scholarly journals THE EFFECT OF NANOSILVER AND CHLORHEXIDINE MOUTHWASH ON ANAEROBIC PERIODONTAL PATHOGENS COUNTS

2019 ◽  
Author(s):  
Amani Abdulhakeem Al-Sharani ◽  
Waddah Al-Hajj ◽  
Hassan A. Al-Shamahy ◽  
Bushra Mohammed Jaadan
Keyword(s):  
Peer Review ◽  
Inhibitory Effect ◽  
Periodontal Pathogens ◽  
Microbial Counts ◽  
Gingival Health ◽  
Group I ◽  
Significant Difference ◽  
Review Reports ◽  
Mouth Wash ◽  
E Mail

The necessitate for frequent application of Chlorhexidine (CHX), and other side effects has encouraged the search for option that are more suitable for patients as nanosilver mouthwash (NS). So the aim of this study was to determine the effects of a mouthwash made with nanosilver on dental plaque microbial counts and compare it with commercially available Chlorhexidine.   Sixty-two plaque-induced gingivitis patients were allocated into two groups and asked to rinse with 10 ml of NS and CHX, immediately after brushing, for 1 min, in the morning and evening. Sub gingival plaque microbial counts were taken at baseline, two weeks, and finally at four weeks for each patient. Subsequently, the samples were collected, transferred and cultured in blood agar in anaerobic media. The colonies were counted and expressed as CFUs. The statistical analysis between CFUs variables within groups was calculated and the variation significance was calculated by performed t-test.  It is very obvious that the values of CFU decreased significantly (p<0.001) as the time of use nanosilver until reaching the highest value when the time of use was 4 weeks [70.3±47 to 32.4±24.6 (2 weeks), and 14.2±9.9 (4 weeks) with inhibition of growth rate after 2 weeks was 46% and after 4 weeks was 79.7%. The effect of commercially available CHX mouthwash was approximately similar to the effect of  NS mouthwash used. In conclusion, both Group I and Group II showed similar effect on inhibition anaerobic periodontal pathogens counts and gingival health. There was significant inhibitory effect on microbial counts where NS mouth-wash had shown better results than CHX, but there was no significant difference between the nanosilver mouth wash and the Chlorhexidine mouthwash. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Mohamed Salama Affiliation: Modern University for Technology & Information, Egypt E-mail: [email protected]   Name: Dr. Tamer Elhabibi Affiliation: Suez Canal University, Egypt E-mail: [email protected] Comments of reviewer(s):

scholarly journals AN OVERVIEW ON CURRENT REGULATION AND EVALUATION OF BIOCIDAL PRODUCTS

2019 ◽  
Author(s):  
Aslı ŞAHİNER ◽  
Evren ALGIN YAPAR
Keyword(s):  
Peer Review ◽  
Chemical Substance ◽  
Biological Action ◽  
Insect Repellents ◽  
Biocidal Products ◽  
Unique System ◽  
Natural Oil ◽  
Review Reports ◽  
E Mail ◽  
Biocidal Product

A biocidal product is a substance or mixture prepared to limit, destroy, neutralize or control the effects of a harmful microorganism, plants and animals. The active substance in a biocidal product can be a natural oil or extract, a chemical substance or a microorganism, virus or fungus. Biocides consist of four main groups: disinfectants, preservatives (wood, paint, etc.), pest control and other type of biocidal products. A biocidal substance can also be added to a product to make the product itself into a biocidal product. These products range from disinfectants, hand sanitizers, preservatives, insect repellents, to rodenticides and insecticides and are used to protect humans, animals, materials and articles by controlling the intended target organism by a chemical or biological action. To make sure the use of biocidal products do not have unacceptable risks for people, animals and the environment, they are regulated to control their marketing, sale and use. In the current study biocidal products have been overviewed in the scope of current European Union regulations, product types and conformity tests. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Name: Dr. Barkat Ali Khan Affiliation: Kampala International University , Uganda E-mail: [email protected]   Name: Dr. Sally A. El-Zahaby Affiliation: Pharos University in Alexandria, Egypt E-mail: [email protected] Comments of reviewer(s):

scholarly journals A REVIEW STUDY ON TRAMADOL ABUSE AMONG EGYPTIAN UNIVERSITY STUDENTS

2020 ◽  
Author(s):  
Lysher Tan Shu Phing ◽  
Muhammad Shahzad Aslam
Keyword(s):  
University Students ◽  
Peer Review ◽  
Data Extraction ◽  
Cross Sectional Study ◽  
Future Research ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Male Youth ◽  
Review Reports ◽  
E Mail

Tramadol, which is a medication used for moderate and severe pains, has caused drug abuse and addiction to the Egyptian community. This study aimed to observe the prevalence of tramadol abuse among Egyptian university students. By following the PRISMA reporting guideline, a systematic review of evidence was conducted. Search strategy was conducted through PubMed-NCBI to yield appropriate published literature between 2014-2019, as well as performed literature screening, eligibility criteria, and data extraction. The process of selection yielded a total number of 2 studies to be eligible for the review inclusion criteria. The characteristics evaluated that correlate to tramadol were classified into four groups: gender, smoking, alcohol consumption, and failure in exams before. In general, tramadol showed positively associated with other prevalence characteristics. Tramadol is the second most commonly abused drug among university students in Egypt. The review highlights that tramadol abuse has become a common phenomenon among Egyptian university students which necessitates for ample attention. Future research is recommended to identify the causal effects of tramadol abuse and its role as a potential gateway drug. Peer Review History: Received 2 January 2020;   Revised 22 February; Accepted 1 March, Available online 15 March 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Name: Hebatallaha A  Moustafa Affiliation: Ain Shams University, Egypt E-mail: [email protected]   Name: Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Ali Abdullah Al-yahawi Affiliation: Al-Razi university, Department of Pharmacy, Yemen E-mail: [email protected] Comments of reviewer(s): Similar Articles: A CROSS-SECTIONAL STUDY ON BENZODIAZIPINE (BZD) ABUSERS OF DHAKA CITY: A SOCIO-PSYCHOLOGICAL CONDITION OF BANGLADESH AWARENESS AMONGST YOUTH ABOUT USE AND ABUSE OF STEROIDS IN KARACHI, PAKISTAN ALCOHOL INFLUENCES AGGRESSIVE BEHAVIOUR THAT INCREASES LIKELIHOOD OF INITIATING DATING VIOLENCE AMONG MALE YOUTH IN COLLEGES WITHIN WESTERN COUNTRIES: A SCOPING REVIEW

scholarly journals ENHANCEMENT OF WOUND HEALING BY TOPICAL APPLICATION OF EPIDERMAL GROWTH FACTOR IN ANIMAL MODEL

2020 ◽  
Author(s):  
George Zhu ◽  
Xu HL ◽  
Zhou XP ◽  
Zhi QW
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Peer Review ◽  
Healing Time ◽  
Epidermal Growth ◽  
Review Reports ◽  
E Mail

Objective: Wound healing is a complex process of biological events involving re-epithelialization and granulation that are mainly mediated by several endogenously released growth factors such as epidermal growth factor. This work was undertaken to study the effects of various doses of locally applied recombinant human epidermal growth factor (rhEGF) on wound healing in rats. Methods: Recombinant human EGF consists of 53 amino acids. In vitro, rhEGF promoted it’s obvious cell growth and proliferation when added to cultured 3T3 cells using MTT assay. In the test groups, in vivo, wound sites were given daily with a solution containing 2, 5, 10, 50ug of EGF spray and 40ug of EGF ointment, respectively. We presented evidence that a significant decreased healing time in wound was observed in all rhEGF groups when compared with the control, and reach to its maximal efficacy at 10ug/ml of rhEGF spray. Results: The rate of wound closure was over 50 per cent at initial 3 days of treatment. Treatment with rhEGF significantly decreased the length of time to over 50 per cent healing by approximately 4-5 days, and that to 70 per cent and 90 per cent healing by approximately 3-4 days and 3 days, respectively. A stimulatory, dose-dependent effect of EGF on wound healing was observed with increased hEGF concentration. In toxicological group, higher doses of 100ug/ml of rhEGF spray was applied by local dorsal incision in rats. Moreover, a dose of single 200ug, single 300ug or 300ug within 24 hours of subcutaneous and intramuscular rhEGF injection was given respectively. There were no significant adverse side effects.Conclusion: Current study recommended a proposal of clinical drug doses in wound at 2µg, 5 µg and 10 µg /ml of rhEGF spray, and 10 µg and even higher 40 µg rhEGF/g of ointment. The results indicated that prepared rhEGF by our genetic engineering is safe, and is emerging in clinical effective use in assisting wound healing time. Peer Review History: Received 8 January 2020;   Revised 12 February; Accepted 2 March, Available online 15 March 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Name: Asmaa Ahmed Mohamed Ahmed Khalifa   Affiliation: Pharos University, Alexandria, Egypt E-mail: [email protected]   Name: Dr. Sabah Hussien El-Ghaiesh  Affiliation: Tanta University, Egypt E-mail: [email protected] Comments of reviewer(s): Similar Articles: POTENTIAL OF SNAKEHEAD FISH (OPHIOCEPHALUS STRIATUS) IN ACCELERATING WOUND HEALING

scholarly journals PURIFICATION AND BIOLOGICAL ACTIVITIES OF COMBINATION OF HEMI-SYNTHESIZED THIOSEMICARBAZONES OF MITRACARPUS SCABER ZUCC

2020 ◽  
Author(s):  
BAMBOLA Bouraima ◽  
HOUNGBEME Gouton Alban ◽  
FAGBOHOUN Louis ◽  
MEDEGAN Sèdami ◽  
GBAGUIDI Ahokanou Fernand
Keyword(s):  
Liquid Chromatography ◽  
Peer Review ◽  
Biological Activities ◽  
Ethanolic Extract ◽  
Medium Pressure ◽  
Crude Extracts ◽  
Medium Pressure Liquid Chromatography ◽  
Review Reports ◽  
Mitracarpus Scaber ◽  
E Mail

The harvested Mitracarpus Scaber plants are identified in the national herbarium and registered under the number AA. 6252/HLB. During this work, three crude extracts are prepared from three organic solvents, namely dichloromethane; ethanol and hydro ethanol in 50/50 v/v proportion. The respective alkaloid extracts obtained from the corresponding crude extracts served as substrates for the hemi synthesis of thiosemicarbazone totals from thiosemicarbazides. The three hemi-synthesis products obtained were tested on eight (08) strains of germs, namely E. coli ATCC 25922, S. aureus ATCC 25923, E. faecalis ATCC 22921, P. aeruginosa ATCC 27853, C. albicans ATCC 10231, S. typhi, K. pneumoniae and Dermatophilus 146. The ethanolic extract of thiosemicarbazones exhibited the best bioactive activity and was found to be the most selective. By a series of bio guided chromatographies: TLC thin layer chromatography; CPA atmospheric pressure chromatography and medium pressure liquid chromatography. MPLC (medium pressure liquid chromatography), separation on dextran gel: Sephadex® LH20). The use of available spectral data, cross-checked with that of the literature, made it possible to identify and purify three (03) molecules of thiosemicarbazones, making it possible to study the biological activity of their combination. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Prof. Dr. Ali Gamal Ahmed Al-kaf Affiliation: Sana'a university, Yemen E-mail: [email protected]   Name: Prof. Dr. Amani S. Awaad Affiliation: College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj. KSA E-mail: [email protected] Comments of reviewer(s): Similar Articles: ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA

scholarly journals OCCLUSAL CHARACTERISTICS OF THE PRIMARY DENTITION AMONG A SAMPLE OF YEMENI PRE-SCHOOL CHILDREN

2020 ◽  
Author(s):  
Lamia A.T. Bin Yehia ◽  
Khaled A AL-Haddad ◽  
Mohammed A Al-labani ◽  
Hassan Abdulwahab Al-Shamahy ◽  
Hussein M Shaga-aldeen
Keyword(s):  
Peer Review ◽  
School Children ◽  
Intestinal Parasites ◽  
Primary Dentition ◽  
Class I ◽  
Class Iii ◽  
Unique System ◽  
Potential Risk Factors ◽  
Review Reports ◽  
E Mail

Objective: The occlusal features change dynamically in the growing children and any disruption in the complex craniofacial growth process may lead to malocclusion, which is a major concern for the pediatric community because of its effects on dental function and beauty, as well as on the child's psyche. The aim of the present study was to study the prevalence of different occlusal traits in the primary dentition of the randomly selected pre-school children from three to five years in the city of Sana’a, Yemen. Methods: The study includes 1106 pre-school children subjected to a dental examination performed in the school premise, using the Foster and Hamilton criteria for occlusal traits. As well as inter- and intra-calibration tests were conducted for assessing the degree of agreeability. Results: Results of the study showed that the Bilateral flush terminal molar relationship was found in 60%, bilateral mesial step in 27.9%, asymmetrical relationship in 8.5% and distal step in 3.5% of tested children. The Bilateral canine class I was detected in 62.8%, asymmetrical relationship (13.6%), class II (12.5%) and class III (11.1%). Normal over-jet (OJ) of 1-3 mm was identified in 39.2%, decreased OJ <1 mm (32.7%) and edge-to-edge (8.8%). Ideal over-bite (OB) of 1-50% was detected in 64.5% and increased OB of > 50% (19.7%). Conclusion: In conclusion theBilateral flush terminal molar, class I canine relationships, normal overjet (OJ) of 1-3mm were the most commonly found sagittal occlusal traits in the current study. Ideal over-bite (OB) of 1-50% were identified in more than half of the children. Peer Review History: Received 2 February 2020;   Revised 21 February; Accepted 3 March, Available online 15 March 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Name: Aya Mohammed Mohammed Essawy Affiliation: MTI University- Mokattam, Egypt E-mail: [email protected]   Name: Dr. Nada Farrag Affiliation: Misr International University, Egypt E-mail: [email protected] Comments of reviewer(s): Similar Articles: COCCIDIAN INTESTINAL PARASITES AMONG CHILDREN IN AL-TORBAH CITY IN YEMEN: IN COUNTRY WITH HIGH INCIDENCE OF MALNUTRITION EVALUATION OF THE IMMUNE RESPONSE TO POLIO VACCINE IN MALNOURISHED CHILDREN IN SANA'A CITY PREVALENCE AND POTENTIAL RISK FACTORS OF HEPATITIS B VIRUS IN A SAMPLE OF CHILDREN IN TWO SELECTED AREAS IN YEMEN

scholarly journals EVALUATION OF METABOLIC SYNDROME IN HEALTHY YEMENI POPULATIONS

2020 ◽  
Author(s):  
Gamil Alrubaiee ◽  
Ali Alyahawi
Keyword(s):  
Metabolic Syndrome ◽  
Peer Review ◽  
Fasting Blood Glucose ◽  
Morbidity And Mortality ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Total Prevalence ◽  
Cardiovascular Morbidity And Mortality ◽  
Significant Difference ◽  
E Mail

The metabolic syndrome is characterized by several cardiovascular risk factors and is associated with an increased incidence of diabetes, cardiovascular events and mortality. The prevalence of metabolic syndrome is increasing in epidemic proportions worldwide. The present study aimed to investigate the prevalence of MS and its components in healthy populations in Sana'a, Yemen. This study was a cross-sectional study conducted from February 2019 to April 2019. A total of 120 healthy populations (>=40 years old) were selected. The study protocol was approved by the institutional ethical committee and informed consent was obtained from all the enrolled study patients for their inclusion in the screening and participation in the research. In the present study, the diagnosis of metabolic syndrome based on the American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHL BI) and to a joint statement from several large organizations. In the current study, the presence of more than or equal to any three of the above mentioned factors is required for the diagnosis of metabolic syndrome. The total prevalence of MS among the study subjects was 40.0% (P< 0.001) and 62.5%of them were within 40-49 years old. In the present study, there was not statically significant difference between the khat chewing and the metabolic syndrome. According the distribution of metabolic syndrome criteria among subjects with metabolic syndrome, the prevalence of fasting blood glucose (FBG) was the highest (85%). The prevalence of metabolic syndrome among healthy Yemeni populations was very high and it is associated with increased morbidity and mortality.  This emphasizes the need for more attention to investigate this condition to decreasing the prevalence of cardiovascular morbidity and mortality in these subjects. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Muhammad Shahzad Aslam Affiliation: Universiti Malaysia Perlis, Malaysia E-mail: [email protected] Comments of reviewer(s): Similar Articles: PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN  

scholarly journals QUALITY EVALUATION OF BIOSIMILAR MEDICINES: AN OVERVIEW

2020 ◽  
Author(s):  
Emrah KORKMAZ ◽  
Mehmet Emre ÖZDEMİRHAN ◽  
Evren ALGIN YAPAR
Keyword(s):  
Quality Control ◽  
Peer Review ◽  
Internal Quality ◽  
Control Methods ◽  
Ambient Conditions ◽  
Purification Method ◽  
Factors Affecting ◽  
Manufacturing Method ◽  
Review Reports ◽  
E Mail

Biosimilar medicines are biotherapeutics that are similar in quality, safety and efficacy to previously licensed reference biotherapeutics. The slightest change in any stage of production can cause differences in the product. Among the factors, affecting production can be listed as; host cell selection, fermenter type, ambient conditions, broth, substances used for cell culture, fermentation method and purification method. The similarity should be demonstrated by comparative quality, non-clinical and clinical tests. Research and development studies in the biopharmaceutical field bring diversity of quality control methods along with the formulation and manufacturing method of the biosimilars. Although there are some standardized and validated quality control methods given in the internationally recognized pharmacopoeias, there are many in house methods of biopharmaceutical product owners that can only be used as internal quality control methods by them. The main international sources for quality control methods of biopharmaceutics can be given as pharmacopoeias, International Organization for Standardization standards and Organization for Economic Co-operation and Development methods. In this review manufacturing process, regulatory guidelines and quality control of biosimilar medicines briefly are given. Peer Review History: Received 11 March 2019; Revised 20 April; Accepted 3 May, Available online 15 May 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Name: Dr. Mohamed Salama Affiliation: Modern University for Technology & Information, Egypt E-mail: [email protected]   Name: Dr.  Maha Khalifa Ahmed Khalifa Affiliation: E-mail: [email protected] Comments of reviewer(s):

scholarly journals CHARACTERIZATION OF PARTIALLY PURIFIED TYROSINASE ISOLATED FROM BITTER KOLA (GARCINIA KOLA)

2022 ◽  
Author(s):  
B.O. Itakorode ◽  
O.E. Agboola ◽  
M.B. Adeboye ◽  
C.C. Benedict ◽  
K.N. Terkula ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Peer Review ◽  
Specific Activity ◽  
Ph Value ◽  
Inhibitory Effect ◽  
Enzymatic Browning ◽  
Partial Purification ◽  
Garcinia Kola ◽  
North East ◽  
Review Reports

Objective: Tyrosinase is a glycosylated, copper-containing oxidase that catalyzes the first two steps of mammalian melanogenesis as well as enzymatic browning events in damaged fruits during post-harvest handling and processing. Human skin hyperpigmentation and enzymatic browning in fruits are both undesirable. In this study, the properties and inhibitory effect of some compounds on bitter kola tyrosinase were investigated. Methods: Bitter kola tyrosinase was isolated and characterized using standard protocols. Partial purification was carried out on Sephadex G-100 loaded column chromatography.  Results: Bitter kola tyrosinase was purified with a specific activity of 3.5 U/mg protein, purification fold of 2.4 and a yield of 34%. The optimum pH value was found to be 6.0 while the optimum temperature value for maximum enzyme activity was observed at 60°C. The enzyme was stable at 40oC for 20 minutes. Metals such as NaCl, KCl, MgCl2 and CaCl2 had inhibitory effect on the activity; though MgCl2 and CaCl2 had minimal effect. Also, EDTA, β-marcaptoethanol and glutathione greatly inhibited the enzyme activity at all the tested concentration. Conclusion: The properties of bitter kola tyrosinase compare very well with the tyrosinase from other sources. Also, the study was able to establish the inhibitory effect of some compounds and this could be applied in food processing industries.                  Peer Review History: Received: 2 November 2021; Revised: 11 December; Accepted: 25 December, Available online: 15 January 2022 Academic Editor:  Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, [email protected] Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected] Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, [email protected] Similar Articles: PHYTOCHEMICAL PURIFICATION OF ACTIVE CONSTITUENTS ISOLATED FROM ROOT OF THE MEDICINAL HERB, CARALLUMA QUADRANGULA

scholarly journals COMPARISON BETWEEN THE EFFECTS OF THYMOQUINONE OBTAINED FROM THE SEEDS OF NIGELLA SATIVA AND VERAPAMIL ON THE VOLUME AND ACIDITY OF GASTRIC ACID SECRETION

2020 ◽  
Author(s):  
Rahma Hamayun ◽  
Muhammad Jan ◽  
Muhammad Fazeel
Keyword(s):  
Peptic Ulcer ◽  
Gastric Secretion ◽  
Peer Review ◽  
Gastric Acid ◽  
Nigella Sativa ◽  
Wound Dressings ◽  
Research Centre ◽  
Unique System ◽  
Review Reports ◽  
E Mail

Background and Objectives: The over production of gastric acid results in peptic ulcer. This study was done to compare the effects of thymoquinone and Verapamil on volume and acidity of carbachol induced gastric secretion. Methods: There were 24 rabbits used, weighing 1-1.5 kg. The rabbits were kept on fasting for 48 hours. After fasting, the pylorus of each rabbit was ligated. Thymoquinone 5 mg/kg, Carbachol 600mg/kg and Verapamil 10 mg/kg body weight were administered intraperitoneally. Pylorus ligation method was used for getting gastric contents and titration method was used for finding out acidity. Results: Verapamil has been proved very effective for the treatment of many diseases. The drug verapamil inhibits the release of histamine, acetylcholine and gastrin. Verapamil has also shown effects in reducing the secretion of gastric acid. It was found that Thymoquinone reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P=0.000) but when we compared the results of Thymoquinones with that of Verapamil, it was non-significant. Conclusions:   It was concluded that Thymoquinone can be used for the treatment of peptic ulcer and all other diseases which are caused by increased gastric acidity like dyspepsia, gastritis and reflux esophagitis. Peer Review History: Received 8 July 2020; Revised 14 August; Accepted 6 September, Available online 16 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Hatem Sameir Abbas Affiliation: Al-Azhar University, Egypt E-mail: [email protected]   Name: Prof. Dr. Ali Gamal Ahmed Al-kaf Affiliation: Sana'a university, Yemen E-mail: [email protected]   Name: Dr. Gehan Fawzy Abdel Raoof Kandeel Affiliation: National Research Centre, Egypt E-mail: [email protected]   Name: Dr. Mahmut Yıldıztekin Affiliation: Muğla Sıtkı Koçman University, Turkey E-mail: [email protected]   Comments of reviewer(s): Similar Articles: COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS WOUND DRESSINGS UPLOADED WITH MYRTLE BERRIES EXTRACT AND NIGELLA SATIVA HONEY

scholarly journals AWARENESS OF PHARMACISTS TOWARDS ASPARTAME SIDE EFFECTS IN KHARTOUM CITY, SUDAN

2020 ◽  
Author(s):  
Musab Hassan Dafaalla ◽  
Ahmed Mustafa Khidir ◽  
Eiman Abubakr Osman ◽  
Ali Awadallah Saeed ◽  
Mohamed A. Mousnad
Keyword(s):  
Side Effects ◽  
Peer Review ◽  
Attention Deficit Disorder ◽  
Community Pharmacists ◽  
High Energy ◽  
Artificial Sweetener ◽  
Initial Stage ◽  
Unique System ◽  
Review Reports ◽  
E Mail

Objective:  Aspartame (or APM) is the name for an artificial, non-saccharide sweetener used as a sugar substitute in many foods and beverages. Aspartame is the methyl ester of a phenylalanine/aspartic acid dipeptide. Aspartame is an artificial sweetener. It is 200 times sweeter than sugar in typical concentrations, without the high-energy value of sugar. Aim of current study was to study the awareness of pharmacists about aspartame side effects. Materials and methods: This study was carried in greater Khartoum, questionnaire for pharmacists to see the consumption and the awareness of them to these interactions during the period from September 2014 to November 2014.Study was conducted among practicing pharmacists. A pre designed and tested questionnaire were used for each category to collect the data. From the hospitals manager. Results: 32% were aware of the number of aspartame products. Pharmacists when asked how many patients purchase aspartame products per day, answers showed that 74.5% ranged between 1-10 patients per day, About pharmacist’s expectations to develop side effects due to aspartame, use regularly showed that 75% agreed that it would. pharmacists claimed that aspartame can or worsen a certain list of some diseases in which that diabetes represented 30%, Alzheimer’s 28% , attention deficit disorder 17.3% , psychological disorders. Conclusion: The majority of community pharmacists expect side effects can be developed due to aspartame regular use by patients but majority didn’t know what are the exact side effects and the exact diseases that can be worsened when using aspartame. Peer Review History: Received 11 June 2020; Revised 28 June; Accepted 3 July, Available online 15 July 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Name: Prof. Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Nada Farrag Affiliation: Misr International University Egypt E-mail: [email protected]   Comments of reviewer(s): Similar Articles: AWARENESS AMONGST YOUTH ABOUT USE AND ABUSE OF STEROIDS IN KARACHI, PAKISTAN

Sign in / Sign up

Export Citation Format

Share Document