scholarly journals Synthesis, spectroscopic characterization and singlet oxygen generation of 5,10,15,20-tetrakis(3,5-dimethoxyphenyl) porphyrin as a potential photosensitizer for photodynamic therapy

2021 ◽  
Author(s):  
CI Chemistry International
Keyword(s):  
Singlet Oxygen ◽  
Spectroscopic Characterization ◽  
Eye Disease ◽  
Oxygen Species ◽  
Photodynamic Treatment ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Age Related ◽  
Human Disorders ◽  
Oxygen Yield

Singlet oxygen is a valuable reactive oxygen species known for its effective action on the elimination of cancers and age-related eye disease such as macular degeneration. In this study, 5,10,15,20-tetrakis (3,5-dimethoxyphenyl) porphyrin was synthesized and characterized using various spectroscopic methods. The λmax for the Soret and Q bands were 417 nm and 514, 547, 589 and 646 (nm) respectively. The estimated singlet oxygen yield (φΔ) for the porphyrin was higher than some literature reports, suggesting a stronger potential of the porphyrin for the photosensitizing photodynamic treatment of cancer and other related human disorders.

scholarly journals Luciferase–Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

2017 ◽  
Vol 53 (33) ◽  
pp. 4569-4572 ◽  
Author(s):  
Seonghoon Kim ◽  
HyeongChan Jo ◽  
Mijeong Jeon ◽  
Myung-Gyu Choi ◽  
Sei Kwang Hahn ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Energy Transfer ◽  
Singlet Oxygen ◽  
Rose Bengal ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Oxygen Species ◽  
Bioluminescence Resonance Energy Transfer ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Luciferase–Rose Bengal conjugates generated reactive oxygen species (ROS) inside cells via bioluminescence resonance energy transfer (BRET) without external light irradiation.

scholarly journals Singlet Oxygen Generation in Classical Fenton Chemistry

2019 ◽  
Author(s):  
Andrew Carrier ◽  
Saher Hamid ◽  
David Oakley ◽  
Ken Oakes ◽  
Xu Zhang
Keyword(s):  
Hydrogen Peroxide ◽  
Singlet Oxygen ◽  
Fenton Reaction ◽  
Organic Molecules ◽  
Oxygen Species ◽  
Fenton Chemistry ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Fenton Reagents ◽  
High Valent

<div><div><div><p>The Fenton reaction, the Fe-catalyzed conversion of hydrogen peroxide to reactive oxygen species (ROS) was discovered more than a century ago. It occurs widely in nature because of the ubiquity of Fenton reagents, i.e., Fe and H2O2, and ROS in environmental and biological systems; however, its mechanisms and the identity of the ROS generated under varying conditions have remained controversial. The widely accepted mechanism is that of successive oxidation and reduction of Fe2+ and Fe3+ by hydrogen peroxide to form ·OH and O2-·, respectively, where ·OH is implicated as the primary oxidant. However, the formation of high-valent Fe4+=O species has also been implicated. Herein, by systematically dissecting the contributions of various ROS species generated in the classical Fenton reaction by using specific ROS traps and scavengers, we identified that singlet oxygen (1O2) is the main ROS from pH 4–7. In contrast, although ·OH is produced in measurable quantities, it was not a major contributor to the oxidation of organic molecules.</p></div></div></div>

scholarly journals Singlet Oxygen Generation in Classical Fenton Chemistry

2019 ◽  
Author(s):  
Andrew Carrier ◽  
Saher Hamid ◽  
David Oakley ◽  
Ken Oakes ◽  
Xu Zhang
Keyword(s):  
Hydrogen Peroxide ◽  
Singlet Oxygen ◽  
Fenton Reaction ◽  
Organic Molecules ◽  
Oxygen Species ◽  
Fenton Chemistry ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Fenton Reagents ◽  
High Valent

<div><div><div><p>The Fenton reaction, the Fe-catalyzed conversion of hydrogen peroxide to reactive oxygen species (ROS) was discovered more than a century ago. It occurs widely in nature because of the ubiquity of Fenton reagents, i.e., Fe and H2O2, and ROS in environmental and biological systems; however, its mechanisms and the identity of the ROS generated under varying conditions have remained controversial. The widely accepted mechanism is that of successive oxidation and reduction of Fe2+ and Fe3+ by hydrogen peroxide to form ·OH and O2-·, respectively, where ·OH is implicated as the primary oxidant. However, the formation of high-valent Fe4+=O species has also been implicated. Herein, by systematically dissecting the contributions of various ROS species generated in the classical Fenton reaction by using specific ROS traps and scavengers, we identified that singlet oxygen (1O2) is the main ROS from pH 4–7. In contrast, although ·OH is produced in measurable quantities, it was not a major contributor to the oxidation of organic molecules.</p></div></div></div>

On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells

2014 ◽  
Vol 2 (10) ◽  
pp. 1412-1418 ◽  
Author(s):  
Liang Yan ◽  
Ya-Nan Chang ◽  
Wenyan Yin ◽  
Gan Tian ◽  
Liangjun Zhou ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Photodynamic Treatment ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
On Demand

We engineered a novel nanocomplex of a photosensitizer, an aptamer and graphene oxide, which could function as a “cage” for controlling singlet oxygen generation, and efficiently deliver the photosensitizers to cancer cells.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

Achieving high singlet-oxygen generation by applying the heavy-atom effect to thermally activated delayed fluorescent materials

2021 ◽  
Author(s):  
Ya-Fang Xiao ◽  
Jia-Xiong Chen ◽  
Wen-Cheng Chen ◽  
Xiuli Zheng ◽  
Chen Cao ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Heavy Atom ◽  
Synergetic Effect ◽  
Heavy Atom Effect ◽  
Oxygen Generation ◽  
Thermally Activated ◽  
Singlet Oxygen Generation ◽  
Fluorescent Materials ◽  
Atom Effect

Applying the heavy-atom effect to TADF photosensitizers achieves ultra-high 1O2 generation (ФΔ = 0.91) by the synergetic effect of small ΔEST and considerable SOC.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

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