scholarly journals Features of energy and adipokine metabolism in patients with acute myocardial infarction and type 2 diabetes after percutaneous coronary intervention

2021 ◽  
Vol 25 (4) ◽  
pp. 599-604
Author(s):  
M. Yu. Koteliukh
Keyword(s):  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Control Group ◽  
Percutaneous Coronary ◽  
Group 2 ◽  
Group 1

Annotation. The study of energy and adipokine metabolism indicators for the development and course of acute myocardial infarction (AMI) with comorbidity remains relevant. The aim of the study was to determine the content of energy and adipokine metabolism in patients with myocardial infarction and ST-segment elevation depending on the presence and absence of type 2 diabetes mellitus (DM) after percutaneous coronary intervention (PCI). The study involved examination of 60 patients with AMI (Group 1) and 74 patients with AMI and type 2 diabetes (Group 2). Each group was divided into 2 subgroups according to coronary artery (CA) stenting. The control group included 20 healthy individuals. Adropin, irisin, fatty acid binding protein 4 (FABP 4), C1q / TNF-associated protein 3 (CTRP 3) were determined by enzyme-linked immunosorbent assay. All patients underwent coronary angiography. Statistical processing of the results of the study was carried out using the software package “IBM SPPS Statistics 27.0”. There was a decrease in the content of adropin, irisin and CTRP 3 and an increase in the concentration of FABP 4 on day 1 in Groups 1 and 2 compared with the control group (p˂0.05). In Groups 1 and 2 on day 14 there was an increase in the concentration of adropin by 23.87% and 41.43%, irisin by 56.59% and 11.11%, CTRP3 by 11.59% and 20.01% compared to day 1 (p<0.05). The level of FABP 4 in Groups 1 and 2 decreased by 19.69% and 26.61% compared to day 1 (p <0.05). In Group 1, an inverse correlation was found between Syntax Score (SS) and adropin (r= -0.432, p=0.01), irisin (r= -0.478, p<0.01), CTRP 3 (r= - 0.473, p<0.01) and a positive correlation between SS and FABP 4 (r= 0.436, p<0.05). In Group 2, there was an inverse relationship between SS and adropin (r= -0.452, p<0.05), irisin (r= -0.458, p<0.05), CTRP 3 (r= -0.437, p<0.05) and the direct relationship between SS and FABP 4 (FABP 4 (r= 0.418, p<0.05). Thus, the peculiarities of the content of energy and adipokine metabolism indicators in patients with AMI with existing and absent type 2 diabetes before and after primary CA stenting were studied.

scholarly journals Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Xiaoyan Zhang ◽  
Lizhen Qi ◽  
Yongxuan Liu
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Cardiac Function ◽  
Coronary Intervention ◽  
Control Group ◽  
Observation Group ◽  
Percutaneous Coronary ◽  
Significant Difference ◽  
Before And After

Objective: To investigate the clinical effect of aspirin combined with clopidogrel on acute myocardial infarction after percutaneous coronary intervention (PCI). Methods: One hundred thirty two patients with acute myocardial infarction who were admitted to the hospital between December 2016 and December 2017 were divided into a control group and an observation group according to random number table, 66 each group. Both groups were given emergency PCI and symptomatic treatment. The control group was given aspirin on the basis of conventional treatment before and after operation, while the observation group was given clopidogrel treatment on the basis of the treatment the same as the control group. The treatment lasted for 4 months. The clinical efficacy of the two groups was analyzed, and the cardiac function indicator, coagulation indicator and occurrence of adverse reactions were compared before and after treatment. Results: There was no thrombosis at the infarct site in coronary angiography after treatment in both groups. The efficacy in the observation group and control group were 89.4% and 81.8%, respectively; there was no significant difference between the two groups. The incidence of re-thrombosis in the two groups was 1.5% and 12.1% respectively, which was significantly lower in the observation group than in the control group (P<0.05). The cardiac function indicator of both groups improved after treatment, especially the observation group (P<0.05). There was no significant difference in prothrombin time (PT), activated partial thromboplastin time (APTT), prothrombin activity (PA) and platelet aggregation rate (PAR) in the two groups before treatment (P>0.05). There was also no significant difference in PT and PA before and after treatment (P>0.05). The APTT and PAR were significantly different after treatment (P<0.05), and the PAR of the observation group was significantly higher than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was 7.58%, which was not significantly different with that of the control group (12.12%) (P<0.05). Conclusion: Aspirin combined with clopidogrel can effectively reduce the occurrence of re-thrombosis after PCI and improve the recovery of cardiac function after acute operation, moreover the safety is high. It has important clinical application values. How to cite this:Zhang X, Qi L, Liu Y. Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.87 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Markers of oxidative stress in acute myocardial infarction treated by percutaneous coronary intervention

Open Medicine ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Eva Sedláková ◽  
Oliver Rácz ◽  
Eva Lovásová ◽  
Roman Beòaèka ◽  
Martin Kurpas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Venous Blood ◽  
Plasma Lipid ◽  
Coronary Intervention ◽  
Control Group ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

AbstractIn the current study, we evaluated the dynamics of oxidative stress markers in patients with acute myocardial infarction (AMI) treated by primary percutaneous coronary intervention (PCI). Thirty consecutive patients with AMI with ST elevation were included. Plasma lipid peroxidation end product malondialdehyde (MDA) and total antioxidant capacity (TAC) in blood plasma were evaluated. Peripheral venous blood samples were obtained prior to reperfusion and at five time points after reperfusion. The control group consisted of 20 ischemic patients without acute coronary syndrome. TAC in the AMI group at admission was lower than in control patients (1.26 + 0.32 vs. 1.52 + 0.24 mmol/l). Within 1 h after reperfusion, in most cases, values significantly declined (1 min, 1.10 + 0.33 mmol/l; 1 h, 1.06 + 0.21 mmol/l [p= 0.03]). After 3 h, values began to increase (1.14 + 0.29 mmol/l) and returned to basal values after 3 d (1.29 + 0.24 mmol/l). MDA levels in AMI patients at admission were higher than in control patients (1.66 + 0.55 vs. 1.44 + 0.55 mmol/l) but showed a sustained decrease over the 3 h after reperfusion of the occluded artery (1 min, 1.57 + 0.37 mmol/l; 1 h, 1.50 + 0.35 μmol/l; 3 h, 1.35 + 0.59 μmol/l [p = 0.03]). Reperfusion of the occluded coronary artery by PCI in AMI lead to an immediate decrease in TAC, suggesting formation of reactive oxygen species. However, the MDA level significantly decreased after reperfusion. This may suggests less reperfusion injury after PCI.

SOLELY INFARC-RELATED ARTERY VERSUS STAGED PERCUTANEOUS CORONARY INTERVENTION IN ST ELEVATION MYOCARDIAL INFARCTION PATIENTS WITH MULTIVESSEL CORONARY DISEASE

2014 ◽  
pp. 56-62
Author(s):  
Anh Tuan Ho ◽  
Van Dien Nguyen ◽  
Anh Tien Hoang
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Bypass Graft ◽  
Coronary Intervention ◽  
St Elevation Myocardial Infarction ◽  
Percutaneous Coronary ◽  
Infarct Related Artery ◽  
St Elevation ◽  
Group 2 ◽  
Group 1

Today, there are different interventional approaches for patients undergoing ST elevation myocardial infarction (STEMI) with multiple vessel diseases. Objectives: to compare the mid-term results of two strategies of myocardial revascularization used for the management of patients with STEMI with multiple vessel diseases. Material and methods: we analyzed retrogradely 64 profiles of patients diagnosed STEMI with multiple vessel diseases on coronary angiography and underwent angioplasty in Cardiovascular department from 5/2013 – 1/2014. The patients had been divided into 2 groups: group 1 (percutaneous coronary intervention (PCI) of the sole Infarct-related artery followed by medical therapy, n=33) and group 2 (staged PCI in STEMI patients with multiple vessel diseases, n=31). Results: group 2 had comparable combined end-points (death + Myocardial infarction + revascularization) rate but higher rate of detection of significantly stenosed non-culprit vessels than those of group 1. Conclusion: for the STEMI patients with multiple vessel diseases admitted to Hue University hospital, staged PCI was better than PCI of the sole infarct-related artery in term of omitting less patients who were appropriate for revascularization (these patients had no indication for coronary artery bypass graft). However, these two approaches had no statistical difference regarding to major adverse cardiac events. Key words: Acute myocardial infarction, Multivessel disease, Primary percutaneous coronary intervention

scholarly journals New Electrocardiographic Algorithm for the Diagnosis of Acute Myocardial Infarction in Patients With Left Bundle Branch Block

2020 ◽  
Vol 9 (14) ◽  
Author(s):  
Andrea Di Marco ◽  
Marcos Rodriguez ◽  
Juan Cinca ◽  
Antoni Bayes‐Genis ◽  
Jose T. Ortiz‐Perez ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Left Bundle Branch Block ◽  
Primary Percutaneous Coronary Intervention ◽  
Validation Cohort ◽  
Coronary Intervention ◽  
Control Group ◽  
Bundle Branch Block ◽  
Percutaneous Coronary

Background Current electrocardiographic algorithms lack sensitivity to diagnose acute myocardial infarction ( AMI ) in the presence of left bundle branch block. Methods and Results A multicenter retrospective cohort study including consecutive patients with suspected AMI and left bundle branch block, referred for primary percutaneous coronary intervention between 2009 and 2018. Pre‐2015 patients formed the derivation cohort (n=163, 61 with AMI ); patients between 2015 and 2018 formed the validation cohort (n=107, 40 with AMI ). A control group of patients without suspected AMI was also studied (n=214). Different electrocardiographic criteria were tested. A total of 484 patients were studied. A new electrocardiographic algorithm ( BARCELONA algorithm) was derived and validated. The algorithm is positive in the presence of ST deviation ≥1 mm (0.1 mV) concordant with QRS polarity, in any lead, or ST deviation ≥1 mm (0.1 mV) discordant with the QRS , in leads with max (R|S) voltage (the voltage of the largest deflection of the QRS , ie, R or S wave) ≤6 mm (0.6 mV). In both the derivation and the validation cohort, the BARCELONA algorithm achieved the highest sensitivity (93%–95%), negative predictive value (96%–97%), efficiency (91%–94%) and area under the receiver operating characteristic curve (0.92–0.93), significantly higher than previous electrocardiographic rules ( P <0.01); the specificity was good in both groups (89%–94%) as well as the control group (90%). Conclusions In patients with left bundle branch block referred for primary percutaneous coronary intervention , the BARCELONA algorithm was specific and highly sensitive for the diagnosis of AMI , leading to a diagnostic accuracy comparable to that obtained by ECG in patients without left bundle branch block.

scholarly journals Efficacy Assessment of Emergency Percutaneous Coronary Intervention (PCI) for Acute Myocardial Infarction (AMI)

2021 ◽  
Vol 10 (1) ◽  
pp. 25
Author(s):  
Jiajuan Chen ◽  
Hezhong Zhu ◽  
Jing Xu ◽  
Zhen Gao ◽  
Fei Cheng ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Research Group ◽  
Coronary Intervention ◽  
Treatment Result ◽  
Control Group ◽  
Percutaneous Coronary ◽  
Efficacy Assessment ◽  
Emergency Percutaneous Coronary Intervention

<p>Objective: To assess the clinic effect of percutaneous coronary intervention in the treatment of acute myocardial infarction. Methods: 90 patients with acute myocardial infarction in our hospital were chosen to be research objects and they were divided into two groups: control group and research group. Patients in control group were only treated by thrombolytic therapy while those in research group were further treated by percutaneous coronary intervention on the basis of this treatment. Result: The efficacy of research group was higher than that in control group. The incidence of adverse events was 4.44%, which is lower than that in control group. Conclusion: We should effectively apply percutaneous coronary intervention in treating acute myocardial infarction so as to improve the cardiac function of the patients. In addition, this treatment is safer and will lower the incidence of heart and renal failure.</p>

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