scholarly journals TREATMENT OF OBJECTS OF URINARY TRACT INFECTION IN OUTPATIENT (AMBULATORY CARE) SETTINGS

2018 ◽  
pp. 109-118
Author(s):  
L.F. Matyukha ◽  
T. A. Titova

The usage effectiveness of oral antimicrobial drug Flaprox was studied and the dynamics of clinical and laboratory indicators were compared versus with nitrofurans therapy in patients with exacerbation of chronic urinary tract infections on an outpatient basis were evaluated. Thеrе were investigated the results of treatment of 40 patients at the age (39.8 ± 8.9) years with exacerbation of chronic pyelonephritis. Patients of the І group (26 persons) received Flaprox 500 mg twice a day 10 days long, group II (14 persons) – nitrofuran 0.1 g 4 times a day 10 days long. The clinical manifestations regression of urinary tract infection in the research/study process was noted in both groups. In the group I, the dynamics of reduction of symptoms of general intoxication and normalization of local symptoms and inflammatory changes in blood and urine has a more pronounced tendency from 5 days of treatment and persisted throughout the course of therapy. Flaprox useing for 10 days allowed to reliably reduce or eliminate dysuria, infection of the urinary tract (bacteriuria), and inflammatory process (leukocythria) without negative changes in the blood biochemistry analysis.

2018 ◽  
pp. 109-118
Author(s):  
L.F. Matyukha ◽  
T. A. Titova

The usage effectiveness of oral antimicrobial drug Flaprox was studied and the dynamics of clinical and laboratory indicators were compared versus with nitrofurans therapy in patients with exacerbation of chronic urinary tract infections on an outpatient basis were evaluated. Thеrе were investigated the results of treatment of 40 patients at the age (39.8 ± 8.9) years with exacerbation of chronic pyelonephritis. Patients of the І group (26 persons) received Flaprox 500 mg twice a day 10 days long, group II (14 persons) – nitrofuran 0.1 g 4 times a day 10 days long. The clinical manifestations regression of urinary tract infection in the research/study process was noted in both groups. In the group I, the dynamics of reduction of symptoms of general intoxication and normalization of local symptoms and inflammatory changes in blood and urine has a more pronounced tendency from 5 days of treatment and persisted throughout the course of therapy. Flaprox useing for 10 days allowed to reliably reduce or eliminate dysuria, infection of the urinary tract (bacteriuria), and inflammatory process (leukocythria) without negative changes in the blood biochemistry analysis.


2018 ◽  
pp. 100-108
Author(s):  
Dinh Khanh Le ◽  
Dinh Dam Le ◽  
Khoa Hung Nguyen ◽  
Xuan My Nguyen ◽  
Minh Nhat Vo ◽  
...  

Objectives: To investigate clinical characteristics, bacterial characteristics, drug resistance status in patients with urinary tract infections treated at Department of Urology, Hue University Hospital. Materials and Method: The study was conducted in 474 patients with urological disease treated at Department of Urology, Hue Universiry Hospital from July 2017 to April 2018. Urine culture was done in the patients with urine > 25 Leu/ul who have symptoms of urinary tract disease or infection symptoms. Patients with positive urine cultures were analyzed for clinical and bacterial characteristics. Results: 187/474 (39.5%) patients had symptoms associated with urinary tract infections. 85/474 (17.9%) patients were diagnosed with urinary tract infection. The positive urine culture rate was 45.5%. Symptoms of UTI were varied, and no prominent symptoms. E. coli accounts for the highest proportion (46.67%), followed by, Staphycoccus aureus (10.67%), Pseudomonas aeruginsa (8,0%), Streptococcus faecali and Proteus (2.67%). ESBL - producing E. coli was 69.23%, ESBL producing Enterobacter spp was 33.33%. Gram-negative bacteria are susceptible to meropenem, imipenem, amikacin while gram positive are vancomycin-sensitive. Conclusions: Clinical manifestations of urinary tract infections varied and its typical symptoms are unclear. E.coli is a common bacterium (46.67%). Isolated bacteria have a high rate of resistance to some common antibiotics especially the third generation cephalosporins and quinolones. Most bacteria are resistant to multiple antibiotics at the same time. Gram (+) bacteria are susceptible to vancomycin, and gram (-) bacteria are susceptible to cefoxitin, amikacin, and carbapenem. Key words: urinary tract infection


2020 ◽  
Vol 16 (4) ◽  
pp. 377-381
Author(s):  
Anna Wachnicka-Bąk ◽  
◽  
Agata Będzichowska ◽  
Katarzyna Jobs ◽  
Bolesław Kalicki ◽  
...  

Introduction: Urinary tract infections are the second most common type of bacterial infection in children. Atypical infections may be associated with a higher future risk of chronic kidney disease. The current range of diagnostic tests in children with a history of urinary tract infections is still a subject of discussions. Aim of the study: We attempted to determine the indications for renal scintigraphy and develop a nephrological care model for children aged ≤24 months based on the analysis of urinary tract infections in this group of patients. Materials and methods: We included 61 children aged ≤24 months [42 (68%) girls and 19 (32%) boys], hospitalised in the Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine in Warsaw from 2008 to 2015 due to their first episode of urinary tract infection, in our retrospective analysis. Depending on the result of DMSA static renal scintigraphy performed 6 months after completed treatment of urinary tract infection, patients were classified into 3 groups: normal scintigraphy (group I), irregular tracer uptake indicating a suspicion of post-inflammatory renal pole lesions (group II), and signs of hypodysplasia (group III). The following variables were compared: age at first infection, gender, fever, inflammatory markers, aetiology, ultrasonographic findings, and the results of voiding cystourethrography for vesicoureteral reflux. Results: The median age at the time of first infection was 5.5 months in group I, 7 months in group II, and 7.5 months in group III. Febrile urinary infection was reported in 6/21 patients in group I, 4/19 patients in group II, and 6/21 patients in group III. Increased C-reactive protein was observed in 7/21 patients in group I, 6/19 patients in group II, and 6/21 patients in group III. Recurrent infections were reported for 5/21 children in group I, 8/19 in group II, and 12/21 children in group III. Atypical aetiology of urinary infection was reported for 3/21 patients in group I, 2/19 in group II, and 2/21 in group III. Abnormal ultrasonographic findings were observed in 4/21 patients in group I, 1/19 patients in group II, and 4/21 patients in group III. Vesicoureteral reflux in voiding cystourethrography was reported in 5/21 patients in group I, 8/19 patients in group II, and 10/21 patients in group III. The analysis of all the investigated parameters showed no statistically significant differences between the groups. Conclusions: Renal scintigraphy should be performed in the youngest children with a history of urinary tract infection as it was not possible to identify patients with post-inflammatory renal scarring secondary to urinary tract infection based on the course of infection, its aetiology, ultrasound findings and the presence of vesicoureteral reflux. Ultrasonography was not sensitive enough to diagnose renal hypodysplasia in our group of children.


2021 ◽  
Vol 15 (7) ◽  
pp. 1890-1893
Author(s):  
Sardar Khan ◽  
Sajjad Hussain ◽  
Zahir Said ◽  
Ihsan Ul Haq ◽  
Habib U Rehman ◽  
...  

Background: Knowing the risk of recurrence of urinary tract infection (UTI) in vesicoureteral reflux (VUR) can assist clinicians to sort therapeutic decisions. The current study's aim was to assess the association of UTI in VUR. Additionally, UTI recurrence might be predicted by the risk score. Materials and Methods: This case-control study was carried out on 123 children at department of Paediatric, Saidu Group of Teaching Hospitals, Swat for the duration of one year from 1st July 2020 to 30thJune 2021. Out of 123 children, the group-I had 57 children with documented previous UTIs history while group-II had 66 children with no previous UTIs and was referred to as a control group. All the patients were VUR diagnosed and were thoroughly followed up at a Renal Unit of single tertiary. UTI recurrence was referred to more than one follow-up episode. A regression model was used for independent variables identification regarding UTI recurrence. . A questionnaire on bowel habits was provided to the parents. The abdominal plain film was evaluated by the observer and recorded on the documented scoring system. The constipation history was compared with the radiological and symptomatic scores. Organism single species with > 105/ml count in a single midstream catch of urine sample was reflected as UTI evidence. Result: Out of 123 children, 88 (71.5%) were females while 35 (28.5%) were male. A total of 123 children had been investigated for UTI complaints. After the multivariable analysis adjustment, five recurrent UTIs predictor variables were the clinical presentation of UTI, female gender, reflux several grades, age less than 6 months, and syndrome dysfunction elimination. The UTIs recurrence risk factors were classified as high, medium, and low with prevalence 52 (42%), 41 (34%), and 30 (24%) respectively. The prevalence of UTIs rate per person-month was 10.9 (95% CI, 9.8, 12.7), 8.2 (95% CI, 6.7, 9.1) for medium, and 5.2 (95% CI, 3.3, 5.5) for the low-risk group. Conclusion: The formulation of therapeutic strategies can be done based on prediction model for UTIs recurrence besides early detection of morbidity long-term risk for the patients. Keywords: Vesicoureteral reflux, Urinary tract infection, Dysfunctional voiding, Constipation


2017 ◽  
Vol 11 ◽  
pp. 117955651770111 ◽  
Author(s):  
Murat Özcan ◽  
S Ümit Sarici ◽  
Yüksel Yurdugül ◽  
Melis Akpinar ◽  
Demet Altun ◽  
...  

Background and purpose: Etiologic role, incidence, demographic, and response-to-treatment characteristics of urinary tract infection (UTI) among neonates, its relationship with significant neonatal hyperbilirubinemia, and abnormalities of the urinary system were studied in a prospective investigation in early (≤10 days) idiopathic neonatal jaundice in which all other etiologic factors of neonatal hyperbilirubinemia were ruled out. Patients and methods: Urine samples for microscopic and bacteriologic examination were obtained with bladder catheterization from 155 newborns with early neonatal jaundice. Newborns with a negative urine culture and with a positive urine culture were defined as group I and group II, respectively, and the 2 groups were compared with each other. Results: The incidence of UTI in whole of the study group was 16.7%. Serum total and direct bilirubin levels were statistically significantly higher in group II when compared with group I ( P = .005 and P = .001, respectively). Decrease in serum total bilirubin level at the 24th hour of phototherapy was statistically significantly higher in group I compared with group II ( P = .022). Conclusions: Urinary tract infection should be investigated in the etiologic evaluation of newborns with significant hyperbilirubinemia. The possibility of UTI should be considered in jaundiced newborns who do not respond to phototherapy well or have a prolonged duration of phototherapy treatment.


2020 ◽  
Vol 68 (6) ◽  
pp. 19-28
Author(s):  
Tatyana A. Khusnutdinova

Urinary tract infections are among the most common infectious diseases in women and often complicate the course of pregnancy. This article reviews current scientific and methodical literature on the management of pregnant women with urinary tract infection. Aspects of clinical importance of urinary tract infections during pregnancy (epidemiology, clinical manifestations, and complications) are discussed, with current recommendations for diagnosis and management of urinary tract infections summarized. Special attention is paid to the problem of antibiotic resistance of urinary tract infection pathogens.


2018 ◽  
Vol 1 (3) ◽  
pp. 26-38
Author(s):  
Abdulghani Mohamed Alsamarai ◽  
Shler Ali Khorshed

Background: Urinary tract infection is common with health impact in women and characterised by failure to treatment and recurrent episodes. Aim: This study was conducted to determine the risk factors for the development of urinary tract infection in diabetic and pregnant women in comparison to student female. Materials and methods: A prospective cross-sectional study conducted during the period from 1st of June 2015 to the end of January 2016. The population included in the study are 563 women, of them 425 were outpatients, and 138 were inpatients. Their age range between 18 and 80 years, with a mean age of 33.59±15.29 years. Urine samples collected and cultured on blood agar and MacConkey agar by spread plate technique. Bacterial colonies with different morphology were selected, purified and identified according to their biochemical characteristics using conventional standard methods. Results: In diabetic women, there were no significant difference in mean age and BMI values between culture positive and culture negative groups. However, pus cell mean scale was significantly higher [P=0.000] in women with urinary tract infection [1.76±1.25] than in those with negative culture [0.69±1.00]. In pregnant women, BMI mean value was significantly [P=0.013] lower in pregnant women with UTI [26.14] as compared to those without infection [26.99]. Pus cell scale mean value was significantly [P=0.000] higher in pregnant women with UTI [1.55] than women with negative UTI [0.85]. While there was no significant difference in mean age between UTI positive and negative pregnant women. In female student, there was a significant difference between UTI infected and non-infected in mean age [P=0.041] and pus cell scale [P=0.000]. However, BMI was not significantly different between infected and non-infected female student. Other risk factors association are variables in the 3 groups when analysed using X2, while AUC and OR show different trends of association between risk factors and UTI. Conclusion: BMI, pus cell scale, child number, delivery method, operation history and hospital setting were significantly associated with culture positivity in the 3 studied groups as determined by AUC. While OR confirmed association with pus sale scale in the 3 groups.


Author(s):  
Rana M. Abdullah Al-Shwaikh ◽  
Abbas Falih Alornaaouti

       Current study obtained (75) isolate of Pseudomonas aeruginosa collected from different cases included : 28 isolates from otitis media, 23 isolates from burn infections, 10 isolates from wound infections, 8 isolates from urinary tract infections and 6 isolates from blood, during the period between 1/9/2014 to 1/11/2014        The result revealed that the tox A gene was present in 54 isolates (72%) of Pseudomonas aeruginosa. The gel electrophoresis showed that the molecular weight of tox A gene was 352 bp. The result shows 17 isolates (60.71%) from otitis media has tox A gene, 18 isolates (78.26%) from burn followed by 8 isolate (80%) from wound infection and 5 isolates (62.5%) from urinary tract infection , finally 6 isolates (100%) from blood have this gene.


Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 997-1002
Author(s):  
Hao Wu ◽  
Rui Zheng

AbstractOrgan abscesses caused by Streptococcus anginosus are relatively rare. We report the case of an elderly woman with splenic abscess caused by S. anginosus bacteremia after urinary tract infection. An 82-year-old woman had a history of frequency of urination, urgency, and fever with chills for over 10 days prior to admission. An abdominal computed tomography (CT) scan performed in the emergency room revealed a low-density lesion in the spleen, kidney cysts, some exudation around the kidney, and cystitis should be valued. She was treated with ceftriaxone and imipenem/cilastatin. After admission, the blood culture yielded positive results for S. anginosus. A contrast-enhanced abdominal CT scan showed that the low-density lesion previously found in the spleen was smaller than before. After percutaneous drainage of the splenic abscess and treatment with piperacillin/tazobactam based on the antibiotic sensitivity pattern, repeated abdominal CT scan revealed a significant reduction in the low-density lesion. The patient was discharged without recurrence or complications. A systematic review of organ abscess caused by S. anginosus bacteremia was performed. To our knowledge, there has been no report of splenic abscess caused by S. anginosus bacteremia secondary to urinary system tract infection, although urinary tract infections are also an important source.


2017 ◽  
Vol 38 (8) ◽  
pp. 998-1001 ◽  
Author(s):  
Taniece Eure ◽  
Lisa L. LaPlace ◽  
Richard Melchreit ◽  
Meghan Maloney ◽  
Ruth Lynfield ◽  
...  

We assessed the appropriateness of initiating antibiotics in 49 nursing home (NH) residents receiving antibiotics for urinary tract infection (UTI) using 3 published algorithms. Overall, 16 residents (32%) received prophylaxis, and among the 33 receiving treatment, the percentage of appropriate use ranged from 15% to 45%. Opportunities exist for improving UTI antibiotic prescribing in NH.Infect Control Hosp Epidemiol 2017;38:998–1001


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