scholarly journals Prevalence of thyroid dysfunction in patients with Type 2 diabetes mellitus and its correlation with insulin resistance and serum markers for autoimmune thyroiditis

2015 ◽  
Vol 6 (6) ◽  
pp. 33-38 ◽  
Author(s):  
Sulagna Sahu ◽  
Soumya Kanti Dutta ◽  
Shib Shankar Kuiri ◽  
Mintu Mohan Nandi ◽  
Pranay Kabiraj ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Serum Markers ◽  
P Value ◽  
Fasting Insulin ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus

Background: The term “THYROID DIABETES” was coined in early literature to depict the influence of thyroid hormone excess in deterioration of glucose control. Although autoimmune thyroid disease is more prevalent in Type1 Diabetes mellitus as a result of their common origin, the prevalence of hypothyroidism and hyperthyroidism is supposed to be similar to that of general population in patient with type2 DM. The purpose of the study was to evaluate the prevalence of thyroid dysfunction in patients with type2 diabetes mellitus and to correlate thyroid abnormalities with insulin resistance and serum markers for autoimmune thyroiditis. Methods: 120 cases of type2 diabetes mellitus patients satisfying WHO criteria without pre-existing thyroid disease were included in the study. Thyroid function test, fasting serum insulin was done.HOMA-IR & HOMA-B (HOMA-Homeostatic model assessment) was calculated. Serum antithyroid peroxidase anibody (anti-TPO) and antithyroglobulin antibodies (anti-TG) and ANA were done. Results: Prevalence of thyroid dysfunction in type2 diabetes mellitus was 28.33% according to our study, which included overt hypothyroidism (15%), subclinical hypothyroidism (8.33%), secondary hypothyroidism (0.83%), overt hyperthyroidism (1.67%) and subclinical hyperthyroidism (2.5%). Anti TPO and anti TG antibodies were elevated in 62.07% cases of hypothyroidism, 40% cases of hyperthyroidism and 6.9% euthyroid cases of type2 DM. Anti TPO and antiTG antibodies were significantly raised in type2DM patient with hypothroidism than that of euthyroid (p value<0.0001). Compared to euthyroid diabetics, hypothyroid cases had lower values of insulin resistance markers like fasting insulin, HOMA-IR and HOMA-B. Hyperthyoid cases had higher values. Conclusion: Hyperthyroid diabetics have higher insulin resistance as fasting insulin, HOMA-IR, HOMA-B showed negative correlation with TSH. (p value<0.05).DOI: http://dx.doi.org/10.3126/ajms.v6i6.12603 Asian Journal of Medical Sciences Vol.6(6) 2015 33-38

scholarly journals Frequency of Insulin Resistance in People with Thyroid Dysfunction

2021 ◽  
Author(s):  
Shaza Abdalla Elwali ◽  
Sulaf I Abdelaziz
Keyword(s):  
Insulin Resistance ◽  
Thyroid Dysfunction ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Military Hospital ◽  
P Value ◽  
Fasting Insulin ◽  
Significant Difference ◽  
The Difference ◽  
Fasting Insulin Level

Background: Thyroid dysfunction is an endocrine disorder with a recognized association with type 2 diabetes mellitus. Thyroid hormones have a remarkable effect on glucose metabolism and can cause insulin resistance (IR). This study was aimed at assessing the relationship between IR and thyroid dysfunction. Methods: This case–control study was conducted at the endocrinology outpatient clinics of Ibrahim Malik Hospital and Omdurman Military Hospital in Khartoum State, Sudan between May 2018 and January 2019. Fasting blood glucose (FBG), fasting insulin level, and thyroid function test (TFT) were measured for each candidate and IR was estimated using the HOMA-IR equation. Results: Thirty-one patients with thyroid dysfunction and fifty-seven control participants were enrolled. The highest mean FBG was found among cases (105.3 ± 15.7 mg/dl) compared to the controls (97 ± 12.1 mg/dl), but the difference was not statistically significant (P-value = 0.598). The mean fasting insulin level was 9.22 ± 4 IU/ml in the cases and 9.4 ± 4.2 IU/ml in controls, without a significant difference (P-value = 0.681). The highest HOMA-IR score was found among cases (2.4 ± 1.2). It was 2.4 ± 1.3 in hyperthyroidism, 2.3 ± 1.1 in hypothyroidism, and 2.4 ± 1.2 in controls, and the difference was insignificant (P-value = 0.859). IR was higher in the cases (58.1%) compared to the controls (52.6%) but again not statistically significant (P-value = 0.396). Among cases, IR was encountered in 61.9% and 50% of hyperthyroid and hypothyroid patients, respectively. Conclusion: Patients with thyroid dysfunction have some level of IR that was not statistically significant when compared with controls.

scholarly journals STUDY OF THYROID FUNCTION IN TYPE 2 DIABETES MELLITUS PATIENTS OF MALWA REGION.

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Deepasha Shahi Bagzai ◽  
Darshna Jain ◽  
Anurag Kesarwani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Diabetic Patients ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Tsh Levels

Background: Thyroid disorders and diabetes mellitus are two common endocrine disorders that are commonly encountered in clinical practice.  The relationship between thyroid disease and diabetes is important for physicians to understand in order to provide the best treatment for both conditions. The aim of this study was to assess thyroid function in Type2 Diabetes Mellitus patients of malwa region and raise awareness about thyroid dysfunction in newly diagnosed T2DM patients. Methods: In this case control study, a total of 200 subjects were chosen. Group I consisted of 100 diagnosed type 2 diabetes cases and Group II 100 sex matched stable controls. After receiving informed consent, patients were enrolled. Thyroid dysfunction in Type2 diabetes mellitus was assessed using biochemical parameters such as fasting plasma glucose, total triiodothyronine T3, total thyroxine T4, and thyroid stimulating hormone (TSH). Results: When diabetic patients were compared to healthy controls, their fasting blood glucose and serum TSH levels were substantially higher. In these two classes, however, there was no substantial difference in serum T3 and T4 levels. The findings suggest that diabetic patients have subclinical hypothyroidism as opposed to the control group in the study population Conclusion: From this current study it has been observed that thyroid function levels were altered in Diabetes mellitus patients, especially TSH levels. so it is suggested that diabetes mellitus patients should be screened for thyroid function studies on a regular basis to prevent further complications of thyroid dysfuction. Keywords: Type 2 diabetes mellitus, Thyroid dysfunction.

scholarly journals Circulating levels of asprosin and its association with insulin resistance and renal function in type2 diabetes mellitus and diabetic nephropathy patients

2021 ◽  
Author(s):  
Golnoosh Goodarzi ◽  
Leila Setayesh ◽  
Reza Fadaei ◽  
Mohammad Ebrahim Khamseh ◽  
Fereshteh Aliakbari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Renal Function ◽  
Serum Levels ◽  
Glucose And Lipid Metabolism ◽  
Type2 Diabetes ◽  
Tnf Α ◽  
Patient Groups ◽  
Type2 Diabetes Mellitus

Abstract Introduction : Adipokines have an important role in development and progression of type 2 diabetes mellitus (T2DM) and its complications such as nephropathy. Asprosin is a recently discovered adipokine that involve in glucose metabolism and inflammation process. The present study sought to evaluate asprosin levels in patients with T2DM and T2DM + nephropathy (NP) compared to controls and its relation with markers of insulin resistance, inflammation and renal function. Methods Serum levels of asprosin, adiponectin, IL-6 and TNF-α were measured in 55 control, 54 T2DM and 55 T2DM + NP patients using ELISA kits. Results Asprosin was found to be higher in T2DM (6.73 ± 1.67) and T2DM + NP (7.11 ± 1.54) compared to controls (4.81 ± 1.09) (p < 0.001), while adiponectin indicated a lower concentration in both patient groups compared with controls. Moreover, IL-6 and TNF-α indicated higher levels in both patients group compared with controls. Asprosin indicated a positive correlation with HbA1c, FBG, TC, LDL-C, IL-6 and TNF-α in T2DM group. In the patients with T2DM + NP asprosin positively correlated with BMI, HbA1c, insulin, HOMA-IR, Cr, UAE, IL-6 and TNF-α and inversely correlated with eGFR. Conclusion Higher concentration of asprosin in T2DM and T2DM + NP and its relation with glucose and lipid metabolism, and markers of renal function and inflammation suggested a possible role for this adipokine in the pathogenesis of T2DM and nephropathy.

scholarly journals Echocardiographic Changes in Controlled Type 2 Diabetes Mellitus with Reference to Body Mass Index and Waist Hip Ratio

2020 ◽  
pp. 1-5
Author(s):  
G. Meenakshi ◽  
N. N. Anand
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Statistical Correlation ◽  
Left Ventricular ◽  
Cross Sectional ◽  
Medical College ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus

Type2 diabetes mellitus is associated with central obesity. Studies shows that central obesity, leads to insulin resistance is an important determinant for insulin resistance and cardiovascular morbidity. In the present study clinical profile of type2 diabetics with special reference to cardiac changes were studied and their relationship were established. This is a prospective cross-sectional study conducted in Sree Balaji Medical College and Hospital. 50 obese patients with controlled diabetes less than 5 years of duration were compared with obese non diabetics. There is significant statistical correlation with obese diabetic subjects particularly females, alterations in LV geometry. Obese female subjects had predominantly higher left ventricular mass. From the data of the present study high BMI, WHR have increased incidence of cardiovascular disease.

Ghrelin and Obesity-An Update

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Gandhi M. ◽  
Swaminathan S.
Keyword(s):  
Diabetes Mellitus ◽  
Cardiac Output ◽  
Energy Balance ◽  
Vascular Resistance ◽  
The Body ◽  
Ghrelin Receptor ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Natural Hormones

Ghrelin as human natural hormones is involved in fundamental regulatory process of eating and energy balance. It is a stomach derived hormone that acts as at the ghrelin receptor in multiple tissues throughout to the body. Its properties includes increasing appetite, decreasing systemic inflammation, decreasing vascular resistance ,increasing cardiac output, increasing glucose and IGF-1 levels, Hence it may play a significant role in Diabetes mellitus. Many studies have linked ghrelin to obesity and this paper is an attempt to bring out recent findings on the role of ghrelin in Diabetes Mellitus, particularly type2 Diabetes mellitus.

Serum level of Arginine and Symmetric dimethyl arginine in patients with prediabetes and type2 diabetes mellitus

2019 ◽  
Vol 22 (12) ◽  
pp. 218-226
Author(s):  
Basheer Sultan Dayir ◽  
Mohammed I. Hamzah ◽  
Mahmood S.H. Khudair
Keyword(s):  
Diabetes Mellitus ◽  
Serum Level ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Dimethyl Arginine

SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN

2014 ◽  
Vol 20 (2) ◽  
pp. 1-7
Author(s):  
Shereen El Tarhouny ◽  
Soha Zakaria ◽  
Khaled d Hadhoud ◽  
Manal Hanafi ◽  
Azza Kamel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Globulin Gene

scholarly journals Obstructive Sleep Apnea as a Risk Factor of Insulin Resistance in Nondiabetic Adults

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 50
Author(s):  
Monika Michalek-Zrabkowska ◽  
Piotr Macek ◽  
Helena Martynowicz ◽  
Pawel Gac ◽  
Grzegorz Mazur ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Glucose Concentration ◽  
Insulin Concentration ◽  
Fasting Insulin ◽  
Sleep Habits ◽  
Obstructive Sleep

Objective: The aim of this research was to assess the relationship between prevalence and severity of obstructive sleep apnea (OSA) and insulin resistance among patients with increased risk of OSA without diabetes mellitus. Method and materials: our study group involved 102 individuals with suspected OSA, mean age 53.02 ± 12.37 years. Data on medical history, medication usage, sleep habits, sleep quality and daytime sleepiness, were obtained using questionnaires. All patients underwent standardized full night polysomnography. Serum fasting insulin and glucose concentration were analyzed, the homeostatic model assessment-insulin resistance (HOMA-IR) index was calculated. Results: polysomnographic study indicated that in the group with OSA mean values of apnea–hypopnea index (AHI), oxygen desaturation index (ODI), duration of SpO2 < 90% and average desaturation drop were significantly higher compared to the group without OSA, while the minimum SpO2 was significantly lower. The carbohydrate metabolism parameters did not differ within those groups. Significantly higher fasting insulin concentration and HOMA-IR index were found in the group with AHI ≥ 15 compared to the group with AHI < 15 and in the group with AHI ≥ 30 compared to the group with AHI < 30. Higher AHI and ODI were independent risk factors for higher fasting insulin concentration and higher HOMA-IR index. Increased duration of SpO2 < 90% was an independent risk factor for higher fasting glucose concentration. Conclusions: Individuals with moderate to severe OSA without diabetes mellitus had a higher prevalence of insulin resistance.

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