Dynamics of body weight during lifestyle modification in patients with high cardiovascular risk, depending on the carriage of various variants of thrifty genes

2021 ◽  
Author(s):  
G. S. Isayeva ◽  
O. O. Buryakovska ◽  
M. M. Vovchenko ◽  
I. R. Komir ◽  
N. Y. Emelyanova ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Real Time ◽  
Body Mass ◽  
Polymorphic Locus ◽  
High Cardiovascular Risk ◽  
Anthropometric Parameters ◽  
Polymorphic Variants

Objective — to study the relationship between the carriage of polymorphic variants PPARG2 (Pro12Ala), ADRB2 (Gln27Glu), ADRB2 (Agr16Gly), ADRB3 (Trp64Agr), FABP2 (Thr54Ala) and changes in anthropometric parameters under the influence of increased physical activity in individuals with high cardiovascular risk. Materials and methods. In total, 205 people were examined during the period of years 2019 — 2021. Patients were advised to use physical activity frequently in the form of regular exercises. Among patients who passed the 2nd observation point, 60.5 % (124 patients) reported that they expanded their physical activity, 39.5 % (81 patients) began regular exercises. The study included patients with high cardiovascular risk. The International Physical Activity Questionnaire (IPAQ) was used to assess physical activity. Assessments included anthropometric parameters (weight, height, body mass index, waist and hip circumference, body composition (Composition Monitor BF511, Omron, China, 2015)), levels of total cholesterol, triglycerides, low‑density lipoproteins. Muscle strength (kg/cm2) was assessed using an electric dynamometer on the wrist Camry EH101 2013 (2018). Isolation and purification of DNA from the whole blood was carried out using a set of reagents «DNA‑sorb‑B» (Amplisens, RF) according to the manufacturer’s instructions. Amplification of DNA and genotyping at polymorphic sites in the genes PPARG2, ADRB2, ADRB3, FABP2 was performed by real‑time PCR using a set of reagents «SNP‑EXPRESS‑SHOT» («Litech», RF) according to the manufacturer’s instructions using the product detection system real‑time CFX96 Touch (BioRad Laboratories Pte.Ltd.). Results. Depending on the changes in anthropometric parameters, patients were divided into 2 subgroups: in subgroup 1 there was no decrease in BMI before 30.69 ± 7.25 kg/m2, after 29.03 ± 6.84 kg/m2; p = 0.436, and in subgroup 2 a significant decrease in BMI before 31.85 ± 3.68 kg/m2, after 26.79 ± 3.91 kg/m2; p = 0.041. It was revealed that the decrease in BMI in subgroup 2 was accompanied by a statistically significant decrease in the proportion of adipose tissue (р = 0.011) and an increase the proportion of muscle tissue (р = 0.030). In both groups, blood pressure significantly decreased. Heart rate (HR) decreased in both groups, but these changes did not reach statistical significance (p = 0.43). Changes in anthropometric parameters were not accompanied by significant changes in total cholesterol, LDL cholesterol, triglycerides levels. A significant increase in HDL cholesterol levels was revealed. It was found that patients with CC and GG variants of the polymorphic locus PPARG2 (Pro12Ala), CG and GG variants of the polymorphic locus ADRB2 (Gln27Glu) and TT variant of the polymorphic locus ADRB3 (Trp64Agr) prevailed in group 2. No significant differences were found for the FABP2 locus (Thr54Ala). In subgroup 1, there were no significant differences in people with various polymorphic variants of genes. Conclusions. Associations have been established between the carriage of CG/CG + GG PPARG2 (rs1801282), AA/AA + AG ADRB2 (rs1042713) and TT ADRB3 (rs4994) and a decrease in body mass index during exercise expansion in individuals with high cardiovascular risk.  

scholarly journals Factors Associated with Cardiovascular Risk in High School Students of a Public School in the City of Santiago de Cali, Colombia

2020 ◽  
Vol 18 (1) ◽  
pp. 24 ◽  
Author(s):  
Carmelina Zorrilla-López ◽  
Juan David Ceballos-Santacruz ◽  
Christian Daniel Ramírez-Giraldo ◽  
Brayan Esneider Patiño-Palma ◽  
Pedro Calero-Saa
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Alcohol Consumption ◽  
Body Mass ◽  
Educational Institution ◽  
Factors Associated ◽  
The City ◽  
Low Cardiovascular Risk

Introduction: Cardiovascular diseases are the leading cause of death worldwide, and they have become a problem of interest of public health, both for developed and developing countries. In this regard, the decrease in time devoted to physical activity and the increase of sedentary activities stand out, thus making physical inactivity one of the many risk factors for Cardiovascular diseases. The objective was to determine the factors associated with cardiovascular risk in students of an educational institution in the city of Cali, Colombia. Materials and Methods: It is an observational and analytical epidemiological study with a sample of 227 randomly selected students, with 95 % reliability. To determine the level of physical activity in schoolchildren, researchers applied the international IPAQ physical activity questionnaire, and took anthropometric measures such as weight, height, and waist and hip circumference. Results: 96 % of the participants presented low cardiovascular risk. Likewise, the variables that showed a statistically significant association with cardiovascular risk were alcohol consumption and body mass index, which predict 81 % of the possibility of being at risk. Conclusions: The low cardiovascular risk and the high level of physical activity prevailed in the evaluated schoolchildren, significant differences regarding gender were observed, finding that men have higher values in weight, height, and waist/hip ratio compared to females. Finally, it was established that the factors associated with cardiovascular risk are body mass index and alcohol consumption.

scholarly journals The Effects of Reduced Physical Activity on the Lipid Profile in Patients with High Cardiovascular Risk during COVID-19 Lockdown

2021 ◽  
Vol 18 (16) ◽  
pp. 8858
Author(s):  
Marco Alfonso Perrone ◽  
Alessandro Feola ◽  
Massimo Pieri ◽  
Bruno Donatucci ◽  
Chiara Salimei ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Vigorous Physical Activity ◽  
High Cardiovascular Risk ◽  
Reduced Physical Activity ◽  
The Government ◽  
Statin Drug ◽  
Age Range

Background: The COVID-19 pandemic is a serious global health problem. In Italy, to limit the infections, the government ordered lockdown from March 2020. This measure, designed to contain the virus, led to serious limitations on the daily life of the individuals it affected, and in particular in the limitation of physical exercise. The aim of this study was to evaluate the effects of reduced physical activity on the lipid profile in patients with high cardiovascular risk. Methods: We enrolled 38 dyslipidemic patients, 56% male, with an age range of 44–62 years, considered to be at high cardiovascular risk. All patients were prescribed statin drug therapy (atorvastatin 40 mg) and a vigorous physical activity program four times a week, 1 h per session. In addition, a personalized Mediterranean diet was prescribed to all the patients. Total cholesterol, LDL, HDL and triglycerides were measured in patients at T0 before lockdown and at T1 during lockdown. Results: Data showed a significant increase (p < 0.01) in total cholesterol (+6,8%) and LDL (+15,8%). Furthermore, the analysis of the data revealed a reduction in HDL (−3%) and an increase in triglycerides (+3,2%), although both were not significant (p > 0.05). Conclusions: Our study showed that the reduction in physical activity during lockdown led to an increase in LDL levels, and therefore, in the risk of ischemic heart disease in dyslipidemic patients with high cardiovascular risk.

Abstract P180: Low Prevalence of Ideal Cardiovascular Health in Patients With Severe Hypercholesterolemia in a Largely Rural Population

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Nicole A Groth ◽  
Catherine P Benziger
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Sex Differences ◽  
Total Cholesterol ◽  
Body Mass ◽  
Cardiovascular Health ◽  
Healthy Diet ◽  
Ideal Cardiovascular Health ◽  
Health Factors ◽  
Low Prevalence

Introduction: The American Heart Association’s ideal cardiovascular health (ICH) score is determined by 3 ideal health factors (normal blood pressure, untreated total cholesterol, and glucose) and 4 ideal health behaviors (non-smoking, normal body mass index, high physical activity, and heart healthy diet). Achieving ICH, defined as meeting 5 of the 7 metrics, decreases risk of cardiovascular disease. Prevalence estimates of ICH in patients with severe hyperlipidemia (SH) living in rural areas are lacking. Hypothesis: We aimed to determine the prevalence of poor, intermediate, and ICH in patients with SH in a large healthcare system (Essentia Health), where over 60% of the population is rural. Methods: The electronic medical record-based SH registry is a cross-sectional cohort study at the Essentia Health of patients who have ever had a low-density lipoprotein - cholesterol value of 190 mg/dL or higher, since 01/01/2000 (n=17,925). Patients were excluded if they did not have a visit at the institution within the past 5 years (n=209) or were outside of the age 20-75 years (n=3,153). Physical activity and healthy diet were not available in the record and were excluded from the score. Patients with missing data were assumed ideal given low clinical suspicion of conditions. Methods: A total of 14,544 (81.1%) of the SH registry patients met inclusion criteria (mean age 63 +13 years; 58.9% female). Figure 1 shows the prevalence of ICH metrics in the total population. Only 3 (0.02%) people met all five of the ideal metrics (score of 10); more females had a score of 8-10 than males (12.5% vs. 9.6%). A total of 13 (0.08%) had a score of 0 (poor) and 3.0% had a score of 0-2 with no sex differences. Not smoking and ideal glucose were the most prevalent health factors. The mean score was 5.6 (+1.6) with no sex differences. Conclusions: There is low prevalence of ICH in patients with SH living in rural populations. The metrics with the lowest prevalence and therefore highest potential for improvement are the health factors: total cholesterol and body mass index.

scholarly journals Systemic hypertension, diabetes mellitus, and dyslipidemia in relation to body mass index: evaluation of a Brazilian population

2004 ◽  
Vol 59 (3) ◽  
pp. 113-118 ◽  
Author(s):  
Cintia Cercato ◽  
Márcio Corrêa Mancini ◽  
Ana Maria Carvalho Arguello ◽  
Vanessa Quintas Passos ◽  
Sandra Mara Ferreira Villares ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
High Risk ◽  
Total Cholesterol ◽  
Body Mass ◽  
Brazilian Population ◽  
Systemic Hypertension ◽  
Index Method ◽  
Risk Patients

OBJECTIVE: To determine the prevalence of systemic hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia in a Brazilian population in relation to body mass index. METHOD: Retrospective evaluation of 1213 adults (mean age: 45.2 ± 12.8; 80.6% females) divided into groups according to body mass index [normal (18.5 - 24.4 kg/m²); overweight (25 - 29.9 kg/m²); grade 1 obesity (30 - 34.9 kg/m²); grade 2 obesity (35 - 39.9 kg/m²), and grade 3 obesity (> 40 kg/m²)]. The prevalence of hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia were analyzed in each group. The severity of cardiovascular risk was determined. High-risk patients were considered those reporting 2 or more of the following factors: systemic hypertension, HDL < 35 mg/dL, total cholesterol > 240 mg/dL, triglycerides > 200 mg/dL when HDL < 35 mg/dL, and glycemia > 126 mg/dL. Moderate-risk patients were those reporting 2 or more of the following factors: systemic hypertension, HDL < 45, triglycerides > 200 mg/dL, and total cholesterol > 200 mg/dL. RESULTS: The prevalence of systemic hypertension, diabetes mellitus, hypertriglyceridemia, and low HDL-cholesterol levels increased along with weight, but the prevalence of hypercholesterolemia did not. The odds ratio adjusted for gender and age, according to grade of obesity compared with patients with normal weight were respectively 5.9, 8.6, and 14.8 for systemic hypertension, 3.8, 5.8, and 9.2 for diabetes mellitus and 1.2, 1.3, and 2.6 for hypertriglyceridemia. We also verified that body mass index was positively related to cardiovascular high risk (P < .001) CONCLUSION: In our population, cardiovascular risk increased along with body mass index.

Association of body mass index with kidney function and mortality in high cardiovascular risk population: A nationwide prospective cohort study

Nephrology ◽  
2021 ◽  
Author(s):  
Noppawit Aiumtrakul ◽  
Annop Kittithaworn ◽  
Ouppatham Supasyndh ◽  
Rungroj Krittayaphong ◽  
Arintaya Phrommintikul ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Kidney Function ◽  
Body Mass ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
High Cardiovascular Risk ◽  
Risk Population

scholarly journals Cambios antropométricos y asociación del nivel de actividad física en docentes universitarios

2017 ◽  
Vol 14 (2) ◽  
pp. 38 ◽  
Author(s):  
Nancy Janneth Molano-Tobar ◽  
Magdi Yannette Ordoñez-Fernández ◽  
Dolly Ximena Molano-Tobar
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Statistical Significance ◽  
Female Gender ◽  
The Body ◽  
Short Version ◽  
Hip Circumference ◽  
Anthropometric Parameters

Objetivo: Evaluar los cambios antropométricos de un grupo de docentes universitarios y la relación actual con el nivel de actividad física. Material y Métodos: estudio cuantitativo, descriptivo con corte longitudinal. La toma de datos se realizó en dos momentos: el primero entre los años 2000 a 2003, valorando las variables antropométrica de peso, talla, índice de masa corporal, perímetros de cintura, cadera, así como la presión arterial, y el segundo momento entre los años 2013 a 2015, teniendo en cuenta las variables anteriores y aplicando el International Physical Activity Questionn, versión corta. El tamaño de muestra fue intencional según los criterios de inclusión, correspondiendo a 162 docentes, 97 hombres y 65 mujeres. Resultados: se evidenciaron cambios relacionados con el aumento de medidas antropométricas, el índice de masa corporal, la presión arterial con significancia estadística (p<0.05) para variables como la presión arterial, perímetros de cintura y cadera en los participantes. Se registró un alto nivel de inactividad física. Conclusiones: los parámetros antropométricos tuvieron una evolución hacia el incremento, manifestando una significancia estadística relacionada con el género femenino. Por lo anterior, se destaca la necesidad de implementar estrategias de prevención de la enfermedad y promoción de la salud, para mejorar los niveles de actividad física y, de este modo, disminuir el riesgo de enfermedades que afecten la salud.PALABRAS CLAVE: actividad física, antropometría, docentes.ANTHROPOMETRIC CHANGES AND RELATIONSHIP WITH THE LEVEL OF PHYSICAL ACTIVITY IN TEACHERSABSTRACT Objective: To evaluate the anthropometric changes of a group of university teachers and the current relationship with physical activity. Material and Methods: Quantitative study, descriptive with a longitudinal section. The data was taken in two different points in time. The first time between the years 2000 to 2003, evaluating the anthropometric variables of weight, size, body mass index, waist and hip circumference, as well as blood pressure, and the second time between 2013 and 2015 considering the previous variables and applying the International Physical Activity Question (short version), the size of the sample was intentional according to the criteria of inclusion, corresponding to 162 of the teachers, 97 men and 65 women. Results: Changes were evidenced, related to the increase of anthropometric sizes, the body mass index, blood pressure with statistical significance (p<0.05) for variables such as blood pressure, waist and hip circumference of  the participants. A high level of physical inactivity was registered. Conclusions: the anthropometric parameters had an evolution towards the increment, demonstrating a statistical significance related to the female gender. Consequently, the necessity of implementing strategies of prevention of disease and promotion of health is emphasized, to improve the levels of physical activity thus decreasing the risk of diseases that affect the health.KEYWORDS: physical activity, anthropometry, teachers.ALTERAÇÕES ANTROPOMÉTRICAS E SUA RELAÇÃO COM O NÍVEL DE ATIVIDADE FÍSICA DOS PROFESSORESRESUMOObjetivo: Avaliar as alterações antropométricas de um grupo de professores universitários e a relação atual com o nível de atividade física. Materiais e Métodos: estudo quantitativo, descritivo com corte longitudinal. A toma de dados se realizou em dois momentos, o primeiro entre os anos 2000 a 2003, valorando as variáveis antropométricas de peso, altura, índice de massa corporal, circunferência da cintura, quadril, assim como a pressão arterial, e o segundo momento entre os anos 2013 a 2015 tendo em conta as variáveis anteriores e aplicando o International Physical Activity Question versão curta, o tamanho de amostra foi intencional de acordo com os critérios de inclusão, correspondendo a 162 dos professores, 97 homens e 65 mulheres. Resultados: evidenciaram-se alterações relacionadas com o aumento de medidas antropométricas, o índice de massa corporal, a pressão arterial com significância estadística (p<0,05) para variáveis como a pressão arterial, circunferência da cintura e do quadril nos participantes. Registrou-se um alto nível de inatividade física. Conclusões: os parâmetros antropométricos tiveram uma tendência crescente, manifestando uma significância estadística relacionada com o género feminino. Portanto, destaca-se a necessidade de implementar estratégias de prevenção da doença e promoção da saúde, para melhorar os niveles de atividade física e deste modo diminuir o risco de doenças que afetem a saúde.Palavras-chave: antropometria, atividade física, professores.

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