Occupational conditionality of cardiovascular diseases in workers exposed to fibrogenic dust

2019 ◽  
pp. 56-60
Author(s):  
Tatyana Yu. Obukhova
Keyword(s):  
Cardiovascular Diseases ◽  
Left Ventricle ◽  
Arterial Hypertension ◽  
Sinus Tachycardia ◽  
Cardiovascular Disorders ◽  
Single Factor ◽  
Length Of Service ◽  
Single Factor Analysis ◽  
Etiologic Fraction ◽  
Left Ventricle Myocardium

Using single-factor analysis, the study covered prevalence and occupational conditionality of cardiovascular diseases in workers exposed to fibrogenic dust. The findings are higher prevalence of arterial hypertension, left ventricle myocardium hypertrophy, sinus tachycardia, obesity, hypertriglyceridemia, fasting hyperglycemia in silicosis and asbestosis patients if compared to refractory and asbestos-enrichment production workers with long length of service. Based on calculated relative risk and etiologic fraction, the authors revealed average occupational conditionality of arterial hypertension (etiologic fraction 45%), high occupational conditionality of left ventricle myocardium hypertrophy (etiologic share 59.7%), sinus tachycardia syndrome and obesity, and extremely high occupational dependence of carbohydrate metabolism (etiologic fraction 77.2%) on fibrogenic dust — that helps to assign this metabolic and cardiovascular disorders to occupationally-conditioned diseases.

Forecasting the course of occupational chronic fl uorine intoxication by means of univariate analysis

2019 ◽  
pp. 80-85
Author(s):  
L. N. Budkar’ ◽  
V. B. Gurvich ◽  
T. Yu. Obukhova ◽  
S. I. Solodushkin ◽  
A. A. Fedoruk ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Work Conditions ◽  
Purine Metabolism ◽  
Aluminum Production ◽  
Health State ◽  
Single Factor ◽  
Length Of Service ◽  
Occupational Factors ◽  
Single Factor Analysis ◽  
Magnetic Fi Eld

Relevance. In contemporary occupational pathology, diagnosis of occupational fluorosis is based on locomotory apparatus disorder such as fluorine osteopathy. Other significant consequences of negative effects of fluorine compounds are deactivation of enzymatic systems, metabolic disorders — that results in pathologic involvement of many organs and systems (hepato-biliary, cardiovascular, respiratory, nervous, endocrine, gastrointestinal). Topical issue is search of a complex of factors influencing development of the occupational disease, to optimize management of occupational fluorine intoxication risk.Objective. To determine spectrum of factors that promote development of occupational fl uorine intoxication in workers exposed to inorganic fl uorine compounds, for forecasting the disease outcome and selecting main trends of preventive measures.Materials and methods.Single-factor analysis methods helped to carry retrospective cohort study of occupational fl uorine intoxication development in 201 workers of aluminum production in Ural region. Th e study covered infl uence of main occupational factors and somatic health parameter s on occupational fl uorosis development.Results.Findings are reliable infl uence of age (k=0.532, p<0.001), length of service in hazardous work conditions (p<0.001), hydrofl uoride level (p<0.001) and constant magnetic fi eld (p=0.005). Besides that, analysis of immune and metabolic state of the workers revealed signifi cant infl uence of disordered lipid, carbohydrate, purine metabolism, altered immune parameters on occupational fl uorosis development. Other evidence was reliable dependence between concomitant cardiovascular diseases and period of occupational chronic fl uorine intoxication development.Conclusion.Using single-factor analysis helped to determine wide spectrum of factors associated with the workers’ health state and work conditions, that signifi cantly infl uence development of fl uorine intoxication. Th e authors proved that period of occupational chronic fl uorine intoxication is notably infl uenced by occupational factors (length of service, hydrofl uoride level, fl uorine load degree, magnetic fi eld) and somatic state characteristics as age, parameters of carbohydrate, lipid, purine metabolism, status of cardiovascular, excretory systems, kidneys and gastrointestinal tract functions. 

scholarly journals Оцінка стану серцево-судинної системи машиністів локомотивів

2012 ◽  
Vol 3 (2) ◽  
pp. 42-47
Author(s):  
O. Р. Korzhenevs’ka ◽  
O. В. Severynovs’ka
Keyword(s):  
Blood Pressure ◽  
Left Ventricle ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
The State ◽  
Daily Work ◽  
Daily Monitoring ◽  
Structural Abnormalities ◽  
Left Ventricle Myocardium

With the help of daily monitoring of blood pressure we assessed the state of the cardiovascular system of foot-platemen of the Prydniprovsk railway Pjatykhatky Depot. Foot-platemen having the I stage of arterial hypertension demonstrated the 11–17% increase of arterial pressure during daily work. It is related to inefficient adaptation to the physical and psychoemotional overloads. With aggravation of the disease the change of arterial pressure during the work, especially night work, ismisaligned and characterised by considerable structural abnormalities of the left ventricle myocardium.

Assessment of risk factors for multifocal atherosclerosis in the workers of the main professions of coal enterprises in the South of Kuzbass

2020 ◽  
pp. 157-161
Author(s):  
E. S. Filimonov ◽  
O. Yu. Korotenko ◽  
O. A. Rumpel ◽  
O. N. Blazhina
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Glycated Hemoglobin ◽  
Significant Risk ◽  
Coal Industry ◽  
Atherosclerotic Plaques ◽  
The South ◽  
Coal Miners ◽  
Coal Enterprises

Introduction. The problem of high mortality from cardiovascular diseases is caused, among other things, by asymptomatic atherosclerosis, which proceeds latently for a long time and manifests itself as a serious vascular catastrophe, which is of particular importance for people working at production facilities with difficult and dangerous working conditions.The aim of the study was to assess the risk factors for atherosclerosis and the state of the vascular wall in the workers of the main professions of coal enterprises in the South of Kuzbass.Material and methods. In total, the study included 384 people (men), of whom 266 were the workers in coal mines in the South of Kuzbass and 118 people who were not employed in the coal industry, aged 40 to 55 years. The diagnosis of atherosclerosis was carried out on the ultrasound system “Vivid E9” of the manufacturing company GE using a linear sensor for measuring the thickness of the intima-media complex and visualization of atherosclerotic plaques. To identify significant risk factors, anthropometric, anamnestic data, indices of lipid and carbohydrate metabolism, and the presence of arterial hypertension were studied.Results. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in intima-media thickness by more than 1 mm and / or the presence of atherosclerotic plaques in both groups were not found: 60.2% among the miners and 62.3% among non-coal mining workers (p=0.703); at the same time, the percentage of detection of atherosclerotic plaques in arteries was significantly lower among coal workers — 46.9% versus 60.5% among people in the comparison group (p=0.016). The common risk factors for all examined subjects were arterial hypertension and increased level of glycated hemoglobin; in turn, in coal miners additional risk factors were increased values of low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases, and among the individuals not employed in the coal industry it was smoking.Conclusions. The most significant risk factors for atherosclerosis in coal industry workers were arterial hypertension, raised values of glycated hemoglobin, low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in the thickness of the intima-media complex of the main arteries and the presence of atherosclerotic plaques in both groups were not established, but the percentage of the detection of atherosclerotic plaques was lower among coal miners.The authors declare no conflict of interests.

Analysis of the quality of early diagnostics of cardiovascular diseases in students of educational institutions of Khabarovsk (according to the data of preventive examinations)

2020 ◽  
pp. 13-16
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Sinus Tachycardia ◽  
Blood Pressure Level ◽  
Educational Institutions ◽  
Conduction Disturbances ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

To identify the prevalence of early pathology of cardiovascular diseases, a survey of 400 200 girls) in the age group 15 and 17 years old was conducted as a part of routine medical of the level of blood pressure (BP) was carried out, with the calculation of the average level pressure on the basis of three separate measurements estimated by percentile tables for a registration of a standard resting ECG in 12 leads. According to the results of the survey, into 3 groups: with an increase in blood pressure above 95 ‰ (group 1 – 16 people), which recorded in males (p<0,05); Group 2 (67 people) – adolescents with a normal blood pressure level and group 3 of adolescents with a decrease in blood pressure below 5 ‰ changes in the form of rhythm and conduction disturbances were noted in almost every a predominance of sinus tachycardia in the first group. In the third group of adolescents, form of ectopic rhythm and pacemaker migration were significantly more frequently only 78 % of adolescents were referred for consultation and in-depth examination by a pediatric cardiologist.

Study on the precision of the activated charcoal solvent desorption procedure - Correlation of desorption efficiencies

1981 ◽  
Vol 46 (6) ◽  
pp. 1332-1347 ◽  
Author(s):  
Martin Koval
Keyword(s):  
Activated Charcoal ◽  
Carbon Disulphide ◽  
Internal Standard ◽  
Standard Addition ◽  
Published Data ◽  
Single Factor ◽  
Gas Chromatograph ◽  
Model Compounds ◽  
Single Factor Analysis ◽  
Acceptable Agreement

The described method uses activated charcoal sampling tubes for air sampling. Adsorbed compounds are eluted by the static desorption procedure with 1 ml of carbon disulphide, 0.5 ml of the supernatant is filtered off and, after internal standard addition, analysed on a gas chromatograph. Using synthetic calibration mixtures of model organic compounds with air, cumulative sampling and desorption efficiencies for 24 substances were determined for concentration ranges and sample volumes according to current Czechoslovak hygienic standards. Experimental results were treated with the single factor analysis of variance and the precision of the described procedure was estimated for the studied model compounds on the basis of residual sums of squares. Calculated values of cumulative sampling and desorption efficiencies and their precisions were compared with available published data and an acceptable agreement was found. In addition to that, cumulative sampling and desorption efficiencies were also found to be significantly correlated to molar volumes and other related molecular properties for some types of compounds.

scholarly journals Significance of pepsinogen in screening for gastric intestinal metaplasia in Guangdong, China

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052199049
Author(s):  
Xujuan Liu ◽  
Min Zhang ◽  
Riyu Luo ◽  
Keran Mo ◽  
Xingxiang He
Keyword(s):  
Logistic Regression ◽  
Intestinal Metaplasia ◽  
Single Factor ◽  
Antibody Testing ◽  
Cross Sectional ◽  
Gastric Intestinal Metaplasia ◽  
Risk Detection ◽  
Tree Models ◽  
Single Factor Analysis ◽  
Serological Biomarkers

Objective Diagnosis of gastric intestinal metaplasia (GIM) relies on gastroscopy and histopathologic biopsy, but their application in screening for GIM is limited. We aimed to identify serological biomarkers of GIM via screening in Guangdong, China. Methods Cross-sectional field and questionnaire data, demographic information, past medical history, and other relevant data were collected. Blood samples were collected for pepsinogen (PG)I, PGII, gastrin-17, and Helicobacter pylori antibody testing, and gastroscopy and histopathologic biopsy were performed. Single factor and logistic regression analyses were used to evaluate the correlation between these indicators and GIM, and decision tree models were used to determine the cut-off points between indicators. Results Of 443 participants enrolled, 87 (19.6%) were diagnosed with GIM. Single factor analysis showed that pepsin indicators (PGI, PGII, and PGI/PGII ratio) and the factors Mandarin as native language, urban residency, hyperlipidemia, and age were associated with GIM. Logistic regression analysis showed that PGI and age were associated with GIM. Conclusions Age is an important factor for predicting GIM progression; age >60 years increased its risk. Detection of GIM was higher in individuals with PGI levels >127.20 ng/mL, which could be used as a threshold indicating the need to perform gastroscopy and histopathologic biopsy.

Subclinical Hypothyroidism as a Risk Factor for Cardiovascular Disease

2021 ◽  
Vol 15 (9) ◽  
pp. 2748-2752
Author(s):  
Roman Evgenyevich Tokmachev ◽  
Andrey Valerievich Budnevsky ◽  
Andrey Yakovlevich Kravchenko ◽  
Tatiana Alexandrovna Chernik ◽  
Sudakov Oleg Valerievich ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Cause Of Death ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Epidemiological Studies ◽  
Cardiovascular Disorders ◽  
The World

Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism

scholarly journals COMPARISON OF ENALAPRIL AND PERINDOPRIL IN PATIENTS WITH ARTERIAL HYPERTENSION AND LEFT VENTRICLE SYSTOLIC DYSFUNCTION

2010 ◽  
Vol 6 (2) ◽  
pp. 179-184
Author(s):  
Yu. I. Grinshtein ◽  
O. L. Barbarash ◽  
D. A. Yakhontov ◽  
A. E. Popelysheva ◽  
V. V. Shabalin ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Arterial Hypertension ◽  
Systolic Dysfunction

scholarly journals Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Francesca Colazzo ◽  
Paolo Gelosa ◽  
Elena Tremoli ◽  
Luigi Sironi ◽  
Laura Castiglioni
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Inflammatory Diseases ◽  
Asthma Management ◽  
Cardiovascular Disorders ◽  
Cysteinyl Leukotrienes ◽  
Pathway Activation ◽  
Cardioprotective Effects ◽  
Progression Of Atherosclerosis

Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders. 5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases. Moreover, the cardioprotective effects observed by using CysLT modifiers are promising and contribute to elucidate the link between CysLTs and cardiovascular disease. The aim of this review is to summarize the state of present research about the role of the CysLTs in the pathogenesis and progression of atherosclerosis and myocardial infarction.

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