scholarly journals Considerations for mosquito microbiome research from the Mosquito Microbiome Consortium

2020 ◽  
Author(s):  
Nsa Dada ◽  
Natapong Jupatanakul ◽  
Guillaume Minard ◽  
Sarah M. Short ◽  
Jewelna Akorli ◽  
...  
Keyword(s):  
Mosquito Species ◽  
Data Handling ◽  
Laboratory Studies ◽  
Future Directions ◽  
Design And Implementation ◽  
The Past ◽  
Disease Vector ◽  
Microbiome Research ◽  
Geographical Locations

In the past decade, there has been increasing interest in mosquito microbiome re-search, leading to large amounts of data on different mosquito species, with various underlying physiological characteristics, and from diverse geographical locations. However, guidelines and standardized methods for conducting mosquito microbiome research are lacking. To streamline methods in mosquito microbiome research, optimize data quality, reproducibility, and comparability, as well as facilitate data curation in a centralized location, we are establishing the Mosquito Microbiome Consortium, a collaborative initiative for the advancement of mosquito microbiome research. Our overall goal is to collectively work on unravelling the role of the mosquito microbiome in mosquito biology, while critically evaluating its potential for mosquito borne disease control. This perspective serves to introduce the consortium and invite broader participation. It highlights the issues we view as most pressing to the community and proposes guidelines for conducting mosquito microbiome re-search. We focus on four broad areas in this piece (1) sampling/experimental design for field, semi-field or laboratory studies, (2) metadata collection (3) sample processing, sequencing, and use of appropriate controls, and (4) data handling and analysis. We finally summarize current challenges and highlight future directions in mosquito microbiome research. We hope that this piece will spark discussions around this area of disease vector biology, as well as encourage careful considerations in the design and implementation of mosquito microbiome research.

scholarly journals Considerations for mosquito microbiome research from the Mosquito Microbiome Consortium

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Nsa Dada ◽  
Natapong Jupatanakul ◽  
Guillaume Minard ◽  
Sarah M. Short ◽  
Jewelna Akorli ◽  
...  
Keyword(s):  
Mosquito Species ◽  
Data Handling ◽  
Laboratory Studies ◽  
Future Directions ◽  
Design And Implementation ◽  
The Past ◽  
Disease Vector ◽  
Microbiome Research ◽  
Geographical Locations

AbstractIn the past decade, there has been increasing interest in mosquito microbiome research, leading to large amounts of data on different mosquito species, with various underlying physiological characteristics, and from diverse geographical locations. However, guidelines and standardized methods for conducting mosquito microbiome research are lacking. To streamline methods in mosquito microbiome research and optimize data quality, reproducibility, and comparability, as well as facilitate data curation in a centralized location, we are establishing the Mosquito Microbiome Consortium, a collaborative initiative for the advancement of mosquito microbiome research. Our overall goal is to collectively work on unraveling the role of the mosquito microbiome in mosquito biology, while critically evaluating its potential for mosquito-borne disease control. This perspective serves to introduce the consortium and invite broader participation. It highlights the issues we view as most pressing to the community and proposes guidelines for conducting mosquito microbiome research. We focus on four broad areas in this piece: (1) sampling/experimental design for field, semi-field, or laboratory studies; (2) metadata collection; (3) sample processing, sequencing, and use of appropriate controls; and (4) data handling and analysis. We finally summarize current challenges and highlight future directions in mosquito microbiome research. We hope that this piece will spark discussions around this area of disease vector biology, as well as encourage careful considerations in the design and implementation of mosquito microbiome research.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

Virus Decline of Strawberry in California and the Role of Insect Vectors and Associated Viruses

2015 ◽  
Vol 16 (4) ◽  
pp. 211-215 ◽  
Author(s):  
Surendra K. Dara
Keyword(s):  
Frankliniella Occidentalis ◽  
Western Flower Thrips ◽  
Trialeurodes Vaporariorum ◽  
Current Status ◽  
Insect Vectors ◽  
The Past ◽  
Disease Vector ◽  
Flower Thrips ◽  
Purple Coloration

Greenhouse white fly, Trialeurodes vaporariorum (Westwood); western flower thrips, Frankliniella occidentalis (Pergande); and strawberry aphid, Chaetosiphon fragaefolii (Cockerell), are common pests of strawberries in California and are vectors of one or more viruses. Most of the viruses transmitted by these vectors do not cause symptoms on strawberry when the infection occurs individually. However, when one of the viruses (Beet pseudoyellows virus or Strawberry pallidosis-associated virus) transmitted by T. vaporariorum is present along with one of the viruses transmitted by F. occidentalis, C. fragaefolii, or other sources, it results in a virus decline of strawberry, which can cause significant crop losses. Stunted root and plant growth, purple coloration of foliage, and dieback of the plant are some of the symptoms associated with virus decline. Increases in T. vaporariorum infestations during the past few years significantly elevated the risk of whitefly as a crop pest and a disease vector. This article reviews virus decline of strawberry, symptoms of infection, and the current status of insect vectors in California strawberries. Accepted for publication 17 November 2015. Published 20 November 2015.

Women in the history of linguistics

2020 ◽  
pp. 1-30
Author(s):  
Wendy Ayres-Bennett ◽  
Helena Sanson
Keyword(s):  
Language Acquisition ◽  
Central Section ◽  
Future Directions ◽  
The Past ◽  
Early Stages ◽  
Challenges And Opportunities ◽  
History Of Linguistics ◽  
History Of ◽  
Role Of Women

This Introduction outlines the need for a ‘true history’ (Lerner 1976) of the role of women in the history of linguistics, which considers them on their own terms, and challenges categories and concepts devised for traditional male-dominated accounts. We start by considering what research has already been conducted in the field, before exploring some of the reasons for the relative dearth of studies. We outline some of the challenges and opportunities encountered by women who wished to study the nature of language and languages in the past. The geographical and chronological scope of this volume is then discussed. In a central section we examine some of the major recurring themes in the volume. These include attitudes towards women’s language, both positive and negative; women and language acquisition and teaching; and women as creators of new languages and scripts. We further explore women as authors, dedicatees, or intended readers of metalinguistic texts, as interpreters and translators, and as contributors to the linguistic documentation and maintenance. We consider how women supported male relatives and colleagues in their endeavours, sometimes in invisible ways, before reviewing the early stages of their entry into institutionalized contexts. The chapter concludes with a brief section on future directions for research.

A survey of instrumented indentation studies on metallic glasses

2004 ◽  
Vol 19 (1) ◽  
pp. 46-57 ◽  
Author(s):  
C.A. Schuh ◽  
T.G. Nieh
Keyword(s):  
Metallic Glasses ◽  
Structural Changes ◽  
Shear Banding ◽  
Depth Sensing ◽  
Future Directions ◽  
Fundamental Physics ◽  
New Approach ◽  
The Past ◽  
Rate Dependent

The development of instrumented nanoindentation equipment has occurred concurrently with the discovery of many new families of bulk metallic glass during the past decade. While indentation testing has long been used to assess the mechanical properties of metallic glasses, depth-sensing capabilities offer a new approach to study the fundamental physics behind glass deformation. This article is a succinct review of the research to date on the indentation of metallic glasses. In addition to standard hardness measurements, the onset of plasticity in metallic glasses is reviewed as well as the role of shear banding in indentation, structural changes beneath the indenter, and rate-dependent effects measured by nanoindentation. The article concludes with perspectives about the future directions for nanocontact studies on metallic glasses.

scholarly journals Microbiome Studies from Saudi Arabia over the Last 10 Years: Achievements, Gaps, and Future Directions

2021 ◽  
Vol 9 (10) ◽  
pp. 2021
Author(s):  
Khalid J. Alzahrani
Keyword(s):  
Saudi Arabia ◽  
Food Processing ◽  
Animal Health ◽  
Pharmaceutical Products ◽  
Industrial Enzymes ◽  
Space Applications ◽  
Future Directions ◽  
Global Trends ◽  
The Past ◽  
Microbiome Research

In the past ten years, microbiome studies have shown tremendous potentiality for implementation of understanding microbiome structures and functions of various biomes and application of this knowledge for human betterment. Saudi Arabia is full of geographical, ecological, ethnical, and industrial diversities and scientific capacities. Therefore, there is a great potential in Saudi Arabia to conduct and implement microbiome-based research and applications. However, there is no review available on where Saudi Arabia stands with respect to global microbiome research trends. This review highlights the metagenome-assisted microbiome research from Saudi Arabia compared to the global focuses on microbiome research. Further, it also highlights the gaps and areas that should be focused on by Saudi microbiome researchers and the possible initiatives to be taken by Saudi government and universities. This literature review shows that the global trends of microbiome research cover a broad spectrum of human and animal health conditions and diseases, environmental and antimicrobial resistance surveillance, surveillance of food and food processing, production of novel industrial enzymes and bioactive pharmaceutical products, and space applications. However, Saudi microbiome studies are mostly confined to very few aspects of health (human and animal) and environment/ecology in last ten years, without much application. Therefore, Saudi Arabia should focus more on applied microbiome research through government, academic, and industry initiatives and global cooperation to match the global trends.

Cabozantinib plus immunotherapy combinations in metastatic renal cell and urothelial carcinoma

2021 ◽  
pp. 00-00
Author(s):  
Luis Meza ◽  
Jasnoor Malhotra ◽  
Crystal Favorito ◽  
Sumanta K Pal
Keyword(s):  
Urothelial Carcinoma ◽  
Renal Cell ◽  
Progressive Disease ◽  
Treatment Options ◽  
Future Directions ◽  
The Past ◽  
Metastatic Urothelial Carcinoma ◽  
Novel Approaches

Treatment options for metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC) have increased dramatically over the past decade. However, even when novel approaches have proven to be effective as monotherapy, many patients still develop progressive disease, and different strategies are needed to increase clinical response and quality of life. Strategies combining targeted therapy (TT) and immunotherapy (IO) have emerged as a way to shorten the gap between responders and nonresponders to monotherapy and have reported promising results. In this review, we discuss the current role of cabozantinib in combination with IO agents in the treatment of metastatic RCC and UC and go over future directions in the field.

scholarly journals New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Peng Chen ◽  
Fuchao Chen ◽  
Yue Wu ◽  
Benhong Zhou
Keyword(s):  
Molecular Mechanisms ◽  
Wide Spectrum ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Future Directions ◽  
The Past ◽  
The Central Nervous System ◽  
Spontaneous Recurrent Seizures ◽  
Patients With Epilepsy

Data accumulated over the past four decades have confirmed that adult hippocampal neurogenesis (HN) plays a key role in the wide spectrum of hippocampal pathology. Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although neurogenesis in persistent germinative zones is altered in the adult rodent models of epilepsy, the effects of seizure-induced neurogenesis in the epileptic brain, in terms of either a pathological or reparative role, are only beginning to be explored. In this review, we described the most recent advances in neurogenesis in epilepsy and outlooked future directions for neural stem cells (NSCs) and epilepsy-in-a-dish models. We proposed that it may help in refining the underlying molecular mechanisms of epilepsy and improving the therapies and precision medicine for patients with epilepsy.

A Review of Influences on Sexual Fantasy: Attitudes, Experience, Guilt, and Gender

1987 ◽  
Vol 7 (1) ◽  
pp. 61-76 ◽  
Author(s):  
David Chick ◽  
Steven R. Gold
Keyword(s):  
Sexual Attitudes ◽  
Sexual Experience ◽  
Sexual Attitude ◽  
Sexual Fantasy ◽  
Future Directions ◽  
Sex Guilt ◽  
The Past ◽  
Functional Aspects ◽  
And Gender

The important role of sexual fantasy in human sexuality has received wide support in the past decade and a half. The initial interest in establishing fantasy's normality has shifted to examining the functional aspects of fantasy and the variables that influence it. The following article reviews variables that affect sexual fantasies including the role of an individual's personality/sexual attitude, sexual experience, sex guilt, and gender. Also, a hypothesized link between parental sexual attitudes and their children's fantasy production is explored. A variety of methods have been implemented to investigate fantasy and a number of these methods are critiqued and some possible methodological improvements are suggested. Finally, the similarity of findings across studies and methods seem to warrant expanding fantasy investigation to other areas and some future directions are suggested.

Immune System Functioning and Mental Health

2016 ◽  
Author(s):  
Colin Jenney ◽  
Angela Liegey Dougall
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Past Research ◽  
Delayed Wound Healing ◽  
Future Directions ◽  
The Past ◽  
Age Related ◽  
System Functioning ◽  
Increased Susceptibility

During the past few decades, research from multiple disciplines has elucidated the profound connections between the immune system and mental health. This chapter provides a review of this literature, placing emphasis on the connections between inflammation and cytokines, and stress, depression, posttraumatic stress disorder, schizophrenia, bipolar disorder, and social support. Additionally, brief overviews of the role of the natural immune system and adaptive immunity, as well as past research investigating stress are included. Further attention is focused on the physical health consequences of immune system dysregulation, ranging from increased susceptibility to infectious diseases, delayed wound healing, autoimmune responses, age-related elevations in proinflammatory cytokines, and decreased effectiveness of protective vaccinations. The chapter concludes with a discussion of the health effects and clinical implications of the relationships discussed throughout, as well as future directions to advance this field of study.

Sign in / Sign up

Export Citation Format

Share Document