scholarly journals Chronic duodenal stasis and the state of cavity intestinal microbiota

2020 ◽  
pp. 4-10
Author(s):  
Ya. M. Vakhrushev ◽  
M. S. Busygina ◽  
A. P. Lukashevich
Keyword(s):  
Small Intestine ◽  
Bacterial Growth ◽  
The State ◽  
Short Term ◽  
Digestive Tube ◽  
Postprandial Period ◽  
Exhaled Air ◽  
Respiratory Test ◽  
Comprehensive Study

Objective: to study the motor-evacuation function of the gastrointestinal tract in chronic duodenal stasis and the conjugation of their disorders with excessive bacterial growth.Materials and methods. Thirty patients with chronic duodenostasis (DS) aged 37.1 ± 13.8 years were examined. Anamnestic and physical data, results of X-ray and endoscopic examinations, intracavitarymanometry were used in the verification of DS. The determination of excess bacterial growth (IDB) in the small intestine was carried out by analyzing the results of the hydrogen respiratory test (VDT). The assessment of the motor function of the stomach and duodenum was carried out using the gastroenteromanometer GEM-01 “Gastroskan-GEM”. For conducting short-term pH-measurement, the Gastroskan-5M device was used.Results. All patients with DS presented dyspeptic complaints, revealed asthenic syndrome. In the postprandial period, impaired propulsive motility in all sections of the digestive tube was also expressed, which proves a 1.5-fold decrease in fasting urea, jejunum and ileum by 1.5 times in both phases of the study (p& <0.001). In patients with DS, IDB was detected in 22 (78.6%) cases. Among all examined patients in 19 (67.9%) patients, IDB was associated with increased bacterial activity in the small intestine. Colon dysbiosis was detected in 3 (10.7%) patients (χ2 = 7.093, p = 0.008). A correlation analysis between the hydrogen content in exhaled air and the rhythmic coefficient of the large intestine showed a reliable strong feedback (r& = 0.65, p = 0.015).Conclusion. A comprehensive study of the motor-evacuation function of the digestive system and the state of enteric microbiocenosis expands the possibilities of pathogenetically substantiated therapy for diseases of the organs of the gastroduodenobiliary pancreatic zone.

Diagnosis of the Syndrome of Excessive Bacterial Growth of the Small Intestine in Patients with Bauhinia Insufficiency and After its Surgical Correction (First Results)

2020 ◽  
pp. 1-6
Author(s):  
Vladimir Leonidovich Martynov ◽  
◽  
Natalia Vladimirovna Kazarina ◽  
Keyword(s):  
Small Intestine ◽  
Bacterial Growth ◽  
Ileocecal Valve ◽  
Normal Function ◽  
Main Group ◽  
Surgical Correction ◽  
Control Group ◽  
Distal Small Intestine ◽  
First Results ◽  
Respiratory Test

Objective: To determine the syndrome of excessive bacterial growth in the small intestine (SIBO) in patients with insufficiency of the bauhinia valve (NBZ) and after its surgical correction. Methods of examination: Patients of the studied groups were examined using direct and indirect methods of diagnosis of SIBO. Bacteriological examination of ileal aspirate and other surgical material was performed. All patients underwent a hydrogen respiratory test with a load of lactulose and performed a qualitative reaction of urine to indican. Characteristics of the material: 50 patients were examined, of which 30 were included in the main group, who underwent surgical correction of NBZ - Bauginoplasty; 20 patients are included in the control group in which the ileocecal valve is consistent. Patients of the main group were examined before surgery and on the 7th and 45th day after Bauhinoplasty. Main results: All patients of the main group had SIBS of varying severity, in 80% of patients SIBS was localized in the distal small intestine. Patients with normal function of ileocecal valve syndrome of excessive bacterial growth did not suffer. Intraoperatively, 76% of patients showed signs of mesenteric mesentery of the small intestine, and the fact of bacterial translocation in SIBO was also confirmed. After 7 days after surgical correction of the Bauhinia valve, the normalization of peak and background excretion of hydrogen was observed in 37% of patients. For 45 days in all patients the hydrogen curve corresponded to the norm. Conclusions: the deficiency of the bauhinia valve is obligately accompanied by the syndrome of excessive bacterial growth in the small intestine, surgical correction is an effective method for correcting the syndrome of excessive bacterial growth in patients with NBD.

scholarly journals Biological determination of low concentrations of arsenic in exhaled air

2021 ◽  
Vol 32 (7) ◽  
pp. 562-566
Author(s):  
A. Ya. Pleshchitser ◽  
A. A. Preobrazhensky
Keyword(s):  
The State ◽  
Complete Picture ◽  
Labor Protection ◽  
State Of Health ◽  
Central Institute ◽  
Low Concentrations ◽  
Exhaled Air ◽  
Biological Determination

In the report of Dr. Obukh and the Central Institute for Labor Protection on the state of health of the workers of the arsenic workshop, it was emphasized that the organization of studies of exhaled air for arsenic a few hours after the end of the work is of great interest and that given the exhalation of arsenic by the lungs, taking into account its enormous surface, it is possible it would be to get a more complete picture of the balance of receipts and outputs of As from these workers.

scholarly journals Current trends in the development of the Russian agrarian economy in ensuring food security

2020 ◽  
Vol 27 ◽  
pp. 00035
Author(s):  
Olga V. Kirillova ◽  
Alfiya F. Sadreeva ◽  
Svetlana V. Markova ◽  
Farida A. Mukhametshina
Keyword(s):  
Food Security ◽  
Raw Materials ◽  
The State ◽  
Short Term ◽  
State Support ◽  
Agrarian Economy ◽  
Current Trends ◽  
The Russian Federation ◽  
The Creation

The situation in the Russian Federation in the spring of 2020 is quite serious and directly related to ensuring food security. Achieving the country’s food security always depends on the ability of the state to overcome threats and risks of various kinds. There is the situation that requires a rapid study of information, accumulation of available resources, the creation of the necessary reserves and the determination of current directions for the development of the agrarian economy in such emergency conditions. But in these conditions, Russia has faced many problems that need to be addressed in the short term. The need for state support for agriculture in this situation is clear and more necessary than ever. At the same time, we must consider its features determining the directions, forms and methods of state support. The article determines that for the development of the agrarian economy and ensuring food security of the country require sustainable development of agricultural production, raw materials and food, the implementation of policies to support the neediest segments of the population and poverty alleviation, the development of interregional integration, the development of transport and logistics infrastructure to support the regions, support for farms, the formation of the state reserve of agricultural products, raw materials and products nutrition, the creation of a network of distribution centres under the mechanism of domestic food assistance to the population, etc.

Urine indican and hydrogen respiratory test as methods of screaning diagnostics of excessive bacterial growth syndrome in a small intestine

2017 ◽  
pp. 117-121
Author(s):  
V.L. Martynov ◽  
A.G. Semenov ◽  
A.A. Tulupov ◽  
A.A. Chesnokov ◽  
V.A. Kurilov ◽  
...  
Keyword(s):  
Small Intestine ◽  
Bacterial Growth ◽  
Respiratory Test

scholarly journals Endotoxemia in metabolic syndrome and some mechanisms of its development

2020 ◽  
pp. 11-17
Author(s):  
M. V. Lyapina ◽  
A. P. Lukashevich ◽  
Ya. M. Vakhrushev
Keyword(s):  
Metabolic Syndrome ◽  
Small Intestine ◽  
Electrical Activity ◽  
Bacterial Growth ◽  
Empty Stomach ◽  
Control Group ◽  
Intestinal Damage ◽  
Endotoxin Level ◽  
Postprandial Period ◽  
The Metabolic Syndrome

The aim. Assessment of the relationship between the occurrence of endotoxemia and impaired resorption function of the small intestine, arrhythmia of the motility of the stomach and intestines, and excessive bacterial growth in the metabolic syndrome (MS).Materials and methods. 62 patients with MS were examined. The average age was 48.62+3.75 years. The motor function of the gastrointestinal tract was studied using peripheral electrogastroenterocolography. To assess the absorption processes in the small intestine, stress tests with glucose and d-xylose were used. Blood endotoxin level, quantitative and& qualitative composition of parietal microbiota of small intestine were determined using an Agilent gas chromatograph with mass-selective and flame-ionization detectors (Agilent Technologies, USA).Results. 82.9% of the examined patients with MS showed clinical signs of intestinal damage. The electrical activity of& the& small intestine departments in the postprandial period was low in 70% of patients. The electrical activity of& the& colon on an empty stomach was not changed, and after a food load was reduced. Discoordination of motility is observed between small intestine and the colon, aggravated after food stimulation. A significant decrease in the rhythm of contractions is observed at the frequencies of the jejunum, ileum, and colon both on an empty stomach and in the postprandial period, which indicates a weakening of propulsive bowel contractions in patients with MS. In patients with MS, an increase in& the& absorption of glucose and d-xylose was revealed in comparison with the group of healthy individuals. In patients with MS, excessive bacterial growth in small intestine is observed mainly due to conditionally pathogenic microbiota strains. According to the results of the study of blood endotoxin level in patients with MS, a significant increase was revealed in comparison with the control group. Correlation analysis showed a moderate negative relationship between the level of endotoxin and electrical activity of small intestine, between the level of endotoxin and the ratio of the ratio of& the& colon to the ileum. A moderate positive relationship was established between the degree of endotoxemia increase and glucose absorption in small intestine.Conclusion. A study of the level of endotoxin and indicators of excessive bacterial growth, motor evacuation and resorption functions of small intestine revealed important pathogenetic patterns regarding the contributing role of the latter in& the development of endotoxemia in patients with MS.

Determination of allostatic load dynamics in the assessment of adaptation in temporary workers in the Arctic

2020 ◽  
pp. 547-548
Author(s):  
O. Yu. Atkov ◽  
S. G. Gorokhova
Keyword(s):  
Body Mass Index ◽  
Glucose Level ◽  
Shift Work ◽  
Allostatic Load ◽  
The Arctic ◽  
Temporary Workers ◽  
Short Term ◽  
Short Term Adaptation ◽  
The Individual

The individual dynamics of the allostatic load index was revealed mainly due to changes in the glucose level, body mass index, which makes it applicable for assessing the short-term adaptation to the stay in the conditions of shift work

Simultaneous Determination of Eight Potential Q-Markers in Zishen Tongguan Capsules Based on UHPLC-MS/MS

2020 ◽  
Vol 17 (1) ◽  
pp. 47-56
Author(s):  
Shun Liu ◽  
Xun Wang ◽  
Kaiping Zou ◽  
Wei Liu ◽  
Cunyu Li ◽  
...  
Keyword(s):  
Quality Control ◽  
Chinese Medicine ◽  
Simultaneous Determination ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Gradient Elution ◽  
Quality Markers ◽  
High Repeatability ◽  
Comprehensive Study

Background: Zishen Tongguan (ZSTG) capsules were prepared at the Affiliated Hospital of Nanjing University of Chinese Medicine and have been proven to be clinically effective for treating pyelonephritis and benign prostatic hyperplasia. However, the quality standards are not ideal; a comprehensive study of the “quality markers” (Q-markers), the chemicals inherent in traditional Chinese medicine and its preparations, has not been carried out. Experimental Methods: In this paper, a sensitive and specific ultra-high-performance liquid chromatographictandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of eight potential Q-markers of ZSTG, including timosaponin A3, berberine, jatrorrhizine, phellodendrine, palmatine, mangiferin, neomangiferin, and timosaponin BII. A Kromasil 100-3.5 C18 column was used with a mobile phase of 0.2% formic acid with acetonitrile, and gradient elution at a flow rate of 0.2 mL/min was achieved in 13 minutes and used for separation. Detection was performed in positive/negative mode with multiple reaction monitoring (MRM). Results: The analytical method was validated in terms of the sensitivity, linearity, accuracy, precision, repeatability, stability and recovery. The method established here was successfully applied to study the potential Q-markers in 8 batches of commercial samples, which demonstrated its use in improving the quality control of ZSTG. Conclusion: The developed method had high repeatability and accuracy and was suitable for the simultaneous analysis of multiple Q-markers, which may provide a new basis for the comprehensive assessment and overall quality control of ZSTG.

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