Study of serum lipase level in pregnant woman presenting with nausea and vomiting

Background: Hyperemesis gravidarum is a complex condition characterized by excessive nausea and vomiting during pregnancy. It presents with various symptoms which include disturbed nutrition, electrolyte imbalance, ketosis and extreme weight loss. The objective of this study is to compare serum lipase, amylase and glucose in Hyperemesis gravidarum with non-pregnant women. Materials and methods: A total of 100 subjects among which 50 were nonpregnant women as controls and 50 were women with hyperemesis gravidarum as cases were enrolled in the study. Serum lipase, amylase and glucose levels were estimated in all the subjects. Results: The levels of mean serum lipase were lesser in cases (23.55 ± 4.91U/L) compared to that in controls (25.45 ± 5.97U/L) with p=0.086. However, the levels of mean serum amylase were higher in cases (76.40 ± 33.86 U/L) compared to that in controls (69.66 ± 16.45U/L) with p= 0.210. Serum amylase activity was raised in 8% of the patients whereas the activity of pancreatic lipase was within normal range. Serum glucose levels were lower in cases (84.72 ± 11.28 mg/dl) than that in controls (87.04 ± 10.65 mg/dl) with p=0.293. Conclusions: From this study we conclude that lipase activity was statistically insignificant in hyperemesis gravidarum. Therefore, pancreatic activities were less affected by hyperemesis gravidarum. So, this condition needs further exploration regarding biochemical basis to minimize the risk associated with it.

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An Automated, Saccharogenic Method for Determining Serum Amylase Activity

Clinical Chemistry ◽

10.1093/clinchem/16.12.985 ◽

1970 ◽

Vol 16 (12) ◽

pp. 985-989 ◽

Cited By ~ 12

Author(s):

Wendell R O'Neal ◽

Nathan Gochman

Keyword(s):

Glucose Oxidase ◽

Blood Donors ◽

Serum Amylase ◽

Amylase Activity ◽

Serum Glucose ◽

Normal Range ◽

Reducing Substances ◽

Serum Amylase Activity

Abstract An automated adaptation of the Somogyi saccharogenic determination of serum amylase is described in which conventional AutoAnalyzer modules are used. Adequate sensitivity with short incubation is achieved by incorporating glucose oxidase and catalase in the substrate to destroy serum glucose during incubation. Maltose and other dialyzable oligosaccharides are measured with the alkaline copper-neocuproine reaction. A simultaneous blank run is performed to determine reducing substances other than glucose in serum. Precision studies and correlation with a manual saccharogenic method are presented. The normal range was determined from data for 49 healthy blood donors.

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Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum?

Case Reports in Obstetrics and Gynecology ◽

10.1155/2015/359239 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4

Author(s):

Amanda Johnson ◽

Bethany Cluskey ◽

Nina Hooshvar ◽

Daphne Tice ◽

Courtney Devin ◽

...

Keyword(s):

Acute Pancreatitis ◽

Biochemical Marker ◽

Hyperemesis Gravidarum ◽

Elevated Serum ◽

Clinical Findings ◽

Nausea And Vomiting ◽

Imaging Studies ◽

Severe Nausea ◽

Serum Lipase ◽

Severe Manifestation

Hyperemesis gravidarum is a severe manifestation of nausea and vomiting of pregnancy and it is associated with weight loss and metabolic abnormalities. It is known that abnormal laboratory values, including mildly elevated serum lipase level, could be associated with hyperemesis gravidarum. However, in this case report details of two women with hyperemesis gravidarum but with significantly elevated serum lipase levels were discussed. These patients presented with severe nausea and vomiting but without abdominal pain. They were found to have severely elevated lipase levels over 1,000 units/liter. In the absence of other findings of pancreatitis, they were treated with conservative measures for hyperemesis gravidarum, with eventual resolution to normal lipase levels. Although significantly elevated lipase level in pregnant patients with nausea and vomiting is a concern for acute pancreatitis, these two cases of significantly elevated serum lipase without other clinical findings of pancreatitis led to this report that serum lipase could be quite elevated in hyperemesis gravidarum and that it might not be an accurate biochemical marker for acute pancreatitis. Imaging studies are thus necessary to establish the diagnosis of acute pancreatitis.

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Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-0830-1346 ◽

2019 ◽

Vol 79 (04) ◽

pp. 382-388 ◽

Cited By ~ 6

Author(s):

Marlena Fejzo ◽

Peter Fasching ◽

Michael Schneider ◽

Judith Schwitulla ◽

Matthias Beckmann ◽

...

Keyword(s):

Hyperemesis Gravidarum ◽

Familial Aggregation ◽

Twin Studies ◽

Serum Levels ◽

Nausea And Vomiting ◽

Electrolyte Imbalance ◽

Significant Weight Loss ◽

Control Groups ◽

Severe Nausea ◽

In Pregnancy

Abstract Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity. Familial aggregation studies and twin studies suggest a genetic component. In a recent GWAS, we showed that placentation, appetite, and cachexia genes GDF15 and IGFBP7 are linked to hyperemesis gravidarum (HG). The purpose of this study is to determine whether GDF15 and IGFBP7 are upregulated in HG patients. Methods We compared serum levels of GDF15 and IGFBP7 at 12 and 24 weeksʼ gestation in women hospitalized for HG, and two control groups, women with nausea and vomiting of pregnancy (NVP), and women with no NVP. Results We show GDF15 and IGFBP7 serum levels are significantly increased in women with HG at 12 weeksʼ gestation. Serum levels of hCG are not significantly different between cases and controls. At 24 weeks gestation, when symptoms have largely resolved, there is no difference in GDF15 and IGFBP7 serum levels between cases and controls. Conclusion This study supports GDF15 and IGFBP7 in the pathogenesis of HG and may be useful for prediction and diagnosis. The GDF15-GFRAL brainstem-activated pathway was recently identified and therapies to treat conditions of abnormal appetite are under intense investigation. Based on our findings, HG should be included.

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Simplified Turbidimetric Assay for Lipase Activity

Clinical Chemistry ◽

10.1093/clinchem/17.12.1150 ◽

1971 ◽

Vol 17 (12) ◽

pp. 1150-1153 ◽

Cited By ~ 61

Author(s):

Zakariya K Shihabi ◽

Charles Bishop

Keyword(s):

Olive Oil ◽

Lipase Activity ◽

Convenient Method ◽

Serum Amylase ◽

Amylase Activity ◽

Serum Lipase ◽

Oil Emulsion ◽

Turbidimetric Assay ◽

Serum Amylase Activity

Abstract Serum lipase is determined by following turbidity changes during two 1-min intervals after adding serum to an olive oil emulsion containing desoxycholate. The olive oil emulsion is simply prepared and is stable for a month under refrigeration. Our observations confirm the findings of other investigators that increases in serum lipase activity are more accentuated than increases in serum amylase activity during pancreatitis. With the present fast and convenient method, serum lipase appears to be a better test for pancreatitis than is serum amylase.

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DIAGNOSIS AND MANAGEMENT OF NAUSEA AND VOMITING IN PREGNANCY

Fetal and Maternal Medicine Review ◽

10.1017/s0965539505001701 ◽

2006 ◽

Vol 17 (1) ◽

pp. 45-67 ◽

Cited By ~ 3

Author(s):

LAURA MAGEE ◽

ALON SHRIM ◽

GIDEON KOREN

Keyword(s):

Weight Loss ◽

Hyperemesis Gravidarum ◽

Wide Spectrum ◽

First Trimester ◽

The Other ◽

Nausea And Vomiting ◽

Electrolyte Imbalance ◽

The Common ◽

Moderate Nausea ◽

In Pregnancy

Nausea and vomiting of pregnancy (NVP) is a term used to describe a wide spectrum of symptoms. At one end of the spectrum is the common, mild to moderate nausea and vomiting that is usually limited to the first trimester. At the other end of the spectrum are the intractable, severe symptoms of hyperemesis gravidarum (HG) that is associated with weight loss, dehydration, electrolyte imbalance and hospitalisation.

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HIPEREMESIS GRAVIDARUM PADA IBU HAMIL DI KLINIK BIDAN SUPRIYATI SRIBIT BERBAH SLEMAN

Surya Medika: Jurnal Ilmiah Ilmu Keperawatan dan Ilmu Kesehatan Masyarakat ◽

10.32504/sm.v14i1.108 ◽

2019 ◽

Vol 14 (1) ◽

pp. 51

Author(s):

Pramukti Dian Setianingrum ◽

Farah Irmania Tsani

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Hyperemesis Gravidarum ◽

Unwanted Pregnancy ◽

The Body ◽

Nausea And Vomiting ◽

Daily Activities ◽

World Health ◽

The World

Backgroud: The World Health Organization (WHO) explained that the number of Hyperemesis Gravidarum cases reached 12.5% of the total number of pregnancies in the world and the results of the Demographic Survey conducted in 2007, stated that 26% of women with live births experienced complications. The results of the observations conducted at the Midwife Supriyati Clinic found that pregnant women with hyperemesis gravidarum, with a comparison of 10 pregnant women who examined their contents there were about 4 pregnant women who complained of excessive nausea and vomiting. Objective: to determine the hyperemesis Gravidarum of pregnant mother in clinic. Methods: This study used Qualitative research methods by using a case study approach (Case Study.) Result: The description of excessive nausea of vomiting in women with Hipermemsis Gravidarum is continuous nausea and vomiting more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the body weight decreases and interferes with daily activities days The factors that influence the occurrence of Hyperemesis Gravidarum are Hormonal, Diet, Unwanted Pregnancy, and psychology, primigravida does not affect the occurrence of Hyperemesis Gravidarum. Conclusion: Mothers who experience Hyperemesis Gravidarum feel nausea vomiting continuously more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the weight decreases and interferes with daily activities, it is because there are several factors, namely, hormonal actors, diet, unwanted pregnancy, and psychology.

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