scholarly journals Biology of increased tolerance and validation of the psychoactive substance dependence

2022 ◽  
Vol 5 (1) ◽  
pp. 01-05
Author(s):  
D.G. Baitubayеv

The article shows that the current level of physiology does not disclose the biological mechanisms of the organism transition from one range to adapt to a higher with an increase in the regular forces of the stimulus above sub-extreme. A new trend in the physiology of adaptation - proqredient adaptation, explains the mechanism of increasing the tolerance of the organism, with dependence on psychoactive substances (PAS ). It is scientifically proved, that dependences of the organism on PAS are the states of progredient adaptation.

2021 ◽  
Vol 6 (11) ◽  

The article shows that the current level of physiology does not disclose the biological mechanisms of the organism transition from one range to adapt to a higher with an increase in the regular forces of the stimulus above sub-extreme. A new trend in the physiology of adaptation - proqredient adaptation, explains the mechanism of increasing the tolerance of the organism, with dependence on psychoactive substances (PAS). It is scientifically proved, that dependences of the organism on PAS are the states of progredient adaptation.


2021 ◽  
Vol 5 (1) ◽  
pp. 027-031
Author(s):  
Baitubayеv DG ◽  
Baitubayeva MD

The article shows that the current level of physiology does not disclose the biological mechanisms of the organism’s transition from one range to adapt to a higher one with an increase in the regular forces of the stimulus above sub-extreme. A new trend in the physiology of adaptation - proqredient adaptation, explains the mechanism of increasing the tolerance of the organism, with dependence on psychoactive substances (PAS). Scientific has reasonably shown that depending on the organism from PAS - not the disease, and the states like proqredient adaptation.


2018 ◽  
Vol 2 (2) ◽  

The article shows that the current level of physiology does not explain the biological mechanisms of the organism transition from one adaptation range to a higher one, with an increase in the strength of the regular stimulus above the sub-extreme level. A new trend in the physiology of adaptation - proqredient adaptation - explains the mechanism of increasing the resistance of the organism with dependence on psychoactive substances (PAS). It is scientifically proved, that dependence of the organism on PAS is not the disease, but the state of proqredient adaptation.


BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S245-S245
Author(s):  
Dean Connolly ◽  
Emma Davies ◽  
Michael Lynskey ◽  
Monica Barratt ◽  
Larissa Maier ◽  
...  

AimsTo describe and compare psychoactive substance misuse help-seeking among transgender (trans) and cisgender (cis) participants from a large multi-national cross-sectional survey.BackgroundTrans people experience stressors related to their minority status which have been associated with increased rates of psychoactive substance use and related harm. Despite this, there is a paucity of evidence relating to the treatment needs of trans people who use psychoactive substances, beyond a small body of literature describing a culture of transphobic hostility in general substance misuse services. This paper aims to describe and compare psychoactive substance misuse help-seeking among trans and cis participants from a large multi-national cross-sectional survey.MethodOver 180,000 participants, recruited from the world's largest annual survey of drug use - the Global Drug Survey (GDS) - during 2018 and 2019, reported use of a range of psychoactive substances in the preceding 12 months. Five gender groups (118,157 cis men, 64,319 cis women, 369 trans men, 353 trans women and 1,857 non-binary people) were compared, using Chi-square and z-tests with Bonferroni correction, on items relating to the desire to use less psychoactive substances and the need to seek help to achieve this. Respondents from GDS 2018 were also assessed for substance dependence. Binary logistic regression was used to compare gender groups on self-reported substance dependence to frame the help-seeking analyses.ResultTrans respondents (n = 1,710) to GDS 2018 were significantly more likely than cis respondents to report use of illicit substances (OR = 1.66-2.93) and dependence on cannabis (OR = 2.39), alcohol (OR = 3.28) and novel psychoactive substances (OR = 4.60). In the combined GDS 2018 and 2019 dataset, there were no significant differences between trans (n = 2,579) and cis (n = 182,476) participants on the desire to reduce substance use. However, among those who did report wanting to use less, non-binary people and trans women were most likely to want help to achieve this.ConclusionTrans respondents reported a greater need for help with reducing substance use than cis respondents. Given the deficit of specialist services for psychoactive substance users who are trans, there is a need for a more thorough understanding of the barriers and facilitators to their engagement in general substance misuse services. In the interim, substance misuse service providers require education about gender minority status to help meet the needs of trans clients.


Author(s):  
Т.И. Невидимова ◽  
Т.В. Давыдова ◽  
Д.Н. Савочкина ◽  
Е.И. Мастерова ◽  
Л.А. Ветрилэ ◽  
...  

Цель исследования - изучение взаимосвязи психофизиологических и иммунорегуляторных показателей лиц, находящихся на разных этапах формирования зависимости от психоактивных веществ (ПАВ). Методика. В обследовании приняли участие 347 человек: пациенты с психическими и поведенческими расстройствами, вызванными употреблением ПАВ (233 чел.), эпизодические потребители ПАВ (28 человек), условно здоровые лица (84 чел.). Иммуноглобулины, кортизол, нейромедиаторы и антитела к нейромедиаторам определяли методом иммуноферментного анализа. Субпопуляционный состав иммунокомпетентных клеток определяли с помощью проточной цитометрии. При помощи программно-аппаратного комплекса БОСЛАБ Профессиональный регистрировались электрокардиограмма, фотоплетизмограмма, параметры электрической активности кожи. Исследованы степень тревожности и агрессивности с помощью тестов Спилбергера-Ханина и Басс-Дарки соответственно. Статистическая обработка данных проводилась с использованием программы «Statistica». Межгрупповые сравнения проводились с применением критерия Манна-Уитни. Для построения факторных моделей использовался метод главных компонент. В них включались стандартизированные нормально распределенные признаки. Нормальность распределения проверялась с использованием критериев Колмогорова-Смирнова и Шапиро-Уилка. Результаты. Наиболее выраженные изменения нейромедиаторных, иммунных, психологических характеристик и параметров симпатоадреналовой системы наблюдаются у лиц с синдромом зависимости от ПАВ. Для них характерны повышенная продукция всех исследованных антител к нейромедиаторам на фоне сниженного уровня дофамина крови, типичный иммунный дисбаланс с дефицитом клеточного звена и стимуляцией гуморального, разнонаправленные сдвиги со стороны симпатоадреналовой системы при возрастании тревожности и показателей агрессии. У потребителей ПАВ с вредными последствиями на фоне тенденции к возрастанию уровня серотонина крови наблюдается возрастание относительного количества лимфоцитов при сдвиге вегетативного баланса в сторону парасимпатической активности. Заключение. Построенные факторные модели для всех обследованных групп свидетельствуют о том, что изменения продукции антител к нейромедиаторам вносят наибольший вклад в разброс представленных в моделях параметров. У пациентов параметры иммунорегуляции, вегетативных и психологических реакций изменяются независимо друг от друга, тогда как у условно здоровых лиц и, особенно, у эпизодических потребителей ПАВ наблюдается их большая взаимозависимость. Aim. To investigate the relationship between psychophysiological and immunoregulatory indexes at different stages of forming psychoactive substance dependence. Methods. The study involved 347 subjects, including patients with psychiatric and behavioral disorders caused by psychoactive substances (233 subjects); occasional users of psychoactive substances (28 subjects); and subjects without apparent disease (84 subjects). Immunoglobulins, cortisol, neurotransmitters, and antibodies to neurotransmitters were determined by enzyme-linked immunosorbent assay (ELISA). Subpopulations of immunocompetent cells were identified by flow cytometry. Electrocardiogram, photoplethysmogram, and parameters of skin electrical activity were recorded using the BOSLAB Professional software and hardware complex. Anxiety and aggressiveness were evaluated using the Spielberger-Khanin and Buss-Durkee tests, respectively. Statistical analyses were performed using the Statistica software. The Mann-Whitney test was used for intergroup comparisons. Factorial models were constructed using the principal component method. The models included standardized, normally distributed characteristics. Distribution normality was verified by Kolmogorov-Smirnov and Shapiro-Wilk criteria. Results. The most pronounced changes in neurotransmitter, immune, psychological characteristics, and parameters of the sympathoadrenal system were observed in patients with the psychoactive substance dependence syndrome. Such patients were characterized by increased production of all neurotransmitter antibodies associated with reduced blood levels of dopamine. This is a typical immune imbalance with deficiency of the cell component and stimulation of the humoral component, multidirectional shifts in the sympathoadrenal system, and progressive anxiety and aggression. Consumers of psychoactive substances with adverse consequences associated with a tendency to increase blood levels of serotonin showed an increased relative count of lymphocytes with a shift in the autonomic balance toward the parasympathetic activity. Conclusions. Factorial models indicated that the contribution of changes in the production of neurotransmitter antibodies to the dispersion of model parameters was the greatest. In patients, immunoregulatory, autonomic and psychological reactions changed independently of each other whereas in individuals without apparent disease and occasional users, tighter interrelations of these reactions were observed.


2008 ◽  
Vol 2 (3) ◽  
pp. 393-414 ◽  
Author(s):  
Edward MacRae

The article deals with the different effects of tolerant and prohibitionist policies associated with psychoactive substance use in Brazil. Whereas the licit use of ayahuasca has been successfully incorporated into mainstream Brazilian society, the ritual use of cannabis by one of the Santo Daime religious groups has never been fully accepted and remains a constant source of problems for the ayahuasca churches, their followers and society at large.


2011 ◽  
Vol 58 (2) ◽  
pp. 151-155
Author(s):  
Ivan Dimitrijevic ◽  
Zoran Zoricic ◽  
Miodrag Milenovic ◽  
Ivan Palibrk ◽  
Draga Dimitrijevic ◽  
...  

Proper diagnosis of psychoactive substance abuse and addiction, as well as acute intoxication, withdrawal syndrome and overdosing are of great importance in patients who are preparing for surgical intervention. There are some specific details in their preoperative preparation whether they underwent emergency or elective surgery. Good knowledge of the characteristics of psychoactive substance abuse and addiction, interaction of psychoactive substances and anesthetics and any other drugs that could be used in the perioperative period is important especially for anastesiologist. In this work we present key issues for recognizing theese patients as well as some guidelines for adequate preoperative preparation and postoperative care.


2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110337
Author(s):  
Elena Beccegato ◽  
Angelo Ruggeri ◽  
Massimo Montisci ◽  
Claudio Terranova

A comparative case study (2017–2020) was conducted to identify demographic, social, medico-legal, and toxicological variables associated with non-fatal accidents in driving under the influence (DUI) subjects. A second aim was to identify the factors predictive of substance use disorders among subjects. Drivers charged with alcohol DUI (blood alcohol concentration (BAC) > 0.5) and/or psychoactive substance DUI were included; cases included those involved in an accident while intoxicated, and the comparison group included DUI offenders negative for road accident involvement. Significance was determined by chi-square and Mann–Whitney tests. To prevent confounding effects, a multivariate binary logistic regression analysis was performed. Our sample encompassed 882 subjects (381 in the case group and 501 in the comparison group). Parameters such as psychoactive substances and BAC at the time of the road crash/DUI and the day of the week, when subjects were involved in the road accident or found DUI, resulted in significant differences ( p < 0.01) between groups. The model’s independent variables of BAC > 1.5 g/L ( p = 0.013), BAC > 2.5 g/L ( p < 0.001), and concurrent alcohol and psychoactive substance use ( p < 0.001) were independent risk factors for an accident. Smoking >20 cigarettes/day was an independent risk factor for unfitness to drive ( p < 0.01). Unfitness to drive was based primarily on ethyl glucuronide levels >30 pg/mg. Our results suggest a detailed assessment of DUI subjects with variables associated with accidents (BAC > 1.5 g/L and concurrent intake of psychoactive substances). Hair analysis, including ethylglucuronide (EtG) concentration, should be always performed. Based on our results, nicotine use should be investigated in cases of driving license regranting.


Author(s):  
Chioma N. P Mbachu ◽  
Joy C. Ebenebe ◽  
Ikechukwu I. Mbachu ◽  
Chizalu I. Ndukwu ◽  
Jacinta C. Elo-Ilo ◽  
...  

AbstractObjectivesUse of Psychoactive substances by young people poses an important public health threat despite mass campaigns and education. There have been documentations of rise in prevalence and use of psychoactive substances by Nigerian adolescents in urban areas of Nigeria. Few reports exist on in-school adolescents in rural areas, and differences in their sociodemographic profile such as public/private school attendance, day/boarding status and socioeconomic status of students. The study determined the rate and sociodemographic profile of psychoactive substance use among secondary school students in selected rural communities in Anambra state, Nigeria.MethodsThis was a cross-sectional study in which multistage sampling was used to select 494 students from selected secondary schools in Anambra state. Data on age, gender, socioeconomic status, student status, school category, alcohol, tobacco and intravenous drug use were obtained using pretested semi-structured questionnaires. Analysis of data was done using IBM SPSS statistics software version 20.0, frequency, percentages and means were calculated, with cross-tabulation done for variables (Chi-square and Fishers exact test where applicable). Level of significance for tests of association set at 5%.ResultsA total of 494 participants were studied of which 48.8% (n=241) were males. The mean age was 14.5 ± 1.8 years. The prevalence of lifetime use of psychoactive substance was 22.5%. Prevalence for individual substances were 21.9% (n=108), 1.8% (n=9) and 0.8% (n=4) respectively for alcohol, tobacco and illicit intravenous drugs. Neither gender {6 males (2.5%), 3 females (1.2%), p=0.890}, age {10–13 years (1.3%), 14–16 years (2.1%), >16 years (1.7%), p=0.329}, student status {day (2.6%), boarding (1.2%), p=0.320}, social class {upper (0.9%), middle (0.6%), lower (3.1%), p=0.208 } nor school category {private (1.5%), public (2.1%), p=0.742} of students was significantly associated with smoking and respectively. More males (73/241=30.3%, p<0.001) took alcohol than females (35/253 = 13.8%) and this was statistically significant. Participants from the lower socioeconomic class (30.3%, p<0.001) had a significantly higher rate of alcohol consumption than those from the upper (11.8%) and middle classes (16.7%) respectively. Higher rate was noted among those who attended public schools (30.8%, p<0.001) compared to those who attended private schools (13.8%). Day students (30.2%, p<0.001) indulged more in alcohol than boarding students (14.3%). There was no association between either the class (junior=22.5%, senior=21.3%, p=0.759) or age of participants (10–13 years=20.7%, 14–16 years=20.1%, >16 years=33.3%, p=0.071) and alcohol consumption. No association was found between age (0.7%, 1.1%, p=1.000), gender (male=1.2%, female=0.4%, p=0.362), social class (lower=1.3%, upper=0.9%, p=0.443), student status (day=0.9%, boarding=0.8%, p=1.000), school category (junior=0.8%, senior=0.8%, p=1.000) and intravenous drug use.ConclusionsThe rate of about 22% alcohol use by secondary school students in rural south eastern Nigeria, which is strongly associated with male gender, low socioeconomic status, day student status and public school attendance is high.


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