Familial Bipolar Disorder: Preliminary Results from the Otago Familial Bipolar Genetic Study

1998 ◽  
Vol 32 (6) ◽  
pp. 823-829 ◽  
Author(s):  
Liza K. Edmonds ◽  
Barbara J. Mosley ◽  
Anita J. Admiraal ◽  
Robin J. Olds ◽  
Sarah E. Romans ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
New Zealand ◽  
Panic Disorder ◽  
Genetic Study ◽  
Suicidal Behaviour ◽  
Age Of Onset ◽  
Genetic Research ◽  
Genetic Studies ◽  
Compulsive Disorder ◽  
First Degree Relatives

Objective: This paper outlines the methodologies used, and preliminary descriptive data collected, on a cohort of familial bipolar disorder (BPD) probands and first-degree relatives taking part in a descriptive and genetic study into familial BPD in New Zealand. Method: Fifity-five bipolar probands and 67 first-degree relatives were interviewed using the modified Diagnostic Interview for Genetic Studies (DIGS) and Family Interview for Genetic Studies (FIGS). Data was also collated from other sources. Blood samples were taken for DNA genomic analysis. Results: New Zealand families in which BPD segregates proved willing participants in this familial based genetic research. The methodologies used were acceptable. High rates of comorbidity were found in probands (27.3% met DSM-IV criteria for panic disorder/sub-threshold panic disorder; 12.7% for phobic disorder; 1.8% for obsessive-compulsive disorder; 9.1% for alcohol-related disorders and 7.3% for an eating disorder) and relatives (major depression 34.3%; panic disorder/sub-threshold panic disorder 12.0%; phobias 11.9% and alcohol-related disorders 11.9%). The polarity of index BPD illness was related to age of onset and frequency of comorbidity. Suicidal behaviour was common. Conclusions: Psychiatric genetic research in New Zealand families is highly feasible. Emerging trends in the familial transmission of BPD include high rates of comorbidity, illness patterns based on polarity of index episode and frequent suicidal behaviour. Such trends will be delineated further as numbers accrue, perhaps enabling identification of more homogenous phenotypic subgroups than currently produced by diagnostic schemes.

Epidemiology and Risk Factors of Bipolar Disorder and Schizophrenia in the Conceptualization of the Disease Spectrum

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
C. Höschl ◽  
P. Stopková
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Age Of Onset ◽  
Prenatal Development ◽  
Type I ◽  
Perinatal Complications ◽  
Birth Seasonality ◽  
Genetic Studies ◽  
Disease Spectrum ◽  
Disorder Type

Both disorders are worldwide, lifelong, and recurrent illnesses with periods of exacerbation and partial or full remissions. Lifetime prevalence of schizophrenia and bipolar disorder type I is around 1%. Women and men are affected at proximately equal rates and the typical age of onset is similar. Both disorders also share risk factors showing evidence for impaired prenatal development, such as birth seasonality, abnormal dermatoglyphs and higher incidence of perinatal complications. However, there is evidence for differences in prevalence in geographical isolates, in presence of minor physical abnormalities and possibly also in influence of psychosocial factors, urbanicity and use of cannabis. However, based only on similar epidemiological parameters, it is not possible to assume any degree of continuity between bipolar disorder and schizophrenia. The main evidence for partially shared pathophysiology is given by genetic studies.

scholarly journals Characterization and Development of Genomic SSRs in Pecan (Carya illinoinensis)

Forests ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 61 ◽  
Author(s):  
Chengcai Zhang ◽  
Xiaohua Yao ◽  
Huadong Ren ◽  
Jun Chang ◽  
Jun Wu ◽  
...  
Keyword(s):  
Genetic Study ◽  
Polymorphic Information Content ◽  
Genetic Research ◽  
Geographic Origin ◽  
Pcr Amplification ◽  
Genetic Studies ◽  
New Development ◽  
Ssr Loci ◽  
Simple Sequence

Research Highlights: The distribution of simple sequence repeat (SSR) motifs in two draft genomes of pecan was evaluated. Sixty-six SSR loci were validated by PCR amplification in pecan. Twenty-two new development markers can be used for genetic study in genus Carya. Background and Objectives: Pecan has good nutritional and health benefits and is an important crop worldwide. However, the genetic research in this species is insufficient. One of the main reasons for this is the lack of enough accurate, convenient, and economical molecular markers. Among different marker types, SSR loci are enormously useful in genetic studies. However, the number of SSRs in C. illinoinensis (Wangenh.) K. Koch is limited. Materials and Methods: The distribution of SSR motifs in the pecan genome was analyzed. Then, the primers for each SSR were designed. To evaluate their availability, 74 SSR loci were randomly selected and amplified in pecan. Finally, 22 new SSRs and eight former ones were picked to evaluate the genetic diversity in 60 pecan genotypes and to determine their transferability in other Carya species. Results: 145,714 and 143,041 SSR motifs were obtained from two draft genomes of ‘87MX3-2’ and ‘Pawnee’, respectively. In total, 9145 candidate primers were obtained. Sixty-six (89.19%) primers amplified the target products. Among the 30 SSRs, 29 loci showed polymorphism in 60 pecan genotypes. The polymorphic information content (PIC) values ranged from 0.012 to 0.906. In total, 26, 25, and 22 SSRs can be used in C. cathayensis Sarg., C. dabieshanensis W. C. Cheng & R. H. Chang, and C. hunanensis W.C. Liu, respectively. Finally, the dendrogram of all individuals was constructed. The results agree with the geographic origin of the four species and the pedigree relationships between different pecan cultivars. Conclusions: The characterization of SSRs in the pecan genome and the new SSRs will promote the progress of genetic study and breeding in pecan, as well as other species of genus Carya.

Prevalence of Psychiatric Disorders in New Zealand Prisons: A National Study

2001 ◽  
Vol 35 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Philip M.J. Brinded ◽  
Alexander I.F. Simpson ◽  
Tannis M. Laidlaw ◽  
Nigel Fairley ◽  
Fiona Malcolm
Keyword(s):  
Bipolar Disorder ◽  
New Zealand ◽  
Substance Misuse ◽  
Psychiatric Treatment ◽  
Prison Population ◽  
Psychiatric Inpatient ◽  
National Study ◽  
Prevalence Rates ◽  
Compulsive Disorder ◽  
Male Inmates

Objective: The paper describes the methodologies and results obtained on a large cohort of prison inmates in New Zealand who were screened for psychiatric disorder. Method: All women and remanded male inmates in New Zealand prisons, and a randomly selected cohort of 18% of sentenced male inmates were interviewed. Interviewers used the Composite International Diagnostic Interview –Automated to establish DSM-IV diagnoses, and the Personality Disorders Questionnaire to identify personality disorder. All prisons in New Zealand were visited. Results: The results indicate markedly elevated prevalence rates for major mental disorder in the prison population when compared with community samples. This is especially the case for substance misuse, psychotic disorders, major depression, bipolar disorder, obsessive–compulsive disorder and posttraumatic stress disorder. Of particular concern is not only the increased prevalence rates for schizophrenia and related disorders but also the high level of comorbidity with substance misuse disorders demonstrated by this group. While 80.8% of inmates diagnosed with bipolar disorder were receiving psychiatric treatment in the prison, only 46.4% of depressed inmates and 37% of those suffering from psychosis were receiving treatment. Maori inmates were grossly overrepresented in the remand, female and male sentenced inmate population compared with the general population. Conclusions: A significant increase in provision of mental health services is required to cope with the high number of mentally ill inmates. The level of need demonstrated by this study requires a level of service provision that is quite beyond the capacity of current forensic psychiatry services, Department of Corrections Psychological Services or the prison nursing and medical officers. The elevated rates of common mental disorders argues for the use of improved psychiatric screening instruments, improved assessment and treatment capacities in the prison and an increased number of forensic psychiatric inpatient facilities to care for those psychotic inmates who are too unwell to be treated in the prison.

scholarly journals Psychiatry and Molecular Genetics

CNS Spectrums ◽  
1999 ◽  
Vol 4 (5) ◽  
pp. 16-16
Author(s):  
Michele T. Pato ◽  
Humberto Nicolini ◽  
Carlos N. Pato
Keyword(s):  
Age Of Onset ◽  
Molecular Genetic ◽  
Obsessive Compulsive ◽  
Genetic Studies ◽  
Subsequent Issue ◽  
Complex Disorders ◽  
Compulsive Disorder ◽  
Genome Scanning ◽  
Repeat Expansions ◽  
Work Done

Molecular genetic studies of complex disorders require a number of parallel strategies. Many of the more familial psychiatric syndromes are highly prevalent and may represent a collection of a number of distinct genetic subtypes and possibly a number of nongenetic subtypes. A nongenetic form of illness may appear clinically indistinguishable from a genetic form. These nongenetic subtypes of a syndrome would be considered phenocopies. In this and the subsequent issue of CNS Spectrums, a number of papers are presented that review the current state of psychiatric genetics of major disorders. Clinical strategies to narrow phenotypes and better define study populations are paired with laboratory and statistical strategies to optimize both candidate gene and genome scanning methods.In this issue, Kennedy and colleagues focus on a review of the genetics of schizophrenia, highlighting genome scans already completed and studies on special populations. Schindler and colleagues present a unique and efficient method for defining the homogeneity of a study population, surname analysis, and the importance of population selection in the design of genetic studies. Macedo and colleagues demonstrate the study of anticipation in bipolar mood disorder. Genetic anticipation is the observation of an earlier age of onset and greater disease severity in younger generations. This pattern has been associated with dynamic repeat expansions in the DNA in several neuropsychiatric disorders, and represents a good example of a unique genetic mechanism causing a unique phenotypic pattern. Nicolini and colleagues present work done to date on obsessive-compulsive disorder.

Personality traits as an endophenotype in genetic studies on suicidality in bipolar disorder

2016 ◽  
Vol 29 (2) ◽  
pp. 115-121 ◽  
Author(s):  
J. Pawlak ◽  
M. Dmitrzak-Węglarz ◽  
M. Maciukiewicz ◽  
P. Kapelski ◽  
P. Czerski ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Personality Traits ◽  
Suicidal Behaviour ◽  
Tryptophan Hydroxylase ◽  
Control Group ◽  
Temperament And Character Inventory ◽  
Genetic Studies ◽  
Character Inventory ◽  
Dsm Iv ◽  
Genetically Determined

IntroductionThe influence of personality traits on suicidal behaviour risk has been well documented. Personality traits and suicidal behaviour are partially genetically determined and personality has been described as an endophenotype of suicidal behaviour. The aim of this study was to investigate a possible association between personality traits with suicidal behaviour and selected serotonergic gene polymorphisms.MethodsIn the study we included 156 patients meeting DSM-IV criteria for bipolar disorder (BP) and 93 healthy controls. The personality dimensions were assessed using the Temperament and Character Inventory (TCI). We genotyped two selected polymorphisms of the tryptophan hydroxylase 1 (TPH1) gene (rs1800532 218A>C and rs1799913 779A>C) and polymorphism in the promoter region of serotonin transporter gene (5-HTTLPR, rs25531) related to serotoninergic neurotransmission. Multiple poisson regression, logistic regression and Kruskal–Wallis tests were applied.ResultsWe found numerous differences between the BP patients and the control group in terms of their TCI dimensions/subdimensions. Significant differences were found between patients with, and without, suicidal attempts in fatigability and asthenia (Ha4), as well as in harm avoidance (Ha). We also found that the interactions between TCI subdimensions (the interaction of disordiness (Ns4) and spiritual acceptance (St3), disordiness (Ns4) and integrated conscience (C5), extravagance (Ns3) and resourcefulness (Sd3)) were significantly contributing for suicidal behaviour risk. We found association between all studied genetic polymorphisms and several TCI dimensions and subdimensions.ConclusionOur results confirm that personality traits are partially determined by genes. Both personality traits and the interactions between temperament and character traits, may be helpful in predicting suicidal behaviour.

Obsessive–compulsive disorder and separation anxiety co-morbidity in early onset panic disorder

2001 ◽  
Vol 31 (7) ◽  
pp. 1307-1310 ◽  
Author(s):  
R. GOODWIN ◽  
J. D. LIPSITZ ◽  
T. F. CHAPMAN ◽  
S. MANNUZZA ◽  
A. J. FYER
Keyword(s):  
Anxiety Disorder ◽  
Panic Disorder ◽  
Obsessive Compulsive Disorder ◽  
Separation Anxiety ◽  
Age Of Onset ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Co Morbidity

Background. This study was undertaken to examine the relationship between anxiety co-morbidity and age of onset of panic disorder.Methods. Age of onset of panic disorder and co-morbid anxiety disorders were assessed among 201 panic disorder probands with childhood separation anxiety disorder, obsessive–compulsive disorder, obsessive–compulsive symptoms, social phobia and specific phobia as part of a clinician-administered lifetime diagnostic interview. A generalized linear model was used to test the association between each anxiety co-morbidity and age of panic disorder onset while simultaneously controlling for the potential confounding effects of sociodemographic characteristics and other psychiatric co-morbidity.Results. Earlier onset of panic disorder was found in patients with co-morbid obsessive–compulsive disorder, obsessive–compulsive symptoms and separation anxiety disorder, but not simple phobia or social phobia. Patients with both childhood separation anxiety disorder and obsessive–compulsive disorder had an even earlier panic onset than those with either childhood separation anxiety disorder or obsessive–compulsive disorder.Conclusions. The association between anxiety co-morbidity and earlier onset of panic disorder is specific to obsessive–compulsive disorder and childhood separation anxiety disorder.

scholarly journals Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses

2020 ◽  
Vol 54 (11) ◽  
pp. 1086-1094
Author(s):  
Amala Someshwar ◽  
Bharath Holla ◽  
Preeti Pansari Agarwal ◽  
Anza Thomas ◽  
Anand Jose ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Adverse Childhood Experiences ◽  
Substance Dependence ◽  
Age Of Onset ◽  
Obsessive Compulsive ◽  
Childhood Experiences ◽  
Compulsive Disorder ◽  
First Degree Relatives ◽  
Adverse Childhood ◽  
Psychiatric Conditions

Objective: Adverse childhood experiences are linked to the development of a number of psychiatric illnesses in adulthood. Our study examined the pattern of adverse childhood experiences and their relation to the age of onset of major psychiatric conditions in individuals from families that had ⩾2 first-degree relatives with major psychiatric conditions (multiplex families), identified as part of an ongoing longitudinal study. Methods: Our sample consisted of 509 individuals from 215 families. Of these, 268 were affected, i.e., diagnosed with bipolar disorder ( n = 61), obsessive–compulsive disorder ( n = 58), schizophrenia ( n = 52), substance dependence ( n = 59) or co-occurring diagnoses ( n = 38), while 241 were at-risk first-degree relatives who were either unaffected ( n = 210) or had other depressive or anxiety disorders ( n = 31). All individuals were evaluated using the Adverse Childhood Experiences – International Questionnaire and total adverse childhood experiences exposure and severity scores were calculated. Results: It was seen that affected males, as a group, had the greatest adverse childhood experiences exposure and severity scores in our sample. A Cox mixed effects model fit by gender revealed that a higher total adverse childhood experiences severity score was associated with significantly increased risk for an earlier age of onset of psychiatric diagnoses in males. A similar model that evaluated the interaction of diagnosis revealed an earlier age of onset in obsessive–compulsive disorder and substance dependence, but not in schizophrenia and bipolar disorder. Conclusion: Our study indicates that adverse childhood experiences were associated with an earlier onset of major psychiatric conditions in men and individuals diagnosed with obsessive–compulsive disorder and substance dependence. Ongoing longitudinal assessments in first-degree relatives from these families are expected to identify mechanisms underlying this relationship.

Achieving practical outcomes from genetic studies of rare Australian plants

2000 ◽  
Vol 48 (3) ◽  
pp. 375 ◽  
Author(s):  
Patricia M. Hogbin ◽  
Rod Peakall ◽  
Marita A. Sydes
Keyword(s):  
Genetic Study ◽  
Genetic Research ◽  
Rare Plants ◽  
Future Research ◽  
Potential Contribution ◽  
Management Options ◽  
Genetic Studies ◽  
Conservation Implications ◽  
Cost Efficient ◽  
Management Recommendations

An increasing number of genetic studies of rare plants are motivated by the potential contribution they can make to the conservation of the species concerned. However, while these studies frequently identify conservation implications, few have demonstrated practical conservation outcomes. In this paper, we criticallyevaluate the practical outcomes of our genetic study of three endangered plant species: Haloragodendron lucasii, Zieria prostrata and Wollemia nobilis. Each genetic study provided a number of conservation implications or management recommendations for the species concerned. However, for three reasons, not all of the implications actually led to practical outcomes. First, similar recommendations were already in place. Second, management recommendations, while sound, were not relevant to the current management priorities. Third, irrespective of the genetic outcome, a given recommendation prevailed as the preferred management option. In order to achieve effective and cost-efficient recovery of threatened flora, we need to identify those cases where genetic studies are likely to produce practical outcomes for conservation management. This may best be achieved by first, assessing and critically evaluating the outcomes of genetic research already conducted, and second, evaluating the potential for practical outcomes of future research by considering the range of possible outcomes in the context of the management options available for the species.

scholarly journals Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder

2011 ◽  
Vol 42 (7) ◽  
pp. 1449-1459 ◽  
Author(s):  
F. S. Goes ◽  
M. G. McCusker ◽  
O. J. Bienvenu ◽  
D. F. MacKinnon ◽  
F. M. Mondimore ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Panic Disorder ◽  
Anxiety Disorders ◽  
Social Phobia ◽  
Clinical Characteristics ◽  
Familial Aggregation ◽  
Specific Phobia ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity

BackgroundCo-morbidity of mood and anxiety disorders is common and often associated with greater illness severity. This study investigates clinical correlates and familiality of four anxiety disorders in a large sample of bipolar disorder (BP) and major depressive disorder (MDD) pedigrees.MethodThe sample comprised 566 BP families with 1416 affected subjects and 675 MDD families with 1726 affected subjects. Clinical characteristics and familiality of panic disorder, social phobia, specific phobia and obsessive-compulsive disorder (OCD) were examined in BP and MDD pedigrees with multivariate modeling using generalized estimating equations.ResultsCo-morbidity between mood and anxiety disorders was associated with several markers of clinical severity, including earlier age of onset, greater number of depressive episodes and higher prevalence of attempted suicide, when compared with mood disorder without co-morbid anxiety. Familial aggregation was found with co-morbid panic and OCD in both BP and MDD pedigrees. Specific phobia showed familial aggregation in both MDD and BP families, although the findings in BP were just short of statistical significance after adjusting for other anxiety co-morbidities. We found no evidence for familiality of social phobia.ConclusionsOur findings suggest that co-morbidity of MDD and BP with specific anxiety disorders (OCD, panic disorder and specific phobia) is at least partly due to familial factors, which may be of relevance to both phenotypic and genetic studies of co-morbidity.

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