Evaluation of Serum C-Reactive Protein, Plasma Fibrinogen, and Blood Leukocytes in Patients with Chronic Periodontitis

2021 ◽  
Vol 5 (1) ◽  
pp. 11-18
Author(s):  
Shristi Kafle ◽  
Erika Shrestha ◽  
Sanjay Yadav
Keyword(s):  
Cardiovascular Diseases ◽  
Chronic Periodontitis ◽  
Healthy Subjects ◽  
Leukocyte Count ◽  
Plasma Fibrinogen ◽  
Total Leukocyte Count ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Leukocyte Counts

Introduction: Periodontal health is crucial and indispensable element of general health. Epidemiologically, it has been linked with cardiovascular diseases with elevated acute phase reactant C-reactive protein, fibrinogen and rheological variables such as total leukocyte count and differential leukocyte counts, which are potential predictors of cardiovascular diseases. Objective: To evaluate and compare cardiovascular disease-related biochemical markers in periodontally healthy subjects, and patients with moderate and severe chronic periodontitis. Methods: An analytical cross-sectional study was conducted in patients attending Department of Periodontology and Oral Implantology, Chitwan Medical College and Teaching hospital, Bharatpur, Chitwan, Nepal from September 2019 to January 2021. A total of 81 individuals of both gender of which 27 periodontally healthy individuals, 27 diagnosed with moderate and 27 diagnosed with severe periodontitis based on gingival index, probing pocket depth and clinical attachment level were enrolled in a study. After which, peripheral blood samples were drawn and serum C-reactive protein, plasma fibrinogen, total leukocyte count and differential leukocyte counts were quantified using the turbidimetric immunoassay. Convenience sampling technique was done. Data was analysed in SPSS v.26.0. Results: The mean serum levels of C-reactive protein, plasma fibrinogen, total leukocyte and differential leukocytes were found to be statistically (P value <0.001) higher in severe and moderate periodontitis subjects compared to periodontally healthy subjects. Conclusion: The increased levels of serum C-reactive protein, plasma fibrinogen, total leukocyte count, and differential leukocyte counts in chronic periodontitis contribute to the inflammatory burden of the individual potentially striking toward an increasing risk for cardiovascular events.  

Utility of Blood Markers in Early Prediction of Bacteraemia in Acute Febrile Paediatric Patients – An Observational Cohort Study in a Tertiary Care Hospital of North India

2021 ◽  
Vol 8 (28) ◽  
pp. 2526-2531
Author(s):  
Rabindra Bhunia ◽  
Bindu T. Nair ◽  
Vandana Negi
Keyword(s):  
Tertiary Care Hospital ◽  
Leukocyte Count ◽  
Tertiary Care ◽  
North India ◽  
Total Leukocyte Count ◽  
Care Hospital ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Neutrophil Percentage ◽  
Observational Cohort

BACKGROUND Bacteraemia is a common cause of children presenting to the paediatric emergency with acute febrile illness. Blood cultures remain the gold standard for detection of bacteraemia but the positivity is low and also takes time to show positive results. A rapid and reliable biomarker like procalcitonin (PCT), C-reactive protein (CRP), total leucocyte count (TLC), and neutrophil-lymphocyte count ratio (NLCR) can be used to identify febrile children with greater risk for bacteraemia or serious bacterial infections. This would be very helpful to start early treatment of bacteraemia with antibiotics. METHODS The study was an observational cohort study conducted in the Department of Paediatrics of a tertiary care hospital in North India in children between age group 6 months to 12 years presenting with fever of > 100.4° F for 2 - 7 days. Blood samples were sent for PCT, CRP, TLC, NLCR and blood cultures. RESULTS The most sensitive biomarker was total leukocyte count (47.36 %) followed by the neutrophil percentage (26.32 %), C-reactive protein (21.05 %), and procalcitonin (15.79 %). The most specific biomarker was procalcitonin (75.14 %) followed by C-reactive protein (58.56 %), neutrophil percentage (22.65 %) and total leukocyte count (11.05 %). The only biomarker that was statistically significant between the bacteraemia and non-bacteraemia group in the present study was total leukocyte count (P – value < 0.05). CONCLUSIONS The sensitivity and specificity of each single biomarker is low and hence these cannot be used singly to predict bacteraemia. There should be a combination of biomarkers with adequate sensitivity and specificity that can be used to create an algorithm to aid in diagnosis and prognostication. KEYWORDS Procalcitonin, C-Reactive Protein, Blood Culture, Acute Febrile Patient

scholarly journals Serum resistin: A possible link between inflammation, hypertension and coronary artery disease

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Sobia Niaz ◽  
Javaria Latif ◽  
Shaista Hussain
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Leukocyte Count ◽  
Total Leukocyte Count ◽  
C Reactive Protein ◽  
Hypertensive Patients ◽  
Reactive Protein ◽  
Artery Disease

Background & Objectives: Inflammation is considered as the main triggering factor in evolution of atherosclerotic pathology of heart and blood vessels. Resistin, an inflammatory cytokine is proved to be a main mediator of initiation and progression of mechanisms leading to atherosclerosis, hypertension and ultimately to coronary artery disease. Our objective was to compare the levels of serum resistin, C-reactive protein and total leucocyte count in subjects of hypertension and coronary artery disease; and to observe the correlation of serum resistin with CRP and TLC in the study participants. Methods: Eighty selected participants were divided into four equal groups including normal healthy participants, newly diagnosed cases of hypertension, stable angina pectoris and myocardial infarction, both with hypertension. The study was conducted in the physiology department of Post Graduate Medical Institute Lahore, during 2013. After consent, history and examination, fasting blood samples of the participants were collected. Serum resistin and C-reactive protein were determined by using standard techniques of enzyme linked immunosorbent assay, while total leukocyte count by automated hematology analyzer. Results: The values of serum resistin, C- reactive protein and total leukocyte count were found significantly raised in patients of hypertension, angina pectoris and myocardial infarction with hypertension as compared to normal participants (p<0.001 for all). Significantly positive correlation of resistin was observed with TLC only in hypertensive patients of myocardial infarction (r = 0.459, n = 20, p = 0.042) while in other study groups correlation between resistin and TLC as well as CRP was non-significant. Conclusion: Serum resistin levels along with CRP and TLC are significantly raised in patients of hypertension and coronary artery disease while resistin levels revealed significantly positive correlation with TLC in hypertensive patients of myocardial infarction. doi: https://doi.org/10.12669/pjms.35.3.274 How to cite this:Niaz S, Latif J, Hussain S. Serum resistin: A possible link between inflammation, hypertension and coronary artery disease. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.274 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Atypical Kawasaki disease in an early infant, a diagnostic challenge: Case report

2021 ◽  
Vol 8 (11) ◽  
pp. 394-396
Author(s):  
Kaifi Siddiqui ◽  
Ayub Ansari ◽  
Ishaq Farooq ◽  
Sheeba Farooqui
Keyword(s):  
Kawasaki Disease ◽  
Leukocyte Count ◽  
Intravenous Immunoglobulins ◽  
Total Leukocyte Count ◽  
C Reactive Protein ◽  
Diagnostic Challenge ◽  
Reactive Protein ◽  
Atypical Kawasaki Disease ◽  
Short Courses ◽  
Echocardiographic Findings

A 4.5-month-old girl presented to us with continuous fever for 10 days and loose stools for 2 days. She received short courses of multiple oral antibiotics during this period however, was not relieved. Initial investigations were suggestive of urinary tract infection for which broad spectrum antibiotics were started. However, fever persisted even after 72 h of antibiotics. Blood counts showed persistently high total leukocyte count and increasing platelet count, along with high C-reactive protein. Consequently, a diagnosis of Kawasaki disease (KD) was suspected, which was supported by echocardiographic findings. After she received intravenous immunoglobulins, her fever subsided and lab parameters showed significant improvement. This case highlights an unusual presentation of KD in an uncommonly young age group without much clinical pointers except for persistent fever.

scholarly journals Comparative study of lipid profile and C-reactive protein in hypertensive and normotensive patients of Andhra Pradesh population

2019 ◽  
Vol 6 (4) ◽  
pp. 1130
Author(s):  
Yasar Arafath Shaikh
Keyword(s):  
Cardiovascular Diseases ◽  
Comparative Study ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Andhra Pradesh ◽  
Morbidity And Mortality ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cardio Vascular

Background: Parameters of lipid profile, C-reactive protein was studied in hypertensive and Normotensive adults aged between 25 to 60 years and compared to predict the cardio-vascular disease.Methods: BP was recorded in both groups and compared. CRP lipid profile was studied in both groups and compared.Results: Systolic BP, diastolic BP in HTN and Normotensive were compared statically and p value was highly significant (p <0.01). C-reactive protein of both HTN and Normotensive was compared and statically highly significant (p <0.01). The lipid profile parameters total cholesterol, triglyceride VLDL, HDL, LDL were also compared in both HTN and Normotensive and all values were statistically highly significant (p <0.01).Conclusion: This study highlighted the diagnostic and prognostic values of HTN and cardiovascular diseases, which have high rates of morbidity and mortality.

scholarly journals Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection

2018 ◽  
Vol 32 ◽  
pp. 205873841880607 ◽  
Author(s):  
Elena De Vecchi ◽  
Carlo Luca Romanò ◽  
Roberta De Grandi ◽  
Laura Cappelletti ◽  
Francesca Villa ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Leukocyte Count ◽  
Joint Infection ◽  
Roc Curves ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Prosthetic Joint ◽  
Synovial Fluids ◽  
Leukocyte Counts

Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified. Despite the important steps forward, identification of a gold standard has not yet been identified. In this study, usefulness of alpha defensin, leukocyte esterase, C-reactive protein (CRP), and white blood cells (WBCs) in synovial fluids alone and in combination for diagnosis of prosthetic joint infection was evaluated. Synovial fluids from 32 infected and 34 not infected patients were analyzed. Sensitivity, specificity, positive and negative predictive values, diagnostic accuracy, and receiver-operating characteristic (ROC) curves were calculated for each parameter. Moreover, combination of coupled variables was also evaluated by logistic regression analysis. Sensitivity of alpha defensin, CRP, leukocyte count, and leukocyte esterase were 84.4%, 87.5%, 93.7%, and 93.8%, respectively. Specificity was 91.2% for leukocyte counts, 94.1% for alpha defensin, 97.0% for CRP, and 97.1% for leukocyte esterase. Diagnostic accuracy was 89.4% for alpha defensin, 92.4% for WBC counts and CRP, and 95.5% for leukocyte esterase. No statistical differences were observed in area under the curve (AUC) of the ROC curves of alpha defensin, CRP, and leukocyte counts. Logistic regression analysis applied to a model comprising all the variables showed an AUC higher than AUC of coupled variables. In conclusion, results of this study confirm the high sensitivity and specificity of synovial leukocyte esterase for diagnosis of prosthetic joint infection, also suggesting the need to assess a panel of markers to optimize diagnosis of these infections.

Role of Leukocyte Count, Neutrophil Percentage, and C-Reactive Protein in the Diagnosis of Acute Appendicitis in the Elderly

2005 ◽  
Vol 71 (4) ◽  
pp. 344-347 ◽  
Author(s):  
Horng-Ren Yang ◽  
Yu-Chun Wang ◽  
Ping-Kuei Chung ◽  
Wei-Kung Chen ◽  
Long-Bin Jeng ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Leukocyte Count ◽  
Young Patients ◽  
The Elderly ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Neutrophil Percentage ◽  
Significant Difference ◽  
Leukocyte Counts

Leukocyte count, neutrophil percentage, and C-reactive protein (CRP) have been shown to give valuable information in the diagnosis of acute appendicitis. However, whether these laboratory tests have the same clinical applicability in the elderly as in young patients remains unclear. This retrospective study aimed to clarify the role of these tests in the diagnosis of acute appendicitis in patients aged 60 years or over. Eighty-five consecutive elderly patients underwent appendectomy for suspected acute appendicitis during a 30-month period. Histologically verified appendicitis was found in 77 of the 85 patients (90.6%). There was no significant difference in leukocyte counts or CRP values between patients with acute appendicitis and those with a normal appendix. The sensitivities of leukocyte count, neutrophil percentage, and CRP in the diagnosis of acute appendicitis were 71.4 per cent, 88.3 per cent, and 90 per cent, respectively, while the specificities were 37.5 per cent, 25 per cent, and 37.5 per cent, respectively. Of 77 patients with acute appendicitis, only two had all three tests simultaneously normal. In conclusion, patients with normal results in all three tests are highly unlikely to have acute appendicitis and should be evaluated with extra caution before surgery.

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