scholarly journals A Comparative Evaluation of Anti-Inflammatory and Antiplaque Efficacy of Citrus Sinesis Mouthwash and Chlorhexidine Mouthwash

2018 ◽  
Vol 2 (1) ◽  
pp. 9-13
Author(s):  
Aritra Mandal ◽  
Balaji Manohar ◽  
Neema Shetty ◽  
Aditi Mathur ◽  
Barkha Makhijani ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Orange Peel ◽  
Plaque Index ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Gingival Inflammation ◽  
Group I ◽  
Mouth Wash

Background: Citrus sinesis belongs to Rutaceae family is an enriched source of vitamin C, flavonoid compounds and antioxidants are helpful in reducing inflammation. Few in-vitro studies the ethanolic extract of orange peels has successfully reduced periodontal pathogens which has influenced us to prepare a mouth wash with ethanolic extract of orange peel. Aim: To evaluate and compare the effect of indigenously prepared 4% ethanolic extract of Citrus sinseis (Orange peel) mouthwash to commercially available 0.2% Chlorhexidine mouthwash as an anti-plaque agent. Materials and Methods: Twenty subjects in the age group of 18-60 years with moderate to severe gingivitis were divided into two equal groups. Clinical parameters like Plaque Index, Sulcus Bleeding Index and Gingival Index were recorded at baseline, 7th and 14th day respectively. Following oral prophylaxis Group-I (n= 10) subjects were instructed to rinse twice daily with 10ml of 0.2% chlorhexidine mouthwash and Group-II (n= 10) subjects were instructed to rinse twice daily with 10ml of 4% ethanolic extract of Citrus sinesis mouthwash for 14 days. All the subjects were recalled on the 7th and 14th day for follow up to record the clinical parameters. Results: Citrus sinesis 4% mouthwash was seen to be as efficient as 0.2% Chlorhexidine in reducing Plaque Index and more effectively reducing gingival inflammation and gingival bleeding index. Conclusion: Citrus sinesis 4% mouthwash can be used for short term purpose without any potential side effects as an alternative to 0.2% Chlorhexidine mouthwash in reducing plaque and gingival inflammation.

scholarly journals Comparative Evaluation of the Effect of Chlorhexidine Gluconate, Raw Propolis and Hydrogen Peroxide on Dental Plaque and Gingival Inflammation

2018 ◽  
Vol 2 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Surbhi Porwal ◽  
Aditi Mathur ◽  
Neema Shetty ◽  
Balaji Manohar ◽  
Barkha Makhijani ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Periodontal Disease ◽  
Dental Plaque ◽  
Chlorhexidine Gluconate ◽  
Plaque Index ◽  
Tooth Surface ◽  
Gingival Index ◽  
Gingival Inflammation ◽  
Group I ◽  
Mouth Wash

Background: Plaque is the soft deposit that forms the biofilm consisting of microorganisms adhering to the tooth surface and is proved beyond doubt to be the initiator of gingival and periodontal disease. Plaque control is the mainstay in periodontal disease. Aim: To compare the effect of 0.2% chlorhexidine gluconate, raw propolis and 3% hydrogen peroxide mouthwash on dental plaque and gingival inflammation. Materials and Methods: Thirty subjects in the age group of 20-40 years were enrolled in the study. Plaque index and Modified Gingival Index were recorded at baseline and oral prophylaxis was performed. Subjects were then randomly divided into three groups (n=10) and were asked to rinse with 10ml mouthwash twice daily for 15 days. Group I received 0.2% chlorhexidine gluconate mouth wash, Group II raw propolis diluted with distilled water (1:1), and Group III 3% hydrogen peroxide (1:1) mouthwash. Subjects were recalled on 7 day and 28 day for re-evaluation and recording plaque index and modified gingival index. Statistical analysis was done to evaluate the efficacy of all the three mouthwashes. Results: The results showed that all the three mouthwashes were effective in reducing plaque and gingival inflammation. Chlorhexidine gluconate 0.2% showed to be the most effective in reduction of dental plaque. Propolis was observed to be the most effective in reducing gingival inflammation over a period of 28 days. Conclusion: Propolis can be effectively used as a mouthwash without any potential side effects as an alternative to chlorhexidine mouthwash in reducing gingival inflammation.

scholarly journals Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited

2021 ◽  
Vol 7 ◽  
Author(s):  
Faraedon Zardawi ◽  
Sarhang Gul ◽  
Ali Abdulkareem ◽  
Aram Sha ◽  
Julian Yates
Keyword(s):  
Cardiovascular Disease ◽  
Periodontal Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Periodontal Pathogens ◽  
Systemic Level ◽  
Prevalent Disease ◽  
Atherosclerotic Cardiovascular Diseases

Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary arteries associated with atheroma formation, which can cause disability and often death. Periodontitis is ranked as the sixth most prevalent disease affecting humans affecting 740 million people worldwide. In the last few decades, researchers have focused on the effect of periodontal disease (PD) on cardiovascular disease. The aim of this review was to investigate the association between these two diseases. PD is a potential risk factor that may initiate the development, maturation, and instability of atheroma in the arteries. Two mechanisms were proposed to explain such association, either periodontal pathogens directly invade bloodstream or indirectly by increasing systemic level of inflammatory mediators. Interestingly, it has been suggested that improvement in the condition of one disease positively impact the condition of the other one. Highlighting the association between these two diseases, the importance of early diagnosis and treatment of PD and its impact on cardiovascular status may be of great value in reducing the complications associated with ACVDs. Further in vitro and in vivo studies with longer follow up are necessary to confirm the causal relationship between PD and ACVDs.

scholarly journals Does Modification of Amalgomer with Propolis Alter Its Physicomechanical Properties? An In Vitro Study

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Reham M. Abdallah ◽  
Amr M. Abdelghany ◽  
Neven S. Aref
Keyword(s):  
Compressive Strength ◽  
Color Change ◽  
In Vitro Study ◽  
Ethanolic Extract ◽  
Color Stability ◽  
Physicomechanical Properties ◽  
X Ray ◽  
Group I ◽  
Significant Difference

Objective. To assess if incorporating ethanolic extract of propolis into ceramic-reinforced glass ionomer (Amalgomer CR) might have an influence on its physicomechanical properties. Materials and Methods. Three groups were assessed; group I: Amalgomer CR (control) and two experimental groups (II and III) of propolis added to the liquid of Amalgomer CR with 25 and 50 v/v %, respectively. Evaluation parameters were color stability, compressive strength, microhardness, and surface roughness. Representative specimens of each group were analyzed by Fourier-transform infrared spectroscopy, energy-dispersive X-ray, X-ray diffraction, and scanning electron microscopy. Analysis of variance (ANOVA) was used to compare the results, followed by a Tukey post hoc test (p<0.05). Results. Nonsignificant color change for both groups of modified Amalgomer CR. Meanwhile, the two experimental groups exhibited a significant increase in both compressive strength and microhardness. Simultaneously, there was a significant difference in roughness values among groups with the lowest roughness values exhibited by the 50 v/v % propolis concentration. Conclusions. Modification of Amalgomer CR with 50 v/v % propolis may increase its mechanical properties without compromising its esthetic. Clinical Significance. Modification of Amalgomer CR by 50 v/v % propolis is supposed to be a hopeful restorative material with favorable characteristics.

scholarly journals Effect of electric, ultrasonic and manual toothbrushes on biofilm removal and gingivitis control

2021 ◽  
Vol 20 ◽  
pp. e219280
Author(s):  
Thamiris Cirelli ◽  
Guilherme José Pimentel Lopes de Oliveira ◽  
Andressa Vilas Boas Nogueira ◽  
Isis Jordão Pinheiro Ribaldo ◽  
Emelly Yukiko Diz Furuta ◽  
...  
Keyword(s):  
Tooth Wear ◽  
Plaque Index ◽  
Controlled Clinical Trial ◽  
Biofilm Removal ◽  
The Us ◽  
Manual Toothbrush ◽  
Crevicular Fluid ◽  
And Control

Aim: To evaluate the effect of manual (M), electric (E) and ultrasonic (US) toothbrushes on the removal of oral biofilm and control of gingivitis. Also, the roughness and tooth wear production were evaluated in vitro. Methods: For the in vitro analyses, thirty bovine dentin specimens were submitted to a 3-month brushing simulation (9 minutes) with the three types of toothbrushes (n = 10). Subsequently, a randomized controlled clinical trial was performed with 36 patients divided into 3 groups according to the toothbrushes used (n = 12). Gingival index, visible plaque index and the volume of crevicular fluid were evaluated at baseline and 3 months after the beginning of the toothbrush use. Furthermore, the performance of the biofilm removal per brushing cycle of 1 and 3 minutes with each toothbrush was made monthly until the end of the experiment. Results: The US group had the highest dentin wear. Clinically, the US group had a lower plaque index at 3 months than the M group. The M group also showed less biofilm removal efficiency from the second month of follow-up and more worn bristles at the end of the 3 month period than the E and US groups. Conclusion: The ultrasonic, electric and manual toothbrushes showed no differences in gingivitis control in the present study. The ultrasonic and electric toothbrushes had a more significant effect on biofilm removal than a manual toothbrush, but the ultrasonic toothbrush promoted greater dentin tissue wear.

scholarly journals Subgingival Periodontal Pre-Treatment Irrigation with 0.75% Boric Acid as an Adjunct to Mechanical Periodontal Therapy in Localised Chronic Periodontitis

2019 ◽  
Vol 3 (1) ◽  
pp. 9-12
Author(s):  
Swagata Banerjee ◽  
Aditi Mathur ◽  
Neema Shetty ◽  
Barkha Makhijani ◽  
Ashish Bali ◽  
...  
Keyword(s):  
Boric Acid ◽  
Chronic Periodontitis ◽  
Plaque Index ◽  
Aetiological Factor ◽  
Gingival Index ◽  
Periodontal Pathogens ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Group I ◽  
Group Ii

Introduction: Dental plaque is the primary aetiological factor for periodontal disease. Scaling and root planing may fail to eliminate periodontal pathogenic species because of limited access to the root surface and tissue-invading properties of some periodontal pathogens. Considerable attention has been devoted to the possibility of using antimicrobial agents such as chlorhexidine to eliminate periodontal pathogens with limited success. Studies show that boric acid has antibacterial and anti-inflammatory properties. Objective: The aim of the study was to evaluate the efficacy of 0.75% boric acid when used as a subgingival irrigation agent as an adjunct to oral prophylaxis in treatment of localised chronic periodontitis. Methods: A total of 40 individuals who reported to the dental college with localised periodontitis (pocket depth of ≥ 6 mm) participated in the study. Plaque Index, Gingival Index and Probing Pocket Depth were recorded at baseline and one month post irrigation with either 0.75% boric acid (Group I) or 0.2% chlorhexidine (group II). Intragroup comparison was done using student “t” test. Results: Intra-group comparison in Group I and Group II showed significant results for reduction in Plaque Index, Gingival Index and Probing Pocket Depth. Significant results observed for reduction of Probing Pocket Depth (<0.025) between the two groups - Plaque Index (>0.54) and Gingival Index (>0.93) were non-significant one month postoperatively. Conclusion: The results of this study suggest that 0.75% boric acid has similar efficacy as 0.2% chlorhexidine as a coadjuvant in the treatment of periodontitis.

scholarly journals Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wiwied Ekasari ◽  
Dewi Resty Basuki ◽  
Heny Arwati ◽  
Tutik Sri Wahyuni
Keyword(s):  
Ethanolic Extract ◽  
Positive Control ◽  
Antiplasmodial Activity ◽  
In Vivo Test ◽  
Cassia Spectabilis ◽  
Chloroquine Diphosphate ◽  
Better Than

Abstract Background In previous studies, Cassia spectabilis DC leaf has shown a good antiplasmodial activity. Therefore, this study is a follow-up study of the extract of leaf of C. spectabilis DC on its in vitro and in vivo antiplasmodial activity and mechanism as an antimalarial. Methods The extract was fractionated, sub-fractionated and isolated to obtain the purified compound. In vitro antiplasmodial activity test against Plasmodium falciparum to find out the active compound. In vivo test against P. berghei ANKA-infected mice was conducted to determine prophylactic activity and antiplasmodial activity either alone or in combination with artesunate. The inhibition of heme detoxification test as one of the antimalarial mechanisms was carried out using the Basilico method. Results The results showed that active antimalarial compound isolated from C. spectabilis DC leaf had a structural pattern that was identical to (−)-7-hydroxycassine. Prophylactic test of 90% ethanolic extract of C. spectabilis DC leaf alone against P. berghei ANKA-infected mice obtained the highest percentage inhibition was 68.61%, while positive control (doxycycline 13 mg/kg) was 73.54%. In combination with artesunate, 150 mg/kg three times a day of C. spectabilis DC (D0-D2) + artesunate (D2) was better than the standard combination of amodiaquine + artesunate where the inhibition percentages were 99.18 and 92.88%, respectively. The IC50 of the extract for the inhibitory activity of heme detoxification was 0.375 mg/ml which was better than chloroquine diphosphate (0.682 mg/ml). Conclusion C. spectabilis DC leaf possessed potent antiplasmodial activity and may offer a potential agent for effective and affordable antimalarial phytomedicine.

scholarly journals THE EFFECT OF NANOSILVER AND CHLORHEXIDINE MOUTHWASH ON ANAEROBIC PERIODONTAL PATHOGENS COUNTS

2019 ◽  
Author(s):  
Amani Abdulhakeem Al-Sharani ◽  
Waddah Al-Hajj ◽  
Hassan A. Al-Shamahy ◽  
Bushra Mohammed Jaadan
Keyword(s):  
Peer Review ◽  
Inhibitory Effect ◽  
Periodontal Pathogens ◽  
Microbial Counts ◽  
Gingival Health ◽  
Group I ◽  
Significant Difference ◽  
Review Reports ◽  
Mouth Wash ◽  
E Mail

The necessitate for frequent application of Chlorhexidine (CHX), and other side effects has encouraged the search for option that are more suitable for patients as nanosilver mouthwash (NS). So the aim of this study was to determine the effects of a mouthwash made with nanosilver on dental plaque microbial counts and compare it with commercially available Chlorhexidine.   Sixty-two plaque-induced gingivitis patients were allocated into two groups and asked to rinse with 10 ml of NS and CHX, immediately after brushing, for 1 min, in the morning and evening. Sub gingival plaque microbial counts were taken at baseline, two weeks, and finally at four weeks for each patient. Subsequently, the samples were collected, transferred and cultured in blood agar in anaerobic media. The colonies were counted and expressed as CFUs. The statistical analysis between CFUs variables within groups was calculated and the variation significance was calculated by performed t-test.  It is very obvious that the values of CFU decreased significantly (p<0.001) as the time of use nanosilver until reaching the highest value when the time of use was 4 weeks [70.3±47 to 32.4±24.6 (2 weeks), and 14.2±9.9 (4 weeks) with inhibition of growth rate after 2 weeks was 46% and after 4 weeks was 79.7%. The effect of commercially available CHX mouthwash was approximately similar to the effect of  NS mouthwash used. In conclusion, both Group I and Group II showed similar effect on inhibition anaerobic periodontal pathogens counts and gingival health. There was significant inhibitory effect on microbial counts where NS mouth-wash had shown better results than CHX, but there was no significant difference between the nanosilver mouth wash and the Chlorhexidine mouthwash. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Mohamed Salama Affiliation: Modern University for Technology & Information, Egypt E-mail: [email protected]   Name: Dr. Tamer Elhabibi Affiliation: Suez Canal University, Egypt E-mail: [email protected] Comments of reviewer(s):

scholarly journals ANTI-MICROBIAL EFFICACY OF AN ETHANOLIC EXTRACT OF MURRAYA KOENIGII AGAINST PERIODONTAL PATHOGENS LIKE PORPHYROMONAS GINGIVALIS AND AGGREGATIBACTER ACTINOMYCETEMCOMITANS: IN VITRO ANALYSIS

2021 ◽  
Vol 12 (3) ◽  
pp. 41-45
Author(s):  
Nagaraj B Kalburgi ◽  
Arati C Koregol ◽  
Ruchita S Patil ◽  
Tejashwini Puttarevanna
Keyword(s):  
Porphyromonas Gingivalis ◽  
Bactericidal Activity ◽  
Ethanolic Extract ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Chemotherapeutic Agents ◽  
Periodontal Pathogens ◽  
Murraya Koenigii ◽  
Disk Diffusion Test ◽  
Periodontal Tissues

Periodontitis is primarily an infectious disease with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans present in plaque biofilm as the key pathogens, causing destruction of supporting periodontal tissues. Herbal formulations are widely substituting synthetic anti-microbials due to their minimal adverse effects and cost effectiveness. Murraya koenigii (M. koenigii) is a well-known anti-microbial agent used in treating systemic infections. Hence its anti-microbial efficacy against key periodontal pathogens also needs to be tested. The aim of this study is to determine Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and zone of inhibition of M. koenigii ethanolic extract against P. gingivalis and A. actinomycetemcomitans. Thioglycollate agar was used for culturing both P. gingivalis and A. actinomycetemcomitans. For determination of MIC and MBC broth dilution technique was used. For MIC, serial dilutions of extract were made and culture tubes were incubated in an anaerobic jar and observed for their turbidity. For MBC determination, dilution tubes sensitive to MIC were plated and incubated for the next 24 hours to monitor growth, and colony count was taken. MIC results showed A. actinomycetemcomitans was more sensitive to M. koenigii extract than P. gingivalis and got inhibited at 0.8 μg/ml. Also, MBC results showed extract has strong bactericidal activity towards A. actinomycetemcomitans. Disk diffusion test results showed bactericidal activity against both A. actinomycetemcomitans and P. gingivalis with a larger inhibition zone (15 mm) towards P. gingivalis at a concentration of 75 μl/ml. M. koenigii ethanolic extract is bactericidal against periodontal pathogens like A. actinomycetemcomitans and P. gingivalis and can be used as a safe and effective alternative for synthetic chemotherapeutic agents in the future.

Potentiation of doxorubicin (DXR)'s genotoxic activities by ethanolic extract from Thai Plumbago indica roots (EEPIR) in human lymphocytes in vitro

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
T Ratanavalachai ◽  
S Thitiorul ◽  
S Tanuchit ◽  
A Itharat ◽  
I Sakpakdeejaroen
Keyword(s):  
Human Lymphocytes ◽  
Ethanolic Extract ◽  
Plumbago Indica
Sign in / Sign up

Export Citation Format

Share Document