scholarly journals Spectrum of Lesions in Urinary Bladder- A Histopathological Study

2018 ◽  
Vol 6 (2) ◽  
pp. 24-27 ◽  
Author(s):  
Anita Shah ◽  
Manglesh Srivastava ◽  
Ashok Samdurkar ◽  
Ghanshyam Sigdel
Keyword(s):  
Urinary Bladder ◽  
Early Stage ◽  
Granulomatous Inflammation ◽  
Urinary Bladder Cancer ◽  
Histopathological Study ◽  
Common Source ◽  
Institutional Review ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Urothelial Tumors

Introduction: The lesions of urinary bladder both non-neoplastic and neoplastic pose a common source of both morbidity and mortality. An accurate diagnosis of these lesions requires cystoscopy which allows a direct visualization of the bladder mucosa and biopsies of suspected lesions. Urinary bladder cancer is sixth most common cancer worldwide and represents a heterogeneous group of neoplasms. The current study aimed to study the different bladder lesions and its clinical features to detect it in early stage and as a mainstay option in the diagnosis and follow up.  Materials and methods: This was a retrospective analysis of biopsies of urinary bladder submitted to the department of pathology over a period of 12 months. The study was approved by the institutional review board of the Universal College of Medical Sciences (UCMS-TH). All the urinary bladder biopsies received in the department were included in the study whereas autolysis of specimen and inadequate biopsies were excluded.  Results: Among the 36 cases of urinary bladder lesions, the majority (35.36%) were in age group 61-70 years (22.33%). The patients had combination of lower urinary tract symptoms, the commonest being hematuria. 30.55%  had non-neoplastic lesions and 69.55% had neoplastic lesion. Among non- neoplastic cases, 5.55% had chronic granulomatous inflammation. Most common neoplastic lesions was infiltrating urothelial carcinoma (n=6) followed by non- invasive urothelial neoplasia (n=5).  Conclusion: A variety of lesions occur in urinary bladder and is commonly encountered by pathologist. Hematuria was commonest symptom and the clinicians investigated these patients further, which led to discovery of the urothelial tumors. Identification of these patients has an important impact on prognosis as well as on therapeutic approach.

Histopathological Study of Cystoscopic Bladder Biopsies in a Tertiary Care Center

2021 ◽  
Vol 6 (1) ◽  
pp. 1310-1314
Author(s):  
Rachana Dhakal ◽  
Hem Nath Joshi ◽  
Ramesh Makaju ◽  
Shailendra Sigdel
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Pathological Condition ◽  
Care Center ◽  
Tertiary Care ◽  
University Hospital ◽  
World Health ◽  
Histopathological Study ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

Introduction: Non-neoplastic urinary bladder lesions are not life threatening, but are an important source to cause clinical symptoms and signs. However, neoplasms of the bladder are a source of morbidity, mortality, and exhibit more clinical challenges. Cystoscopy provides overall information about an anatomical/pathological condition of the urinary bladder which will be helpful for patients' management. A cystoscopic biopsy is a primary diagnostic tool for diagnosing urinary bladder cancer. Objectives: The objective of the study was to find the frequency and histomorphological characteristics of urinary bladder lesions in Dhulikhel Hospital, to find the clinical presentation of urinary bladder lesions and to grade the urothelial tumors based on the World Health Organization (WHO)/ International Society of Urological Pathology (ISUP) classification 2004. Methodology: This was a retrospective, cross-sectional, observational study carried out in the Department of Pathology, Dhulikhel Hospital-Kathmandu University Hospital. Convenient sampling was done. All cystoscopy biopsies received from January 2014 to December 2018 were studied. All tissue blocks were retrieved, cut, and stained with Hematoxylin and Eosin. The stained slides were examined under a light microscope by the primary investigator. Result: A total of 70 cystoscopic biopsies were analyzed. The majority of patients 20 (28.6%) were in the age group between 60 and 69 years and males were predominant 43 (61.4%). The neoplastic lesions constituted 40 (57.1%) of all bladder lesions, among them urothelial carcinoma accounted for 38 (54.2%). Similarly, chronic cystitis 27(38.6%) was the most common non-neoplastic lesion. Conclusion: The study found that the neoplastic lesions were commonly encountered in urinary bladder lesions. Among them, lowgrade urothelial carcinoma was the most common bladder tumor. However, most of the non-neoplastic lesions were inflammatory in origin. Cystoscopy combined with histomorphological examination helps in the early detection of bladder lesions. 

CLINICOPATHOLOGICAL STUDY OF GASTRIC BIOPSIES

2021 ◽  
pp. 38-40
Author(s):  
Manu Jethalya ◽  
Saurabh Totla
Keyword(s):  
Clinical Presentation ◽  
Early Stage ◽  
Gastric Biopsy ◽  
Histopathological Study ◽  
Age Group ◽  
Malignant Tumours ◽  
Early Management ◽  
Medical College ◽  
Neoplastic Lesions ◽  
Gastric Biopsies

Background: Stomach is an important site for variety of lesions especially malignant tumours. Gastric biopsies along with clinical prole of cases play an important role in the diagnosis of gastric neoplasm and therefore aids in early management. Aim and Objectives: To study the histopathology of Gastric biopsies and correlate them with clinical presentation, age, sex and to differentiate them between neoplastic and non neoplastic lesions. Materials and Methods: The prospective study was done in the Department of Pathology Geetanjali Medical College and Hospital, Udaipur between 1stJanuary 2019 to 30thJune 2020. A total of 83 gastric biopsies were included in the study and were analyzed along with their clinical proles. Results: A total of 83 gastric biopsies were included in the study. Most commonly affected age group was 50-69 years with 41 patients (49.40%) followed by 40-49 years with 14(16.87%). Out of 83 cases, 58 (69.88%) were males & 25 (30.12%) were females, 26 (31.33%) cases were non neoplastic & 57 (68.67%) cases were neoplastic.Conclusion: The gastric biopsy not only permits exact diagnosis of specic entity but also helps to plan for early medical or surgical therapy. The histopathological study detects mucosal lesions at an early stage especially atrophy, metaplasia and dysplasia as to prevent progress of these lesions to invasive cancer.

scholarly journals Histopathological study of cystoscopic bladder biopsies

2015 ◽  
Vol 5 (9) ◽  
pp. 717-719
Author(s):  
R Baidya ◽  
B Sigdel ◽  
NL Baidhya
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Developed Countries ◽  
Histopathological Study ◽  
Low Grade ◽  
Neoplastic Lesions ◽  
Clinical Signs And Symptoms ◽  
Hematoxylin And Eosin Stain

Background: Urinary bladder diseases constitute an important source of clinical signs and symptoms which are more disabling than lethal. The prevalence of bladder tumor in developed countries is approximately six times higher compared with that in developing countries. The aim of this study was to find out various lesions in urinary bladder biopsies and its frequencies.Materials and Methods: This was a five year retrospective study from January 2008 to December 2013, carried out at B&B Hospital, Lalitpur. All the relevant data of 324 patients who had undergone cystoscopic biopsy of urinary bladder were included in the study. All blocks were retrieved and stained with Hematoxylin and Eosin stain and examined under light microscope.Results: The spectrum of pathological lesions included inflammations and tumors. Non-neoplastic lesions were predominant (61.11%) followed by Transitional cell tumors accounted for 124 cases (38.27%). Non-neoplastic lesions comprises of cystitis and tuberculosis. Papillary urothelial neoplasms was the most common tumors seen in this study with 55 low grade, and 54 high grade Papillary urothelial carcinoma according to recent WHO grading. Single cases each of adenocarcinoma and paraganglioma were diagnosed.Conclusion: Cystoscopic biopsies help in the early diagnosis and treatment of various bladder lesions. Analysis of cystoscopic biopsies was done to ascertain the type of urinary bladder lesions in our country.Journal of Pathology of Nepal (2015) Vol. 5, 717-719

scholarly journals Histopathological Study of Lower Gastrointestinal Tract Biopsies in 600 Cases

2021 ◽  
Author(s):  
Jasmin Haridas Jasani ◽  
Shivani Bhaveshbhai Vora ◽  
Nidhi Amrutlal Patel
Keyword(s):  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Large Intestine ◽  
Histopathological Examination ◽  
Microscopic Analysis ◽  
Histopathological Study ◽  
Lower Gastrointestinal Tract ◽  
Delay In Diagnosis ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

Introduction: Broadly the whole gastrointestinal tract can be divided into upper and lower segments by taking the insertion of ligament of Treitz as a landmark. The disorders of Lower Gastrointestinal Tract (LGIT) are responsible for a great number of morbidity. The microscopic analysis and the determination of histological types are thus helpful in deciding treatment options, predicting prognosis and conducting epidemiological studies and research. Delay in diagnosis causes direct as well as distant metastasis leading to advanced stage of the disease. Aim: To emphasise the usefulness of LGIT biopsy in diagnosing the conditions, thus helping the surgeons to decide further management prior to resection, especially in malignant cases. Materials and Methods: An observational retrospective study of various LGIT biopsies sent for Histopathological Examination (HPE) at Pathology department of Sumandeep Vidyapeeth, Vadodara, Gujarat, India was carried out. The study was based on the HPE of lesions received in the duration from June 2019 to September 2020. In this study, the records of LGIT specimens including small intestine, large intestine, rectum and anus were included. Due importance was paid to brief clinical history with patient’s age, inpatient number and presenting signs and symptoms. A total of 600 specimens were analysed. Results: Non-neoplastic lesions were more common than neoplastic lesions cases out of the total 600 cases. Lesions were more common in 2nd to 5th decades with male preponderance. Among non-neoplastic lesions, majority of non-neoplastic lesion were of appendiceal lesion (247) followed by non-specific inflammation (138). Out of 30 neoplastic lesions; most common were of adenocarcinoma (15 cases). Conclusion: A wide variety of neoplastic and non-neoplastic lesions were diagnosed in the present study. In small intestine, non-neoplastic lesions were common while most of the malignant lesions were common in large intestine. The most common non-neoplastic lesion was appendicitis followed by non-specific inflammation and the most common neoplastic lesion was adenocarcinoma.

scholarly journals Histopathological Study of Endoscopic Biopsies

1970 ◽  
Vol 52 (190) ◽  
Author(s):  
Rupendra Thapa ◽  
Mamta Lakhey ◽  
Pradeep Kumar Yadav ◽  
Prakash Kandel ◽  
Choodamani Aryal ◽  
...  
Keyword(s):  
Chronic Gastritis ◽  
Histopathological Study ◽  
Chronic Active Gastritis ◽  
Endoscopic Biopsies ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Gastric Biopsies ◽  
H Pylori ◽  
One Year ◽  
Upper Gastrointestinal

Introduction: Diseases of upper gastrointestinal tract are responsible for a great deal of morbidity and mortality. The histopathological study of endoscopic biopsies permits exact diagnosis for further management.The aim of this study is to find out the histopathological pattern of endoscopic biopsy.Methods: A descriptive study was conducted in consecutive endoscopic gastric biopsies in a Hospital over a period of one year. The patient of all ages and both sexes who underwent gastric biopsy during the study period was included.Results: Endoscopic biopsies were studied on patients of age ranging from 20 years female to 84 years male. The histopathology revealed non-neoplastic lesions 54 (67.5%) and neoplastic lesions 26 (32.5%). Most common non-neoplastic lesion noted was mild chronic gastritis 22(27.5%) followed by chronic active gastritis 15 (18.75%) while H. pylori was present in 13 (16.25%) and absent in 2 (2.5%).Conclusions: Mild chronic gastritis was the commonest lesion noted in non-neoplastic lesions and adenocarcinoma was the commonest neoplastic lesion in the endoscopic gastric biopsies.______________________________________________________________________________________Keywords: biopsy; endoscopy; gastritis; histopathological.

scholarly journals Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis

2019 ◽  
Vol 28 (1) ◽  
pp. 4-12
Author(s):  
Suvradeep Mitra ◽  
Pavithra Ayyanar ◽  
Gurwinder Kaur
Keyword(s):  
Urinary Bladder ◽  
Villous Adenoma ◽  
Gastrointestinal Endoscopy ◽  
Diagnostic Challenge ◽  
Bladder Biopsy ◽  
Lineage Differentiation ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
A Minor ◽  
Rule Out

Villous morphology in urinary bladder biopsy is a relatively uncommon finding. Villi are slender, finger-like structures that are commonly seen in the small intestine or in neoplastic lesions of gastrointestinal lineage/differentiation. Importantly, placenta also exhibits villi that are morphologically and functionally different from the intestinal one. Majority of the neoplastic lesions of urinary bladder are urothelial in origin with a minor subset showing glandular differentiation. While the presence of benign villi in urinary bladder biopsy necessitates a search for an occult perforation, provided a sample mismatch is ruled out, cytoarchitecturally abnormal/dysplastic villi indicate a neoplastic lesion of the urinary bladder encompassing villous adenoma and adenocarcinoma and urothelial carcinoma with villoglandular differentiation. The dysplastic villi in urinary bladder also imply a lower gastrointestinal endoscopy to rule out a colorectal primary. The development of the villous lesions in the urinary bladder and the colorectum are embryologically related and pose a major diagnostic challenge to the clinicians and surgical pathologists due to identical histomorphology and immunohistochemistry. We tend to discuss the morphological differentials and diagnostic approach to the villous lesions in the urinary bladder biopsy.

scholarly journals Skin and Soft Tissue Lesions in a District Hospital in Central Nigeria: A Histopathological Study

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Babatunde M. Duduyemi ◽  
Abidemi E. Omonisi ◽  
Nicholas A. Titiloye
Keyword(s):  
Soft Tissue ◽  
Secondary Data ◽  
The Body ◽  
Histopathological Study ◽  
Cross Sectional ◽  
Inflammatory Lesions ◽  
Soft Tissue Lesions ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Tissue Specimens

Introduction. Skin and soft tissue diseases form a large and heterogeneous group of mesenchymal extraskeletal and dermatologic lesions in humans. Diseases of the skin and soft tissue can develop virtually anywhere in the body, extremities, the trunk, the retroperitoneum, the head, and the neck. Our study aims to review skin and soft tissue specimens from our centre describing the histopathological patterns. Method. A cross sectional study was done using secondary data of all skin and soft tissue specimens over a 3 year period. Patients’ demographics, sites of specimen, and histological diagnoses were extracted from the surgical day book. The data were analysed in terms of age and sex distribution and histological characteristics of pathologic lesions using the SPSS version 22. The data for these patients were presented in tables and figures. Result. 451 skin and soft tissue specimens constituting 18% of all the specimens with an M : F ratio of 1 : 1.2. The age range of our patients was 4–85 years with a mean of 33.52 ± 15.05 years. The peak age of occurrence was 30–39 years. Most of our cases were seen in the extremities (50.7%) followed by head (22.2%), while the least common sites were the perineal and neck areas (5.3% each). The commonest site in females was the upper limb (32.4%); the head and lower limb were the commonest sites in males (28.4% each). Most of our patients have neoplastic lesions of skin and soft tissue constituting 68.3%, inflammatory lesions (16.9%), and the least common lesion being hamartoma (0.2%). The most common category of lesions includes inflammatory (nonspecific dermatitis 6.5%); cysts (dermoid cyst 6%); reactive (hypertrophic scar 1%); and neoplastic (lipoma 32.4%). The benign neoplasms were more common (92.9%) than the malignant ones (7.1%). The neoplastic lesions were relatively more common in males than females and the reverse was true for the inflammatory lesions. Conclusion. Skin and soft tissue lesions are relatively common in our environment with majority being benign neoplastic lesion.

scholarly journals Spectrum of Urothelial lesions in Cystoscopic biopsies: A Histopathological Perspective

2018 ◽  
Vol 7 (1) ◽  
pp. 6-10
Author(s):  
Nirajan Mainali ◽  
Prabesh Chaudhary ◽  
Niraj Nepal ◽  
Jit Shrestha
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Low Grade ◽  
Medical College ◽  
Common Diagnosis ◽  
Neoplastic Lesions ◽  
Urothelial Tumors ◽  
Age Range ◽  
Age And Sex

 Background: Urinary Bladder lesions are one of the most common presenting lesions in the Outpatient department. On the other hand neoplastic conditions of the urinary bladder are the major cause of morbidity and mortality. Bladder carcinoma is the 7th most common carcinoma worldwide and is the major cause of morbidity and mortality.Material & Methods: All the cystoscopic biopsy received in the Department of Pathology at Nobel medical college and teaching hospital from August 1st 2016 to July 31st 2017 was included in the study. Received cystoscopic biopsies were processed and classified as per 2004 WHO/ISUP classification of urothelial tumors Patients were also categorized according to the age and sex to find out the prevalence of urothelial lesions on them.Results: Out of the 78 patients 54 were males and 24 were females. Very few (n=15, 19.23%) cases of non neoplastic lesions were biopsied. Low grade urothelial carcinoma was the most common diagnosis in the patients which accounts for 49.2 % (n=31) of the total neoplastic conditions.Conclusion: Low grade urothelial carcinoma was the most common lesion encountered with the peak age range of 61-70 years.Journal of Nobel Medical College Volume 7, Number 1, Issue 12, January-June 2018, Page: 6-10

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