Manifestations of Polycystic Ovary Syndrome are Similar Regardless of the Degree of Menstrual Cycle Variation

Background: Menstrual irregularities may predict over adverse consequences in polycystic ovary syndrome (PCOS).Objective: To observe the relation of variants of menstrual cycles with clinical and biochemical features of PCOS.Methods: This cross-sectional study encompassed 200 PCOS women diagnosed by Rotterdam criteria and 120 age-matched healthy controls. Subgroups were classified according to menstrual cycle length as: polymenorrheic (<21 days), eumenorrheic (21-35 days), oligomenorrheic (36 days-3 months) and amenorrheic (>3 months). Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenenase-peroxidase and all hormones by chemiluminescent immuno-assay method.Results: Around 86% of PCOS patients had menstrual irregularity, among which 75% had oligomenorrhea followed by amenorrhea (9%) and polymenorrhea (2%). All the subgroups of PCOS patients (polymenorrhea excluded from further analyses) had significantly poor metabolic manifestations than the control namely insulin resistance (IR), impaired glycaemic status, general and central obesity, metabolic syndrome and dyslipidaemia. Acanthosis nigricans (AN), hyperandrogenemia (HA) and IR had significant predictive association with PCOS patients with both irregular [OR (95% CI)- AN: 21.994 (6.427, 75.267), p<0.001; HA: 27.735 (8.672, 88.704), p<0.001; IR: 7.268 (2.647, 19.954), p<0.001] and regular cycle [AN: 16.449 (3.830, 70.643), p<0.001; HA: 24.635 (6.349, 95.590), p<0.001; IR: 6.071 (1.658, 22.234), p=0.006] in reference to control group. None of the variables had significant predictive associations with irregular cycle in reference to regular cycle in patients with PCOS.Conclusion: Oligomenorrhea was the most common variant of menstrual irregularity in PCOS patients. All menstrual variants including eumenorrhea had similar manifestations in PCOS women, but poorer than controls.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 96-103

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Association of SNP rs700519 in CYP19A1 Gene with Polycystic Ovary Syndrome (PCOS) Among Females of Quetta, Pakistan

International Journal of Human Genetics ◽

10.31901/24566330.2021/21.03.782 ◽

2021 ◽

Vol 21 (03) ◽

Author(s):

Rozeena Shaikh

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Control Group ◽

Ovary Syndrome ◽

Chi Square ◽

Cross Sectional ◽

Significant Difference ◽

Reproductive Disorder ◽

Pcos Group

ABSTRACT Polycystic Ovary Syndrome (PCOS) is endocrine reproductive disorder which causes oligomenorrhea/ amenorrhea, infertility, type II diabetes. The present study aims in CYP19A1 polymorphism rs700519 (C/T) identification that elevates androgen among PCOS females in Quetta, Pakistan. Cross-sectional study involved enrollment of 100 control and 100 affected females. Blood samples were collected for genetic and hormonal analysis. The samples were amplified via ARMS PCR and analyzed by sequencing. The frequency of CC genotype in control and PCOS group was 48 percent and 33 percent. For CT, it was 52 percent and 67 percent. In control group, the allele frequency for C and T was 0.74 and 0.26. In PCOS group, it was 0.67 and 0.33 for C and T, respectively. The Pearson Chi-Square p=0.031 (p<0.05) at 95% Confidence Interval inferred a significant difference between the observed genotypes. The study inferred that CT genotype is a risk factor for PCOS progression in the population of Quetta.

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Application of WeChat Public Account in Lifestyle Management of Polycystic Ovary Syndrome: a Cross-sectional Study

10.21203/rs.3.rs-130788/v1 ◽

2020 ◽

Author(s):

Fang-Fang Zhang ◽

Fan Qu

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Small Sample ◽

Control Group ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

Lifestyle Management ◽

Public Account

Abstract BackgroundLifestyle management has been proved to improve both metabolic and reproductive outcomes for women with polycystic ovary syndrome (PCOS). In China, WeChat has become the most popular social media platform. Previous studies have confirmed the effectiveness of WeChat in health intervention and its potential to improve health behaviours. Therefore the present study tried to investigate the efficacy of online education through WeChat public account on the lifestyle interventions of women with PCOS.MethodsWe set up a cross-sectional study between January 2020 and July 2020. Data were collected through online questionnaires. All participants completed a questionnaire, including age, educational level, WeChat activeness, physical exercise, dietary habits, self-reported symptoms and medical history.ResultsA total of 258 women were included in this study, including 96 women with PCOS (PCOS group) and 162 women without PCOS (control group). Among them, 130 women followed our WeChat public account (follower group) and 128 women did not follow the WeChat public account (non-follower group). There were no significant differences in terms of physical activity assessment and dietary assessment between the PCOS and control groups (P>0.05), neither between the followers and non-follower groups (P>0.05). ConclusionsApplication of WeChat public account seems useless in lifestyle management for women with PCOS, however, the conclusion might be limited by the small sample size.

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Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.107 ◽

2016 ◽

Vol 4 (4) ◽

pp. 607-612

Author(s):

Sasha Jovanovska-Mishevska ◽

Aleksandra Atanasova-Boshku ◽

Iskra Bitoska ◽

Irfan Ahmeti ◽

Biljana Todorova ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Reproductive Age ◽

Control Group ◽

Oral Glucose ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional

BACKGROUND: Polycystic ovary syndrome (PCOS) is complex hormonal, metabolic and reproductive disorder and is a leading cause of female infertility. Hyperinsulinemia secondary to insulin resistance plays important role in the pathogenesis of PCOS.AIM: To assess the sensitivity of different indices of insulin resistance and their relevance in a clinical setting.MATERIAL AND METHODS: A cross-sectional study of 43 patients with PCOS and 29 noromo ovulatory women as a control group was conducted. Standard clinical, anthropometrical and hormonal testing for hyperandrogenism was conducted, as well as oral glucose tolerance test with determination of basal and stimulated glucose and insulin values.RESULTS: The dynamic I/G index showed the highest sensitivity and specificity, but the static indexes HOMA-IR and QUICKI, although based on only basal glycemic and insulinemic values, showed good sensitivity, 90.38% and 94.01% respectively. HOMA-IR showed significant positive correlation with the stimulated insulin values.CONCLUSIONS: Our results support the use of static indexes in the evaluation of insulin resistance in women with PCOS in a clinical setting, offering a simple assessment of insulin resistance in PCOS, which holds great prognostic and treatment implications.

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Association of SNP rs700519 in CYP19A1 Gene with Polycystic Ovary Syndrome (PCOS) Among Females of Quetta, Pakistan

International Journal of Human Genetics ◽

10.31901/24566330.2021/21.02.782 ◽

2021 ◽

Vol 21 (02) ◽

Author(s):

Rozeena Shaikh

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Control Group ◽

Ovary Syndrome ◽

Chi Square ◽

Cross Sectional ◽

Significant Difference ◽

Reproductive Disorder ◽

Pcos Group

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Comparison of Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Endometriosis: A cross-sectional Study

10.21203/rs.3.rs-27545/v1 ◽

2020 ◽

Author(s):

Zahra Daneshfar ◽

shahideh Jahanian Sadatmahalleh ◽

Nadia Jahangiri

Keyword(s):

Sexual Dysfunction ◽

Polycystic Ovary Syndrome ◽

Sexual Function ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Control Group ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

Infertile Women

Abstract Introduction: Infertility is one of the issues affecting sexual function (SF). Infertility is also one of the complications of polycystic ovary syndrome (PCOS) and endometriosis. This research seeks to assess and compare SF and the prevalence of sexual dysfunction with PCOS and endometriosis in infertile women. Methods: A cross-sectional study was carried out on 630 samples (210 infertile women with endometriosis, 210 infertile women with PCOS, and 210 healthy women of childbearing age as the control group). SF was assessed by the Female Sexual Function Index (FSFI). Descriptive statistics and inferential statistics (One Way ANOVA and logistic regression) were used to analyze the data.Results: The results showed that the mean score of total FSFI in the two groups of PCOS and endometriosis was lower than the control group (P<0.001). In addition, women with higher education (university education) had a significantly higher score of total FSFI. Conclusion: Sexual dysfunction rates are high in infertile women with endometriosis and PCOS, so infertility service providers in infertility centers need to pay attention to this issue.

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Factors influencing self-consciousness in polycystic ovary syndrome (PCOS): A cross-sectional study.

SSRN Electronic Journal ◽

10.2139/ssrn.3930759 ◽

2021 ◽

Author(s):

Mohammed Abdalla ◽

Harshal Deshmukh ◽

Thozhukat Sathyapalan

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

Factors Influencing

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Physical activity and sedentary behaviour in women with and without polycystic ovary syndrome: An Australian population‐based cross‐sectional study

Clinical Endocrinology ◽

10.1111/cen.14205 ◽

2020 ◽

Vol 93 (2) ◽

pp. 154-162

Author(s):

Chau Thien Tay ◽

Lisa J. Moran ◽

Cheryce L. Harrison ◽

Wendy J. Brown ◽

Anju E. Joham

Keyword(s):

Physical Activity ◽

Polycystic Ovary Syndrome ◽

Sedentary Behaviour ◽

Polycystic Ovary ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Ovary Syndrome ◽

Australian Population ◽

Cross Sectional

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Prevalence of Self-reported Polycystic Ovary Syndrome and Profiles of Health Among Women of Different Generations: A Cross Sectional Study

Fertility & Reproduction ◽

10.1142/s2661318219500154 ◽

2019 ◽

Vol 01 (03) ◽

pp. 141-147

Author(s):

Jodie C. Avery ◽

Lisa J. Moran ◽

Vivienne Moore ◽

Renae C. Fernandez ◽

Melissa Whitrow ◽

...

Keyword(s):

Cardiovascular Disease ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Age Groups ◽

South Australia ◽

Cross Sectional Study ◽

Age Group ◽

Ovary Syndrome ◽

Cross Sectional ◽

Younger Women

Objective: Although polycystic ovary syndrome (PCOS) is considered a lifelong disorder, very little is understood about the diagnosis and impact of this condition in women outside of the peak reproductive years. We examined the frequency of diagnosed PCOS and concurrent health conditions in women across the lifespan. Methods: Data were analysed from 1509 women aged 15–95 years participating in a cross-sectional, face-to-face population survey in South Australia, 2015. We assessed the prevalence of PCOS in 10-year age groups and the frequency of comorbidities in women with and without PCOS subgrouped by age (< 45, [Formula: see text] 45 years). The main outcome measures were Diagnosed PCOS and other chronic conditions; lifestyle factors. Logistic regression analyses determined the risk of comorbidities in women with PCOS adjusting for age and BMI. Results: Overall prevalence of PCOS was 5.6% (95% confidence interval (CI) 4.6–6.9%), peaking in the 35–44 year age group (9.1%), and lowest in those aged 15–24 (4.1%) or [Formula: see text] 65 (3.7%) years. Women with PCOS and aged <45 years were more likely to report diabetes (16.7% vs. 3.8%), cardiovascular disease (15.5% vs. 7.2%) and arthritis (15.5% vs. 7.2%) than their peers; these differences were diminished in the [Formula: see text] 45 year age group. The odds of diabetes and cardiovascular disease were more than doubled among women with PCOS (adjOR 2.23, 95% CI 1.49–4.31; adjOR 3.18, 95% CI 1.31–7.68). Conclusion: PCOS is underdiagnosed in young and post-menopausal women. Diabetes and cardiovascular disease are key comorbidities requiring greater attention in younger women with PCOS.

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Clinical and Hormonal Profile of Polycystic Ovary Syndrome

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1023 ◽

2009 ◽

Vol 1 (2) ◽

pp. 22-25

Author(s):

Ferdousi Begum

Keyword(s):

Menstrual Cycle ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Serum Insulin ◽

Pcos Patient ◽

Serum Prolactin ◽

Transvaginal Sonography ◽

Ovary Syndrome ◽

Cross Sectional ◽

Hormonal Profile

ABSTRACT Objectives The objectives of the study were to find out the clinical features, biochemical and hormonal profile of patients with polycystic ovary syndrome (PCOS) in Bangladesh. Material and Methods A case control and cross-sectional study was undertaken among 78 PCOS patients attending infertility clinic and 33 controls at BIRDEM Hospital, Dhaka. Inclusion criteria for cases were oligo/amenorrhea, transvaginal sonography suggesting PCO and/ or features of hyperandrogenemia with exclusion of other causes. Controls were women with regular menstrual cycle. Results Age and height of cases and controls were similar. BMI >25 was 67% among cases and 19% among controls (P<0.001); waist hip ratio >0.8 was 64% among cases and 29% among controls (P<0.001). Mean BMI of cases was 28.2 + 4.5 and that of cases was 21.05 + 4.1; mean fasting glucose among cases was 5.93 + 1.08 and among controls was 4.4 + 1.11 mmol/L (P<0.01); mean fasting serum insulin level was 32.15+ 12.13 among cases was 11.32 +10.02 ìU/ml among controls(P<.001); insulin resistance (fasting HOMA-IR>6.8) was 42.32% in cases and 12% in control (P<.001). Patients with PCOS had following clinical and biochemical parameters: oligomenorrhea- 74%, amenorrhea- 26%, mean Ferriman-Galaway score -19.89 + 5.06. At day 3 of menstrual cycle meanserum LH was 12.79+7.1 mmol/L, serum FSH was 5.23 + 2.5 miu/ml and serum prolactin was 415.15+180.5 mmol/L; 30% had biochemical hyperandrogenemia. Conclusions PCOS patient in Bangladesh are usually overweight, hirsute (grade I and II), hyperandrogenemic, insulin resitant and have altered LH to FSH ratio.

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