Frequency of Insulin Resistance in People with Thyroid Dysfunction

Sudan Journal of Medical Sciences ◽

10.18502/sjms.v16i4.9950 ◽

2021 ◽

Author(s):

Shaza Abdalla Elwali ◽

Sulaf I Abdelaziz

Keyword(s):

Insulin Resistance ◽

Thyroid Dysfunction ◽

Fasting Blood Glucose ◽

Insulin Level ◽

Military Hospital ◽

P Value ◽

Fasting Insulin ◽

Significant Difference ◽

The Difference ◽

Fasting Insulin Level

Background: Thyroid dysfunction is an endocrine disorder with a recognized association with type 2 diabetes mellitus. Thyroid hormones have a remarkable effect on glucose metabolism and can cause insulin resistance (IR). This study was aimed at assessing the relationship between IR and thyroid dysfunction. Methods: This case–control study was conducted at the endocrinology outpatient clinics of Ibrahim Malik Hospital and Omdurman Military Hospital in Khartoum State, Sudan between May 2018 and January 2019. Fasting blood glucose (FBG), fasting insulin level, and thyroid function test (TFT) were measured for each candidate and IR was estimated using the HOMA-IR equation. Results: Thirty-one patients with thyroid dysfunction and fifty-seven control participants were enrolled. The highest mean FBG was found among cases (105.3 ± 15.7 mg/dl) compared to the controls (97 ± 12.1 mg/dl), but the difference was not statistically significant (P-value = 0.598). The mean fasting insulin level was 9.22 ± 4 IU/ml in the cases and 9.4 ± 4.2 IU/ml in controls, without a significant difference (P-value = 0.681). The highest HOMA-IR score was found among cases (2.4 ± 1.2). It was 2.4 ± 1.3 in hyperthyroidism, 2.3 ± 1.1 in hypothyroidism, and 2.4 ± 1.2 in controls, and the difference was insignificant (P-value = 0.859). IR was higher in the cases (58.1%) compared to the controls (52.6%) but again not statistically significant (P-value = 0.396). Among cases, IR was encountered in 61.9% and 50% of hyperthyroid and hypothyroid patients, respectively. Conclusion: Patients with thyroid dysfunction have some level of IR that was not statistically significant when compared with controls.

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Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient

Bangladesh Journal of Neuroscience ◽

10.3329/bjn.v33i2.57519 ◽

2017 ◽

Vol 33 (2) ◽

pp. 63-69

Author(s):

Md Azizul Haque ◽

Md Rafiqul Islam ◽

Sheikh Mahbub Alam ◽

Muhammad Nazmul Haque ◽

Md Aynul Haque ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Glucose ◽

Sodium Valproate ◽

Fasting Blood Glucose ◽

Insulin Level ◽

Control Group ◽

Fasting Insulin ◽

Epileptic Patients ◽

One Year ◽

Fasting Insulin Level

Background: Epilepsy is a common neurological disorder. Sodium valproate is one of the commonest broad spectrum antiepileptic drugs and it is used worldwide. Weight gain is the common side effect which is known to be associated with insulin resistance. The aim of this study was to see the association of sodium valproate therapy with insulin resistance among epileptic patients. Methods: It was a cross-sectional analytical study. Total 102 patients (51 epileptic patients with valproate monotherapy for at least one year and another 51 age and sex matched newly diagnosed epileptic patients without any anti-epileptic drugs) were selected in this study. The study was carried out from March 2016 to April 2017 for one year in the epilepsy clinic and outpatient Department of Neurology at Bangabandhu Sheikh Mujib Medical University, Dhaka. Participants underwent anthropometric evaluations and biochemical tests including fasting blood sugar and fasting insulin level. Insulin resistance (IR) index was calculated. Result: In this study mean duration of valproate treatment was 3.12±1.26 years and mean sodium valproate dose was 1133±440.5 mg/day (17.7±6.65 mg/kg/day). This study revealed serum fasting insulin level in valproate group and non-valproate group was 11.05±4.86 (ìU/ml) and 7.39±2.01 (ìU/ml) respectively. Fasting blood glucose was 4.71±0.79 (mmol/L) in valproate group and 4.41±0.62 (mmol/L) in non- valproate group. Calculated IR index in valproate group and non-valproate group was 2.17±0.55 and 1.46±0.39 respectively. IR index, fasting insulin and blood glucose all were significantly higher in valproate group than non- valproate group. This study also revealed mild positive correlation of IR index with dose and duration of valproate treatment. Conclusion: Sodium valproate treated patient had significantly higher IR index than control group. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 63-69

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Higher toenail selenium is associated with increased insulin resistance risk in omnivores, but not in vegetarians

10.21203/rs.2.19743/v1 ◽

2019 ◽

Author(s):

Qiuyun Gu ◽

Xueying Cui ◽

Kun Du ◽

Bian Wang ◽

Wei Cai ◽

...

Keyword(s):

Insulin Resistance ◽

Inductively Coupled Plasma ◽

Fasting Blood Glucose ◽

Resistance Index ◽

Insulin Level ◽

Fasting Insulin ◽

Dietary Intakes ◽

Multilinear Regression ◽

Cross Sectional ◽

Resistance Risk

Abstract Background The relationship between selenium (Se) and insulin resistance remains unclear. We aim to evaluate the association between toenail Se levels and insulin resistance in China.Methods In this cross-sectional study, 220 vegetarians and 220 age-sex- matched omnivores from Shanghai were included. The toenail Se levels were measured by inductively coupled plasma mass spectrometry method. Dietary Se intakes were assessed by the 24-hour dietary recall questionnaire. Blood samples were collected to examine fasting blood glucose and fasting insulin concentrations. Insulin resistance index (HOMA-IR) and insulin secretion index (HOMA-B) were calculated to assess insulin resistance. The multilinear regression models were performed, and the following covariates were included in the models: age, sex, BMI, alcohol consumption, income, and daily dietary intakes (energy, protein, fat, carbohydrate, and fiber).Results Toenail Se levels were not associated with insulin resistance among vegetarians but were positively associated with fasting insulin levels (β=1.030, 95% CI: 0.393, 1.667) and HOMA-IR (β=0.245, 95% CI: 0.098, 0.392) in omnivores. Stratifying the results by Se intake levels in the omnivores revealed a significant association among those with dietary Se intake ≥ 60 μg/d; insulin level (β=1.053, 95% CI: 0.415, 1.691) and HOMA-IR (β=13.271, 95% CI: 4.433, 22.109) but not in those with < 60 μg/d ; insulin level (β=2.146, 95% CI: -0.710, 5.002) and HOMA-IR (β=13.766, 95% CI: -46.868, 74.400).Conclusions Higher toenail Se levels were associated with increased insulin resistance risk in Chinese omnivores, but not in vegetarians.

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Assessment of Hepatic Steatosis in Patients with Chronic Hepatitis B Using Fibroscan and its Relation to Insulin Resistance

The Open Biomarkers Journal ◽

10.2174/1875318301909010070 ◽

2019 ◽

Vol 9 (1) ◽

pp. 70-78

Author(s):

Reham M. Gameaa ◽

Nehad Hawash ◽

Rehab Badawi ◽

Sherief Abd-Elsalam ◽

Gamal K. Kasem ◽

...

Keyword(s):

Insulin Resistance ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Hepatic Steatosis ◽

Chronic Hepatitis B ◽

P Value ◽

Fasting Insulin ◽

Group I ◽

Significant Difference ◽

Group Ii

Background & Aim: Simple hepatic steatosis is a benign condition, but it may cause serious liver damage as it may lead to steatohepatitis, fibrosis and cirrhosis. The Controlled Attenuation Parameter (CAP) of fibroscan assesses hepatic steatosis. The aim of this work was to assess hepatic steatosis in patients with chronic hepatitis B infection using FibroScan and to detect its relation to insulin resistance. Methods: Seventy-seven patients with chronic HBV were enrolled in this study. Body mass index, complete lipid profile, fasting insulin, HOMA-IR, pelviabdominal ultrasound and fibroscan were assessed in all patients. Results: According to the presence of significant steatosis, seventy-seven patients enrolled in this study were divided into different groups, such as group I 47 patients (61.04%) with CHB virus infection with non-significant steatosis and group II 30 patients (38.96%) with CHB infection with significant steatosis. There was a statistically significant increase in fasting insulin and HOMA-IR in group II (p-value <0.001). CAP results ranged from 100-396 db/m with no significant difference in liver stiffness measurements in two studied groups (P value= 0.886). There was a significant positive correlation between the degree of hepatic steatosis measured by fibroscan and fasting insulin blood level, HOMA-IR, serum cholesterol and LDL. At cutoff > 222 db/m steatosis measured by fibroscan had a sensitivity of 63.33% and specificity of 82.35% for the detection of insulin resistance. Conclusion: In CHB infected patients, steatosis measurement by fibroscan was a strong predictor of Insulin Resistance (IR) and vice versa.

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Burnout among surgeons; depression, anxiety and stress between consultant versus post-graduate trainee

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.7.1415 ◽

2020 ◽

Vol 36 (7) ◽

Author(s):

Saleh Khurshied ◽

Aliya Hisam ◽

Nawal Khurshid ◽

Madiha Khurshid

Keyword(s):

Marital Status ◽

Sampling Technique ◽

Cross Sectional Study ◽

Military Hospital ◽

P Value ◽

Cross Sectional ◽

Post Graduate ◽

Creative Commons ◽

Significant Difference ◽

The Difference

Objective: To compare depression, anxiety and stress between consultant and post-graduate trainee (PG-trainee) surgeons and to find the difference of different factors i.e. gender, marital status, physical activity, BMI, comorbidity and Income per month between the two. Methods: A descriptive cross-sectional study of eight months duration from March 2018 to August 2018 was conducted in Military Hospital and Combined Military Hospital, Rawalpindi, Pakistan. Convenient sampling technique was used. DASS 21 questionnaire was used for data collection. Data were entered and analysed by SPSS 22. A p-value of < 0.05 was considered statistically significant. Results: The mean age of participants was 37.44±10.512 years. Out of 68 participants, 54 (79.4%) were males and 14 (20.6%) were females. There was a significant difference between the consultants and PG trainees in terms of gender, marital status and income per month (p= <0.005) PG-trainees were more depressed and anxious but not stressed as compared to consultants (p= 0.014, 0.012 and 0.280 respectively). Conclusions: There was a significant association in terms of gender, marital status and income per month between consultants and PG trainees. A statistically significant association was found between consultants and PG trainees concerning depression and anxiety showing PG trainees were more depressed and anxious. doi: https://doi.org/10.12669/pjms.36.7.1415 How to cite this:Khurshied S, Hisam A, Khurshid N, Khurshid M. Burnout among surgeons; depression, anxiety and stress between consultant versus post-graduate trainee. Pak J Med Sci. 2020;36(7):1745-1748. doi: https://doi.org/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prevalence of thyroid dysfunction in patients with Type 2 diabetes mellitus and its correlation with insulin resistance and serum markers for autoimmune thyroiditis

Asian Journal of Medical Sciences ◽

10.3126/ajms.v6i6.12603 ◽

2015 ◽

Vol 6 (6) ◽

pp. 33-38 ◽

Cited By ~ 1

Author(s):

Sulagna Sahu ◽

Soumya Kanti Dutta ◽

Shib Shankar Kuiri ◽

Mintu Mohan Nandi ◽

Pranay Kabiraj ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Autoimmune Thyroiditis ◽

Thyroid Disease ◽

Thyroid Dysfunction ◽

Serum Markers ◽

P Value ◽

Fasting Insulin ◽

Type2 Diabetes ◽

Type2 Diabetes Mellitus

Background: The term “THYROID DIABETES” was coined in early literature to depict the influence of thyroid hormone excess in deterioration of glucose control. Although autoimmune thyroid disease is more prevalent in Type1 Diabetes mellitus as a result of their common origin, the prevalence of hypothyroidism and hyperthyroidism is supposed to be similar to that of general population in patient with type2 DM. The purpose of the study was to evaluate the prevalence of thyroid dysfunction in patients with type2 diabetes mellitus and to correlate thyroid abnormalities with insulin resistance and serum markers for autoimmune thyroiditis. Methods: 120 cases of type2 diabetes mellitus patients satisfying WHO criteria without pre-existing thyroid disease were included in the study. Thyroid function test, fasting serum insulin was done.HOMA-IR & HOMA-B (HOMA-Homeostatic model assessment) was calculated. Serum antithyroid peroxidase anibody (anti-TPO) and antithyroglobulin antibodies (anti-TG) and ANA were done. Results: Prevalence of thyroid dysfunction in type2 diabetes mellitus was 28.33% according to our study, which included overt hypothyroidism (15%), subclinical hypothyroidism (8.33%), secondary hypothyroidism (0.83%), overt hyperthyroidism (1.67%) and subclinical hyperthyroidism (2.5%). Anti TPO and anti TG antibodies were elevated in 62.07% cases of hypothyroidism, 40% cases of hyperthyroidism and 6.9% euthyroid cases of type2 DM. Anti TPO and antiTG antibodies were significantly raised in type2DM patient with hypothroidism than that of euthyroid (p value<0.0001). Compared to euthyroid diabetics, hypothyroid cases had lower values of insulin resistance markers like fasting insulin, HOMA-IR and HOMA-B. Hyperthyoid cases had higher values. Conclusion: Hyperthyroid diabetics have higher insulin resistance as fasting insulin, HOMA-IR, HOMA-B showed negative correlation with TSH. (p value<0.05).DOI: http://dx.doi.org/10.3126/ajms.v6i6.12603 Asian Journal of Medical Sciences Vol.6(6) 2015 33-38

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Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City

Journal of Agromedicine and Medical Sciences ◽

10.19184/ams.v7i2.24117 ◽

2021 ◽

Vol 7 (2) ◽

pp. 84

Author(s):

Sitti Monica Astrilia Ambon ◽

Nuzulia Irawati ◽

Almurdi Almurdi

Keyword(s):

Insulin Sensitivity ◽

Metabolic Diseases ◽

Fasting Blood Glucose ◽

Sampling Technique ◽

Infected Group ◽

P Value ◽

Fasting Insulin ◽

Cross Sectional ◽

Soil Transmitted Helminths ◽

Significant Difference

Helminth infections in Indonesia are most often caused by Soil-transmitted Helminths (STH) species. It turns out that STH infection has a protective effect against metabolic diseases by affecting glucose metabolism and insulin sensitivity. The effect related to the immune response that caused by STH infection. The aim of this study was to investigate the relationship between STH infection with insulin sensitivity in adults at Padang City. This study design was a comparative cross-sectional study with multistage random sampling technique. Stool samples were taken from 127 adults and there were 24 subjects (18.9%) infected with STH. Furthermore, We took another 24 uninfected subjects and compared their fasting blood glucose (FBG) and fasting insulin. Then, from the data We calculated it’s Homeostatic Model for Insulin Resistance (HOMA-IR) score to assess insulin sensitivity. Unpaired T test and chi-square were used to analyze the data. The study result showed the average levels of FBG and fasting insulin were lower in STH-infected group than STH-uninfected group. However, there was no significant difference between two groups (FBG p=0.678; fasting insulin p=0.075). Also, STH-infected group tend to had good insulin sensitivity (66.7%) than STH-uninfected group (45.8%), but statistically, there was no significant relationship between STH infection and insulin sensitivity with p value=0.244. In conclusion, there is no relationship between STH infection and insulin sensitivity. Keywords: Soil-transmitted Helminths, Insulin Sensitivity, FBG

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SYNDESMOSIS FIXATION IN BIMALLEOLAR WEBER C ANKLE FRACTURES;

The Professional Medical Journal ◽

10.29309/tpmj/2008.15.01.2696 ◽

2008 ◽

Vol 15 (01) ◽

pp. 49-53

Author(s):

SAJID EJAZ RAO ◽

SOHAIL MUZAMMIL ◽

ABDUL HAFEEZ KHAN

Keyword(s):

Objective Assessment ◽

Military Hospital ◽

Controlled Clinical Trial ◽

P Value ◽

Ankle Motion ◽

Group I ◽

Loss Of Reduction ◽

Significant Difference ◽

The Difference ◽

Randomised Controlled

Objective: To study the influence of size of screws for syndesmosis fixationin bimalleolar Weber C ankle fracture. Design: A prospective randomised controlled clinical trial. Place and Durationof Study: Orthopaedic Department at Combined Military Hospital Malir. Period: From October 2002 to September2005. Patients and Methods: 17 consecutive young active patients with Weber type C bimalleolar ankle fractureshaving syndesmotic injuries treated with open reduction and internal fixation were randomly allocated to two groups.1 2 In group I (n = 9) 3.5mm small fragment and in group II (n =8) 4.5mm large fragment AO cortical screws were usedfor syndesmotic fixation. All patients were followed up for 12 months. Fracture healing or loss of reduction ofsyndesmosis was taken as the study end point. Hardware loosening or breakage and need for hardware removal werethe outcome measures. Subjective and objective assessment with Olerud-Molander Ankle (OMA) scores , range of 1motion and radiographic criteria was done. Results: Loss of reduction was not seen in any patient in both groups.Comparing two groups using paired sample t-test, there was no difference in screw loosening and breakage (p values> 0.05). We did not find a statistically significant difference between range of motion (p = 1.08) and OMA score (p-value= 0.805). Conclusion: Size of the syndesmotic screw does not appear to influence healing of syndesmotic injury.Screw loosening, which can result in reduced range of ankle motion postoperatively was more common in smallerscrew group though the difference was not significant.

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Perbedaan Penggunaan Antikoagulan K2EDTA DAN K3EDTA Terhadap Hasil Pemeriksaan Indeks Eritrosit

Jurnal Laboratorium Khatulistiwa ◽

10.30602/jlk.v1i2.147 ◽

2018 ◽

Vol 1 (2) ◽

pp. 114

Author(s):

Wahdaniah Wahdaniah ◽

Sri Tumpuk

Keyword(s):

Screening Test ◽

Venous Blood ◽

The Body ◽

Ethylene Diamine ◽

P Value ◽

Cross Sectional ◽

Significant Difference ◽

Ethylene Diamine Tetra Acetate ◽

The Difference ◽

Index Value

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk K2EDTA dan K3EDTA. K3EDTA biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.

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