their teachers’ works and the less of their consciousness to the environment are crucial problems in some islamic boardingschool, especially in Nurul Jadid. These issues will be settled by implementation of religious preaching (dakwah) with poem (syi’ir) in Syu’abul Iman of Kiai Zaini Mun’im and prefentive action to the illness through herbal medicines of family crops medicine (tanaman obat keluarga). The program is undertaken with some phases, including planting family crops medicine, making herbal medicines, musicalisation of poem in book of Syu’abul Iman, socialization of the herbal medicine and musical poem of Syu’abul Iman. These phases have been structured with long-term, middle-term, and short-term programs which were finished during approximately 4 months (Augustus – November 2019). The involvement of many parties, such as activists of environment in Nurul Jadid, has strongly influenced on the successful implementation of these programs.Keywords: Family Crops Medicine, Nurul Jadid Islamic Boardingschool, Book of Syu’abul Iman

scholarly journals Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations

2021 ◽  
Vol 15 (1) ◽  
pp. 2
Author(s):  
Cristina Martín-Sabroso ◽  
Mario Alonso-González ◽  
Ana Fernández-Carballido ◽  
Juan Aparicio-Blanco ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Shelf Life ◽  
Stability Study ◽  
Eye Drops ◽  
Microbiological Analysis ◽  
Nitrogen Gas ◽  
Long Term Stability ◽  
Main Degradation Product ◽  
The Stability ◽  
Unstable Molecule

Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications. Cysteamine eye drop compounded formulations, commonly prepared by hospital pharmacy services, are meant to diminish the build-up of corneal cystine crystals. The objective of this work was to analyze whether the shelf life proposed for six formulations prepared following different protocols used in hospital pharmacies is adequate to guarantee the quality and efficacy of cysteamine eye drops. The long-term and in-use stabilities of these preparations were studied using different parameters: content of cysteamine and its main degradation product cystamine; appearance, color and odor; pH and viscosity; and microbiological analysis. The results obtained show that degradation of cysteamine was between 20% and 50% after one month of storage in the long-term stability study and between 35% and 60% in the in-use study. These data confirm that cysteamine is a very unstable molecule in aqueous solution, the presence of oxygen being the main degradation factor. Saturation with nitrogen gas of the solutions offers a means of reducing cysteamine degradation. Overall, all the formulae studied presented high instability at the end of their shelf life, suggesting that their clinical efficacy might be dramatically compromised.

scholarly journals Acupuncture plus Chinese Herbal Medicine for Irritable Bowel Syndrome with Diarrhea: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Jing Yan ◽  
Zhi-wei Miao ◽  
Jun Lu ◽  
Fei Ge ◽  
Li-hua Yu ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Western Medicine ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Combined Method ◽  
Chinese Herbal ◽  
Irritable Bowel

Purpose. To comprehensively evaluate the efficacy and safety of acupuncture combined with Chinese herbal medicine (CHM) in treating irritable bowel syndrome with diarrhea (IBS-D). Methods. Relevant randomized controlled trials (RCTs) were systemically retrieved from electronic databases from inception to March 2018, including the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biological Medical Database (CBM, SinoMed), China Science and Technology Journal Database (VIP), and Wan Fang Data. Meanwhile, pooled estimates, including the 95% confidence interval (CI), were calculated for primary and secondary outcomes of IBS-D patients. Besides, quality of relevant articles was evaluated using the Cochrane Collaboration’s risk of bias tool, and the Review Manager 5.3 and Stata12.0 softwares were employed for analyses. Results. A total of 21 RCTs related to IBS-D were included into this meta-analysis. Specifically, the pooled results indicated that (1) acupuncture combined with CHM might result in more favorable improvements compared with the control group (relative risk [RR] 1.29; 95% CI 1.24–1.35; P =0.03); (2) the combined method could markedly enhance the clinical efficacy in the meantime of remarkably reducing the scores of abdominal pain (standardized mean difference [SMD] –0.45; 95% CI –0.72, –0.17; P = 0.002), abdominal distention/discomfort (SMD –0.36; 95% CI –0.71, –0.01; P = 0.04), diarrhea (SMD –0.97; 95% CI –1.18, –0.75; P < 0.00001), diet condition (SMD –0.73; 95% CI –0.93, –0.52; P<0.00001), physical strength (SMD –1.25; 95% CI –2.32, –0.19; P = 0.02), and sleep quality (SMD –1.02; 95% CI –1.26, –0.77; P < 0.00001) compared with those in the matched groups treated with western medicine, or western medicine combined with CHM. Additionally, a metaregression analysis was constructed according to the name of prescription, acupuncture type, treatment course and publication year, and subgroup analyses stratified based on the names of prescriptions and acupoints location were also carried out, so as to explore the potential heterogeneities; and (3) IBS-D patients treated with the combined method only developed inconspicuous adverse events; more importantly, the combined treatment had displayed promising long-term efficacy. Conclusions. Findings in this study indicate that acupuncture combined with CHM is suggestive of an effective and safe treatment approach for IBS-D patients, which may serve as a promising method to treat IBS-D in practical application. However, more large-scale, multicenter, long-term, and high-quality RCTs are required in the future, given the small size, low quality, and high risk of the studies identified in this meta-analysis.

scholarly journals Pangi Leaf (Pangium edule Reinw) Herbal Medicine: A Marvelous Candidate for the Prominent HIV Herbal Medicine

2019 ◽  
Vol 2 (2) ◽  
pp. 097-104 ◽  
Author(s):  
Arend L Mapanawang ◽  
Hendry Izaac Elim
Keyword(s):  
Gas Chromatography ◽  
Fourier Transform ◽  
T Cell ◽  
Herbal Medicine ◽  
Fast Fourier Transform ◽  
Human Body ◽  
Hexadecanoic Acid ◽  
High Concentration ◽  
Hiv Virus ◽  
Very High

A medicine named as Love herbal (LH) fabricated using zingiberaceae fruit (Golobe halmahera) with a very high concentration ofIC50 = 6.54 ng/ml [1-6] had been compared with pangileaf  (Pangium edule Reinw) as well as the combination of pangi-LH herbal medicine especially in their functions of stopping the growth of HIV virus inside T Cell with CD 4 in its surface. By using optical spectroscopy techniques of fast Fourier transform infrared (FTIR), photo cells, and gas chromatography mass spectrometer (GCMS), we found their significant differences. Based on our former finding, the inhibition of pangi leaf was 2.19 times larger than that in love herbal medicine [7]. Such pangi leaf medicine has advantages of optical uniqueness behaviors due to CC at 2260 cm-1 which might be closely in conjunction with very strong alkaline function associated with at least 4 compounds ofoctadecanoic acid (24.6 %), squalene (21.22 %), hexadecanoic acid (15.08 %), and  phytol (10.33 %) to kill HIV virus more effectively and safely in human body. The results of our observation under real time photo cells with pure pangileaf medicine at concentration of 400 to 800 ppm were superior to LH medicine. Such output suggests that pangi leaf medicine is very promising for healing HIV patients in the future applications.

scholarly journals Idiopathic mesenteric phlebosclerosis associated with long-term use of Chinese herbal medicine

2018 ◽  
Vol 29 (1) ◽  
pp. 138-140 ◽  
Author(s):  
Hsing Jung Yeh ◽  
Pao Ying Lin ◽  
Wei-Yu Kao ◽  
Ching Huei Kun ◽  
Chun Chao Chang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Chinese Herbal

scholarly journals Associations Between Using Chinese Herbal Medicine and Long-Term Outcome Among Pre-dialysis Diabetic Nephropathy Patients: A Retrospective Population-Based Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jenny Chun-Ling Guo ◽  
Heng-Chih Pan ◽  
Bo-Yan Yeh ◽  
Yen Chu Lu ◽  
Jiun-Liang Chen ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Lower Risk ◽  
Population Based ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Chinese Herbal ◽  
Risk Of Mortality ◽  
All Cause Mortality

Background: Chronic kidney disease (CKD) has become a worldwide burden due to the high co-morbidity and mortality. Diabetic nephropathy (DN) is one of the leading causes of CKD, and pre-dialysis is one of the most critical stages before the end-stage renal disease (ESRD). Although Chinese herbal medicine (CHM) use is not uncommon, the feasibility of using CHM among pre-dialysis DN patients remains unclear.Materials and methods: We analyzed a population-based cohort, retrieved from Taiwan’s National Health Insurance Research Database, to study the long-term outcome of using CHM among incident pre-dialysis DN patients from January 1, 2004, to December 31, 2007. All patients were followed up to 5 years or the occurrence of mortality. The risks of all-cause mortality and ESRD were carried out using Kaplan-Meier and competing risk estimation, respectively. Further, we demonstrated the CHM prescriptions and core CHMs using the Chinese herbal medicine network (CMN) analysis.Results: A total of 6,648 incident pre-dialysis DN patients were analyzed, including 877 CHM users and 5,771 CHM nonusers. With overlap weighing for balancing all accessible covariates between CHM users and nonusers, we found the use of CHM was associated with lower all-cause mortality (0.22 versus 0.56; log-rank test: p-value &lt;0.001), and the risk of mortality was 0.42 (95% CI: 0.36–0.49; p-value &lt;0.001) by adjusting all accessible covariates. Further, the use of CHM was associated with a lower risk of ESRD (cause-specific hazard ratio: 0.59, 95%CI: 0.55–0.63; p-value &lt;0.001). Also, from the 5,901 CHM prescriptions, we found Ji-Sheng-Shen-Qi-Wan, Astragalus mongholicus Bunge or (Astragalus membranaceus (Fisch.) Bge.), Plantago asiatica L. (or Plantago depressa Willd.), Salvia miltiorrhiza Bunge, and Rheum palmatum L. (or Rheum tanguticum (Maxim. ex Regel) Balf., Rheum officinale Baill.) were used as core CHMs for different CHM indications. Use of core CHMs was associated with a lower risk of mortality than CHM users without using core CHMs.Conclusions: The use of CHM seemed feasible among pre-dialysis DN patients; however, the beneficial effects still need to be validated by well-designed clinical trials.

scholarly journals A system for reporting and evaluating adverse drug reactions of herbal medicine in Taiwan from 1998 to 2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hen-Hong Chang ◽  
Su-Yin Chiang ◽  
Pei-Chun Chen ◽  
Chia-Han Tsai ◽  
Rong-Chi Yang ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Herbal Medicine ◽  
Adverse Drug Reaction Reporting ◽  
Subcutaneous Tissue ◽  
Herbal Medicines ◽  
System Organ Class ◽  
Wide Range ◽  
Datura Suaveolens

AbstractThe Taiwan Adverse Drug Reaction Reporting System for Herbal Medicine (TADRRS-HM) has systematically documented suspected adverse events from adverse drug reaction (ADR) reports from 1998 (prior to its formal establishment in 2001) and evaluates safety profiles of herbal medicines. This article describes findings from 2079 ADR reports filed between 1998 and 2016: 941 reports involved single herbs and 87 involved folk herbals; 842 were generated from clinical trials, while 209 ADR reports involving foods, health foods, dietary supplement foods and herbal cuisine were grouped as Other. Severity assessments using the Modified Hartwig and Siegel scale classified 72.4% of ADRs as mild, 17.4% as moderate and 6.5% as severe. System Organ Class classification of the ADRs identified gastrointestinal system disorders as the most common (33.4%), followed by skin and subcutaneous tissue disorders (21.2%). The TADRRS-HM records indicate that herbal medicines may cause a wide range of ADRs. Aconiti Radix, Xiao-Qing-Long-Tang, and Datura suaveolens were the most commonly reported single herb, herbal formula, and folk herbal, respectively. The data indicate that herbal medicines may cause a wide range of ADRs. This system will confer long-term benefits for the development of Taiwan’s herbal medicines adverse reaction database and facilitate epidemiological analysis.

scholarly journals The Discovery of NEW Golobe and Its Amazing Healing System

2019 ◽  
Vol 2 (1) ◽  
pp. 066-070 ◽  
Author(s):  
Science Nature
Keyword(s):  
Herbal Medicine ◽  
Late Afternoon ◽  
Healing System

Here, one reported a discovery of new golobe or a novel kind of zingiberaceae fruit in a forest of Layeni village located in Teon-Nila-Serua (TNS) district of Seram island, Maluku province, Indonesia in the late afternoon on 25th February 2019. The new golobe is very different from the four (4) formal types of golobe fruits studied before. After intense prompt investigations, the new golobe was named as Elim alliacea based on the taller tree and fruit hard skin structures as well as its unique taste. Furthermore, the healing system of the golobe was identified to be very excellence in handling toxic instantly. This discovery suggests a prominent potential of this fruit as multitasking healing herbal medicine for future complicated deceases on earth.

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