scholarly journals Congenital Tuberculosis

2014 ◽  
Vol 34 (2) ◽  
pp. 144-146
Author(s):  
Nandita Chatterjee
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lymph Nodes ◽  
Ct Scan ◽  
Chronic Inflammation ◽  
Congenital Tuberculosis ◽  
Caries Spine

2 month old baby presented with huge hepato-splenomegaly, ascites & pallor, , born to a mother suffering from fever and backache since last 4 months. Hypo-echoic shadows in liver, spleen and abdominal lymph nodes on USG & CT-scan and acute-on-chronic inflammation of liver by FNAC suggested Congenital Tuberculosis. Investigations in mother revealed Pulmonary Tuberculosis & Caries Spine, confirming the diagnosis of Congenital Tuberculosis in the baby. DOI: http://dx.doi.org/10.3126/jnps.v34i2.10910 J Nepal Paediatr Soc 2014;34(2):144-146 

scholarly journals CLEC-2 promotes inflammatory peritoneal macrophage emigration to draining lymph nodes during endotoxemia

2020 ◽  
Author(s):  
Joshua H. Bourne ◽  
Nonantzin Beristain-Covarrubias ◽  
Malou Zuidscheroude ◽  
Joana Campos ◽  
Ying Di ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lymph Nodes ◽  
Chronic Inflammation ◽  
Peritoneal Macrophages ◽  
Sterile Inflammation ◽  
Mesenteric Lymph Nodes ◽  
Specific Strategy ◽  
Inflammatory Macrophages ◽  
Draining Lymph Nodes ◽  
Macrophage Accumulation

AbstractMacrophage recruitment during sterile inflammation and infection is essential to clear pathogens, apoptotic cells and debris. However, persistent macrophage accumulation leads to chronic inflammation. Platelets are emerging as key modulators of the inflammatory response. Here, we identify that platelet C-type-lectin-like receptor-2 (CLEC-2) is a crucial immunomodulatory receptor through the interaction with podoplanin, upregulated on inflammatory macrophages.Mechanistically, platelet CLEC-2 upregulates the expression of podoplanin and its co-ligands CD44 and ERM proteins, leading to actin rearrangement and promotion of cell migration; this is mimicked by recombinant CLEC-2-Fc (rCLEC-2-Fc). Treatment of LPS-challenged mice with rCLEC-2-Fc induces a rapid emigration of peritoneal macrophages to mesenteric lymph nodes, through a gradient generated by the podoplanin ligand, CCL21, to prime T cells. We propose that crosslinking podoplanin using rCLEC-2-Fc is a novel, cell-specific strategy to accelerate macrophage removal from the site of inflammation, and hence promote the resolution of the inflammatory response.Visual AbstractSummaryPersistent macrophage accumulation in inflamed tissue leads to chronic inflammation and organ damage. Bourne et al. identify recombinant CLEC-2-Fc crosslinking podoplanin on inflammatory macrophages, as a cell-specific strategy to accelerate their emigration to draining lymph nodes, and reduce local inflammation.

scholarly journals Carcinosarcoma of the Gallbladder with Chondrosarcomatous Differentiation and Intracytoplasmic Eosinophilic Hyaline Globules (Thanatosomes): A Report of a Case and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Jumana A. Alratroot ◽  
Amani A. Joudeh ◽  
Samir S. Amr
Keyword(s):  
Computed Tomography ◽  
Abdominal Pain ◽  
Lymph Nodes ◽  
Ct Scan ◽  
Unusual Case ◽  
Distal Gastrectomy ◽  
Malignant Cells ◽  
Review Of The Literature ◽  
Hyaline Globules ◽  
Transverse Colectomy

A 52-year-old woman presented with abdominal pain and vomiting. Computed tomography (CT) scan of the abdomen revealed a huge exophytic gallbladder mass displacing or invading the surrounding structures. The patient underwent radical cholecystectomy, transverse colectomy, distal gastrectomy, and liver bed resection. Histologically, the tumor showed both carcinomatous and sarcomatous components, with prominent chondrosarcomatous differentiation. In addition, several malignant cells showed intracytoplasmic eosinophilic hyaline globules (Thanatosomes). The tumor showed metastatic deposits to the omentum, the liver, and the peripancreatic lymph nodes. We report this unusual case and present a review of all cases of carcinosarcoma of the gallbladder with chondrosarcomatous differentiation.

Vocal fold palsy due to plombage for tuberculosis

2005 ◽  
Vol 119 (2) ◽  
pp. 138-139 ◽  
Author(s):  
G C Barnett ◽  
I E Smith ◽  
F C Wells ◽  
J M Shneerson
Keyword(s):  
Pulmonary Tuberculosis ◽  
Ct Scan ◽  
Direct Laryngoscopy ◽  
Vocal Fold ◽  
Arm Pain ◽  
Supraclavicular Fossa ◽  
Vocal Fold Palsy ◽  
Hoarse Voice

A 67-year-old patient, who had previously undergone Lucite ball plombage for pulmonary tuberculosis, presented with a hoarse voice, intermittent stridor and breathlessness. Direct laryngoscopy confirmed a left vocal fold palsy. A left supraclavicular mass became apparent and a computerized tomograph (CT) scan showed that a Lucite ball had migrated into her supraclavicular fossa. Subsequently she developed left arm pain and weakness. The balls were removed surgically, following which her arm symptoms improved but her voice remained unchanged. Migration of implanted material should be considered when new symptoms appear in patients who have undergone plombage treatment.

scholarly journals Metastatic Melanoma of Uncertain Primary with 5-Year Durable Response after Conventional Therapy: A Case Report with Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Jomjit Chantharasamee ◽  
Jitsupa Treetipsatit
Keyword(s):  
Lymph Nodes ◽  
Ct Scan ◽  
Metastatic Melanoma ◽  
Unknown Primary ◽  
Conventional Chemotherapy ◽  
Durable Response ◽  
Inguinal Lymph Nodes ◽  
Radiation Fields ◽  
Physical Examinations ◽  
Leg Edema

A 51-year-old Thai woman presented with bilateral leg edema and painful left inguinal mass for 6 months. Physical examination revealed matted bilateral inguinal lymph nodes up to 9 cm in size. Otherwise, physical examinations including skin were unremarkable. The result of the lymph node incisional biopsy is consistent with that of metastatic melanoma. The extensive investigation demonstrated multiple intra-abdominal and inguinal lymph nodes without detectable primary tumor. Palliative radiation and conventional chemotherapy were prescribed. The CT scan between treatments showed that the response was stable disease, but the following CT scan demonstrated a gradual decrease in size from August 2012 to November 2017 including the lesions outside radiation fields. Moreover, she developed vitiligo during a follow-up visit. The previous data reported the median overall survival among the patients who were treated with conventional chemotherapy ranging from 9.1 to 9.3 months and whose 5-year survival was less than 10%. This case represented a metastatic melanoma of unknown primary who achieved a durable response by conventional treatment. The clinical features including nodal-only disease, vitiligo, and abscopal effect of radiation were considered to be the favorable factors.

scholarly journals Clinical spectrum and outcome of extra-pulmonary tuberculosis in children.

2021 ◽  
Vol 28 (09) ◽  
pp. 1336-1340
Author(s):  
Asma Mushtaq ◽  
Aysha Mansoor Lodhi ◽  
Wajiha Rizwan ◽  
Carol Ruth ◽  
Meher Muzaffar ◽  
...  
Keyword(s):  
Weight Loss ◽  
Pulmonary Tuberculosis ◽  
Lymph Nodes ◽  
Tertiary Care ◽  
Clinical Spectrum ◽  
Care Hospital ◽  
Cross Sectional ◽  
Duration Of Symptoms ◽  
Extra Pulmonary Tuberculosis ◽  
Extra Pulmonary

Objective: To determine the types, clinical spectrum and outcome of Extra-Pulmonary Tuberculosis (EPTB) in children admitted at a tertiary care hospital. Study Design: Cross Sectional study. Setting: The Children's Hospital and The Institute of Child Health, Lahore. Period: May to December 2019. Material & Methods: A total of 63 patients diagnosed with EPTB aged 1 month to 16 years were included. All patients with lung involvement were excluded from the study. Anti-tuberculous therapy (ATT) was started in all patients and outcome was monitored during the hospital stay. Results: In a total of 63 patients, mean age was 9.03+3.1 years. There were 35 (55.5%) male and 28 (44.4%) female. The mean duration of symptoms at the time of presentation was 5.93+2.4 months. The common sites of EPTB were meninges noted in 17(26.9%), pleural in 13 (20.6%), abdominal in 12 (19.04%), lymph nodes in 11 (17.4%), disseminated in 6 (9.52%) and bone and joints in 4 (6.34%) patients. The most common systemic complaints were fever in 58 (92.06%), weight loss in 48 (76.1%) and anorexia in 45 (71.4%). After treatment, fifty-four patients improved and discharged while 9 (14.2%) patients died. Conclusion: The commonest sites of EPTB were meninges, pleural, abdomen and lymph nodes. Fever, weight loss and anorexia were the most frequent systemic complaints. Most of the patients recovered while the most common cause of mortality was tuberculous meningitis.

scholarly journals Stage 4 Lung Cancer with Brain and Pericardial Metastases Which Are First Considered as Pulmonary Tuberculosis Infection and Heart Failure

2020 ◽  
Vol 16 (2) ◽  
pp. 127
Author(s):  
Haryati Haryati ◽  
Marsheilla Riska
Keyword(s):  
Lung Cancer ◽  
Pericardial Effusion ◽  
Pulmonary Tuberculosis ◽  
Tyrosine Kinase ◽  
Ct Scan ◽  
Kinase Inhibitor ◽  
Clinical Symptoms ◽  
Egfr Mutations ◽  
Contrast Enhanced Ct ◽  
Patient Reported

Abstract: Lung cancer and pulmonary tuberculosis become a global problem in the world. The similarities of clinical symptoms and radiological appearances often complicates diagnosis especially in TB endemic countries. A 43-year-old man presented with shortness of breath for 6 months, accompanied by intermittent cough mixed with blood streaks. He had been taking anti-tuberculosis for 2 months, but there’s no improvement. On physical examination, ronchi were heard in the lower 2/3 of the right lung and heart sounds diminished. Motoric movement of the left hand was difficult to grasp hard. A contrast-enhanced CT scan of the head revealed hyperdense multiple nodules. Chest X-ray showed cardiomegaly with right lung consolidation and a primary malignant right lung mass accompanied by pericardial effusion at thoracic CT scan. Cytology and EGFR examination of pericardial effusion found adenocarcinoma metastasis with exon 18 and 21 mutations. Evaluation of clinical symptoms and radiological examination during tyrosine kinase inhibitor (TKI) therapy showed improvement. Lung cancer can resemble pulmonary tuberculosis in various manifestations. Adenocarcinoma with positive EGFR mutations is more commonly found in Asians. Cytology and EGFR examination of pericardial effusion became the basis of diagnosis in this case. He was given TKI therapy. Re-evaluation must be carried out in patients who do not improve with antibiotics or anti-tuberculosis. Patient reported a good response after consuming EGFR-TKI. Keywords: lung cancer, tuberculosis, tyrosine kinase inhibitors

scholarly journals The impact of irradiation dose on the computed tomography radiographic response of metastatic nodes and clinical outcomes in cervix cancer in a low-resource setting

2017 ◽  
Vol 06 (02) ◽  
pp. 054-058
Author(s):  
Matthew Ryan McKeever ◽  
Lindsay Hwang ◽  
Jennifer Barclay ◽  
Yin Xi ◽  
April Bailey ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lymph Nodes ◽  
Ct Scan ◽  
Clinical Outcomes ◽  
Complete Response ◽  
Resource Poor Setting ◽  
Free Survival ◽  
Resource Setting ◽  
Nodal Size ◽  
The Impact

Abstract Introduction: The aim of this study is to investigate the relationship between the radiation dose to pelvic and para-aortic lymph nodes, nodal response, and clinical outcomes in a resource-poor setting based on computed tomography (CT) nodal size alone. Materials and Methods: This retrospective study from 2009 to 2015 included 46 cervical cancer patients with 133 metastatic pelvic and para-aortic lymph nodes definitively treated with chemoradiation and brachytherapy in a public hospital with limited access to positron emission tomography (PET) scans. Hence, short axis of the lymph node on CT scan was used as a measure of metastatic nodal disease, before and following radiation therapy. Inclusion criteria required the pelvic and para-aortic nodes to have the shortest axis diameter on CT scan of ≥8 mm and ≥10 mm, respectively. Based on PET resolution, a node that decreased to half of its inclusion cutoff size was considered to have a complete response (CR). Relevant clinical outcomes were documented and correlated with nodal features, nodal radiation doses, and treatment characteristics. Results: After controlling for other predictive factors, increased nodal dose was associated with increased probability of CR per study definition (P = 0.005). However, there was no statistically significant association between dose and pelvic/para-aortic, distant and total recurrence (TR), and any recurrence at any location (P = 0.263, 0.785, 1.00, respectively). Patients who had no CR nodes had shorter pelvic/para-aortic recurrence-free survival (PPRFS) and TR-free survival (TRFS) than patients who had at least one CR node (P = 0.027 and 0.046, respectively). Patients with no CR nodes also had shorter PPRFS than patients who had all nodes completely respond (P < 0.05). Conclusions: Using CT-based measures, we found that increased nodal dose is associated with an increased probability of CR (as defined) and nodal CR is associated with increased PPRFS and TRFS. We were unable to determine the cutoff dose required for a CR.

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