Efficacy of application of the luteotropic drug for the prevention of intrauterine growth restriction in dairy cows

2021 ◽  
pp. 46-51
Author(s):  
L. Savchenko ◽  
V. Mikhalev
Keyword(s):  
Embryonic Development ◽  
Intrauterine Growth Restriction ◽  
Negative Control ◽  
Intrauterine Growth ◽  
The Third ◽  
Physiological Flow ◽  
Ultrasound Study ◽  
Yellow Body ◽  
New Knowledge ◽  
Newborn Calves

Purpose: studying the effectiveness of the use of luteotropic action for preventing embryonic development disorders.Materials and methods. The research object is lactating animals in 60-75 days after a selection that manifests sex cyclicity and separated into 4 groups. The first group (n = 11) – in the insemination of parenterally injected the preparation of tautin at a dose of 5 ml. The second group (n = 11) – tautin was administered at a dose of 10 ml on the same time as cows of the first group. The third group (n = 12) – tautin injected 10 ml twice: during seeding and on the 14th day after seeding. The fourth group (n = 12) – was injected with saline per day of seeding and on the 14th day at a dose of 10 ml (negative control). Conducted a transrectal and ultrasound study at the end of the 1st and 2nd month of gestation, in which the size of the yellow body of pregnancy, embryo and the fetus was taken into account. Upon completion of pregnancy, all animals are taken into account: the nature of the flow of labor (physiological flow, objectiveness, fulbirth, detention, postpartum), postpartum period (physiological flow, submissiveness of the uterus, endometritis), the state of newborn calves (gender of the fetus, the time of manifestation of confident poses of standing, sucking reflex, body mass).Results. It has been established that the twofold administration of the tautin during seeding and on the 14th day after a dose of 10,0 ml is accompanied by an increase in fertilization by 19,7-28,8%, a decrease in the delay syndrome of the fetus development of 1,4-4,0 times, Absence of embryonic mortality. The use of the drug Tautin twice in a dose of 10,0 ml is accompanied by an increase in the size of the yellow body of pregnancy in 1,43-2,15 times, in comparison with other modes of its use, cockerel-dump-sized – by 12,9-37,6% and diameter Cases – by 10,1-46,6%. The use of a luteotropic drug is accompanied by a decrease in the incidence of cows to the detention of the last 1,8 times, the submissive of the uterus – 1,8 times, endometritis – by 2,7 times, the time of manifestation of confident posture of the standing of newborns of newborn calves – by 15,6 minutes, a sucking reflex – on 16,5 min and diarrheal syndrome – 2,7 times.Conclusion. The scientific novelty of research lies in the fact that new knowledge is obtained on the effectiveness of the use of the drug of luteotropic action, created using the technology of recombinant proteins, for the prevention of violations of embryonic development in cows.

Impact of maternal malaria and under-nutrition on intrauterine growth restriction: a prospective ultrasound study in Democratic Republic of Congo

2008 ◽  
Vol 137 (2) ◽  
pp. 294-304 ◽  
Author(s):  
S. H. LANDIS ◽  
V. LOKOMBA ◽  
C. V. ANANTH ◽  
J. ATIBU ◽  
R. W. RYDER ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Growth Restriction ◽  
Third Trimester ◽  
Republic Of Congo ◽  
Intrauterine Growth ◽  
Under Nutrition ◽  
Ultrasound Study ◽  
Binomial Regression

SUMMARYMaternal malaria and under-nutrition are established risk factors for small-for-gestational-age (SGA) births; however, whether malaria is associated with intrauterine growth restriction (IUGR) is unknown. We investigated IUGR risk among 177 HIV-negative pregnant women enrolled in a longitudinal ultrasound study conducted in Democratic Republic of Congo from May 2005 to May 2006. Malaria infection, maternal anthropometrics, and ultrasound estimated fetal weight were measured monthly. All positive malaria cases were treated and intermittent presumptive therapy (IPTp) provided. Log-binomial regression models for IUGR were fitted using generalized estimating equations to account for statistical clustering of repeat IUGR measurements. Twenty-nine percent of fetuses experienced an episode of IUGR with the majority occurring in the third trimester. The risk of IUGR associated with malaria was greatest after three or more cumulative infections (RR 3·3, 95% CI 1·3–8·2) and was two- to eight-fold higher among women with evidence of under-nutrition. Receiving antimalarial treatment in the previous month (for IPTp or treatment) was significantly protective against IUGR (RR 0·5, 95% CI 0·3–0·7). The interaction observed between malaria and under-nutrition suggests that antenatal programmes in malaria endemic areas should incorporate nutritional screening and supplementation in addition to IPTp.

Fetal upper arm volume in predicting intrauterine growth restriction: A three-dimensional ultrasound study

2005 ◽  
Vol 31 (11) ◽  
pp. 1435-1439 ◽  
Author(s):  
Chiung-Hsin Chang ◽  
Chen-Hsiang Yu ◽  
Huei-Chen Ko ◽  
Chu-Ling Chen ◽  
Fong-Ming Chang
Keyword(s):  
Intrauterine Growth Restriction ◽  
Three Dimensional ◽  
Growth Restriction ◽  
Upper Arm ◽  
Intrauterine Growth ◽  
Ultrasound Study

scholarly journals P07.14: Value of umbilical vein blood flow in the third trimester to predict intrauterine growth restriction

2006 ◽  
Vol 28 (4) ◽  
pp. 572-572
Author(s):  
M. Comas ◽  
S. Fernandez ◽  
F. Figueras ◽  
O. Gomez ◽  
J. M. Jimenez ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intrauterine Growth Restriction ◽  
Umbilical Vein ◽  
Growth Restriction ◽  
Third Trimester ◽  
Intrauterine Growth ◽  
The Third

scholarly journals Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice

2019 ◽  
Vol 116 (42) ◽  
pp. 21047-21053 ◽  
Author(s):  
Shogo Matoba ◽  
Shoko Nakamuta ◽  
Kento Miura ◽  
Michiko Hirose ◽  
Hirosuke Shiura ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Embryonic Development ◽  
Intrauterine Growth Restriction ◽  
Molecular Mechanisms ◽  
Growth Restriction ◽  
Metabolome Analysis ◽  
Placental Development ◽  
Short Side ◽  
Intrauterine Growth

The placenta is critical in mammalian embryonic development because the embryo’s supply of nutrients, including amino acids, depends solely on mother-to-embryo transport through it. However, the molecular mechanisms underlying this amino acid supply are poorly understood. In this study, we focused on system A amino acid transporters Slc38a1/SNAT1, Slc38a2/SNAT2, and Slc38a4/SNAT4, which carry neutral, short-side-chain amino acids, to determine their involvement in placental or embryonic development. A triple-target CRISPR screen identified Slc38a4/SNAT4 as the critical amino acid transporter for placental development in mice. We established mouse lines from the CRISPR founders with large deletions in Slc38a4 and found that, consistent with the imprinted paternal expression of Slc38a4/SNAT4 in the placenta, paternal knockout (KO) but not maternal KO of Slc38a4/SNAT4 caused placental hypoplasia associated with reduced fetal weight. Immunostaining revealed that SNAT4 was widely expressed in differentiating cytotrophoblasts and maturing trophoblasts at the maternal–fetal interface. A blood metabolome analysis revealed that amino acid concentrations were globally reduced in Slc38a4/SNAT4 mutant embryos. These results indicated that SNAT4-mediated amino acid transport in mice plays a major role in placental and embryonic development. Given that expression of Slc38a4 in the placenta is conserved in other species, our Slc38a4/SNAT4 mutant mice could be a promising model for the analysis of placental defects leading to intrauterine growth restriction in mammals.

scholarly journals Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction

2012 ◽  
pp. 184-188 ◽  
Author(s):  
Paola Andrea Ayala Ramírez ◽  
Reggie García Robles ◽  
Juan Diego Rojas Barrera ◽  
Martha Cecilia Bermúdez ◽  
Jaime Eduardo Bernal Villegas
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Messenger Rna ◽  
Maternal Plasma ◽  
Growth Restriction ◽  
Placental Lactogen ◽  
Chain Reaction ◽  
Intrauterine Growth ◽  
The Third ◽  
Plasma Rna

Objective: to quantify placenta-specific RNA in plasma of women carrying foetuses with intrauterine growth restriction and pregnant women with normal pregnancies. Materials and methods: 8 pregnant women with foetuses with intrauterine growth restriction were studied as well as 18 women with uncomplicated pregnancies in the third pregnancy trimester. Total free RNA was quantified in maternal plasma by spectrophotometry and the gene expression of hPL (Human Placental Lactogen) at the messenger RNA level through technical Real Time-Chain Reaction Polymerase. Results: plasma RNA of fetoplacental origin was successfully detected in 100% of pregnant women. There were no statistically significant differences between the values of total RNA extracted from plasma (p = 0.5975) nor in the messenger RNA expression of hPL gene (p = 0.5785) between cases and controls. Conclusion: messenger RNA of fetoplacental origin can be detected in maternal plasma during pregnancy.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

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