The relationships between high-sensitivity C-reactive protein and incident depressed mood among older adults

2010 ◽  
Vol 70 (2) ◽  
pp. 75-79 ◽  
Author(s):  
Heikki Luukinen ◽  
Jari Jokelainen ◽  
Pirjo Hedberg
Keyword(s):  
Older Adults ◽  
Depressed Mood ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Pain Intensity and Pain Interference in Older Adults: Role of Gender, Obesity and High-Sensitivity C-Reactive Protein

Gerontology ◽  
2016 ◽  
Vol 63 (1) ◽  
pp. 3-12 ◽  
Author(s):  
Vahid Eslami ◽  
Mindy J. Katz ◽  
Robert S. White ◽  
Erin Sundermann ◽  
Julie M. Jiang ◽  
...  
Keyword(s):  
Older Adults ◽  
Pain Intensity ◽  
Short Form ◽  
High Sensitivity ◽  
Pain Interference ◽  
C Reactive Protein ◽  
Medical Outcomes ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Aging Study

Background: Among older adults, pain intensity and pain interference are more common in women than men and associated with obesity and inflammatory markers. Objective: We examined whether the obesity and pain relationship is mediated by the high-sensitivity C-reactive protein (hsCRP), a nonspecific marker of systemic inflammation, and whether this relationship differs by sex. Methods: Items from Medical Outcomes Study Short Form-36 were used to measure pain intensity and pain interference in daily life. Ordinal logistic regression was used to assess the cross-sectional association among body mass index (BMI), hsCRP levels, pain intensity and pain interference using gender-stratified models adjusted for demographic variables. Results: Participants included 667 community-residing adults over the age of 70 years, free of dementia, enrolled in the Einstein Aging Study (EAS). In women (n = 410), pain intensity was associated with obesity [BMI ≥30 vs. normal, odds ratio (OR) = 2.29, 95% confidence interval (CI) 1.43-3.68] and higher hsCRP (OR = 1.28, 95% CI 1.08-1.51). In a model with obesity and hsCRP, both remained significant, but the association between hsCRP and pain intensity was somewhat attenuated. Obesity (OR = 3.04, 95% CI 1.81-5.11) and higher hsCRP levels (OR = 1.30, 95% CI 1.08-1.56) were also independently associated with greater pain interference in women. After adjustment for pain intensity and BMI, hsCRP was no longer associated with pain interference in women. Greater pain intensity and being overweight or obese continued to be significantly associated with pain interference in women. In men (n = 257), obesity and hsCRP were not associated with pain intensity or pain interference. Conclusions: In women, the relationship between obesity and higher levels of pain intensity or interference may be accounted for by factors related to hsCRP.

scholarly journals High-sensitivity C-reactive protein and mobility disability in older adults

2012 ◽  
Vol 41 (4) ◽  
pp. 541-545 ◽  
Author(s):  
Joe Verghese ◽  
Roee Holtzer ◽  
Richard B. Lipton ◽  
Cuiling Wang
Keyword(s):  
Older Adults ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Mobility Disability ◽  
Reactive Protein

The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults

2010 ◽  
Vol 110 (1) ◽  
pp. 161-169 ◽  
Author(s):  
Raul A. Martins ◽  
Ana P. Neves ◽  
Manuel J. Coelho-Silva ◽  
Manuel T. Veríssimo ◽  
Ana Maria Teixeira
Keyword(s):  
Older Adults ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Strength Based

Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults

2011 ◽  
Vol 5 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Moatassem S. Amer ◽  
Amal E. Elawam ◽  
Mohamed S. Khater ◽  
Omar H. Omar ◽  
Randa A. Mabrouk ◽  
...  
Keyword(s):  
Older Adults ◽  
Carotid Artery ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Media Thickness

scholarly journals Age-Related Differences in the Association between Plasma High-Sensitivity C-Reactive Protein and Noncalcified or Mixed Coronary Atherosclerotic Plaques

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tiewei Li ◽  
Ning Chen ◽  
Zhengan Liu ◽  
Zhiming Shan ◽  
Geng Dong ◽  
...  
Keyword(s):  
Older Adults ◽  
Multiple Logistic Regression Analysis ◽  
Laboratory Data ◽  
High Sensitivity ◽  
Coronary Plaque ◽  
Control Group ◽  
C Reactive Protein ◽  
Old Adults ◽  
Reactive Protein ◽  
Age Related

Background. Previous studies have demonstrated that plasma high-sensitivity C-reactive protein (hsCRP) was the predictor for unstable coronary plaque. Patients with noncalcified plaque (NCP) or mixed plaque (MP) have a higher risk of poor outcomes. However, the association between hsCRP and the presence of NCP or MP (NCP/MP) in old adults remains unclear, and if present, whether there exist differences between young and old adults remain unknown. Thus, the aim of this study was to investigate the role of hsCRP in predicting the presence of NCP/MP and evaluate whether age has any impact on this association. Methods. A total of 951 subjects were included in this study. Complete clinical and laboratory data were collected. According to the characteristics of the most stenotic plaque, we divided them into 2 groups: calcified plaque (CP) and NCP/MP. Subjects with no plaque were classified as the control group (CR). Subjects with age≥60 years were defined as older adults, and those with age<60 years were classified as nonelderly people. Results. Patients with NCP/MP had significantly higher hsCRP level compared with subjects with CR or CP in older adults but not in nonelderly people. The proportion of NCP/MP was significantly increased from 27.0% in the hsCRP<1.25 mg/L group to 42.7% in the hsCRP>2.70 mg/L group in older adults. Multiple logistic regression analysis showed that hsCRP was an independent risk factor for the presence of NCP/MP (odds ratio OR=1.093, 95% CI 1.032–1.157, P=0.001) only in older adults. Conclusions. hsCRP is independently associated with the presence of NCP/MP in older adults but not in nonelderly people. These results suggest the potential significance of hsCRP-lowering regimens in older adults with NCP/MP.

scholarly journals ASSOCIATIONS BETWEEN HIGH-SENSITIVITY C-REACTIVE PROTEIN AND ANKLE BRACHIAL INDEX IN ASYMPTOMATIC OLDER ADULTS

2012 ◽  
Vol 59 (13) ◽  
pp. E1647
Author(s):  
Jang Hoon Lee ◽  
Kyun Hee Kim ◽  
Won Suk Choi ◽  
Sun Hee Park ◽  
Myung Hwan Bae ◽  
...  
Keyword(s):  
Older Adults ◽  
Ankle Brachial Index ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

Daily Consumption of Oregon Hazelnuts Affects α-Tocopherol Status in Healthy Older Adults: A Pre-Post Intervention Study

2018 ◽  
Vol 148 (12) ◽  
pp. 1924-1930
Author(s):  
Alexander J Michels ◽  
Scott W Leonard ◽  
Sandra L Uesugi ◽  
Gerd Bobe ◽  
Balz Frei ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin E ◽  
Lymphocyte Proliferation ◽  
Plasma Concentrations ◽  
High Sensitivity ◽  
Control Group ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Post Intervention ◽  
Reactive Protein

ABSTRACT Background Inadequate vitamin E and magnesium intakes are of concern for older adults owing to the associated incidence of age-related diseases. Objective This study was designed to determine the extent to which a 16-wk intervention with hazelnuts alters vitamin E and magnesium status in a group of older men and women, and used a pre-post intervention design without a control group to adjust for temporal changes. Methods Participants (n = 32 including 22 women; mean ± SD age: 63 ± 6 y) consumed hazelnuts (∼57 g/d) for 16 wk. Blood and urine samples and anthropomorphic measures were taken at the start and end of the intervention to determine plasma concentrations of α-tocopherol and serum concentrations of magnesium, lipids, glucose, insulin, and high-sensitivity C-reactive protein along with urinary vitamin E metabolites; several other micronutrients were measured by a lymphocyte proliferation assay. There were 3 primary endpoints, calculated as the mean changes in measurements between baseline and the end of the 16-wk intervention for 1) plasma α-tocopherol, 2) urinary α-carboxyethyl hydroxychromanol (α-CEHC; an α-tocopherol metabolite), and 3) serum magnesium. Results Hazelnut consumption increased concentrations of the urinary α-tocopherol metabolite α-CEHC (mean ± SD: 0.84 ± 0.45 to 1.14 ± 0.50 µmol/g creatinine; P = 0.0006). In addition, hazelnut consumption increased serum concentrations of magnesium (+2.1%, P = 0.05), decreased concentrations of fasting glucose (−3.4%, P = 0.03) and LDL cholesterol (−6.0%, P = 0.02), and decreased total:HDL cholesterol ratios (−4.5%, P = 0.009). No significant changes were observed in blood pressure, lymphocyte proliferation assays, and serum concentrations of insulin, high-sensitivity C-reactive protein, triglyceride, α-tocopherol, or HDL cholesterol. Conclusions Consuming hazelnuts improves a biomarker of vitamin E status in older adults. Vitamin E is a shortfall micronutrient, as identified by the Dietary Guidelines for Americans 2015–2020, which frequently is consumed at levels less than the Estimated Average Requirement of 12 mg/d; thus, hazelnuts should be considered as part of a healthy dietary pattern. This trial was registered at clinicaltrials.gov as NCT03485989.

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