Osteotropic Drug Delivery System (ODDS) Based on Bisphosphonic Prodrug. IV Effects of Osteotropic Estradiol on Bone Mineral Density and Uterine Weight in Ovariectomized Rats

1998 ◽  
Vol 5 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Jiro Fujisaki ◽  
Yuji Tokunaga ◽  
Toshiya Takahashi ◽  
Fumio Shimojo ◽  
Sumihisa Kimura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Bone Mineral ◽  
Delivery System ◽  
Ovariectomized Rats ◽  
Uterine Weight ◽  
Mineral Density

Dissolution Medium Responsive Simvastatin Release from Biodegradable Apatite Cements Drug Delivery System - The Therapeutically Effect and their Histology in Osteoporosis Rats -

2011 ◽  
Vol 493-494 ◽  
pp. 684-688 ◽  
Author(s):  
Makoto Otsuka ◽  
Hideyuki Hamada ◽  
Kuniko Otsuka ◽  
Hiroyuki Ohshima
Keyword(s):  
Bone Mineral Density ◽  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Bone Mineral ◽  
Delivery System ◽  
Dissolution Medium ◽  
Mineral Density ◽  
Apatite Cement

A biodegradable drug delivery system was established using an apatite cement containing simvastatin. The in-vitro drug release from apatite with lower-crystallinity was investigated under simulated osteoblast and osteoclast conditions (SOB and SOC). Apatite cement containing 6% simvastatin had lower crystallinity as the same as natural bone. In-vitro drug release tests were performed under SOB in simulated body fluid (pH 7.8), and then under SOC in acetate buffer (pH4.5) at 37.0｡C, and the process repeated twice. The device had lower drug release rates under SOB, but significantly higher rates under SOC. The simvastatin release rate was 15 times higher under SOC than SOB. The device showed dissolution medium responsive drug release. After implantation of the APC containing simvastatin in osteoporosis rats, the bone mineral density was evaluated by the X-ray computed tomography. The result indicated that the bone mineral density of APC implanted rat was significantly higher than that of control diseased.

scholarly journals Jumping exercise preserves bone mineral density and mechanical properties in osteopenic ovariectomized rats even following established osteopenia

2017 ◽  
Vol 28 (4) ◽  
pp. 1461-1471 ◽  
Author(s):  
R . Okubo ◽  
L. S. Sanada ◽  
V. A. Castania ◽  
M. J. Q. Louzada ◽  
F. J. A. de Paula ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Jumping Exercise

Influence of electro-acupuncture on bone mineral density, bone strength and ultrastructure in ovariectomized rats

Bone ◽  
2006 ◽  
Vol 38 (3) ◽  
pp. 27-28 ◽  
Author(s):  
Z.G. Luo ◽  
A.T. Wang ◽  
W.S. Yu ◽  
Y. Zhao ◽  
P. Hu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Strength ◽  
Bone Mineral ◽  
Ovariectomized Rats ◽  
Mineral Density

scholarly journals Protective effect ofGlycyrrhiza glabraroots extract on bone mineral density of ovariectomized rats

BioMedicine ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 8 ◽  
Author(s):  
Dimitrios Galanis ◽  
Konstantinos Soultanis ◽  
Pavlos Lelovas ◽  
Alexandros Zervas ◽  
Panagiotis Papadopoulos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Protective Effect ◽  
Bone Mineral ◽  
Proximal Tibia ◽  
Glycyrrhiza Glabra ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Three Point Bending ◽  
Significant Difference

Objective: The aim of this study was to evaluate the potential effect of the methanolic extract of plantGlycyrrhiza glabraroots on bone mineral density and femoral bone strength of ovariectomized rats.Methods: Thirty 10-month-old Wistar rats were randomly separated into three groups of ten, Control, Ovariectomy and Ovariectomy-plus-Glycyrrhiza in their drinking water. Total and proximal tibial bone mineral density was measured in all groups before ovariectomy (baseline) and after 3 and 6 months post ovariectomy. Three-point-bending of the femurs and uterine weight and histology were examined at the end of the study.Results: No significant difference was noted in bone density percentage change of total tibia from baseline to 3 months between Control and Ovariectomy-plus-Glycyrrhiza groups (+5.31% ± 4.75 and +3.30% ± 6.31 respectively,P = non significant), and of proximal tibia accordingly (+5.58% ± 6.92 and +2.61% ± 13.62,P = non significant) demonstrating a strong osteoprotective effect. There was notable difference in percentage change of total tibia from baseline to 6 months between groups Ovariectomy and Ovariectomy-plus-Glycyrrhiza (−13.03% ± 5.11 and −0.84% ± 7.63 respectively,P < 0.005), and of proximal tibia accordingly (−27.9% ± 3.69 and −0.81% ± 14.85 respectively,P < 0.001), confirming the protective effect ofGlycyrrhiza glabraextract in preserving bone density of the Ovariectomy-plus-Glycyrrhiza group. Three-point-bending did not reveal any statistically significant difference between Ovariectomy and Ovariectomy-plus-Glycyrrhiza groups. Uterine weights of the Ovariectomy-plus-Glycyrrhiza group ranged between the other two groups with no statistically significant difference to each.Conclusions:Glycyrrhiza glabraroot extract notably protected tibial bone mineral density loss in Ovariectomy-plus-Glycyrrhiza rats in comparison with ovariectomized rats, but did not improve biomechanical strength.

scholarly journals Recovery Effects of a 180 mT Static Magnetic Field on Bone Mineral Density of Osteoporotic Lumbar Vertebrae in Ovariectomized Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Shenzhi Xu ◽  
Hideyuki Okano ◽  
Naohide Tomita ◽  
Yoshito Ikada
Keyword(s):  
Magnetic Field ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Static Magnetic Field ◽  
Lumbar Vertebrae ◽  
Exposed Group ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Moderate Intensity ◽  
Mineral Density

The effects of a moderate-intensity static magnetic field (SMF) on osteoporosis of the lumbar vertebrae were studied in ovariectomized rats. A small disc magnet (maximum magnetic flux density 180 mT) was implanted to the right side of spinous process of the third lumbar vertebra. Female rats in the growth stage (10 weeks old) were randomly divided into 4 groups: (i) ovariectomized and implanted with a disc magnet (SMF); (ii) ovariectomized and implanted with a nonmagnetized disc (sham); (iii) ovariectomized alone (OVX) and (vi) intact, nonoperated cage control (CTL). The blood serum 17--estradiol (E2) concentrations were measured by radioimmunoassay, and the bone mineral density (BMD) values of the femurs and the lumbar vertebrae were assessed by dual energy X-ray absorptiometry. The E2concentrations were statistically significantly lower for all three operated groups than those of the CTL group at the 6th week. Although there was no statistical significant difference in the E2concentrations between the SMF-exposed and sham-exposed groups, the BMD values of the lumbar vertebrae proximal to the SMF-exposed area statistically significantly increased in the SMF-exposed group than in the sham-exposed group. These results suggest that the SMF increased the BMD values of osteoporotic lumbar vertebrae in the ovariectomized rats.

Effects of dihydrotestosterone alone and combined with estrogen on bone mineral density, bone growth, and formation rates in ovariectomized rats

Bone ◽  
1996 ◽  
Vol 19 (2) ◽  
pp. 107-114 ◽  
Author(s):  
V. Coxam ◽  
B.M. Bowman ◽  
M. Mecham ◽  
C.M. Roth ◽  
M.A. Miller ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Growth ◽  
Ovariectomized Rats ◽  
Mineral Density
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