scholarly journals Errors in the diagnosis and treatment of Helicobacter pylori infection: in anticipation of new conciliation documents

2021 ◽  
pp. 5-14
Author(s):  
D. S. Bordin
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Practice ◽  
Helicobacter Pylori Infection ◽  
Diagnosis And Treatment ◽  
High Prevalence ◽  
H Pylori ◽  
European Registry

The high prevalence of H. pylori and diseases caused by this infection determine the relevance of discussing the problems of its diagnosis and treatment on the eve of the emergence of new international and domestic agreements. Studies published in recent years, including articles on the materials of the European Registry on the management of Helicobacter pylori infection (Hp-EuReg), provide a rich background for the analysis of errors in diagnosis and treatment of this infection, and the development of approaches to optimize clinical practice.

scholarly journals European registry Helicobacter pylori (Hp-EuReg): how has clinical practice changed in Russia from 2013 to 2018 years

2019 ◽  
Vol 91 (2) ◽  
pp. 16-24 ◽  
Author(s):  
D S Bordin ◽  
Yu V Embutnieks ◽  
L G Vologzhanina ◽  
T A Ilchishina ◽  
I N Voynovan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Practice ◽  
Serological Test ◽  
Eradication Therapy ◽  
Diagnostic Methods ◽  
Helicobacter Pylori Infection ◽  
Rapid Urease Test ◽  
Urease Test ◽  
H Pylori ◽  
European Registry

The multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group (EHMSG) is conducted in 27 countries in Europe. The data from the Russian part of the European registry for the management of Helicobacter pylori infection (European Registry on the management of Helicobacter pylori infection, protocol: “Hp-EuReg”) allows us to analyze the real clinical practice of diagnosis and treatment of H. pylori and compare it with international recommendations. Materials and methods. A comparative analysis of the data entered in the register by the Russian research centers “Hp-EuReg”, in the period from 2013 to 2018, was conducted. Results and discussion. Invasive diagnostic methods prevail for the primary diagnosis of H. pylori [histology - 20.3% (in 2013 year) - 43.9% (in 2018 year), rapid urease test - 31.7% and 47.8% respectively]. The most popular mode of eradication therapy is a 10-day triple therapy (62.8-76.2%), the effectiveness of which does not exceed 79% (per protocol). Invasive tests (histology) are the leading method for control the effectiveness of therapy, however, there is a tendency towards a wider use of non-invasive methods (H. pylori stool antigen - from 17% in 2013 to 29.3% in 2018 and urea breath test from 6.9 to 18.3%, respectively). Serological test to control the effectiveness of eradication is still used from 8.2% (2013) to 6.1% (2018). Eradication therapy was not performed in 28% of patients throughout the entire observation period. Conclusion. In Russia, despite approved domestic and international recommendations, deviations in clinical practice persist, both during eradication therapy and in monitoring the effectiveness of eradication therapy.

scholarly journals Empirical or susceptibility-guided treatment for Helicobacter pylori infection? A comprehensive review

2020 ◽  
Vol 13 ◽  
pp. 175628482096873
Author(s):  
Javier P. Gisbert
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Practice ◽  
Helicobacter Pylori Infection ◽  
Alternative Methods ◽  
First Line ◽  
Time Saving ◽  
Line Therapy ◽  
H Pylori ◽  
Guided Therapy

Although susceptibility-guided therapy is frequently recommended for Helicobacter pylori infection, the evidence available to date supporting this strategy is limited. The aim of the present article is to review the advantages and limitations of the susceptibility-guided and the empirical strategies to treat this infection. We performed a bibliographic search to identify studies investigating H. pylori susceptibility-guided therapy. Culture is not the only way to assess antibiotic resistance, as different polymerase chain reaction-based approaches have been developed as alternative methods. For detecting H. pylori antimicrobial resistance, a molecular approach based on a stool sample might enable more convenient, time-saving methods. Unfortunately, the antimicrobial susceptibility cannot be obtained in all cases. Furthermore, antibiotic susceptibility testing in clinical practice yields useful information only for a few antibiotics: clarithromycin, metronidazole, and quinolones. In addition, susceptibility towards clarithromycin and metronidazole in vitro does not necessarily lead to eradication in vivo. In the case of H. pylori therapy failure, we should not re-administer any of the antibiotics against which H. pylori has probably become resistant. Our updated meta-analysis showed that susceptibility-guided treatment is not better than empirical treatment of H. pylori infection in first-line therapy if the most updated quadruple regimens are empirically prescribed, and similar efficacy results were also demonstrated with the two strategies for second-line therapy. Cumulative H. pylori eradication rate with several successive rescue therapies empirically prescribed reaches almost 100%. Finally, the studies that have evaluated the cost-effectiveness of the susceptibility-guided treatment have achieved contradictory results. In summary, we can conclude that the evidence is too limited to support the generalized use of susceptibility-guided therapy for H. pylori treatment in routine clinical practice, either as first-line or as rescue treatment. Nevertheless, it would be recommended that susceptibility tests are performed routinely, even before prescribing first-line treatment, in specialized centers with an interest in H. pylori management.

scholarly journals Helicobacter Pylori Infection: Causes, Diagnosis and Treatment

2020 ◽  
Vol 03 (12) ◽  
Author(s):  
Rahul Rao ◽  
Keyword(s):  
Developing Countries ◽  
Helicobacter Pylori ◽  
Preventive Measure ◽  
Helicobacter Pylori Infection ◽  
Diagnosis And Treatment ◽  
Adults And Children ◽  
The Common ◽  
H Pylori ◽  
Common Infections

Helicobacter Pylori infection is one of the common infections worldwide. The rates of infection are reducing in both developed and developing countries, but it is still a widespread infection. In this paper we will discuss about H. pylori causes and the disease that could arise due to infection, preventive measure, precautions, treatment, and several important information regarding the infection. We also reviewed several papers and studies conducted on patients both adults and children who are affected with H. pylori.

scholarly journals The need to strengthen measures for the diagnosis and treatment of Helicobacter pylori infection in Russia. Memorandum

2021 ◽  
pp. 83-96
Author(s):  
L. B. Lazebnik ◽  
D. S. Bordin ◽  
N. N. Dekhnich ◽  
R. S. Kozlov ◽  
M. A. Livzan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Round Table ◽  
Helicobacter Pylori Infection ◽  
Diagnosis And Treatment ◽  
Medical Community ◽  
Scientific Society ◽  
The Status ◽  
National Congress ◽  
H Pylori

Justification The participants of the round table on diagnosis and treatment of acid - and Helicobacter-dependent diseases, held on November 20, 2020 at the XXIII congress of the Scientific Society of Gastroenterologists of Russia within the framework of the XV National Congress of Therapists (Authors) having discussed the status of the issue, decided on the need to harmonize measures and pool efforts to reduce the incidence of H. pylori infection by approaching the medical community with this Memorandum.

scholarly journals Helicobacter pylori infection and serum magnesium in kidney disease; current concepts

2019 ◽  
Vol 9 (1) ◽  
pp. e11-e11
Author(s):  
Banafsheh Yalameha ◽  
Parto Nasri
Keyword(s):  
Helicobacter Pylori ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Helicobacter Pylori Infection ◽  
World Population ◽  
Serum Magnesium Level ◽  
Gastrointestinal Complications ◽  
High Prevalence ◽  
The World ◽  
H Pylori

One of the problems of renal disease patients, especially patients undergoing dialysis, is gastrointestinal complications caused by Helicobacter pylori infection. H. pylori has still high prevalence in most populations. It is estimated that about half of the world population is infected with this infection and it can change levels of most micronutrients such as magnesium. Different studies demonstrate that H. pylori may affect the metabolism of magnesium in renal failure. The present paper investigated the association of serum magnesium level with H. pylori infection. Nevertheless, it should be more evaluated by researchers and still many studies are necessary to confirm this issue.

Seroprevalence, correlates and trends of Helicobacter pylori infection in the Israeli population

2011 ◽  
Vol 140 (7) ◽  
pp. 1207-1214 ◽  
Author(s):  
K. MUHSEN ◽  
D. COHEN ◽  
A. SPUNGIN-BIALIK ◽  
T. SHOHAT
Keyword(s):  
Helicobacter Pylori ◽  
North America ◽  
South America ◽  
Western Europe ◽  
Helicobacter Pylori Infection ◽  
Igg Antibodies ◽  
Israeli Population ◽  
High Prevalence ◽  
H Pylori ◽  
Recent Immigration

SUMMARYWe examined the prevalence, correlates and trends of H. pylori infection in Israel using residual sera obtained in 2007–2008 from 1466 Jewish subjects aged 0–77 years and 897 Arabs aged 0–19 years, and in 2000–2001 from 627 Jewish and 575 Arab subjects aged 0–19 years. H. pylori IgG antibodies were measured by ELISA. The age-adjusted H. pylori seroprevalence was 45·2% in Jewish participants. Seropositivity increased with age, reaching 60% at age ⩾50 years and ranged from 24·3% in subjects originating from North America/Western Europe/Australia, to 63·2% in those from Asia/Africa/South America. Among Arabs, H. pylori seroprevalence was 42·1% and reached 65% in adolescents. There was no significant change in seroprevalence between 2000–2001 and 2007–2008. High prevalence of H. pylori was found in Arabs, and in Jews originating from countries of high H. pylori endemicity. These findings are characteristic of countries of diverse ethnic structure and recent immigration.

scholarly journals A High-Throughput Metabolic Microarray Assay Reveals Antibacterial Effects of Black and Red Raspberries and Blackberries against Helicobacter pylori Infection

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 845
Author(s):  
Candace Goodman ◽  
Katrina N. Lyon ◽  
Aitana Scotto ◽  
Cyra Smith ◽  
Thomas A. Sebrell ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
High Throughput ◽  
Antibacterial Properties ◽  
Treatment Strategies ◽  
Helicobacter Pylori Infection ◽  
Antibacterial Effects ◽  
Biolog System ◽  
Freeze Dried ◽  
H Pylori

Helicobacter pylori infection is commonly treated with a combination of antibiotics and proton pump inhibitors. However, since H. pylori is becoming increasingly resistant to standard antibiotic regimens, novel treatment strategies are needed. Previous studies have demonstrated that black and red berries may have antibacterial properties. Therefore, we analyzed the antibacterial effects of black and red raspberries and blackberries on H. pylori. Freeze-dried powders and organic extracts from black and red raspberries and blackberries were prepared, and high-performance liquid chromatography was used to measure the concentrations of anthocyanins, which are considered the major active ingredients. To monitor antibiotic effects of the berry preparations on H. pylori, a high-throughput metabolic growth assay based on the Biolog system was developed and validated with the antibiotic metronidazole. Biocompatibility was analyzed using human gastric organoids. All berry preparations tested had significant bactericidal effects in vitro, with MIC90 values ranging from 0.49 to 4.17%. Antimicrobial activity was higher for extracts than powders and appeared to be independent of the anthocyanin concentration. Importantly, human gastric epithelial cell viability was not negatively impacted by black raspberry extract applied at the concentration required for complete bacterial growth inhibition. Our data suggest that black and red raspberry and blackberry extracts may have potential applications in the treatment and prevention of H. pylori infection but differ widely in their MICs. Moreover, we demonstrate that the Biolog metabolic assay is suitable for high-throughput antimicrobial susceptibility screening of H. pylori.

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