scholarly journals BRONCHIAL ASTHMA AS A PROBLEM OF OCCUPATIONAL PATHOLOGY (CLINICAL CASE)

2021 ◽  
Vol 2021 (3) ◽  
pp. 56-60
Author(s):  
A. V. Basanets ◽  
O. V. Ermakova
Keyword(s):  
Allergic Rhinitis ◽  
Occupational Health ◽  
Bronchial Asthma ◽  
Occupational Diseases ◽  
Clinical Case ◽  
Lower Lobe ◽  
State Institution ◽  
Animal Origin ◽  
Pulmonary Insufficiency ◽  
Medical Sciences

BRONCHIAL ASTHMA AS A PROBLEM OF OCCUPATIONAL PATHOLOGY (CLINICAL CASE) A. V. Basanets, O. V. Ermakova State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine Abstract. Aim of the study: to analyze a clinical case of occupational bronchial asthma in a librarian with many years of experience, which was diagnosed in the Clinic of occupational diseases of the State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine». Materials and research methods: Patient`s medical history, results of clinical, radiological, laboratory and functional examinations. Research results. The examined patient B., 63 years old, worked as a librarian for more than 40 years. The diagnosis was established: Bronchial asthma, ІІІ stage, moderate-severe course, uncontrolled, persistent, phase of exacerbation, basal and lower lobe pneumosclerosis, pulmonary insufficiency І-ІІ stage. Year-round allergic rhinitis — occupational diseases (in the profession for more than 40 years, has been in contact with dust of plant and animal origin) Diagnoses are confirmed by physical examination data, results of clinical laboratory, functional and imaging examination, and data on working conditions. Conclusion: An analysis of epidemiological data on occupational bronchial asthma in Ukraine in recent years has shown a decrease in the incidence, while this indicator is increasing throughout the world. Given the current situation, special attention should be paid to the need for a serious improvement in the training of family doctors, therapists and pulmonologists in occupational pathology. Improving the quality of preliminary (hiring) and periodic medical examinations is of great importance for improving the diagnosis of occupational bronchial asthma. Key words: occupational bronchial asthma, allergic rhinitis, allergens. Angela V. Basanets State Institution «Kundiiev Institute of Occupational Health | of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine Head of the department of occupational pathology Corresponding member of NAMS of Ukraine, professor 75, Saksaganskogo str., 01033, Kyiv, Ukraine [email protected] Аsthma and Allergy, 2021, 3, P. 56–60.

scholarly journals Сlinical case of focal alopecia in a child with atopy

2021 ◽  
Vol 23 (1) ◽  
pp. 191-196
Author(s):  
A. A. Barilo ◽  
S. V. Smirnova ◽  
I. M. Olyanina
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Hair Loss ◽  
Clinical Case ◽  
Skin Prick Testing ◽  
Skin Testing ◽  
Calcineurin Inhibitors ◽  
Hair Follicles ◽  
Autoimmune Response ◽  
High Concentration

Alopecia areata is a common inflammatory immune-mediated disorder in which autoimmune response is triggered against hair follicles, thus leading to non-scarring hair loss on the scalp, face and other parts of the skin. Despite numerous studies concerning this issue, today there is no consensus on the etiology and pathogenesis of focal alopecia. In the literature, special attention is paid to association of focal alopecia with autoimmune diseases, such as rheumatoid arthritis, celiac disease, type 1 diabetes, psoriasis, autoimmune thyroiditis, vitiligo. Recent studies have identified the association of focal alopecia with atopic diseases (allergic rhinitis, bronchial asthma, atopic dermatitis) and the early debut of severe forms of hair loss. The aim of this study was to present a clinical case of focal alopecia in an 8-year-old girl with atopic bronchial asthma and seasonal allergic rhinitis. As based on detection of eosinophilia in peripheral blood and a high concentration of total IgE in serum, one may assume that atopic alopecia is the cause of focal hair losses in a child with atopy. The patient underwent skin prick testing, in order to determine sensitization for food components, pollen and fungal allergens. As a result of skin testing, a hyperergic reaction (> 15 mm in diameter) to tree pollen was revealed, a positive response (6-9 mm) to oatmeal, a weakly positive reaction (3-5 mm) to whole chicken egg, carrots, tomato, apple, pear, pollen of meadow, cereal, weed grasses was also revealed. With regard of these allergological data, an individual diet was recommended with the elimination of causally significant allergens (including those eliciting weakly positive reactions), external treatment, i.e., topical calcineurin inhibitors administered for 1 month. One month later, an improvement of the pathological process was registered, and 6 months from the start of therapy, complete restoration of hair follicles was noted in the focus of alopecia. The patient was monitored for a year, no complaints of hair loss were noted. The positive effect of elimination against the background of the appropriate elimination diet with respect to causally significant allergens, was also noted when treating her for respiratory allergy, i.e., the patient did not have seasonal manifestations of hay fever over the next pollination period. This clinical case is demonstrated in order to draw special attention of dermatologists, allergologists, immunologists, general practitioners to the issues of focal alopecia in children against the background of typical allergic diseases.

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

ОЦЕНКА ЦИТОКИНОВОГО ПРОФИЛЯ СЫВОРОТКИ КРОВИ И СУБПОПУЛЯЦИЙ Т-ЛИМФОЦИТОВ У ДЕТЕЙ С АЛЛЕРГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ ОРГАНОВ ДЫХАНИЯ

2019 ◽  
pp. 52-60
Author(s):  
E.V. Prosekova ◽  
A.I. Turyanskaya ◽  
N.G. Plekhova ◽  
M.S. Dolgopolov ◽  
V.A. Sabynych
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cytokine ◽  
Immunological Parameters ◽  
Low Level ◽  
Level Of Significance

Расширение спектра изучаемых клонов Тхелперов определило более сложные иммунные механизмы реализации аллергического воспаления. Цель. Характеристика показателей и взаимосвязей цитокинового профиля сыворотки и субпопуляционного состава Тлимфоцитов периферической крови у детей с бронхиальной астмой и аллергическим ринитом. Материалы и методы. Проведено комплексное обследование 150 детей в возрасте 311 лет с верифицированным диагнозом бронхиальной астмы, аллергического ринита и 30 здоровых сверстников. Иммунологические параметры крови оценивали методом проточной цитометрии, концентрации интерлейкинов и IgE в сыворотке крови определяли методом твердофазного иммуноферментного анализа. При статистической обработке использовали программы Statistica 10 с критическим уровнем значимости р0,05. Результаты. У детей с аллергическими заболеваниями в сыворотке крови определены высокие уровни содержания интерлейкинов4, 8, 13, 17А, сопоставимый с показателями группы контроля уровень IL17F и низкое содержание IFNy. При бронхиальной астме и аллергическом рините у детей выявлено увеличение количества CD3CD8CD45RO, CD3CD8CD45RACD45RO Тлимфоцитов и CD3CD4 Тхелперов и повышение количество Th17 при снижении CD3CD4CD45RO клеток памяти. В группе здоровых детей популяция Th17 составляла 9,491,6, у детей с аллергическими заболеваниями количество данных клеток было значимо выше 14,50,77 (р0,001). Анализ сывороточного содержания цитокинов у детей с изолированным течением БА и в сочетании с аллергическим ринитом выявил разнонаправленные корреляции, отличающиеся по силе и направленности от таковых в группе здоровых детей. Заключение. У детей при изолированном течении бронхиальной астмы и в сочетании с аллергическим ринитом выявлены: сопоставимое с показателями здоровых детей количество CD3CD4 Тклеток, дисбаланс в субпопуляционном составе Тхелперов за счет преобладания Th2 и Th17, активация синтеза IL17A, IL4, IL8, IL13, низкий уровень сывороточного IFNy, изменения силы и направленности взаимосвязей цитокинового профиля и спектра субпопуляций Тлимфоцитов.Expansion of the range of examined Thelper clones has determined more complex immune mechanisms for the implementation of allergic inflammation. Objective. To characterize the parameters and relationships between the serum cytokine profile and Tlymphocyte subpopulation in peripheral blood of children with bronchial asthma and allergic rhinitis. Materials and methods. 150 children aged between 311 years old with bronchial asthma, and allergic rhinitis and 30 healthy volunteers were examined. Immunological parameters were assessed by flow cytometry, the concentration of serum interleukins and IgE were determined by means of enzymelinked immunosorbent assay. Statistical analysis was performed with Statistica 10 program with a critical level of significance p0.05. Results. High levels of interleukins 4, 8, 13, 17A were determined, IL7F level was not significantly different from that in control group and low level of IFNy was found in the serum of children with allergic diseases. The number of CD3CD8CD45RO, CD3CD8CD45RACD45RO Tlymphocytes, CD3CD4 Thelper cells and Th17 were increased and at the same time CD3CD4CD45RO memory cells were decreased In bronchial asthma and allergic rhinitis children. Number of Th17 cells in healthy children was 9.491.6, in allergic children it was significantly higher 14.50.77 (p0.001). Analyses of serum cytokine count in children with isolated BA and in association with allergic rhinitis revealed multidirectional correlations differing in strength and direction from those in the group of healthy children. Conclusion. In children with isolated bronchial asthma and associated with allergic rhinitis the following parameters were found: CD3CD4 Tcells count was comparable to that in healthy children, the imbalance of Thelper subpopulation: prevalence of Th2 and Th17, activation of IL17A, IL4, IL8, IL13 synthesis and low level of serum IFNy.

Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma

2007 ◽  
Vol 59 (9-10) ◽  
pp. 852-882 ◽  
Author(s):  
Michael H. Smolensky ◽  
Bjoern Lemmer ◽  
Alain E. Reinberg
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma

scholarly journals Compatibility as guiding principle for ergonomics work design and preventive occupational health and safety

2021 ◽  
Author(s):  
Helmut Strasser
Keyword(s):  
Occupational Health ◽  
System Performance ◽  
Occupational Diseases ◽  
Health And Safety ◽  
Occupational Health And Safety ◽  
Well Being ◽  
Work Design ◽  
Human Organism ◽  
Machine System ◽  
Human Capacity

AbstractMutual adaptation and inter-changeability of system elements are very important prerequisites for machines, technical devices and products. Similar to that technical compatibility which can be achieved by standards and regulations, optimum design of human-oriented workplaces or a man-machine system cannot be attained without, e.g., a compatible arrangement of connected displays and controls. Over and above those stimulus/response relations, all technical elements and interfaces have to be designed in such a way that they do not exceed human capacity in order to optimize human well-being and overall system performance. Compatibility between the properties of the human organism on the one hand, and the adaptable technical components of a work system on the other hand, offers a great potential of preventive measures. Examples of ergonomically designed working tools show that compatibility is capable of reducing the prevalence of occupational diseases and repetitive strain injuries as well as leading to lower physiological cost in such a way that the same output results from a lower demand of human resources or even a higher performance will be attained. Compatibility also supports the quick perception and transmission of information in a man-machine system, and as a result of lower requirements for decoding during information processing, spare mental capacity may enhance occupational safety. In the field of software, compatibility also helps to avoid psychological frustration. All in all, the center core competency, which reflects the major significant function of the ergonomist in work design, consists in determining the compatibility of human capacity and planned or existing demands of work. In order to provide efficient working tools and working conditions as well as to be successful in occupational health and safety, ergonomics and industrial engineering in the future are expected to pay more attention to the rules of compatibility. Applied in an appropriate way, these rules may convince people that ergonomics can be a powerful means for reducing prevalence of occupational diseases and complaints, and has a positive effect on overall system performance. Besides presenting examples of work design according to the principle of compatibility, also methods will be shown which enable the assessment of the ergonomic quality of hand-held tools and computer input devices.

scholarly journals Improvement of the module for occupational diseases in the structure of occupational health record

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M Iancheva ◽  
T Kundurzhiev ◽  
N Tzacheva ◽  
L Hristova
Keyword(s):  
Public Health ◽  
Occupational Health ◽  
Health Services ◽  
Occupational Disease ◽  
Occupational Diseases ◽  
National Level ◽  
Working Environment ◽  
Occupational Health Services ◽  
Health Record ◽  
Disease Module

Abstract The study is based on the National Science Program 'eHealth in Bulgaria (e-Health)', funded by the Ministry of Education and Science. Partnership Contract No. D-01-200/16.11.2018 Issue Occupational health is closely linked to public health and health system. In Bulgaria there are many software products related to the registration and reporting of occupational health. Description of the Problem It is necessary to study all the determinants of occupational health, including the risks of diseases and accidents in the occupational environment, social and individual factors. The establishment of electronic systems for registering and monitoring both the health status of each worker and the possible hazards in the work environment is associated with the introduction and use of the occupational health record of each worker. Results The methodology for improving the module for occupational diseases in the structure of the occupational health record in Bulgaria has been developed. The classifications are in compliance with the legislation in the country and the requirements of the developing Eurostat methodology for European statistics on occupational diseases are applied. The occupational health record will serve both employers and physicians working in Occupational Health Services. Lessons The occupational disease module in the structure of the occupational health record will contribute to the statistical comparability of occupational disease data at regional and national level. Not only will the registration of the harmful factors of the working environment and the diseases related to the work process, but also the introduction of timely measures to ensure good occupational and public health. Key messages Through the occupational disease module, the structure of the occupational health record introduces the possibility of taking adequate measures to ensure good occupational health. The occupational health record will serve both employers and physicians working in Occupational Health Services.

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