Ways to increase the effectiveness of treatment of psoriasis patients with dystrophic lesions of the nail plates

2021 ◽  
pp. 48-53
Author(s):  
T.О. Lytynska ◽  
L.O. Naumova
Keyword(s):  
Clinical Effect ◽  
Main Group ◽  
Degenerative Changes ◽  
Complex Treatment ◽  
Slight Improvement ◽  
Basic Therapy ◽  
Results Of Treatment ◽  
Positive Clinical Effect ◽  
Complex Therapy ◽  
Dystrophic Nail

Objective — to increase the effectiveness of treatment of psoriasis patients with degenerative changes in the nails, by including in the complex therapy of the topical drug Onychocid® Emtrix, aimed at restoring the integrity of the nail plates. Materials and methods. 38 patients with psoriasis and various forms of onychodystrophy (OD) were examined and treated. The effectiveness of therapy was evaluated based on the results of treatment of patients who were divided into two clinical groups — the main and the comparison ones. Patients in both groups received basic therapy. In addition, patients of the main group were prescribed a combined drug Onychocid® Emtrix, which was applied on the nail plates and under the tips of damaged nails once a day for 3 – 6 months. Results and discussion. Patients with psoriasis are diagnosed with dystrophic changes of nail plates of varying severity. OD of the fingers only was detected in 14 (36.8 %) patients; toes — in 5 (13.2 %); fingers and toes at the same time — in 19 (50.0 %) patients. As a result of complex treatment, in patients of the main group there was an early (already on the 2—4th week of use of the drug Onychocid® Emtrix) improvement of the appearance of deformed nails. After the course of treatment, these patients showed a positive clinical effect, i. e. decrease in thickness, normalization of density, color and structure of nail plates. At the same time, «significant improvement» and «improvement» were noted in 34 (89.5 %), «slight improvement» — in 3 (7.9 %), «no improvement» — in 1 (2.6 %) patients. Conclusions. Treatment of psoriasis patients with dystrophic nail lesions should be complex and focused, including the restoration of the integrity of the nail plates. The inclusion in the complex therapy of patients with psoriatic OD of the combined drug Onychocid® Emtrix increases the effectiveness of treatment, in particular, helps to restore the structure, shape, integrity, thickness and color of the nail plates.

scholarly journals Effi ciency of complex treatment of the patients with vertebral thoracalgia using the manual therapies

2019 ◽  
Vol 27 (3) ◽  
pp. 5-11
Author(s):  
Oleksandr Kozolkіn ◽  
Svitlana Medvedkova ◽  
Lisova
Keyword(s):  
Manual Therapy ◽  
Comparison Group ◽  
Average Duration ◽  
Main Group ◽  
Descriptive Statistics ◽  
Complex Treatment ◽  
Slight Improvement ◽  
Similar Treatment ◽  
Results Of Treatment ◽  
Effi Ciency

Objective: to increase the eff ectiveness of complex treatment of patients with vertebral thoracalgia (VT) through the diff erential use of manual therapy and kinesiotherapy, depending on the character of neurological signs. We observed 507 patients with VT. Among them, 368 patients (72.6 %) were included in the main group, where complex treatment was carried out using manual therapy (MT) and kinesiotherapy. There were 128 men (34.8 %), 240 women (65.2 %). The comparison group consisted of 139 patients (27.4 %) who received similar treatment, but without MT and kinesiotherapy. There were 51 men (36.7 %), women — 88 (63.3 %). Groups of patients with VT were comparable in terms of the duration of the disease, the timing of exacerbation, the severity of pain and the limitation of vertebrodynamics. At the diagnostic phase, all patients were given a detailed vertebral neurological examination according to a specially developed protocol and computed tomography of the spine. Statistical analysis was performed using descriptive statistics methods. As a result of treatment the patients in the main group, where MT was used in complex treatment, 261 patients (70.9 %) were discharged, 75 patients (20.4 %) - with improvement, 29 (7.9 %) - with slight improvement, and only 3 patients (0.8 %) with thoracalgia with autonomicvisceral singns were discharged without improvement. The average bed-day was 13.8 ± 1.9. In the comparison group, the results of treatment were worse: for example, 56 patients (40.3 %) were discharged with a signifi cant improvement, 29 people (20.9 %) — with improvement, with a slight improvement 18 (12.9 %) and 36 patients without improvement (25.9 %). The average duration of inhospital stay was 19.9 ± 1.9. The use of MT in the complex treatment of patients with VT contributed to increased effi ciency, better recovery of patients and reduced length of stay in the department. The results of complex treatment with the using of MT and kinesiotherapy were better in patients who had VT with muscular-tonic signs.

EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING

2020 ◽  
pp. 14-18
Author(s):  
A. M. Fomin
Keyword(s):  
Clinical Effect ◽  
High Efficiency ◽  
Initial Level ◽  
Synthetic Polymer ◽  
Complex Treatment ◽  
Direct Hemoperfusion ◽  
Selective Sorption ◽  
Positive Clinical Effect ◽  
Before And After

A complex treatment of a patient with acute amitriptyline and cyclodol poisoning using enterosorption, intestinal lavage and hemosorption on a new column with a synthetic sorbent is presented. A two-layer synthetic polymer column developed for the selective sorption of cytokines by direct hemoperfusion was used for hemosorption. Quantitative determinations of amitriptyline and cyclodol levels before and after the column, as well as before and after hemosorption have showed high efficiency of the sorbent to remove the toxicant from the blood. The use of 6-hour hemosorption allowed to reduce the level of amitriptyline from the initial level by more than 4 times and the level of cyclodol - by more than 3 times to therapeutic levels and to obtain a pronounced positive clinical effect in the complex treatment of a patient with severe poisoning.

scholarly journals EFFICACY AND SAFETY OF NASAL SPRAY PREVALIN IN THE TREATMENT OF ALLERGIC RHINITIS PATIENTS

2012 ◽  
Vol 9 (5) ◽  
pp. 55-59
Author(s):  
A A Tsyvkina ◽  
L V Luss ◽  
S V Tsarev ◽  
N V Shartanova
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Nasal Spray ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Efficacy And Safety ◽  
Nasal Breathing ◽  
Results Of Treatment ◽  
Functional Methods ◽  
Positive Clinical Effect

Background. To study of efficacy, tolerability and safety of nasal spray Prevalin in the treatment of allergic rhinitis patients. Methods. 30 patients with allergic rhinitis in the age of18 till 45 years were observed. Prevalin was given as one insufflation into each nasal cavity 3 times a day for 21 days. Results of treatment were assessed by the dynamics of clinical symptoms and the results of functional methods . Results. The positive clinical effect was observed in 22 patients (73,3%), using Prevalin. Clinical effect was characterized by the restoration of nasal breathing, reduce swelling of the nasal mucosa. We did not establish a good result of treatment in 8 patients. Conclusion. The study demonstrated clinical efficacy and safety of spray Prevalin.

scholarly journals CURRENT ASPECTS OF DIAGNOSTICS AND TREATMENT OF ACUTE BILLARIAN PANCREATITIS

2018 ◽  
Vol 14 (3-4) ◽  
pp. 74-79
Author(s):  
I.V. Kolosovych ◽  
B.H. Bezrodnyi ◽  
I.V. Hanol
Keyword(s):  
Acute Pancreatitis ◽  
Length Of Stay ◽  
Comparison Group ◽  
Abdominal Cavity ◽  
Main Group ◽  
Duct System ◽  
Results Of Treatment ◽  
Positive Clinical Effect ◽  
Number Of Patients ◽  
Comparative Group

Relevance. The article is devoted to the problem of diagnosis and treatment of acute biliary pancreatitis, which remains one of the most common surgical diseases of the abdominal cavity and accounts for 33.2% of the total number of patients with acute pancreatitis. Objective of the work is to improve the diagnosis and results of surgical treatment of patients with acute pancreatitis of biliary etiology. Materials and methods. The results of treatment of 264 patients with acute pancreatitis of biliary etiology are analyzed. Operative treatment was applied in 92 (34,8 %) patients: endoscopic operations were performed in 44 patients (16,7 %). Thus, in 10 (3,8 %) patients, endoscopic papilloprotectomy was performed with the auditory of the duct system and the extraction of concrements. In other cases, organo-preserving intervention was performed without disturbing the morphofunctional integrity of the sphincter apparatus of the duct system: the cannulation in 6 (2,3%) patients, mechanical (balloon) in 5 (1,9 %) cases, pharmacological (myogenic antispasmodic) dilatation of distal duct and a large duodenal papilla in 11 (4,2 %) patients. In residual choledocholithiasis, a technique of papillotomy under the control of choledochoscopy was proposed – 12 (4,54 %) patients. A comparative analysis of the effectiveness of the treatment of patients who used the "open" (comparative group) and noninvasive endoscopic interventions in the early disease (the main group) was performed. Results. So in the main group the length of stay in the hospital was 12±3,2 days, respectively, in the comparison group – 26±4,3 days. In 42 (95,4 %) patients who had undergone endoscopic surgery, a positive clinical effect, a rapid regress of the symptoms of acute pancreatitis was achieved. In two (4,5 %) patients in the main group, the course was complicated by the development of the abscess of the stuffing box, and puncture under ultrasound control was performed. In patients of the comparison group complications arose in 5 (41,6 %) patients, it is noteworthy that all of them had undergone operative interventions, which were limited only to the rehabilitation and drainage of the abdominal cavity, a stuffing box bag. The mortality rate among unopposed was 1,2 % (2 patients), and among the operated – 11,9 % (11 patients). Among prooperated patients who died, 81,8 % (9 people) were elderly patients. Conclusions. The use of minimally invasive endoscopic interventions in the early phase of the disease reduces the length of stay of patients in the hospital from 26±4,3 days (comparison group) to 12 3,2 days (main group) and the number of complications occurring by 37,1 % (P <0, 05). Application of the proposed method of papillotomy under the control of choledochoscopy makes it possible to reduce the risk of perforation of the wall of the duodenum with the development of peritonitis or retroperitoneal phlegmon by 1,2 % (P <0,05).

Hydrolytic enzymes in therapy of gestosis

2021 ◽  
Vol 50 (2) ◽  
pp. 76-79
Author(s):  
K. A. Gabelova
Keyword(s):  
Blood Pressure ◽  
Immune Complexes ◽  
Clinical Effect ◽  
Hydrolytic Enzymes ◽  
Clinical Effectiveness ◽  
The State ◽  
Complex Treatment ◽  
Traditional Therapy ◽  
Positive Clinical Effect

The clinical effectiveness o f complex enzymotherapy with preparation Vobenzim in treatment o f gestosis was studied in comparison with traditional therapy. The author analyzes the course оf gestation and delivery, and the state оf neonates in women with nephropathy o f I degree, who got common treatment (28 patients) and complex treatment including Vobenzim (17patients). Positive clinical effect o f complex enzymotherapy in case o f nephropathy is displayed in decreasing of edematic syndrome, eliminating or decreasing o f proteinuria, lowering o f blood pressure and impairment o f fetalhypoxia in labors. It goes along with the reduction o f immune complexes fixed in placenta.

Possibilities of osteopathic correction of somatic dysfunctions in children with chronic adenoiditis

2020 ◽  
pp. 62-71
Author(s):  
E. V. Chaiko ◽  
O. I. Kurbatov
Keyword(s):  
Neck Region ◽  
Endoscopic Examination ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
Structural Components ◽  
Thoracic Region ◽  
Head Region ◽  
Complex Therapy ◽  
Chronic Adenoiditis

Introduction. Chronic adenoiditis is one of the most frequent ENT diseases. It is comparatively resistant, and in advanced cases, the pathological process is hardly reversible. Despite the big number of publications on chronic adenoiditis, in a high percentage of cases specialists still encounter frequent recurrence of the disease. That is why issues of standard treatment, especially conservative, the search for adequate and effective methods of medical rehabilitation of patients with chronic inflammatory diseases, including in frequently ill children, are timely and relevant. Osteopathic methods of correction can potentially improve blood circulation and the innervation of adenoids, which will increase the clinical effectiveness of conservative treatment, reduce medication period and achieve a longer remission. However, studies on the influence of osteopathic correction on the course of chronic adenoiditis have not been found in the literature available to us. That is why it was necessary to conduct this study. The goal of research — to justify the possibility of using osteopathic correction in the complex treatment of frequently ill children with chronic adenoiditis.Materials and methods. From January 2018 to March 2019, a prospective controlled randomized study was performed at the MEDSI Clinic (Moscow). Thirty patients with chronic adenoiditis at the age of 4 to 10 years were examined. Patients were divided by the method of simple randomization using a random number generator into two equal groups of 15 people: the main group and the control group. Children of the main group received osteopathic correction along with drug and irrigation therapy for 2 months. In total, 3 osteopathic sessions were conducted with a frequency of 1 time in 14 days. Children in the control group received only pharmacological and irrigation therapy. All patients before the start of treatment and 2 months after the start of treatment were examined by an otorhinolaryngologist with an endoscopic examination, and by an osteopath with the assessment of the main somatic dysfunctions. Otorhinolaryngological examination included history taking and collecting of complaints with fi lling out a special questionnaire, anterior and posterior rhinoscopy, as well as an endoscopic examination of the nasopharynx with the assessment of the revealed changes in points.Results. After the treatment, the number of complaints and the main symptoms of the disease, the number of changes in the nasopharynx and oropharynx, revealed by the results of endoscopic examination, decreased statistically significantly in patients of both groups. The study showed that regional biomechanical disorders are common for children with chronic adenoiditis. Dysfunctions of head region, neck region (visceral component), thoracic region (structural component) were the most frequent. Against the background of the treatment, patients of the main group presented a decrease in the number of regional somatic dysfunctions. Statistically significant differences were obtained in the frequency of occurrence of somatic dysfunctions: head region, neck region (visceral and structural components), thoracic region (visceral and structural components) (p<0,05). In patients of the control group, a statistically significant decrease in the number of somatic dysfunctions was detected only in the head region (p<0,05). A follow-up assessment of the results of the treatment showed that the inclusion of osteopathic correction in the complex therapy of children with chronic adenoiditis contributes to a longer remission (p<0,05).Conclusion. Based on the study, it can be concluded that the direct results of osteopathic correction in the complex treatment of frequently ill children with chronic adenoiditis are comparable with the results of isolated pharmacological and irrigation therapy (reduction in the number of complaints and positive changes in the results of endoscopic examination of the nasopharynx). However, the inclusion of osteopathic correction in the complex therapy of such children contributes to a longer remission, which is of great importance for this group of patients. The results of the research suggest a further study of the possibilities of osteopathic correction of somatic dysfunctions in frequently ill children with chronic adenoiditis.

scholarly journals ALGORITHM OF COMPLEX TREATMENT OF DESTRUCTIVE FORMS OF PULMONARY TUBERCULOSIS AND ITS RATIONALE

2021 ◽  
Vol 19 (1) ◽  
pp. 36-39
Author(s):  
Yu. A. Sheifer ◽  
◽  
I. S. Gelberg ◽  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Comparison Group ◽  
Main Group ◽  
Long Term Results ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
Artificial Pneumothorax ◽  
Cavity Closure

Background. In destructive forms of pulmonary tuberculosis, especially in the presence of drug resistance of mycobacteria, one of the ways to increase the effectiveness of therapy is the use of collapse therapeutic techniques in various modifications. Purpose of the study: to develop and substantiate an algorithm for complex treatment of destructive forms of pulmonary tuberculosis, using artificial pneumothorax (AP). Material and methods: A cohort of 84 people with destructive pulmonary tuberculosis was formed. It was divided into two groups: 42 patients in the main group (chemotherapy (ChT) + AP) and 42 in the comparison group (ChT). Results: an algorithm for the treatment of patients with destructive forms of pulmonary tuberculosis was formulated. Within a period of up to 6 months, abacillation was achieved in 61.9% of cases in the main group (MG), and in 18.9% (p <0.05) in the comparison group (CG). By the 10th month of treatment, the closure of decay cavities was achieved in 78.7% of cases in the MG and in 42.8% (p <0.05) in the CG. By 12 months the closure of decay cavities was observed in 92.1 and 52.4% of cases respectively (p <0.05). Conclusions: The use of the algorithm for the complex treatment of destructive forms of pulmonary tuberculosis makes it possible to achieve abacillation at an earlier time (up to 6 months - in 61.9%). It also allows to increase the frequency of cavity closure by 39.6% as well as achieve an increase in clinical cure (according to long-term results of treatment) by 23.8% and a decrease in the amplification of drug resistance and mortality by 14.3% and 11.9% correspondingly.

scholarly journals COMPLEX THERAPY OF ATOPIC CHEILITIS

2021 ◽  
Vol 74 (2) ◽  
pp. 310-312
Author(s):  
Nataliya M. Ilenko ◽  
Ella V. Nikolishyna ◽  
Iryna Yu. Lytovchenko ◽  
Fardin Atash Bar
Keyword(s):  
Quality Of Life ◽  
Inflammatory Process ◽  
Blood Analysis ◽  
Complex Treatment ◽  
Moderate Severity ◽  
Results Of Treatment ◽  
Literary Sources ◽  
Complex Therapy ◽  
General Profile

The aim: Was to evaluate clinical data after the use of pimecrolimus (1% cream “Elidel”) in patients with mild and moderate severity of atopic cheilitis, according to modern therapeutic requirements. There was an algorithm of treatment the patients with cheilitis proposed it based on the data from literary sources and personal clinical experience. Materials and methods: 22 patients with atopic cheilitis aged from 19 to 40 agreed on a clinical examination in accordance with the protocol of the study. Patients were prescribed “Elidel” in the form of 1% cream for lubrication of the affected areas of the skin and lips, and antihistamine “Erius”, for the normalization of the general condition used sedatives and vitamins after consultation of specialists in the general profile. Results: Patients of both groups during the re-examination after 3, 7, 10 days recorded a positive dynamics of the red border of the lips and skin: a significant reduction in the inflammatory process, normalization of indicators of general blood analysis, improvement in the overall quality of life of patients. Conclusions: The results of treatment allow to consider 1% cream “Elidel” (pimecrolimus) as a preparation of choice in the complex treatment of patients with atopic cheilitis of mild and moderate severity.

Optical neuropathy and edematous exophthalmos. New approaches to treatment

2021 ◽  
pp. 301-305
Author(s):  
G.V. Bratko ◽  
◽  
D.D. Dmitriev ◽  
V.I. Bratko ◽  
A.N. Trunov ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Clinical Effectiveness ◽  
Metabolic Effects ◽  
Positive Trend ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
End Of Treatment ◽  
Wide Range ◽  
Complex Therapy ◽  
Endocrine Ophthalmopathy

Purpose. To study the clinical effectiveness of the administration of complex therapy of drugs to the hemolymphocirculatory organ (pterygopalatine fossa) in edematous exophthalmos in patients with endocrine ophthalmopathy complicated by optical neuropathy. Material and methods. The analysis of the results of treatment of 31 patients (62 eyes) with edematous exophthalmos on the background of endocrine ophthalmopathy complicated by optical neuropathy, who applied for help in the Novosibirsk branch of "MNTC "Eye Microsurgery". All patients were prescribed a 10-day course of intensive complex treatment, consisting of injections into the region of hemolymphocirculation (pterygeal fossa) No. 6 (No. 3 on each side) with an interval of 24 hours of a drug mixture, the formulation of which included Lidocaine 20 mg, Dexazone 4 mg, Hemase 3000 units, Dalargin 1 mg, with additional administration of antioxidants, neuroprotectors, vitamins and keratoprotectors. Results. By the end of treatment, all patients had a pronounced positive trend in the form of a significant (from 0.6 to 1.0) increase in visual acuity, a decrease in exophthalmos (from 2,0 to 3,0 mm), and an increase in color and contrast sensitivity. Conclusions. Due to the violation of venous and lymphatic outflow due to the thickening of extraocular muscles and retrobulbar fiber, injection of drugs with a wide range of decongestant and metabolic effects into the hemolymphocirculation region (pterygeal fossa) is justified and effective. Key words: endocrine ophthalmopathy, optical neuropathy, complex therapy.

scholarly journals Using an ozone therapy in the treatment of trophic ulcers of low extremity

2020 ◽  
Vol 24 (1) ◽  
pp. 98-105
Author(s):  
P.F. Kolisnyk ◽  
I.V. Baranova ◽  
S.P. Kolisnyk ◽  
O.V. Dolynna ◽  
Y.O. Bezsmertnyi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Metabolic Diseases ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
Ozone Therapy ◽  
Treatment Regimens ◽  
Results Of Treatment

Annotation. Diabetes is one of the most common metabolic diseases in the world with a large number of complications. Threatening conditions that significantly reduce the quality of life and even lead to the death include a diabetic foot syndrome. The aim of the study was to investigate the effectiveness of combined ozone therapy in the treatment of patients with type 2 diabetes with chronic lower extremity trophic ulcers. A prospective study of the effectiveness of using the combined method of ozone therapy in the treatment of trophic ulcers of the lower extremities was conducted in the surgical and rehabilitation departments of the University Clinic of the National Pirogov Memorial Medical University. The study involved 52 patients with diadetes mellitus 2 type, who were randomly assigned to the main (n=26) and control (n=26) groups. Subjective and objective changes in the condition of patients were evaluated: an area of trophic ulcers (by A.V. Kuleshov's method), a rate of ulcer’s defect epithelization (by L. Popova's formula) and the quality of life parameters of patients (by the questionnaire SF-36) before and after the treatment. The endpoint of the study was a complete epithelization of the diabetic trophic ulcer. The treatment was carried out according to the generally accepted methodology in both observation groups, and the combination ozone therapy was additionally used for patients of the main group. The latter provided for the intravenous administration of an oxygen-ozonized 0.9% NaCl solution and local exposure of the trophic ulcer defect to the ozonized mixture by chamber aeration. The course of complex treatment was carried out after removal of necrotic tissue and wound cleansing, consisted of 10 local and general ozone therapy procedures, which were carried out every other day. The data obtained were processed using the SPSS for Windows 10.0 and STATISTICA 6.1 application software package (license number BXXR901E245722FA). One month after, the observation changes of the trophic skin defects and Quality of life indicators showed the significantly (p<0.01) better results of treatment in the main group than in the control group. The endpoint of the study was achieved in 85% of patients after complex treatment versus 29% of patients in the control group after a conventional treatment (p<0.01). Using as modern rehabilitation method as ozone therapy is an appropriate complement to the existing treatment regimens, which can significantly accelerate the clinical recovery of patients and, as a result, improve the quality of life. The particular value of the method confirmed by an absence of contraindications and drug overloads of the patient. The study of the effects of ozone therapy on the metabolism of patients with diabetes mellitus type 2 can be a promising area for further research.

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