Antidiabetic Activity of Fractions of the n-Hexane Extract of Leaves of Eriosema psoraleoides (Lam) G. Don (Leguminosae) on Alloxan-induced Diabetic Albino Rats

2019 ◽  
Vol 7 (04) ◽  
pp. 05-09
Author(s):  
N. A. Elechi ◽  
F. W. Ewelike
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Hexane Extract ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Rf Values ◽  
Blood Glucose Concentrations

Diabetes is a chronic disease that is raising health concerns. Eriosema psoraleoides is one of the medicinal plants reported to be used in managing this condition in Eastern Nigeria. This study investigated the effect of four fractions [(n-hexane; n-hexane: dichloromethane (50:50); dichloromethane; and dichloromethane: methanol (95:5)] of the n-hexane leaf extract of this plant on the blood glucose levels of alloxan-induced diabetic rats. The n-hexane extract was obtained by maceration, filtration, and evaporation using a rotary evaporator. Phytochemical screening of the extracts was carried out using standard methods. The extract was fractionated using column chromatography, and ten fractions were obtained. The fractions were pooled together into four fractions based on the similarity in their Rf values. A dose of 200mg/kg of each of the fractions was given orally for 7 days to the alloxan-induced diabetic rats, and plasma blood glucose concentrations determined. Preliminary screening of the extract revealed the presence of flavonoids, steroids, reducing sugars, tannins and combined anthraquinones. Two fractions, the n-hexane: dichloromethane (50:50) and the dichloromethane, produced significant (p 0.05) decrease in blood glucose concentrations in their treated groups compared to that of glibenclamide (standard drug) treated, and the diabetic untreated groups of the diabetic rats. However, the n-hexane and the dichloromethane: methanol (95:5) fractions produced no significant (p 0.05) decrease in blood glucose concentrations. The observed antidiabetic property of the n-hexane: dichloromethane (50:50) and the dichloromethane (100%) fractions suggests that Eriosema psoraleoides could be used in the management of diabetes and this gives credence to its use in ethnomedicine for this purpose.

scholarly journals PRELIMINARY PHYTOCHEMISTRY AND ANTIDIABETIC ACTIVITY OF PORTULACA GRANDIFLORA HOOK PLANT EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN RATS

2019 ◽  
pp. 87-90
Author(s):  
DEVI M ◽  
KOMAL S ◽  
LOGESHWARI B
Keyword(s):  
Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Portulaca Grandiflora ◽  
Streptozotocin Induced Diabetes

Objective: The present study was aimed to evaluate the antidiabetic activity of ethanolic extract of the whole aerial plant of Portulaca grandiflora Hook on streptozotocin (STZ)-induced diabetic rats. Methods: Experimental diabetes was induced by a single dose of intraperitoneal injection of STZ (150 mg/kg). Adult male Wister albino rats were divided into five groups; normal control, diabetic control, diabetic glibenclamide (5 mg/kg), diabetic P. grandiflora H. extract (200 mg/kg), and diabetic P. grandiflora H. extract (400 mg/kg) for 21 days and analyzed for body weight (BW) and blood glucose. Results: The STZ-treated diabetic control rats showed a significant increase in blood glucose with a concomitant decrease in BW. Oral administration of P. grandiflora H. extract (200 and 400 mg/kg) and glibenclamide (5 mg/kg) for 21 days showed a significant reduction in blood glucose levels and elevation in the bodyweight studies as compared to control and glibenclamide-treated rats. Conclusion: The results of the present study showed that a potent antidiabetic activity was present in the aerial part of plant P. grandiflora H. extract.

scholarly journals EFFECT OF TELMISARTAN ON BLOOD GLUCOSE LEVELS AND BLOOD LIPID LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

2019 ◽  
Vol 12 (3) ◽  
pp. 1303-1308
Author(s):  
Siddamma Amoghimath ◽  
R. N. Suresha
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Blood Lipid ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Blood Lipid Levels

To evaluate the effect of telmisartan on blood glucose levels and blood lipid levels in streptozotocin induced diabetic rats. Eighteen Wistar albino rats weighing 150-200gms of either sex were randomly selected from the central animal facility, and divided into 3 groups. Diabetes was induced by injecting Streptozotocin intraperitonelly. The control group received 1% Gum acacia (oral), standard group received 0.5 mg/kg Glibenclamide (oral) and the test group received Telmisartan 7.2mg/kg body weight (oral) from 0-28 days respectively. Body weight of the individual rats were measured on the respective days before blood glucose estimation on 0, 1, 3, 7, 14, 21 & 28th day and fasting blood glucose was estimated by (ACCUCHECK) glucometer. Estimation of fasting lipid profile by lipid screening strips on 1st and 28th day. When compared to control the capillary blood glucose (CBG) levels in the Telmisartan group was less at all the intervals but comparable with that of standard drug Glibenclamide in Streptozotocin induced diabetic rats. Improved lipid profile was seen with the Telmisartan group when compared to control group in Streptozotocin induced diabetic rats. Hypoglycemic activity and improved lipid profile action was seen with Telmisartan group which is comparable to standard drug glibenclamide in streptozotocin induced diabetic albino rats.

scholarly journals ARISTOLOCHIA BRACTEOLATA – ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY IN DEXAMETHASONE-INDUCED DIABETIC RAT MODEL

2017 ◽  
Vol 10 (8) ◽  
pp. 75
Author(s):  
Ganga Rajum ◽  
Hema Sundar Reddy T ◽  
Hema Sundar Reddy T
Keyword(s):  
Blood Glucose ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antihyperlipidemic Activity ◽  
Aristolochia Bracteolata

  Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose levels were determined on 0th and 11th days and MEAB significantly reduced the blood glucose levels in diabetic rats. The effect of MEAB on serum lipid profile such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very LDL (VLDL), and high-density lipoprotein (HDL) was also measured on the 11th day in the diabetic rats. Significant reduction in TC, TGs, LDL, and VLDL levels and improvement in HDL level were observed in diabetic rats.Conclusion: From the results, it was found that the MEAB possess antihyperglycemic and antihyperlipidemic activities.

scholarly journals Evaluation ofMallotus oppositifoliusMethanol Leaf Extract on the Glycaemia and Lipid Peroxidation in Alloxan-Induced Diabetic Rats: A Preliminary Study

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
C. O. Nwaehujor ◽  
I. I. Ezeigbo ◽  
F. C. Nwinyi
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Blood Glucose ◽  
Oral Treatment ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels

Objective. Mallotus oppositifolius(Geiseler) Müll. Arg. (Euphorbiaceae) is folklorically used to “treat” diabetic conditions in some parts of Nigeria therefore the study, to investigate the extract of the leaves for activities on hyperglycaemia, lipid peroxidation, and increased cholesterol levelsin vivoin alloxan diabetic rats as well as its potential antioxidant activityin vitro.Methods. Albino rats (240–280 g) were given an injection of 120 mg/kg body weight, i.p. of alloxan monohydrate. After 8 days, diabetic animals with elevated fasting blood glucose levels (>9 mmol/L) were considered and selected for the study.Results. Oral treatment with the extract administered every 12 h by gavage at doses of 100, 200, and 400 mg/kg of the extract to the test rats, for 14 days, resulted in a significant dose-dependent decrease in blood glucose levels from 12.82 ± 1.02 mmol/dL to 4.92 ± 2.01 mmol/dL at the highest dose of 400 mg/kg compared to the control drug and glibenclamide as well as attendant significant decline in diabetic rats employed in the study.Conclusion. The extract also showedin vitroconcentration-dependent antioxidant activity following the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and ferric reducing assays. Findings further suggest the presence of active antidiabetic and antioxidant principles inM. oppositifoliusleaves.

scholarly journals Evaluation of antihyperglycemic activities of Bangladeshi medicinal plant Cinnamomum tamala Leaf extracts in alloxan treated Albino Rats

2017 ◽  
Vol 7 (1) ◽  
pp. 11
Author(s):  
Abu Zaffar Shibly ◽  
Laila Arjumand Suborna ◽  
Juthi Adhikari ◽  
Md. Shariful Islam
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plant ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Control ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Leaf Extracts ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Diabetic mellitus is a multifactorial disorder associated with its devastating consequences has assumed epidemic proportion in Bangladesh.Methods: The study evaluates the anti-hyperglycemic activity of the aqueous extracts of C. tamala (CTLEt) leaves in blood glucose of albino rats. Type II diabetes mellitus was induced by injecting alloxan at the concentration of 100mg/kg body weight in male albino rats. The diabetic rats were administered orally with aqueous CTLEt at the amount of 1.0ml, 1.5ml and 2.0ml with lab diet and glibenclamide (5mg/kg of body weight). Then blood glucose levels were estimated in all groups after 2 hours, 4 hours, 6 hours, 12 hours and 18 hours of the treatment with CTLEt and a known antidiabetic drug glibenclamide.Results: A comparison was made between the action of CTLEt and glibenclamide. Blood glucose levels of the CTLEt on 18th hours of the study were 8.6 to 5.1mmol/L (1ml CTLEt with lab diet), 10.4 to 4.9mmol/L (1.5ml CTLEt with lab diet), 14.7 to 4.3mmol/L (2.0ml CTLEt with lab diet) in comparison of diabetic control (9.5 to 8.5, 8.7 to 7.8, 7.7 to 7.1mmol/L) and glibenclamide (13.9 to 6.5, 16.3 to 6.1, 9.5 to 5.1mmol/L). Among the sample level, the 2.0ml CTLEt showed a higher efficiency of hypoglycemic effect on alloxan induced diabetic rats.Conclusions: Till date, there is no specific experimental work in Bangladesh about the evolution of antidiabetic activity of C. tamala plant in animal model. Further studies should be undertaken to find out the molecular mechanism of the leaf powder of C. tamala medicinal plant.

scholarly journals Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

2021 ◽  
Vol 12 (1) ◽  
pp. 643-652
Author(s):  
Manohar Reddy ◽  
Raja Sundararajan
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Serum Triglycerides ◽  
Methanol Extracts ◽  
Glucose Levels ◽  
Blood Glucose Levels

Traditionally, Barleria cuspidata Heyne ex Nees is utilized for antidiabetic action with the absence of logical investigation. Thus, the current examination was attempted to explore for its antidiabetic and antihyperlipidemic movement in streptozotocin instigated diabetic animal models. Blood glucose levels were estimated in normoglycemic rats at initial, 60th and 120th minutes intervals and in glucose feed hyperglycemic rats at initial, 30, 60, 90 and 120 minutes after a solitary portion of streptozotocin at 55 mg/kg body weight intraperitoneal were made diabetic in albino rats. Blood glucose levels were estimated at week by week spans after everyday administration of chloroform and methanol extracts of Barleria cuspidata at dosages of 250 and 500 mg/kg body weight. Other biochemical boundaries of serum triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, total protein, albumin, globulin, uric acid, creatinine, urea, transaminases, alkaline phosphatase, alanine aminotransaminase, insulin and glycosylated hemoglobin were likewise estimated toward the finish of the investigation. Chloroform and methanol extracts of Barleria cuspidata by an oral organization for 21 days altogether (P<0.001) decreases the elevated blood glucose extents in diabetic rats whereas in normoglycemic rats it doesn't adjust the blood glucose amounts altogether and in glucose feed hyperglycemic rats significantly decreases the raised blood glucose levels. Likewise, the chloroform and methanol extracts of Barleria cuspidata improved other biochemical boundaries related to diabetes. Moreover, the extracts of Barleria cuspidata favourable affect the histopathological changes of pancreas in streptozotocin initiated diabetic rats. Delayed consequences legitimize the traditional utilization of Barleria cuspidata for its anti-diabetic action.

Therapeutic insights of hydromehtanolic leaf extract of Xanthium indi-cum and α-tocopherol in streptozotocin induced diabetic renal oxidative stress

2017 ◽  
Vol 6 (5) ◽  
pp. 158-166
Author(s):  
Anila Devi Meruva ◽  
Ravi Sahukari ◽  
Venkata Subbaiah Ganjikunta ◽  
Shanmugam Bhasha ◽  
Sathyavelu Reddy Kesireddy
Keyword(s):  
Blood Glucose ◽  
Serum Insulin ◽  
Microvascular Complications ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Body Weights ◽  
Mda Content

Diabetic nephropathy (DN) is one of the important microvascular complications of diabetes mellitus. Several phytochemicals have been reported to show beneficial consequences in Xanthium indicum leaves and α-tocopherol is a well known antioxidant, putting a halt to the fatality of renal dysfunc-tions in DN. In the current study, seven groups of male albino rats six in each group, received the following treatment scheduled for 4 weeks: Normal control, Xanthium indicum, α-tocopherol, Diabetes control, Glibenclamaide treated diabetic, α-tocopherol treated diabetic and Xanthium treated diabetic. Evaluations were made for blood glucose levels, body weights, serum insulin levels, MDA content, creatintne in urine as well as in serum and the histopathological changes were monitored kidney tissues in all experimental rats. Blood glucose levels were significantly (***P<0.001) decreased whereas serum insulin levels and body weights were significantly (***P< 0.001) in-creased, MDA content, serum creatinine levels were significantly (***P< 0.01), (***P<0.001), decreased and urine creatinine levels were increased with the treatment of plant extract and α-tocopherol in diabetic rats. Overall, the findings of this study indicated that the hydromethanolic extract of X. indicum leaves and α-tocopherol possesses a potent capacity that attenuates the renal damage to minimize the deleterious effects of free radicals by maintaining renal hemodynamics in diabetic conditions probably through its antioxidative and hypoglycaemic activity.

scholarly journals Phytochemical and Hypoglycemic Evaluation of Alangium Salviifolium Root Extract

2011 ◽  
Vol 3 (2) ◽  
pp. 393-402 ◽  
Author(s):  
Ahad H. A. ◽  
Padmaja B. S ◽  
Yesupadam P ◽  
Guruprakash P ◽  
Sravanthi M ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Control Group ◽  
Root Extract ◽  
Alcoholic Extract ◽  
Dependent Manner ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels

.The main purpose of present study was to perform phytochemical screening and explore the anti-hyperglycaemic properties of Alangium salvifolium root extract in normal and alloxan induced diabetic rats. A. salvifolium root gave maximum extractive values of 6.4 % w/w with Ethanol and other parameters were within limits. The extract gave positive tests for phytosterols, triterpenes, flavonoids, carbohydrates and alkaloids. The ethanolic extract of A. salvifolium was found to be nearly as potent as tolbutamide in decreasing the blood glucose levels in normal fasting rats. In normal control group the percent reduction in blood glucose indicated that the extract is fast acting. The extract showed significant decrease in blood glucose, when compared with tolbutamide. The evaluated blood glucose levels in alloxan induced diabetic rats were significantly decreased up to 24th h compared to tolbutamide. A single oral administration of alcoholic extract at doses 100, 250 and 500 mg per kg produced a significant blood glucose reduction in a dose dependent manner in normal and diabetic rats. These data confirm the hypoglycaemic and anti-hyperglycaemic effect of alcoholic extract of A. salvifolium root in normal and diabetic rats respectively when compared with standard drug tolbutamide.Keywords: Alangium salvifolium; Ethanolic extract; Alloxan induced; Hypoglycaemic action.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i2.7047                J. Sci. Res. 3 (2), 393-402 (2011)

scholarly journals Effect of turmeric on alloxan induced diabetes mellitus in albino rats

2019 ◽  
Vol 8 (2) ◽  
pp. 264
Author(s):  
Mugdha Rajeeva Padhye ◽  
Sangita Devrao Jogdand
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Adverse Effects ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Organ Systems ◽  
Mean Blood Glucose

Background: Diabetes mellitus is a chronic metabolic disorder of glucose metabolism characterised by hyperglycaemia. Long standing diabetes mellitus leads to various complications affecting multiple organ systems. Management of diabetes mellitus includes lifestyle modification and pharmacotherapy. Pharmacotherapy of diabetes mellitus includes a wide variety of drugs that help in achieving adequate glycaemic control. Anti-diabetic medications are however associated with several adverse effects. Phytochemicals are being used extensively for the treatment of various diseases. Use of phytochemicals would minimize adverse effects due to various anti-diabetic drugs and improve patient compliance. In the present study, authors studied the effect of turmeric on alloxan induced diabetes mellitus in albino rats.Methods: Albino Wistar rats of either sex weighing 180 - 250grams were utilized for the present study. Diabetes mellitus was induced by intraperitoneal administration of alloxan. Ethanolic extract of turmeric was administered to diabetic rats daily orally for duration of 28 days. Blood glucose levels were monitored using glucometer before and after intervention with turmeric.Results: Statistically significant reduction in mean blood glucose levels (p value <0.05) was seen after intervention with turmeric in diabetic rats. There was a significant reduction in mean blood glucose levels.Conclusions: Ethanolic extract of turmeric showed antihyperglycemic effect in diabetic rats.

scholarly journals In-vivo Hypoglycemic Activity of Grewia asiatica Fruit Extract in Streptozotocin Mediated Diabetic Rats

2021 ◽  
pp. 68-75
Author(s):  
Zuneera Akram ◽  
Aisha Noreen ◽  
Muzammil Hussain ◽  
Maryam Inayat ◽  
Sobia Akhter ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Alternative Therapy ◽  
Treated Group ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Fruit Extract ◽  
Standard Drug ◽  
Glucose Levels

Diabetes mellitus has high global prevalence and occurrence and is considered to bean endocrinological and/or metabolic disorder. Conventional drug treatment is costly and has toxic side effects, although it is successful in treating diabetes mellitus. If effective and less toxic, herbal medicine will thus include alternative therapy. This research has been designed to investigate the role of Grewia asiatica extract in the control of diabetes in male albino rats with Streptozotocin mediated type 2 diabetes. Grewia asiatica fruit extract at a dose of 200mg/kg was given to Streptozotocin mediated type II DM Rats. A known anti-diabetic drug, Glibenclamide has been used as a standard drug. The method of the research was to monitor the effect of Grewia asiatica on the blood glucose level of Rats. In this study, Rats were split into four categories i.e. Control, Streptozotocin treated, Streptozotocin + Glibenclamide treated and Streptozotocin +Grewia asiatica extract-treated group.  Grewia asiatica fruit extract significantly improve the blood glucose levels as compared to the standard drug Glibenclamide in Streptozotocin mediated diabetic group. Conclusion: It was concluded that Grewia asiatica may be used in the treatment of diabetes or decreasing the elevated level of blood sugar.

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