scholarly journals Prevalence of multidrug resistant bacteria in causing community acquired urinary tract infection among the patients attending outpatient department of Seti Zonal Hospital, Dhangadi, Nepal

2015 ◽  
Vol 3 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Tek Raj Awasthi ◽  
Narayan Dutt Pant ◽  
Puspa Raj Dahal
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Past History ◽  
Multidrug Resistant ◽  
Outpatient Department ◽  
Public Health Issue ◽  
Resistant Bacteria ◽  
Biochemical Tests ◽  
Multidrug Resistant Bacteria

Involvement of multidrug resistant bacteria in causing community acquired infection is very serious public health issue. The main objective of our study was to determine the prevalence of multidrug resistant bacteria in causing community acquired urinary tract infection. In this study we cultured the 384 mid stream urine samples collected aseptically from the patients attending outpatient department of Seti zonal hospital and having no past history of hospitalization. The organisms isolated were identified by using conventional biochemical tests and antimicrobial susceptibility testing was performed by Kirby Bauer disc diffusion technique. Out of total 384 samples 98 (25.52%) samples showed significant bacterial growth. The most prevalent bacterium isolated was Escherichia coli. 42.86% of the bacteria isolated were found to be multidrug resistant (MDR). The involvement of such large numbers of multidrug resistant bacteria in causing community acquired urinary tract infection is very serious issue and cannot be neglected. And some abrupt initiatives should be taken by the responsible authorities to improve or at least avoid the further worsening of the situation.Nepal Journal of Biotechnology. Dec. 2015 Vol. 3, No. 1: 55-59

scholarly journals Trimethoprim - Sulfamethoxazole in Combination With Meropenem Orpolymyxin is Effective in Management of Acinetobacter Baumannii Associated Pneumonia and Urinary Tract Infection

2020 ◽  
Vol 5 (1) ◽  
pp. 990-994
Author(s):  
Niraj Kumar Keyal ◽  
Niru Nepal ◽  
Amid Bhujel
Keyword(s):  
Intensive Care Unit ◽  
Urinary Tract Infection ◽  
Antibiotic Resistance ◽  
Intensive Care ◽  
Urinary Tract ◽  
Tract Infection ◽  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria

Acinetobacter baumanniiis a common multidrug resistant bacteria that causes pneumonia and urinary tract infection in intensive care unit and requires dual antibiotic for effective management. There are limited expensive antibiotics that are active against. Acinetobacter baumannii. Trimethoprim - Sulfamethoxazole is a cheap, older and easily available antibiotic that can be used in combination with Meropenem or Polymyxin for treatment to decrease antibiotic resistance. This case presentation of three patients describes the successful treatment of hospital acquired Pneumonia and Urinary Tract Infection by Acinetobacter baumannii with Trimethoprim - Sulfamethoxazole in combination with Meropenem and Polymyxin that lead avoidance of costly drugs and decrease in antibiotic resistance. Antibiotic resistance and lack of newer effective antibiotic against multidrug resistant bacteria like Acinetobacter baumannii is a common problem in intensive care unit. Trimethoprim -Sulfamethoxazole may help in combating this problem.

scholarly journals Urinary Tract Infection Associated with Multidrug-Resistant Bacteria in a Second level Hospital During a Two Year Period

2018 ◽  
Vol 3 (4) ◽  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Mortality Rate ◽  
Tract Infection ◽  
Chronic Renal Disease ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Klebsiella Pneumonia ◽  
Bacteria Growth ◽  
Tract Infections

Objective: determine the frequency of urinary tract infections associated with MDR bacteria, characteristics patients with such infections and the mortality rate associated in Hospital ISSSTECALI during 2015-2016. Design: Descriptive, observational, analytic, transversal Methods: We collected data from clinical files of each patient that had been diagnosed with a urinary tract infection and had an uroculture of 10x105 CFU of bacteria with a multidrug-resistant profile. It included, gender, age, comorbidities, predisposing risk factors, obtained isolation, sensibility pattern, days of stay and proper technique of culture. We calculated frequencies and rates. Results: During January 2015- November 2016 a total of 2401 urocultures were solicited, we isolated bacteria in 123 of them (5.12%). 94 urocultures were included, 71% of the cultures were from women with a median age of 68.14 years; comorbidities: Hypertension (50%), diabetes (41.5%), chronic renal disease (14.9%), history of stroke and bed-rest. An average of 14.15 days of stay was calculated. They all had a urinary catheter. Of the total of urocultures obtained, 54 urocultures demonstrated bacteria growth with a MDR phenotype (attack rate: 0.43 cases/1000 discharges) Escherichia coli was isolated in 26 (48.14%) cultures; Pseudomona aeruginosa 7.4%; and Klebsiella pneumonia 5.5%; its mechanism of resistance was calculated according to the reported phenotype on the antimicrobiogram, demonstrating resistance to more than two family of antibiotics. A mortality rate of 21.3% was calculated of which the direct cause was related to the infective process (rate: 0.23 deaths/1000 discharges). Conclusion: the isolation of bacteria with a multidrug-resistant profile is not very common; however, they generate a high morbimortality index and a great weight in resources to our unit. Recommendations: reinforcement of programs that encourage rational use of antibiotics as well as the control of nosocomial infections should be employed in the hospital.

scholarly journals Isolation and Characterization of Multidrug Resistant Enterobacteriaceae in Urine Sample of Patients Suffering from Urinary Tract Infection with Diabetes and Nephropathy

2021 ◽  
Vol 20 (1) ◽  
pp. 87-93
Author(s):  
Nazmul Ahsan ◽  
Monzilur Rahman ◽  
Md Nazrul Islam ◽  
Anwarul Azim Akhand
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Diabetic Patients ◽  
Isolation And Characterization ◽  
Alternative Drug ◽  
Enterobacter Asburiae

Multidrug-resistant (MDR) organisms are spreading widely and becoming an issue of utmost importance to deal with. In the current study, ten urine samples from diabetic patients suffering from multiple complications, including urinary tract infection (UTI) and nephropathy were investigated. Antibiogram assays of the bacterial isolates from collected samples demonstrated resistance against most of the antibiotics tested. Further studies were conducted to determine the types of resistant bacteria that caused UTI. Analyzing the 16S rDNA sequence and phylogenetic tree, 3 isolates were identified as Escherichia coli, 5 as Klebsiella pneumoniae and the rest 2 as Enterobacter asburiae. The findings of this research indicate the necessity of urgent attention to find an effective alternative drug for treating infections caused by these resistant isolates. Dhaka Univ. J. Pharm. Sci. 20(1): 87-93, 2021 (June)

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