scholarly journals Clinical study of anemia in women attending the College of Medical Sciences Bharatpur

2015 ◽  
Vol 10 (3) ◽  
pp. 23-28
Author(s):  
M Pradhan
Keyword(s):  
Teaching Hospital ◽  
Binding Capacity ◽  
Clinical Signs ◽  
Hypochromic Anemia ◽  
Signs And Symptoms ◽  
Dietary Advice ◽  
Iron Level ◽  
Medical Sciences ◽  
Serum Iron Level ◽  
Nutritional Anemia

OBJECTIVE To study the clinical profile of Anemia in Women attending the College of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan.MATERIALS & METHODS The Study was conducted among 100 women patients attended to the College of Medical Sciences- Teaching Hospital, Bharatpur, Chitwan. Their blood samples were tested and related socio-demographic information was collected. The associated Clinical signs and symptoms with hemoglobin level and the occurrence of anemia were assessed.RESULT The peak incidence of Anemia was in the age group of 20-24 yrs (59.7%), and severity of anemia was correlated with sings and symptoms. Majority of them had Microcytic Hypochromic anemia (43.1%) with serum iron level below normal level and increased TIBC (total iron binding capacity) were observed.CONCLUSION The high prevalence of Nutritional anemia suggests the dietary advice to be emphasized strongly.Journal of College of Medical Sciences-Nepal, 2014, Vol-10, No-3, 23-28

scholarly journals Iron deficiency anemia: current strategies for the diagnosis and management

2013 ◽  
Vol 4 (3) ◽  
pp. 193-202 ◽  
Author(s):  
Zühre Kaya
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Ferritin Level ◽  
Nutritional Deficiencies ◽  
Deficiency Anemia ◽  
Iron Level ◽  
Serum Iron Level ◽  
Diagnosis And Management ◽  
Low Serum

Iron deficiency is one of the commonest nutritional deficiencies in the world. It is multifactorial and may be caused by lack of intake, blood loss and intestinal causes. Clinical features are highly variable, and most patients are asymptomatic. Typical laboratory features of iron deficiency anemia (IDA) include a hypochromic microcytic anemia, low serum iron level, high total iron binding capacity, low serum ferritin level. Usefulness of monitoring serum transferrin receptor level (sTfR) and hepcidin for identifying IDA have been examined in a few studies. Available data suggest that sTfR can potentially become a valuable tool for regular testing of patients in the future. Despite IDA is easily corrected with iron therapy, establishing the cause can be difficult, particularly in cases caused by disorders of iron transport. Education for clinician needs to focus on increasing awareness of the importance of failure respond to iron supplementation. The aim of this review was to outline the current strategies for the diagnosis and management of IDA in the light of the latest reports.

scholarly journals STUDY OF SERUM FERRITIN IN SMOKERS

2018 ◽  
Vol 11 (1) ◽  
pp. 374
Author(s):  
Meera Shivasekar ◽  
Vinodhini Vm ◽  
Rupesh Kumar Y
Keyword(s):  
Cigarette Smoking ◽  
Serum Ferritin ◽  
Binding Capacity ◽  
Iron Status ◽  
Public Health Problem ◽  
Premature Death ◽  
Iron Level ◽  
Global Public Health ◽  
Serum Iron Level ◽  
Clinical Biomarkers

 Objective: Cigarette smoking is a major global public health problem and increases in the prevalence of tobacco smoking is the cause premature death worldwide. Serum ferritin an intracellular protein that can store and release iron is considered to be one of the important clinical biomarkers to evaluate iron status. This study explores the effect of cigarette smoking on serum ferritin level.Methods: The study was carried out in 100 cigarette smokers and 100 nonsmokers.Results: Subjects with smoking habits showed a significant increase in the serum ferritin levels compared to nonsmokers. Serum iron level, as well as total iron-binding capacity, showed significant increase compared with nonsmokers. Serum ferritin is found to correlate with serum iron.Conclusion: This study supports the fact that cigarette smoking has adverse effect on serum ferritin and other hematologic parameters, and serum ferritin is one of the most reliable indicators of iron status.

scholarly journals Experimental Production of Pyridoxine Deficiency Anemia in Rats

Blood ◽  
1964 ◽  
Vol 23 (5) ◽  
pp. 679-687 ◽  
Author(s):  
SHU CHU SHEN ◽  
PETER Y. C. WONG ◽  
MASSAO OGURO
Keyword(s):  
Bone Marrow ◽  
Serum Iron ◽  
Normal Values ◽  
Hypochromic Anemia ◽  
Hemoglobin Level ◽  
Deficiency Anemia ◽  
Iron Level ◽  
Experimental Production ◽  
Serum Iron Level ◽  
Pyridoxine Deficiency

Abstract Rats fed a diet deficient in pyridoxine all exhibited a severe microcytic hypochromic anemia after 40 to 50 weeks. This anemia responded promptly to pyridoxine administration. The myeloid:erythroid ratio in the bone marrow of the severely anemic rats was definitely increased, suggestive of hypoplasia of the erythroid series, after prolonged deprivation of pyridoxine. The ratio was markedly decreased shortly after the inception of pyridoxine treatment, indicating active erythropoiesis induced by therapy; the ratio subsequently returned toward normal when hemoglobin level improved. There was no evidence of accumulation of iron in the bone marrow. The serum iron level increased only slightly, to high-normal values in the anemic rats, but fell to low-normal level after the administration of pyridoxine.

scholarly journals Delayed puberty in thalassemia major patients

2016 ◽  
Vol 44 (4) ◽  
pp. 143 ◽  
Author(s):  
Jose RL Batubara ◽  
Arwin Akib ◽  
Diah Pramita
Keyword(s):  
Chelation Therapy ◽  
Binding Capacity ◽  
Thalassemia Major ◽  
Delayed Puberty ◽  
Iron Level ◽  
Pubertal Stage ◽  
Serum Iron Level ◽  
Serum Lh ◽  
Serum Gonadotropin ◽  
Low Levels

Background Delayed puberty is the most common endocrine com-plication in thalassemia major. The main cause of delayed pu-berty in thalassemia major is the failure of the hypothalamic-pitu-itary axis due to iron accumulation in the pituitary.Objectives The purpose of this study was to determine the preva-lence of delayed puberty in β-thalassemia major patients in theDepartment of Child Health, Cipto Mangunkusumo Hospital,Jakarta. This study also evaluated the adequacy of chelationtherapy and determined serum gonadotropin and sex hormonelevels in these patients.Methods Seventy-two patients with β-thalassemia major aged 13-18 years old who visited the Thalassemia Outpatient Clinic of CiptoMangunkusumo Hospital during February-July 2003 were includedin the study. Each subject underwent examinations to determinethe body weight and height, pubertal status, serum iron level, totaliron binding capacity, and the levels of serum LH, FSH, estradiol(in girls) or testosterone (in boys).Results Delayed puberty occurred in 40 of 72 patients (56%). Themajority of patients with delayed puberty showed low levels of se-rum LH, estradiol, and testosterone whereas low levels of serumFSH only occurred in 6 of 21 boys and 11 of 19 girls. Most of thepatients without delayed puberty had normal levels of serum LH,FSH, and estradiol, but 8 of 16 boys showed decreased serumtestosterone levels. Only 3 patients used chelation therapy ad-equately, all of them showed normal puberty.Conclusions The prevalence of delayed puberty in β-thalassemiamajor patients in this study was still high (56%). Periodic examina-tion and recording of pubertal stage need to be done in girls whohave reached 8 years old and boys who have reached 9 years oldso that early detection and management of delayed puberty canbe done.

Influence of hepcidin on iron homeostasis during last trimester of gestation in Bos indicus (cattle)

2019 ◽  
Author(s):  
K. Rajamanickam ◽  
M. Sameer Ali ◽  
V. Leela
Keyword(s):  
Serum Iron ◽  
Iron Homeostasis ◽  
Binding Capacity ◽  
Colorimetric Method ◽  
Maternal Serum ◽  
Iron Bioavailability ◽  
Iron Level ◽  
Iron Binding ◽  
Serum Iron Level ◽  
Iron Binding Capacity

Hepcidin is an important hormone regulating the systemic iron bio-availability. Blood samples were collected from thirty pregnant cattle during their last trimester of pregnancy to assess the relation of hepcidin to iron homeostasis. Serum hepcidin level was quantified using ELISA and serum iron, transferrin iron binding capacity and unsaturated iron binding capacity were estimated by colorimetric method. Correlation between hepcidin and other iron related parameters was assessed. Dependency of serum iron level on hepcidin was also determined by regression method. It was revealed that hepcidin was negatively correlated to serum iron and transferrin iron binding capacity (p less than 0.001) and also hepcidin has highest predictive value on serum iron level and transferrin iron binding capacity (p less than 0.001). It can be concluded that during pregnancy increase in hepcidin reduces the maternal serum iron and also it is a biomarker for iron bioavailability to the developing fetus.

scholarly journals Refractory Sideropenic Anemia in Childhood Due to an Error of Iron Metabolism

Blood ◽  
1955 ◽  
Vol 10 (12) ◽  
pp. 1246-1255 ◽  
Author(s):  
ROLF ZETTERSTRÖM ◽  
SIMONE DELAVA
Keyword(s):  
Iron Metabolism ◽  
Slow Rate ◽  
Alimentary Tract ◽  
Binding Capacity ◽  
Intravenous Iron ◽  
Iron Level ◽  
Serum Iron Level ◽  
Plummer Vinson Syndrome ◽  
Intravenous Iron Therapy ◽  
Iron Binding Capacity

Abstract Two cases of essential hypochronic anemia in childhood are reported. One of the cases which developed a mild Plummer-Vinson syndrome was completely refractory to peroral as well as intravenous iron therapy. In both cases the iron metabolism has been studied by means of radioiron. The following characteristics were found: The serum iron level was extremely low but the iron binding capacity was normal. The absorption of iron from the alimentary tract was defective and intravenously injected radioiron was utilized for hemoglobin synthesis at a slow rate. There was a rapid plasma iron turnover. The hypothesis is offered that the cause of the anemia resided in an abnormality in the regulation of iron metabolism.

scholarly journals The U-shaped association of serum iron level with COVID-19 severity: Is iron a potential therapeutic target?

2021 ◽  
Author(s):  
Kentaro Tojo ◽  
Yoh Sugawara ◽  
Yasufumi Oi ◽  
Fumihiro Ogawa ◽  
Takuma Higurashi ◽  
...  
Keyword(s):  
Disease Severity ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
University Hospital ◽  
Iron Level ◽  
Inadequate Response ◽  
Serum Iron Level ◽  
Median Serum ◽  
Iron Binding Capacity

AbstractObjectiveTo evaluate the association between iron metabolism indicators and disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19).DesignTwo-center observational studySettingA university hospital and a core hospital in Yokohama, JapanPatientsAdults with COVID-19 whose serum iron levels were measured within the first 5 days of hospitalization were included. Patients who refused mechanical ventilation were excluded from the study.Measurements and Main ResultsOne hundred thirty-six patients were included in this study. We analyzed the association between COVID-19 severity and serum iron, total iron binding capacity (TIBC), and transferrin saturation (TSAT) levels. Disease severity was defined as the worst respiratory status during hospitalization. Serum iron levels were significantly lower in patients with mild respiratory failure (RF) (n=55, median serum iron level: 24 [interquartile range: 19–42] mg/dL) than in the non-RF group (n=44, 40 [24–80] mg/dL) and the severe RF group (n=37, 60 [23.5–87] mg/dL); however, there were no significant differences in iron levels between the non-RF and severe RF groups (non-RF vs. mild RF: p=0.019, non-RF vs. severe RF: p>0.999, and mild RF vs. severe RF: p=0.009). That is, there was a U-shaped association between serum iron levels and disease severity. TIBC levels decreased significantly with increasing severity; consequently, TSAT was significantly higher in patients with severe RF than in other patients. Multivariate analysis including only patients with RF adjusted for age and sex demonstrated that higher serum iron or TSAT levels were independently associated with development of severe RF.ConclusionsA U-shaped association between serum iron level and RF severity in hospitalized COVID-19 patients was observed. Higher serum iron levels in COVID-19 patients with RF are associated with the development of severe RF, indicating that inadequate response to lower serum iron might be an exacerbating factor for COVID-19.

Evaluation of serum iron and iron binding capacity in cows with paratuberculosis

2009 ◽  
Vol 37 (06) ◽  
pp. 375-378 ◽  
Author(s):  
Z. Metcitoglu ◽  
M. Ulgen ◽  
E. Borum ◽  
E. Temizel ◽  
S. Kasap ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Serum Iron ◽  
Binding Capacity ◽  
Control Group ◽  
Iron Level ◽  
Iron Binding ◽  
Serum Iron Level ◽  
Haematological Values ◽  
Mycobacterium Avium Subsp Paratuberculosis ◽  
Iron Binding Capacity

Summary Objective: The purpose of the study was to evaluate the results of routine haematological, serum iron and iron binding capacity analyses in cattle with Mycobacterium avium subsp. paratuberculosis (MAP) infection. Material and methods: Thirty-eight cows were included in the study. An ELISA for MAP, intradermal Johnin test and microscopic examination of the animals faecal smears for acid fast organisms were performed. According to the results 19 cows (4–8 years old) were found positive and 19 cows (4–7 years old) from the same herd were negative and served as control group. In all cows routine haematological values as well as serum iron level and iron binding capacity were evaluated. Results: When compared with control animals, routine haematological values including haematocrit, haemoglobin and erythrocyte counts were significantly (p < 0.05) lower in positive cows. Also serum iron level (p < 0.01) and iron binding capacity (p < 0.01) were significantly lower in positive cows than in the control group. Conclusion: As a result, these parameters can be important for the mechanism of the pathogenesis of paratuberculosis.

scholarly journals Determinants of hypoxemia in children associated with pneumonia

2015 ◽  
Vol 7 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Pramila Ramawat ◽  
Balkishan Sharma
Keyword(s):  
Clinical Signs ◽  
Severe Pneumonia ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Specific Sign ◽  
Severe Manifestation ◽  
Clinical Signs And Symptoms ◽  
Very High

Background and Objectives: The most severe manifestation of pneumonia is hypoxemia has been shown to be a risk factor for morbidity and mortality. Authors investigated associating factors and determinants of hypoxemia in children with pneumonia.Materials and Methods: A cross-sectional study is designed among children of pediatric outpatient and emergency department that enrolled at Government Multi-Speciality Hospital, Chandigarh. One hundred fifty children recruited for study. The demographic and clinical parameters were recorded. Oxygen saturation measured by pulse oximeter.Results: The prevalence of hypoxemia was 48% and 61 (84.7%) infants aged 1 year found with hypoxemia. Age (p=0.006), respiratory rate (p=0.001) and severity of pneumonia (p=0.001) were strongly associated with hypoxemia. The prevalence of severe and very severe pneumonia among hypoxemic were 56.1% and 73.7% respectively. Central cyanosis (98.7%), peripheral (98.7%) cyanosis, head nodding (97.4%) grunting (96.15%) were highly specific but suprasternal (62.82%), subcostal (43.58%) and intercostal retractions (44.87%) were fairly specific sign. Sensitivity for subcostal (81.94%) and intercostal retractions (83.33%) was very high but was fair for intercostal (83.33%) retraction. Grunting (p=0.009), nasal flaring (p=0.008), subcostal (p=0.001) and intercostal (p=0.000) retractions were strongly but suprasternal retraction was significantly (p=0.024) associated with hypoxemia. Dyspnea (97.22%) was very sensitive while decrease feeding (84.61%) and irritability (83.33%) was highly but lethargy (58.97%) was fairly specific symptom.Conclusions: Study suggested that clinical signs and symptoms such as chest wall retraction, decrease feeding, dyspnea, grunting and nasal flaring in children with pneumonia may be utilized as markers for hypoxemia in conditions where pulse-oximeter isn’t available. This study supports the view of hypoxemia was disabling factor in better functional recovery in severity of pneumonia.Asian Journal of Medical Sciences Vol.7(2) 2015 64-70

Lack of Predictive Indices in Kernicterus: A Comparison of Clinical and Pathologic Factors in Infants With or Without Kernicterus

PEDIATRICS ◽  
1980 ◽  
Vol 66 (6) ◽  
pp. 852-858
Author(s):  
Mae Hee Kim ◽  
Jing Ja Yoon ◽  
Joanna Sher ◽  
Audrey K. Brown
Keyword(s):  
Serum Bilirubin ◽  
Binding Capacity ◽  
Medical Center ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Molar Ratio ◽  
Downstate Medical ◽  
Sick Newborn ◽  
Clinical Signs And Symptoms ◽  
Bilirubin Binding

A review of 398 neonatal autopsies at Downstate Medical Center revealed 27 cases of kernicterus during the seven-year period from 1971 through 1977. With the current intensive care of the sick newborn, kernicterus continues to occur, mainly in premature infants with relatively low levels of serum bilirubin (mean of 11.5 mg/100 ml). To understand the factors contributing to the development of kernicterus, clinical and pathologic findings in 27 infants with kernicterus were compared to 103 "control" infants retrospectively. Birth weight, gestational age, sex, and Apgar scores were comparable in both groups. The duration of survival was significantly shorter in infants with kernicterus than in the control infants. The clinical signs and symptoms of kernicterus were nonspecific and the premortem diagnosis of kernicterus was not suspected in most of the cases. There were no significant differences in the peak serum bilirubin values, incidence of hypothermia, hypoglycemia, convulsions, anemia, infection, use of phototherapy, transfusion and exchange transfusion in the two groups. Serum albumin values and bilirubin binding capacity measured by 2-(4-hydroxybenzeneazo)benzoic acid were significantly lower in the kernicteric group although the bilirubin-albumin molar ratio was equal in both groups. The incidences of severe acidosis and hypoxic encephalopathy were significantly higher in the kernicteric infants. In this study, acidosis, hypoxia, hypoalbuminemia, and low bilirubin binding capacity were seen more often in kernicteric infants than in control infants. However, analysis of previously suggested risk factors failed to identify any single factor or combination of factors which could be predictive to the development of kernicterus.

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