scholarly journals Protective role of Gymnema sylvestre leaf extract on high sucrose diet-induced diabetic like phenotype, oxidative stress, reproductive fitness and longevity in Drosophila melanogaster

2019 ◽  
Vol 5 (3) ◽  
pp. 535-546 ◽  
Author(s):  
Hassan Rangegowda Harshavardhana ◽  
Mysore Siddaiah Krishna
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Leaf Extract ◽  
Reproductive Fitness ◽  
Protective Role ◽  
Gymnema Sylvestre ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster : Protective role of Syzygium cumini and Bauhinia forficata

2017 ◽  
Vol 89 ◽  
pp. 605-616 ◽  
Author(s):  
Assis Ecker ◽  
Thallita Karla Silva do Nascimento Gonzaga ◽  
Rodrigo Lopes Seeger ◽  
Matheus Mulling dos Santos ◽  
Julia Sepel Loreto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Protective Role ◽  
Syzygium Cumini ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Bauhinia Forficata ◽  
High Sucrose ◽  
And Oxidative Stress

scholarly journals Spirulina Lipids Alleviate Oxidative Stress and Inflammation in Mice Fed a High-Fat and High-Sucrose Diet

Marine Drugs ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 148 ◽  
Author(s):  
Yuhong Yang ◽  
Lei Du ◽  
Masashi Hosokawa ◽  
Kazuo Miyashita
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Lipid Hydroperoxide ◽  
Mrna Levels ◽  
High Fat ◽  
Inflammatory Status ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose ◽  
Pro Inflammatory Cytokines

High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) and then their effects on oxidative stress and inflammation in the mice fed a HFHSD were investigated. The results show that the major lipid classes and fatty acid profiles of SLC and SLE were almost similar, but the gamma-linolenic acid (GLA) and carotenoid contents in SLE was a little higher than that in SLC. Dietary 4% SLC or SLE for 12 weeks effectively decreased the hepatic lipid hydroperoxide levels as well as increased the activities and mRNA levels of antioxidant enzymes in the mice fed a HFHSD. In addition, supplementation with SLC and SLE also markedly decreased the levels of serum pro-inflammatory cytokines and the mRNA expression of pro-inflammatory cytokines in the liver and epididymal white adipose tissue of mice fed a HFHSD, and the effects of SLC and SLE were comparable. These findings confirm for the first time that dietary Spirulina lipids could alleviate HFHSD-induced oxidative stress and inflammation.

scholarly journals Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats

2005 ◽  
Vol 93 (6) ◽  
pp. 957-963 ◽  
Author(s):  
Keiichiro Sugimoto ◽  
Junko Suzuki ◽  
Kazuya Nakagawa ◽  
Shuichi Hayashi ◽  
Toshiki Enomoto ◽  
...  
Keyword(s):  
Eucalyptus Globulus ◽  
Leaf Extract ◽  
Elevated Concentration ◽  
Dependent Manner ◽  
High Fructose ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Hepatic Triacylglycerol ◽  
Dose Dependent ◽  
High Sucrose

Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75 % in calorie base) with or without ELE (10 g/kg diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (sd 37·9)v. 392 (sd 26·0) g (n7);P<0·05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1·44 (sd 0·448)v.2·79 (sd 0·677) mmol/l (n7);P<0·05) and liver (19·1 (sd 5·07)v.44·1 (sd 16·28) μmol/g (n7);P<0·05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 min after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, which inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.

scholarly journals Effect of Chlorella vulgaris extract on high sucrose diet-induced diabetes in Drosophila melanogaster

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Mohamad Agus Salim ◽  
Muhammad Subandi ◽  
Yeni Yuniarti
Keyword(s):  
Drosophila Melanogaster ◽  
Chlorella Vulgaris ◽  
Metabolic Disorders ◽  
Single Treatment ◽  
Wild Type ◽  
Negative Effects ◽  
The Third ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Microalgae Chlorella vulgaris is a microscopic green algae that has known potential as a source of food and medicine (functional food). However, the pharmacological capacity of this microalgae species against disease due to metabolic disorders is still not understood. Thus, this study aims to evaluate the effect of C. vulgaris extract on animal models of Drosophila melanogaster (Drosophila) which are fed high-sucrose diet (HSD). Wild type Drosophila was used in this study for 7 days of observation. Drosophila was divided into four groups consisting of the first group that was not treated as a control. The second group was treated with HSD (30%), the third group was treated with C. vulgaris extract (120 g/L) and the fourth group was treated with double treatment (HSD and C. vulgaris extract). The parameters observed included fecundity, hatchability, hemolymph glucose and triglyceride levels. The results showed that the extract of C. vulgaris was able to reduce the negative effects of giving HSD. The single treatment of C. vulgaris extract and double treatment between C. vulgaris extract and HSD significantly decreased levels of hemolymph glucose, triglycerides of Drosophila, while the parameters of fecundity and hatchability were significantly increased when compared to Drosophila which only received HSD treatment. The conclusion of this study is that C. vulgaris extract can be used as an antihyperglycemic agent which requires further study to prove the results that have been obtained.

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