scholarly journals A comparative prospective observational study on the use of ulipristal acetate versus mifepristone in reduction of the size of uterine leiomyoma

2022 ◽  
Vol 13 (1) ◽  
pp. 129-135
Author(s):  
Lipika Ghosh ◽  
Abhijit Rakshit ◽  
Madhumita De
Keyword(s):  
Uterine Leiomyoma ◽  
Reproductive Age ◽  
Loss Assessment ◽  
Multicentric Study ◽  
Valid Conclusion ◽  
Ulipristal Acetate ◽  
Common Benign Tumor ◽  
Group A ◽  
Group B ◽  
Reproductive Age Group

Background: Fibroid or uterine leiomyoma is the most common benign tumor of the uterus in the reproductive age group and found in one out of every four women. They are symptomatic in 50% of women, with the peak incidence occurring among women in their 30s or 40s. Fibroid can cause a variety of symptoms which include menstrual disturbances commonly menorrhagia and dysmenorrhea. It is a common indication of hysterectomy in Indians. An effective medical treatment option may reduce hysterectomy-associated morbidity and mortality. This study is undertaken to evaluate the efficacy and safety of medical management of myoma and contribution in the reduction of myoma size comparing the two drugs ulipristal and mifepristone. Aims and Objectives: The study was conducted to compare reduction of menorrhagia (By pictorial blood loss assessment chart score), reduction of fibroid size (using transvaginal ultrasonography), and improvement of hemoglobin (Hb) level. We are also evaluating safety or side effects using these drugs. Materials and Methods: The study includes 210 patients who are divided into two groups. Group A includes 105 patients who are treated with tablet Ulipristal Acetate 5 mg daily for 3 months and Group B includes 105 patients who are treated with tablet mifepristone 25 mg daily for 3 months. Results: Ulipristal and mifepristone both are effective in reduction of menorrhagia and improvement of Hb levels, but Ulipristal is more effective in reduction of size of uterine myoma than mifepristone after 3 months of treatment. Conclusion: Multicentric study over a larger population is required to reach a valid conclusion.

scholarly journals A COMPARATIVE CLINICAL STUDY TO ASSESS THE EFFICACY OF KARIMBIRUMBADI KASHAYAM AND VASAGULUCHYADI KASHAYAM IN PANDUROGA WITH SPECIAL REFERENCE TO IRON DEFICIENCY ANEMIA IN THE REPRODUCTIVE AGE GROUP OF WOMEN

2020 ◽  
pp. 13-18
Author(s):  
Muhammed Nizamudheen C H ◽  
Soumya S B
Keyword(s):  
Iron Deficiency ◽  
Special Reference ◽  
Iron Deficiency Anemia ◽  
T Test ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Age Group ◽  
Group A ◽  
Group B ◽  
Reproductive Age Group

This study is an attempt to clinically analyze the independent effect of Karimbirumbadi kashayam and Vasaguluchiadi kashayam in Panduroga and also compare their efficacy. Aims and Objectives: To evaluate the comparative efficacy of Karimbirumbadi kashayam and Vasaguluchyadi kashayam in Panduroga with special reference to iron deficiency anemia in the reproductive age group of women. Methodology: Among 46 registered subjects, 22 were registered in group A and 24were registered in group B. Out of which 20 subjects of A group and 20 subjects of B group completed the study. Group A was administered with 25ml of Karimbirumbadi kashayam with 40ml of luke warm water twice daily before food for 2 months and Group B was administered with 25ml of Vasaguluchyadi kashayam with 40ml of luke warm water and 10ml of Madhu as Anupana twice daily before food for 2 months. Objective and subjective parameters were analyzed using paired T test and Wilcoxon signed rank test respectively. Independent T test and Mann-Whitney U test were used to compare the parameters between the groups. Result: There was statistically significant improvement in the objective and subjective parameters (p<0.05 was observed). Conclusion: The study shows that both Karimbirumbadi kashayam and Vasaguluchyadi kashayam are effective in relieving the symptoms of Panduroga. Symptomatic relief was seen in both the group A & B, but there was no statistically significant difference between the groups in relieving these symptoms.

COMPARATIVE ANALYSIS OF CLOSED REDUCTION AND EXPERT TIBIA NAILING WITH OPEN REDUCTION AND PLATE & SCREW FIXATION IN THE TREATMENT OF PROXIMAL TIBIA EXTRAARTICULAR FRACTURES

2018 ◽  
Author(s):  
Anil Pandey ◽  
Setul Shah ◽  
Deepak S Maravi ◽  
S Uikey
Keyword(s):  
Intramedullary Nailing ◽  
Closed Reduction ◽  
Proximal Tibia ◽  
Plate Fixation ◽  
Surgical Site Infections ◽  
Delayed Union ◽  
Large Sample Size ◽  
Multicentric Study ◽  
Group A ◽  
Group B

Introduction:- Extra-articular proximal tibial fractures account for 5–10 % of all tibial shaft fractures and it result from high-velocity trauma. Closed reduction with minimally invasive plating and locked intramedullary  nailing have been widely used for treatment of proximal tibia extraarticular fractures. Our pupose is to compare the pros and cons of these two methods. Materials and methods:- 22 patients were included in this study for a period of 2 years. Patients treated with IMN were kept in group A patients treated with percutaneus plating were kept in group B. Standard approach of nailing and plating were used and proper follow up were taken for next upcoming 1 year. Results:- Combined average age was 38years. Male were more commonly affected than female (13:8). Majority of fracture were of type A33. Operative time was < 2 hours in both groups. Less blood loss occurred during intramedullary nailing as compared to locking plate fixation. Surgical site infections (SSIs) were seen in two patients in the PTP group. Delayed union occurred in two patients in the IMN group. The average range of motion was 119.7(range 90-150, SD= 19.18) in group A and 115.2(range 80-150, SD = 17.28) in group B. Conclusion:- in treatment of proximal tibia extra articular fracture use of IMN and PTLCP gives comparable results. To validate this issue further a large sample size multicentric study is recommended   Key words: intramedullary nailing (IMN), Extraarticular tibialn fracture, Surgical site infection.

HISTOMORPHOLOGICAL VARIANTS AND SECONDARY CHANGES IN UTERINE LEIOMYOMA

2021 ◽  
pp. 37-39
Author(s):  
Teleflo Boopathy ◽  
Gowri Prakasam ◽  
T.M Vincy ◽  
Dharshini. G.V
Keyword(s):  
Uterine Leiomyoma ◽  
Treatment Protocol ◽  
Abnormal Uterine Bleeding ◽  
Reproductive Age ◽  
Medical College ◽  
Common Causes ◽  
Common Clinical Presentation ◽  
Morphological Variants ◽  
Reproductive Age Group ◽  
Optimal Patient Management

BACKGROUND: Leiomyoma is one of the most common causes of Abnormal Uterine Bleeding. It occurs chiey in women during active reproductive years. It has a lot of morphological variants and secondary changes which may mimic malignancy clinically, radiologically and histologically. A few degenerative changes and variants like Atypical and Mitotically active Leiomyoma may be misdiagnosed as malignancy. It is imperative to have a good knowledge of Leiomyosarcoma as the treatment protocol varies. AIMS AND OBJECTIVES: To analyse the morphological variants and secondary changes in Leiomyoma and to study the associated changes in the endometrium. MATERIALS AND METHODS: 420 Hysterectomy specimens with Fibroid received at Govt. Kilpauk medical College, Chennai were studied from January 2018 to January 2020. RESULTS: Leiomyoma was seen in the reproductive age group and menorrhagia was the most common clinical presentation. Hyalinisation was the most common secondary change seen in Leiomyoma and cellular leiomyoma was the most common morphological variant. CONCLUSION:A good comprehensive and accurate knowledge of the morphological variants and secondary changes in Leiomyoma mandatory to avoid misdiagnosis and ensuring optimal patient management.

scholarly journals Randomised trial of mefenamic acid versus tranexamic acid in management of menorrhagia

2017 ◽  
Vol 6 (10) ◽  
pp. 4608
Author(s):  
Madhu J. ◽  
Shylaja A. S.
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Mefenamic Acid ◽  
Randomised Trial ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Loss Assessment ◽  
Group A ◽  
Group B ◽  
To Receive

Background: The objective of the study was to compare the efficacy of mefenamic acid, a non-inflammatory drug with tranexamic acid, an antifibrinolytic drug in management of menorrhaghia.Methods: Randomised trial of women attending outpatient department of St. Philomena’s hospital, Bangalore with complaints of menorrhagia. Fifty four patients with complaints of menorrhagia were randomly assigned to receive either mefenamic acid 500 mg tid (group A- 24 patients) or tranexamic acid 1 gm TID (group B- 26 patients) from day one to day five for three consecutive menstrual cycles.Results: Reduction in menstrual blood loss as assessed by pictoral blood loss assessment chart was more in group B (50%) than in Group A (30%) (ANOVA, covariates with F=59.647, p<0.001). Difference in improvement of dysmenorrhoea was not statistically significant (p=0.640). Side effects were less in group B compared to group A (p=0.271). Post treatment Hb% significantly improved in both groups (p=0.015 in group A, p<0.001 in gr B). Acceptability was statistically similar in both groups (p>0.05).Conclusions: Both mefenamic acid and tranexamic acid were effective in management of menorrhagia. Tranexamic acid was significantly superior to mefenamic acid in terms of reduction in menstrual blood loss.

Effect of low dose mifepristone on uterine leiomyoma in reproductive age group

2013 ◽  
Vol 100 (3) ◽  
pp. S78 ◽  
Author(s):  
S. Prasad ◽  
N. Varun ◽  
A. Kumar ◽  
S. Prasad
Keyword(s):  
Uterine Leiomyoma ◽  
Low Dose ◽  
Reproductive Age ◽  
Age Group ◽  
Reproductive Age Group

scholarly journals Effect of progressive resisted exercises and aerobic exercises in the management of polycystic ovarian syndrome among young women- A pilot randomized controlled trial

Biomedicine ◽  
2020 ◽  
Vol 39 (4) ◽  
pp. 608-612
Author(s):  
Veena Kirthika S. ◽  
Jibi Paul ◽  
Senthil Selvam P. ◽  
Sathya Priya V.
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Free Testosterone ◽  
Reproductive Age ◽  
Group A ◽  
Young Subjects ◽  
Group B ◽  
Ovarian Syndrome ◽  
Hormonal Levels

Introduction and Aim: Polycystic ovarian syndrome (PCOS) is a heterogenous, multisystem endocrinopathy in women of reproductive age also called as Stein Leventhal syndrome. PCOS is a common female endocrine disorder with prevalence ranging from 2.2% to 26%. Prevalence of PCOS in Indian adolescents is 9.13%. This draws attention to the issue of early diagnosis in adolescent girls. The aim of this study was to determine the effect of progressive resisted exercises (PRE) and aerobic exercises in the management of subjects with PCOS. Materials and Methods: This was an experimental comparative pre and post-test type study. The subjects in the age group of 18-25 years with the diagnosis of PCOS were selected based on Rotterdam criteria and with the BMI ranging between 25-29. Twenty four subjects were recruited and were randomly divided into two groups. group A was treated with PRE +aerobic exercises + diet and group B with aerobic exercises + diet. The duration of the study was 24 weeks and the outcome measures used were BMI, PCOSQ and hormonal levels (SHBG, Free testosterone, HOMA IR, Hs CRP) Results: The result of the study showed that group A treated with PRE + aerobic exercises + diet had significant improvement in BMI at P?0.05 and PCOSQ and specific hormonal levels at P?0.001 when compared to group B. Conclusion: A 24 weeks exercise intervention with a combined PRE +aerobic exercises +diet was superior to aerobic exercises +diet among young subjects with PCOS. Keywords: BMI; quality of life; PRE; PCOSQ; Hormones.

scholarly journals VAGINITIS IN WOMEN OF REPRODUCTIVE AGE GROUP: A HOSPITAL-BASED STUDY FROM NORTH INDIA

2020 ◽  
Vol 05 (02) ◽  
pp. 44-47
Author(s):  
Sweety Singh ◽  
Rumpa Saha ◽  
Amita Suneja ◽  
Shukla Das ◽  
N P Singh
Keyword(s):  
Reproductive Age ◽  
North India ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Group A ◽  
Reproductive Age Group
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