scholarly journals Evaluation the prevalence of moderate chronic periodontitis among smokers and non- smokers in Aljouf province , Kingdom Of Saudi Arabia

2018 ◽  
Vol 2 (3) ◽  
pp. 145 ◽  
Author(s):  
Ahmed Shawkat Hashem ◽  
Hesham Shokry Ismail ◽  
Santosh R Patil ◽  
Mohammad Khursheed Alam
Keyword(s):  
Chronic Periodontitis ◽  
Limited Data ◽  
Significant Relation ◽  
Kingdom Of Saudi Arabia ◽  
Chi Square ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Chi Square Test ◽  
Special Examination ◽  
Attachment Level

Background: Due to limited data about the prevalence of the moderate chronic periodontitis among smokers and non- smokers in Saudi population this study was conducted.Methods: For each participant, full mouth periodontal examination was performed and recorded on a special examination form by one of the 3 examiners. These data included probing depth (PD), clinical attachment level (CAL). The Data was collected and entered into the personal computer. Statistical analysis was done using Statistical Package for Social Sciences (SPSS/version 21) software. Number and percent of each category were calculated, for categorized parameters, chi square test was used. The level of significant was 0.05.Results: On comparison the prevalence of moderate chronic periodontitis among the smoker and non- smoker groups, chi square test was 9.114, with ( p< 0.05) which is statistically significant, while on comparison the age between the two groups, it was found that there was no significant relation between the age and the different grade of chronic periodontitis.Conclusion: Moderate Chronic Periodontitis is more prevalent among smokers in Aljouf province, Kingdom of Saudi Arabia.International Journal of Human and Health Sciences Vol. 02 No. 03 July’18. Page : 145-148

scholarly journals Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

2021 ◽  
Author(s):  
Andreas Grigoriadis ◽  
Symela Koutounidou ◽  
Ismo Räisänen ◽  
Minas Arsenakis ◽  
Dimitra Sakellari
Keyword(s):  
Chi Square ◽  
Clinical Attachment Level ◽  
Exact Test ◽  
Dental Patients ◽  
Genotype Frequencies ◽  
Probing Depth ◽  
Chi Square Test ◽  
Attachment Level ◽  
Tcf7l2 Rs7903146 ◽  
Hba1c Levels

Abstract Objective The aim of the study was to investigate the potential interaction between TCF7L2 rs7903146 genotype, which is implicated for type-2 diabetes mellitus genetic susceptibility, HbA1c levels, and the periodontal status of dental patients. Materials and Methods HbA1c levels, clinical periodontal parameters (probing depth, clinical attachment level, bleeding on probing, and plaque index), and several parameters (such as body mass index [BMI], smoking habits, education level, and age) were recorded in 150 patients who fulfilled the criteria for screening for prediabetes/diabetes of the Centers for Disease Control and Prevention. DNA was extracted and the TCF7L2 single nucleotide polymorphism (SNP) rs7903146 was genotyped in all participants. Results Thirty-one patients out of 150 tested were found with unknown hyperglycemia (20.7%). Regarding sex, education, parent with diabetes, normal BMI, smoking, age ≥45 years and prior testing for diabetes, no differences were observed between patients displaying HbA1c < 5.7 and ≥ 5.7% (Pearson’s Chi-square test, p > 0.05). Regarding periodontal parameters and differences between subgroups (HbA1c levels ≥ 5.7 and HbA1c levels < 5.7), statistically significant differences were observed for probing depth (3.20 ± 0.94 vs. 2.81 ± 0.78 mm), clinical attachment level (3.54 ± 1.20 vs. 3.18 ± 1.06 mm) and bleeding on probing (0.62 ± 0.25 vs. 0.50 ± 0.24%) with hyperglycemic patients exhibiting worse periodontal conditions (Mann–Whitney test p < 0.05). The allelic and genotype frequencies for the transcription factor 7-like 2 (TCF7L2) gene, SNPs 7903146 did not exhibit a significant difference between the HbA1c > 5.7 and HbA1c < 5.7 groups and the periodontitis and nonperiodontitis subgroups respectively (Fisher’s exact test >0.05). Statistical Analysis Patient characteristics and their association with prediabetes were tested by Pearson’s Chi-square test (asymptotic, two sided). Differences of periodontal parameters between subgroups were tested with the Mann–Whitney U-test. The associations of allele and genotype frequencies in the patient and control groups were analyzed using the Fisher’s exact test of independence.The significance level was set at the 0.05 for all tests. Conclusion A statistically significant association between TCF7L2 rs7903146 genotype and periodontal condition or HbA1c levels was not observed in contrast to statistically significant differences of clinical parameters of periodontitis in patients with hyperglycemia.

scholarly journals Transmission of Aggregatibacter actinomycetemcomitans between Brazilian women with severe chronic periodontitis and their children

2007 ◽  
Vol 18 (3) ◽  
pp. 220-224 ◽  
Author(s):  
Rodrigo Otávio Citó César Rêgo ◽  
Denise Madalena Palomari Spolidorio ◽  
Sérgio Luiz de Souza Salvador ◽  
Joni Augusto Cirelli
Keyword(s):  
Chronic Periodontitis ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Selective Medium ◽  
Child Transmission ◽  
Clinical Attachment Level ◽  
Gram Staining ◽  
Probing Depth ◽  
Polymerase Chain ◽  
Attachment Level ◽  
Transport Fluid

This study evaluated the transmission of Aggregatibacter actinomycetemcomitans (Aa) in women with severe chronic periodontitis and their children. Thirty women (mean age = 36.1±6.0 years) who were mothers of at least one child aged 7 to 16 years were enrolled. In order to investigate mother-child transmission of Aa, the children were also evaluated when their mothers were colonized by the bacterium. Subgingival plaque samples of each woman were collected from 3 sites (mean probing depth of 7.3±1.2 mm and mean clinical attachment level of 7.9±1.5 mm) and pooled in reduced transport fluid (RTF). These samples were processed, inoculated onto TSBV-agar selective medium and incubated at 37°C in microaerophilic atmosphere for 5 days. Aa was identified on the basis of colony morphology, Gram staining, catalase and oxidase reactions. Aa was found in 8 out of 30 women. Therefore, 8 children from these women (mean age= 12 ± 3.7 years) were evaluated, but Aa was found only in 2 of them. Aa strains of the two mother-child pairs were evaluated by arbitrarily-primed polymerase chain reaction (AP-PCR), although it was not found similarity between the amplitypes of each pair. No Aa transmission was found between Brazilian women with severe chronic periodontitis and their children.

Quantitative Evaluation of Porphyromonas gingivalis in Indian Subjects With Chronic Periodontitis by Real-Time Polymerase Chain Reaction

2019 ◽  
Vol 10 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Manohar S. Kugaji ◽  
Uday M. Muddapur ◽  
Kishore G. Bhat ◽  
Vinayak M. Joshi ◽  
Vijay M. Kumbar ◽  
...  
Keyword(s):  
Real Time ◽  
Porphyromonas Gingivalis ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Microbiological Analysis ◽  
Rt Pcr ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Significant Difference ◽  
Attachment Level

Background and Aims: Porphyromonas gingivalis ( P. gingivalis) is considered as an important pathogen responsible for periodontal disease which is characterized by inflammation of gingiva and destruction of periodontal ligament and alveolar bone leading to loss of tooth. Along with clinical investigations, suitable microbiological analysis needs to be performed which could provide more insight into the disease severity. We aim to quantify P. gingivalis by real-time PCR (RT-PCR) and analyze its association with demographic data including clinical parameters. Materials and Methods: The study consisted of chronic periodontitis patients (CP group) and healthy subjects (H group) with 120 samples in each group. RT-PCR was carried out by the SYBR Green assay to target 16S ribosomal ribonucleic acid species-specific region of P. gingivalis. Standard strain of P. gingivalis ATCC 33277 was used as a control. Results: In the CP group, 79.16% samples were found positive for P. gingivalis, whereas 29.17% samples were positive in the H group. A significant difference was found when the prevalence was compared within males and females ( P < .001 for both). In the older age groups, we found a higher rate of detection of P. gingivalis. As analyzed by Spearman’s correlation test, the number of cells of P. gingivalis was significantly associated with probing depth ( P = .02) and clinical attachment level ( P = .01) in the CP group. The mean cell number of P. gingivalis was found to be increasing with increasing levels of probing depth and clinical attachment level ( P < .001 and P = .01, respectively). Conclusion: The present study reaffirms that the P. gingivalis microbe is significantly associated with the chronic periodontitis and that its level varies with the severity of the disease. Colonization of the bacterium is significantly associated with severe forms of the disease.

scholarly journals Clinical Assessment of Drug Adjunctive Therapy Effects in Association with Chronic Generalized Periodontitis and Osteoporotic Disease

2015 ◽  
Vol 19 (3) ◽  
pp. 158-162
Author(s):  
Irina-Georgeta Ursarescu ◽  
Liliana Pasarin ◽  
Sorina Solomon ◽  
Alexandra Martu ◽  
Silvia Martu
Keyword(s):  
Chronic Periodontitis ◽  
Adjunctive Therapy ◽  
Control Group ◽  
Study Group ◽  
Clinical Effects ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Periodontal Debridement ◽  
Significant Clinical Improvement ◽  
Attachment Level

SummaryAim: The present study proposes an assessment of the clinical effects on periodontal level generated by the adjunctive periodontal therapy with sub-antimicrobial doses of doxycycline in patients with chronic periodontitis and osteoporosis.Materials and Methods: The study group comprised 26 patients with chronic periodontitis and osteoporosis, divided in the study group (classical periodontal debridement and sub-antimicrobial doses of doxycycline for 3 months) and the control group (classical debridement only). We analyzed the periodontal parameters (probing depth, clinical attachment level, PBI and PI indices) at baseline, in the last day of medication and at 3 months after the drug therapy.Results and Discussion: The reduction of the moderate and profound pockets was higher for the group with drug adjunctive therapy. The sites with an initial depth of 0-3mm in the study group presented also a slight attachment gain.Conclusions: The therapy with sub-antimicrobial doses of doxycycline generated significant clinical improvement in patients with chronic periodontitis and osteoporosis, an improvement which can reduce the necessity of surgical procedures.

scholarly journals Increased Levels of 8-Hydroxydeoxyguanosine and Malondialdehyde and its Relationship with Antioxidant Enzymes in Saliva of Periodontitis Patients

2009 ◽  
Vol 03 (02) ◽  
pp. 100-106 ◽  
Author(s):  
Cenk Fatih Canakci ◽  
Yasin Cicek ◽  
Abdulkadir Yildirim ◽  
Ufuk Sezer ◽  
Varol Canakci
Keyword(s):  
Antioxidant Enzymes ◽  
Chronic Periodontitis ◽  
Antioxidant Activities ◽  
Clinical Attachment Level ◽  
Periodontal Inflammation ◽  
Probing Depth ◽  
Whole Saliva ◽  
Healthy Control ◽  
The Relationship ◽  
Attachment Level

ABSTRACTObjectives: The aim of this study was to evaluate 8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in whole saliva of patients with chronic periodontitis. Moreover, the relationship among the oxidative damage biomarkers, antioxidant enzymes activities and clinical periodontal status were investigated.Methods: Whole saliva samples were collected from 30 patients with chronic periodontitis and 30 periodontally healthy control. To determine the clinical condition of each subject, the plaque index, gingival index, clinical attachment level, and probing depth were measured. The salivary 8-OHdG level was measured using the ELISA method. SOD and GPx activities and MDA levels were determined spectrophotometrically.Results: Higher salivary 8-OHdG and MDA levels (P<.001), and lower salivary SOD and GPx activities (P<.05) were detected in periodontitis patients compared to the healthy controls. Additionally, there were significantnegative correlations between salivary levels of 8-OHdG and both salivary SOD and GPx activities as well as between salivary levels of MDA and both salivary SOD and GPx activities (P<.001).Conclusions: Higher salivary 8-OHdG and MDA levels and lower salivary antioxidant activities seem to reflect increased oxygen radical activity during periodontal inflammation. (Eur J Dent 2009;3:100- 106)

scholarly journals Chronic Periodontal Disease May Influence the Pulp Sensitivity Response: Clinical Evaluation in Consecutive Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Elizangela Partata Zuza ◽  
Ana Luiza Vanzato Carrareto ◽  
Ana Emília Farias Pontes ◽  
Marcelo Brunozzi ◽  
Juliana Rico Pires ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Clinical Response ◽  
Test Data ◽  
Chronic Periodontitis ◽  
Gingival Recession ◽  
Clinical Attachment Level ◽  
Single Root ◽  
Probing Depth ◽  
Chronic Periodontal Disease ◽  
Attachment Level

Purpose. The aim of the present study was to evaluate the clinical response of the pulp in teeth with chronic periodontitis. Methods. Consecutive patients who had been admitted to the Clinics of Periodontology and fulfilled the criteria of inclusion were enrolled from January to December 2007. Ninety-eight single-root teeth from 27 patients with chronic periodontitis were evaluated clinically with regard to clinical attachment level (CAL), probing depth (PD), and gingival recession (REC). After periodontal measurements, Pulpal Sensitivity (PS) was evaluated with the use of a cooling stimulus test. Data was analyzed with Student’s t test and contingency C coefficient. Results. Teeth that responded positively to PS test presented lower values of CAL (7.8 ± 2.8 mm), PD (5.0 ± 2.3 mm), and REC (2.8 ± 1.8 mm) in comparison to those that responded negatively (CAL = 12.0 ± 2.2 mm; PD = 7.9 ± 1.6 mm; REC = 4.1 ± 2.4 mm) (P<0.01, Student’s t test). In addition, significant correlations were observed between PS and periodontal parameters. Conclusions. Within the limits of this study, it could be suggested that the progression of periodontitis may significantly influence the negative pulpal response.

Analysis of IL-10 in HIV-1 patients with chronic periodontitis in northern Brazil

2017 ◽  
Vol 16 ◽  
pp. 1-9
Author(s):  
Silvio Augusto Fernandes de Menezes ◽  
Tatiany Oliveira de Alencar Menezes ◽  
Tânia Maria de Souza Rodrigues ◽  
Brenna Magdalena Lima Nogueira ◽  
Ricardo Roberto de Souza Fonseca
Keyword(s):  
Viral Load ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Northern Brazil ◽  
Crevicular Fluid ◽  
Attachment Level ◽  
Hiv 1

Aim: The objective of this study was to investigate the levels of IL-10 in the gingival crevicular fluid in HIV-1 positive patients with chronic periodontitis and to compare with HIV-1 negative patients with chronic periodontitis, also to correlate clinical periodontal parameters, viral load and count of CD4+ and CD8+ lymphocytes (LTCD4+ and LTCD8+). Methods: 33 patients were selected and splitted into two groups: 16 HIV-1 positive patients and 17 HIV-1 negative patients and all with chronic periodontitis. The clinical periodontal parameters recorded were: Probing Depth (PD) and Clinical Attachment Level (CAL); the sistemical parameters LTCD4+, LTCD8+ and viral load were analized by the gingival crevicular fluid collected from all patients. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentrations of Interleukin (IL)-10. For the statistical analysis the Student t, Mann-Whitney and Spearman tests were performed. IL-10 levels were significantly lower in both patients groups. Results: There was statistical difference betwen groups for probing depth (p=0.015) and clinical attachment level (p=0.011), no significant correlation was found among the analyzed variables. Conclusion: The IL-10 levels in HIV-1 positive patients had no influence in periodontal and medical parameters.

scholarly journals A 12-month randomized controlled trial evaluating erythritol air-polishing versus curette/ultrasonic debridement of mandibular furcations in supportive periodontal therapy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ingvild M. Ulvik ◽  
Terje Sæthre ◽  
Dagmar F. Bunæs ◽  
Stein Atle Lie ◽  
Morten Enersen ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Clinical Attachment Level ◽  
Treatment Difference ◽  
Randomized Controlled ◽  
Air Polishing ◽  
Probing Depth ◽  
Furcation Defects ◽  
Supportive Periodontal Therapy ◽  
Attachment Level

Abstract Background Due to complex morphology and limited access, the cleaning of the furcation area is extremely challenging. Therefore, novel therapeutic approaches need to be tested to potentially overcome debridement limitations. The aim of the present prospective 12-month study was to compare clinical and microbiological effects following erythritol air-polishing versus conventional mechanical debridement of furcation defects in a cohort of periodontal maintenance patients. Methods Twenty patients with grade II mandibular molar furcation defects volunteered to enroll in this single-centre, examiner masked, randomized controlled trial. In a split-mouth study design, two furcation sites in each patient were randomly assigned to either receive subgingival debridement using erythritol air-polishing (test) or conventional ultrasonic/curette debridement (control) at baseline, and at 3, 6, 9 and 12 months. Probing depth, clinical attachment level and bleeding on probing were recorded at 3-month intervals. Subgingival microbiological samples obtained at baseline, 6 and 12 months were analyzed using checkerboard DNA–DNA hybridization. Discomfort from treatment was scored at 12 months using a visual analogue scale. The differences between treatments, and time-points, were tested using multilevel analysis (mixed effect models and robust variance estimates). Results A significant reduction in probing depth took place following both treatments (p < 0.001). Control sites experienced a significant mean gain in clinical attachment level of 0.5 mm (± 0.2) (p = 0.004), whereas a non-significant gain of 0.4 mm (± 0.3) was observed at test sites (p = 0.119). At 6 months, a significant between-treatment difference of 0.8 mm (± 0.4) was observed in favor of the control (p = 0.032). No significant between-treatment differences were observed in microbial load or composition. Notably, at 12 months patients experienced significantly less discomfort following air-polishing compared with control (p = 0.001). Conclusions The 12-month observations indicate that erythritol air-polishing and conventional mechanical debridement both support clinical improvements. A significant between-treatment difference in clinical attachment level was, however, detected in favour of control debridement at 6 months. In terms of patient comfort, erythritol air-polishing is superior. Trial Registration: The clinical trial was retrospectively registered in ClinicalTrial.gov with registration NCT04493398 (07/28/2020).

scholarly journals Evaluation of laboratory markers of progression of HIV disease to death

2011 ◽  
Vol 44 (6) ◽  
pp. 657-660 ◽  
Author(s):  
Graça Maria de Castro Viana ◽  
Maria do Desterro Soares Brandão Nascimento ◽  
Aila de Menezes Ferreira ◽  
Érica Milena Fernandes Rabelo ◽  
João Arnaud Diniz Neto ◽  
...  
Keyword(s):  
Viral Load ◽  
Hiv Disease ◽  
Significant Relation ◽  
Chi Square ◽  
Laboratory Markers ◽  
Cd4 Lymphocyte Count ◽  
Chi Square Test ◽  
Cd4 Lymphocyte ◽  
Hiv Aids

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

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