scholarly journals How the Development, Features and Roll-Out of a SARS-COV-2 Vaccine Shape Public Acceptance: A Conjoint Experiment in a Large Representative Sample of Danes

2021 ◽  
Author(s):  
Frederik Juhl Jørgensen ◽  
Alexander Bor ◽  
Michael Bang Petersen
Keyword(s):  
Large Scale ◽  
Vaccine Development ◽  
Vaccination Strategy ◽  
Three Dimensions ◽  
Vaccine Uptake ◽  
Vaccine Acceptance ◽  
Policy Makers ◽  
The World ◽  
Conjoint Experiment ◽  
Roll Out

While effective vaccines against the SARS-COV-2 virus have been developed and countries around the world have invested heavily to secure vaccine rollout, a fundamental challenge remains. How do policy-makers around the world ensure high vaccine uptake? What is lacking is a comprehensive assessment that captures a total spectrum of features related to the development of a vaccine, the vaccine's characteristics as well as the implementation of the vaccination program. To provide such an assessment, we designed a conjoint experiment embedded in large-scale surveys based on a random sample from the central database of Danish social security numbers (N = 3,099), providing a sample that is representative for the adult Danish population. In the conjoint experiment, we vary features relating to three dimensions: 1) the stage of vaccine development, 2) the specific characteristics of the vaccine, and 3) the implementation of the vaccination strategy. We show that the features relating to characteristics of the specific vaccine have the strongest impact on vaccine acceptance. The features relating to vaccine development were the second most powerful, while the features relating to the implementation of the vaccination strategy were the least.

scholarly journals Ending the Pandemic: How Behavioural Science Can Help Optimize Global COVID-19 Vaccine Uptake

Vaccines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 7
Author(s):  
Michael Vallis ◽  
Simon Bacon ◽  
Kim Corace ◽  
Keven Joyal-Desmarais ◽  
Sherri Sheinfeld Gorin ◽  
...  
Keyword(s):  
Vaccine Development ◽  
Vaccine Uptake ◽  
Individual Choice ◽  
Behavioural Science ◽  
Vaccine Acceptance ◽  
Policy Makers ◽  
Target Time ◽  
Public Health Officials ◽  
Context Specific ◽  
Behavioural Sciences

Governments, public health officials and pharmaceutical companies have all mobilized resources to address the COVID-19 pandemic. Lockdowns, social distancing, and personal protective behaviours have been helpful but have shut down economies and disrupted normal activities. Vaccinations protect populations from COVID-19 and allow a return to pre-pandemic ways of living. However, vaccine development, distribution and promotion have not been sufficient to ensure maximum vaccine uptake. Vaccination is an individual choice and requires acceptance of the need to be vaccinated in light of any risks. This paper presents a behavioural sciences framework to promote vaccine acceptance by addressing the complex and ever evolving landscape of COVID-19. Effective promotion of vaccine uptake requires understanding the context-specific barriers to acceptance. We present the AACTT framework (Action, Actor, Context, Target, Time) to identify the action needed to be taken, the person needed to act, the context for the action, as well as the target of the action within a timeframe. Once identified a model for identifying and overcoming barriers, called COM-B (Capability, Opportunity and Motivation lead to Behaviour), is presented. This analysis identifies issues associated with capability, opportunity and motivation to act. These frameworks can be used to facilitate action that is fluid and involves policy makers, organisational leaders as well as citizens and families.

scholarly journals The Nation of Vaccine Development Influences Vaccine Acceptance

2021 ◽  
Author(s):  
Joan Barceló ◽  
Greg Sheen ◽  
Hans Tung ◽  
Wen-Chin Wu
Keyword(s):  
Public Opinion ◽  
Vaccine Development ◽  
Efficacy Rate ◽  
Vaccine Acceptance ◽  
The World ◽  
Conjoint Experiment ◽  
Practical Implications ◽  
National Borders

What types of vaccines are citizens most likely to accept? We administered a conjoint experiment requesting 15,000 adult citizens across 14 countries from around the world to assess 450,000 profiles of vaccines that randomly varied on seven attributes. Beyond vaccine fundamentals such as efficacy rate, number of doses, and duration of the protection, we find that citizens systematically favor vaccines developed and produced in their own country of residence. These results indicate that a sociological form of vaccine nationalism shapes vaccine acceptance. The extent of preference in favor of vaccines developed and produced within the national borders is particularly large among citizens who identify more strongly with their nation, suggesting nationalism plays a role in explaining the bias in favor of vaccines developed and produced locally. This public opinion bias on vaccine preferences has significant theoretical and practical implications.

scholarly journals SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Nikolaos C. Kyriakidis ◽  
Andrés López-Cortés ◽  
Eduardo Vásconez González ◽  
Alejandra Barreto Grimaldos ◽  
Esteban Ortiz Prado
Keyword(s):  
Neutralizing Antibodies ◽  
Large Scale ◽  
Vaccine Development ◽  
Rna Virus ◽  
Protein S ◽  
Effective Vaccine ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Advantages And Disadvantages ◽  
The World

AbstractThe new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

scholarly journals COVID-19 Vaccination of HCWs in the First Phase of a Large-Scale Mass Vaccination Program within a Healthcare System

2021 ◽  
Vol 1 (S1) ◽  
pp. s11-s11
Author(s):  
Kimberly Korwek ◽  
E. Jackie Blanchard ◽  
Julia Moody ◽  
Katherine Lange ◽  
Ryan Sledge ◽  
...  
Keyword(s):  
Human Resources ◽  
Healthcare Workers ◽  
Large Scale ◽  
Rapid Development ◽  
Vaccination Strategy ◽  
State Level ◽  
Mass Vaccination ◽  
Vaccine Uptake ◽  
Vaccination Program ◽  
Vaccination Rates

Background: The approval of the first SARS-COV-2 vaccines for COVID-19 were accompanied by unprecedented efforts to provide vaccination to healthcare workers and first responders. More information about vaccine uptake in this group is needed to better refine and target educational messaging. Methods: HCA Healthcare used federal guidance and internal experience to create a systemwide mass vaccination strategy. A closed point-of-dispensing (POD) model was developed and implemented. The previously developed enterprise-wide emergency operations strategy was adapted and implemented, which allowed for rapid development of communications and operational processes. A tiering strategy based on recommendations from the National Academies was used in conjunction with human resources data to determine vaccine eligibility for the first phase of vaccination. A comprehensive data and reporting strategy was built to connect human resources and vaccine consent data for tracking vaccination rates across the system. Results: Vaccination of employed and affiliated colleagues began December 15, 2020, and was made available based on state-level release of tiers. Within the first 6 weeks, in total, 203,544 individuals were eligible for vaccine based on these criteria. Of these, 181,282 (89.1%) consented to and received vaccine, 19,788 (9.7%) declined, and 2,474 (1.2%) indicated that they had already been vaccinated. Of those eligible, the highest acceptance of vaccine was among the job codes of specialists and professionals (n = 7,914 total, 100% consent), providers (n = 23,335, 99.6%,), and physicians (n = 3,218, 98.4%). Vaccine was most likely to be declined among job codes of clerical and other administrative (n = 12,889 total, 80.1% consent), clinical specialists and professionals (n = 22,853, 81.0%,) and aides, orderlies and technicians (n = 17,803, 82.6%,). Registered nurses made up the largest eligible population (n = 56,793), and 89.5% of those eligible consented to receive vaccination. Average age among those who consented was slightly older (48.3 years) than those that declined (44.7 years), as was length of employment tenure (6.9 vs 5.0 years). Conclusion: A large-scale, closed POD, mass vaccination program was able to vaccinate nearly 200,000 healthcare workers for SARS-CoV-2 in 6 weeks. This program was implemented in acute-care sites across 20 different US states, and it was able to meet the various state-level requirements for management of processes, product, and required reporting. The development of a standardized strategy and custom, centralized monitoring and reporting facilitated insight into the characteristics of early vaccine adopters versus those who decline vaccination. These data can aid in the refining and targeting of educational materials and messaging about the SARS-CoV-2 vaccine.Funding: NoDisclosures: None

scholarly journals Population preferences and attitudes towards COVID-19 vaccination: a cross-sectional study from Pakistan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Muhammad Junaid Tahir ◽  
Muhammad Saqlain ◽  
Waleed Tariq ◽  
Summaiya Waheed ◽  
Steven H. S. Tan ◽  
...  
Keyword(s):  
Large Scale ◽  
Positive Attitude ◽  
Family Income ◽  
Vaccine Development ◽  
Population Level ◽  
Cross Sectional Study ◽  
Vaccine Uptake ◽  
Sectional Study ◽  
Government Officials ◽  
Cross Sectional

Abstract Background While vaccine development is itself a challenge; ensuring optimal vaccine uptake at population level can present an even more significant challenge. Therefore, this study aimed to assess the Pakistani population’s attitude and preferences towards the Coronavirus disease 2019 (COVID-19) vaccine. Method A cross-sectional study was carried out through an online self-administered questionnaire from 27 September 2020 to 11 October 2020. A total of 883 people responded to the survey. The questionnaire included the participants’ socio-demographic variables, attitudes, beliefs towards the COVID-19 vaccine and acceptance and rejection of vaccination, and reasons for them. Logistic regression analysis was used to analyze the predictors for vaccine acceptance and willingness to pay for the vaccine. Results A majority (70.8%) of respondents will accept the COVID-19vaccine if available, and 66.8% showed a positive attitude towards vaccination. Monthly family income, education level, self-diagnosis of COVID-19 or a friend, family member, or colleague are significant factors influencing the acceptance of COVID-19 vaccination. The dogma of being naturally immune to COVID-19 was a key reason for the refusal of the vaccine. Less than half (48%) of those who refuse will vaccinate themselves if government officials have made it compulsory. A third (33.9%) of participants were willing to pay up to (7 USD) 1000 Pkr (Pakistani Rupees) for the vaccine. Conclusion The population’s positive attitude should be improved by increasing awareness and eradicating false myths about vaccines through large-scale campaigns.

scholarly journals Local Evolutionary Patterns of Human Respiratory Syncytial Virus Derived from Whole-Genome Sequencing

2015 ◽  
Vol 89 (7) ◽  
pp. 3444-3454 ◽  
Author(s):  
Charles N. Agoti ◽  
James R. Otieno ◽  
Patrick K. Munywoki ◽  
Alexander G. Mwihuri ◽  
Patricia A. Cane ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Large Scale ◽  
Vaccine Development ◽  
Human Respiratory Syncytial Virus ◽  
Genomic Variation ◽  
Genomic Sequences ◽  
The Novel ◽  
Sequencing Method ◽  
The World ◽  
Syncytial Virus

ABSTRACTHuman respiratory syncytial virus (RSV) is associated with severe childhood respiratory infections. A clear description of local RSV molecular epidemiology, evolution, and transmission requires detailed sequence data and can inform new strategies for virus control and vaccine development. We have generated 27 complete or nearly complete genomes of RSV from hospitalized children attending a rural coastal district hospital in Kilifi, Kenya, over a 10-year period using a novel full-genome deep-sequencing process. Phylogenetic analysis of the new genomes demonstrated the existence and cocirculation of multiple genotypes in both RSV A and B groups in Kilifi. Comparison of local versus global strains demonstrated that most RSV A variants observed locally in Kilifi were also seen in other parts of the world, while the Kilifi RSV B genomes encoded a high degree of variation that was not observed in other parts of the world. The nucleotide substitution rates for the individual open reading frames (ORFs) were highest in the regions encoding the attachment (G) glycoprotein and the NS2 protein. The analysis of RSV full genomes, compared to subgenomic regions, provided more precise estimates of the RSV sequence changes and revealed important patterns of RSV genomic variation and global movement. The novel sequencing method and the new RSV genomic sequences reported here expand our knowledge base for large-scale RSV epidemiological and transmission studies.IMPORTANCEThe new RSV genomic sequences and the novel sequencing method reported here provide important data for understanding RSV transmission and vaccine development. Given the complex interplay between RSV A and RSV B infections, the existence of local RSV B evolution is an important factor in vaccine deployment.

Conceptualizing a Contextual Measurement for Digital Divide/s

2010 ◽  
pp. 630-644 ◽  
Author(s):  
Karine Barzilai-Nahon ◽  
Ricardo Gomez ◽  
Rucha Ambikar
Keyword(s):  
Digital Divide ◽  
Public Access ◽  
Three Dimensions ◽  
Single Factor ◽  
Research Project ◽  
Policy Makers ◽  
The World

Measurements for the digital divide/s have often engaged in simplified, single factor measurements that present partial and static conceptualization and, therefore, measurements of the digital divide/s. The following chapter encourages policy makers to choose appropriate tools and programs to measure digital divide/s according to three dimensions: (1) the purpose of the tool; (2) levels of observation; and (3) methods of approaching the data. Then it describes an integrated contextual iterative (ICI) approach suggested by the authors as an effective way to assess digital divide/s including perspectives of different stakeholders. The approach is illustrated with examples from a research project studying public access venues in 25 countries around the world.

scholarly journals Evidence of antigenic imprinting in sequential Sarbecovirus immunization

2020 ◽  
Author(s):  
Huibin Lv ◽  
Ray T. Y. So ◽  
Meng Yuan ◽  
Hejun Liu ◽  
Chang-Chun D. Lee ◽  
...  
Keyword(s):  
Antibody Response ◽  
Neutralizing Antibodies ◽  
Vaccine Development ◽  
Vaccination Strategy ◽  
Vaccine Effectiveness ◽  
Major Focus ◽  
The World ◽  
The One ◽  
The Impact

SUMMARYAntigenic imprinting, which describes the bias of antibody response due to previous immune history, can influence vaccine effectiveness and has been reported in different viruses. Give that COVID-19 vaccine development is currently a major focus of the world, there is a lack of understanding of how background immunity influence antibody response to SARS-CoV-2. This study provides evidence for antigenic imprinting in Sarbecovirus, which is the subgenus that SARS-CoV-2 belongs to. Specifically, we sequentially immunized mice with two antigenically distinct Sarbecovirus strains, namely SARS-CoV and SARS-CoV-2. We found that the neutralizing antibodies triggered by the sequentially immunization are dominantly against the one that is used for priming. Given that the impact of the background immunity on COVID-19 is still unclear, our results will provide important insights into the pathogenesis of this disease as well as COVID-19 vaccination strategy.

scholarly journals Challenges in Vaccine Acceptance– A Framework & Toolkit for the COVID -19 Battle

2021 ◽  
Vol 33 (2) ◽  
pp. 239-241
Author(s):  
Thanjavur S Ravikumar ◽  
Rakesh Kakkar ◽  
Vinoth Kumar Kalidoss
Keyword(s):  
Public Health ◽  
Moving Average ◽  
Relative Performance ◽  
Reverse Direction ◽  
World Population ◽  
Vaccine Acceptance ◽  
The Poor ◽  
The World ◽  
Roll Out

During the first wave of this COVID-19 pandemic, India’s performance was relatively superior among the countries that had their first cases in January 2020. We grouped these countries as ‘January Cohort’ and analysed their relative performance (IJCH, April 2020), supporting India’s management. Fast forward to the present, India’s performance is woefully lacking, accounting for 30% of daily cases and 31% daily deaths with 18% of the world population [Worldometer Coronavirus database, June1,2021). On this same day, 50% of the countries worldwide (110 of 222) reported no deaths and 25% (57) without any daily new cases. Thus, we have faltered with a series of public health missteps despite a good start. The latest and the most remarkable failure of India is the vaccination, despite being the world’s foremost producer. Many of the poor performers initially in the January Cohort, such as UK and USA, focused on ‘vaccinating their way out of the pandemic’ since the roll out of vaccines in December2020. The results are in display starting February 2021- to date, with cases/ deaths on decline in these countries, while India is in a reverse direction. On June 1st, UK reported no COVID-19 deaths and USA had about 31% decline of 14-day moving average.

scholarly journals Perceptions of an Insufficient Government Response at the Onset of the COVID-19 Pandemic are Associated with Lower Mental Well-Being

2020 ◽  
Author(s):  
Thiemo Fetzer ◽  
Marc Witte ◽  
Lukas Hensel ◽  
Jon Jachimowicz ◽  
Johannes Haushofer ◽  
...  
Keyword(s):  
Time Variation ◽  
Large Scale ◽  
Well Being ◽  
Policy Makers ◽  
Government Response ◽  
Country Level ◽  
The World ◽  
Large Scale Survey ◽  
The Uk ◽  
Mental Well Being

We conducted a large-scale survey covering 58 countries (N = 108,075) at the onset of the COVID-19 pandemic—between March 20th and April 7th 2020—to explore how beliefs about citizens’ and government’s response to the COVID-19 pandemic, and the actions taken by governments, affected mental well-being. Our analyses reveal three findings. First, many respondents indicate that their country’s citizens and government’s response was insufficient. Second, respondents’ perception of an insufficient public and government response was associated with lower mental well-being. Third, we exploit time variation in country-level lockdown announcements, both around the world and through an event-study in the UK, and find that strong government actions—i.e., announcing a nationwide lockdown—were related to an improvement in respondents’ views of their fellow citizens and government, and to better mental well-being. These findings suggest that policy-makers may not only need to consider how their decisions affect the spread of COVID-19, but also how such choices influence the mental well-being of their population.

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