scholarly journals The ‘I’ in the Monad: Leibniz and the Essential Indexical

2021 ◽  
Author(s):  
Eros Corazza ◽  
Christopher Genovesi
Keyword(s):  
Essential Role ◽  
First Person ◽  
Person Pronoun ◽  
Indexical Reference ◽  
Individual Actions ◽  
Essential Indexical

Some modern and contemporary philosophers argue that the first-person indexical plays an essential role in the explanation of individual actions. As such it cannot be explained away or replaced by a co-referring term without destroying the cognitive force that its use conveys. There are important aspects of Leibniz’s work that anticipate the view of the essential indexical. The activity in the monad, such as the petites perceptions and appetitions, plays the cognitive role of grounding indexical reference and uses of the first-person pronoun to explain an agent’s perspective and behaviour.

scholarly journals Behavioral Evaluations of Anesthesiology Residents and Overuse of the First-Person Pronoun in Personal Statements

2011 ◽  
Vol 3 (2) ◽  
pp. 151-154 ◽  
Author(s):  
John J. Badal ◽  
Wayne K. Jacobsen ◽  
Bradley W. Holt
Keyword(s):  
First Person ◽  
Residency Programs ◽  
Behavioral Traits ◽  
Clinical Evaluations ◽  
Person Pronoun ◽  
Personal Statement ◽  
Subjective Measurements ◽  
Admissions Process ◽  
The Relationship

Abstract Background The admissions process for residency encompasses numerous objective and subjective measurements by which an applicant is evaluated. The personal interview and clinical evaluations are widely considered the most reliable method to identify unwanted behavioral characteristics. However, the role of a personal statement is less clear. There are reports of residency programs attempting to identify selfish or egocentric behavioral traits by counting the frequency of the first-person pronoun “I” in personal statements. The purpose of this study is to define the relationship between anesthesiology resident evaluations and the frequency of the first-person pronoun within their personal statements. Methods Resident evaluations of 48 anesthesiology graduates were collected for 5 competencies. The iScore was calculated by determining the frequency of “I” in relation to total word count. Results Correlation analysis between iScore and the 5 evaluation categories showed no significant relationship. Conclusion When examining the relationship between resident evaluations and iScore, the lack of significant correlation makes it difficult to predict resident performance based on “I” counts. This may be because the personal statement is a thoughtfully developed document that undergoes extensive editing, which may suppress or minimize writing styles that suggest the presence of unwanted behavioral traits. Further examination of personal statements with a larger sample size and data from other institutions and specialties are needed.

Me, Myself, and Us

2013 ◽  
pp. 4-18
Author(s):  
Timothy Gould
Keyword(s):  
First Person ◽  
Philosophical Method ◽  
Person Pronoun

With the publication of Stanley Cavell’s autobiography, it has become possible to think about the role of autobiography in Cavell’s work as a whole. Some readers regard this book as recording Cavell’s achievement of his challenge to philosophy, as contained in the closing question of The Claim of Reason: Can philosophy become literature and still know itself? This question clearly resonates with the question of autobiography. And yet when we look at the work where Cavell begins to insist on the issue of autobiography and the first person pronoun, he first connections he draws are not from philosophy to literature but rather from the philosopher’s writing to philosophical method or, indeed we might say, to the authority of philosophy.

scholarly journals First person – Bernhard N. Bohnert

2021 ◽  
Vol 14 (9) ◽  
Keyword(s):  
Essential Role ◽  
Early Career ◽  
University Hospital ◽  
First Person ◽  
Glomerular Injury ◽  
Oedema Formation ◽  
Early Career Researchers ◽  
The University ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Bernhard N. Bohnert is first author on ‘ Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice’, published in DMM. Bernhard is a physician/postdoc in the lab of Prof. Dr. med. Ferruh Artunc at the University Hospital Tübingen, Tübingen, Germany, investigating oedema formation in nephrotic syndrome.

Pronominal system in Croatian Sign Language

2006 ◽  
Vol 9 (1-2) ◽  
pp. 95-132 ◽  
Author(s):  
Tamara Alibašić Ciciliani ◽  
Ronnie B. Wilbur
Keyword(s):  
Sign Language ◽  
First Person ◽  
Second Person ◽  
Fundamental Properties ◽  
Person Pronoun ◽  
Hand Orientation ◽  
Person Reference ◽  
Third Person ◽  
Pronominal System

In this article we present some fundamental properties of the Croatian Sign Language (Hrvatski Znakovni Jezik, HZJ) pronominal system. The most common functions of pointing in HZJ are pronominal, demonstrative, locative, possessive and reflexive. Examination of the first person pronoun shows that the signer uses nonmanuals to indicate that she has taken the role of another person. Thus, the signer points to herself, but the intended reference is to a character in the story and not to the signer. These findings are used to provide evidence for grammatical first person. Viewed from Berenz’s (2002) perspective, grammatical second and third person pronouns show some degree of consistency within each category and differences across categories. When reference to the second person is intended, the characteristics hand orientation, eyegaze and the head will usually line up. In contrast, when reference to third person is intended, disjunction of some of these features occurs. Thus, the distinction between second and third person pronoun is linguistically marked in HZJ. Therefore we argue against Liddell (1995, 2003), who treats pointing as deictic, gestural, hence nonlinguistic. Furthermore we argue with Berenz against Meier (1990), who claims that at least for ASL there is no distinction between second and third person reference. Our morphological analysis reveals no gender distinction in the pronoun system, but there are distinctions between singular, plural, inclusive and exclusive pronouns. No correlation between spoken Croatian case marking and either HZJ handshape choice or systematic mouthing was found.

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
N Lange ◽  
S Sieber ◽  
A Erhardt ◽  
G Sass ◽  
HJ Kreienkamp ◽  
...  
Keyword(s):  
Essential Role ◽  
Primary Hepatocytes

Different Abilities of Thrombin Receptor Activating Peptide and Thrombin to Induce Platelet Calcium Rise and Full Release Reaction

1995 ◽  
Vol 74 (05) ◽  
pp. 1323-1328 ◽  
Author(s):  
Dominique Lasne ◽  
José Donato ◽  
Hervé Falet ◽  
Francine Rendu
Keyword(s):  
Essential Role ◽  
Calcium Influx ◽  
Dense Granule ◽  
Receptor Interaction ◽  
Thrombin Receptor ◽  
Release Reaction ◽  
External Calcium ◽  
Maximum Rise ◽  
Granule Release

SummarySynthetic peptides (TRAP or Thrombin Receptor Activating Peptide) corresponding to at least the first five aminoacids of the new N-terminal tail generated after thrombin proteolysis of its receptor are effective to mimic thrombin. We have studied two different TRAPs (SFLLR, and SFLLRN) in their effectiveness to induce the different platelet responses in comparison with thrombin. Using Indo-1/AM- labelled platelets, the maximum rise in cytoplasmic ionized calcium was lower with TRAPs than with thrombin. At threshold concentrations allowing maximal aggregation (50 μM SFLLR, 5 μM SFLLRN and 1 nM thrombin) the TRAPs-induced release reaction was about the same level as with thrombin, except when external calcium was removed by addition of 1 mM EDTA. In these conditions, the dense granule release induced by TRAPs was reduced by over 60%, that of lysosome release by 75%, compared to only 15% of reduction in the presence of thrombin. Thus calcium influx was more important for TRAPs-induced release than for thrombin-induced release. At strong concentrations giving maximal aggregation and release in the absence of secondary mediators (by pretreatment with ADP scavengers plus aspirin), SFLLRN mobilized less calcium, with a fast return towards the basal level and induced smaller lysosome release than did thrombin. The results further demonstrate the essential role of external calcium in triggering sustained and full platelet responses, and emphasize the major difference between TRAP and thrombin in mobilizing [Ca2+]j. Thus, apart from the proteolysis of the seven transmembrane receptor, another thrombin binding site or thrombin receptor interaction is required to obtain full and complete responses.

Collagen-Induced Platelet Aggregation: -Evidence Against the Essential Role of Platelet Adenosine Diphosphate

1979 ◽  
Vol 42 (04) ◽  
pp. 1193-1206 ◽  
Author(s):  
Barbara Nunn
Keyword(s):  
Platelet Aggregation ◽  
Time Course ◽  
Essential Role ◽  
Atp Release ◽  
Adenosine Diphosphate ◽  
Human Platelets ◽  
High Doses ◽  
Induced Aggregation

SummaryThe hypothesis that platelet ADP is responsible for collagen-induced aggregation has been re-examined. It was found that the concentration of ADP obtaining in human PRP at the onset of aggregation was not sufficient to account for that aggregation. Furthermore, the time-course of collagen-induced release in human PRP was the same as that in sheep PRP where ADP does not cause release. These findings are not consistent with claims that ADP alone perpetuates a collagen-initiated release-aggregation-release sequence. The effects of high doses of collagen, which released 4-5 μM ADP, were not inhibited by 500 pM adenosine, a concentration that greatly reduced the effect of 300 μM ADP. Collagen caused aggregation in ADP-refractory PRP and in platelet suspensions unresponsive to 1 mM ADP. Thus human platelets can aggregate in response to collagen under circumstances in which they cannot respond to ADP. Apyrase inhibited aggregation and ATP release in platelet suspensions but not in human PRP. Evidence is presented that the means currently used to examine the role of ADP in aggregation require investigation.

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