scholarly journals Ethyl-cellulose rumen-protected methionine alleviates inflammation and oxidative stress and improves neutrophil function during the periparturient period and early lactation in Holstein dairy cows

2018 ◽  
Vol 101 (1) ◽  
pp. 480-490 ◽  
Author(s):  
F. Batistel ◽  
J.M. Arroyo ◽  
C.I.M. Garces ◽  
E. Trevisi ◽  
C. Parys ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Ethyl Cellulose ◽  
Neutrophil Function ◽  
Early Lactation ◽  
Periparturient Period ◽  
And Oxidative Stress ◽  
Holstein Dairy Cows

scholarly journals Ethyl-cellulose rumen-protected methionine enhances performance during the periparturient period and early lactation in Holstein dairy cows

2017 ◽  
Vol 100 (9) ◽  
pp. 7455-7467 ◽  
Author(s):  
F. Batistel ◽  
J.M. Arroyo ◽  
A. Bellingeri ◽  
L. Wang ◽  
B. Saremi ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Ethyl Cellulose ◽  
Early Lactation ◽  
Periparturient Period ◽  
Holstein Dairy Cows

scholarly journals Relationship between inflammatory biomarkers and oxidative stress with uterine health in dairy cows with different dry period lengths1

2019 ◽  
Vol 3 (2) ◽  
pp. 607-619
Author(s):  
Novi Mayasari ◽  
Erminio Trevisi ◽  
Annarita Ferrari ◽  
Bas Kemp ◽  
Henk K Parmentier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Negative Energy ◽  
Inflammatory Biomarkers ◽  
Early Lactation ◽  
Dry Period ◽  
Inflammatory Status ◽  
Uterine Health ◽  
Uterine Environment ◽  
And Oxidative Stress

Abstract Earlier studies indicated that the inflammatory status of dairy cows in early lactation could not be fully explained by the negative energy balance (NEB) at that moment. The objective of the present study was to determine relationships between inflammatory biomarkers and oxidative stress with uterine health in dairy cows after different dry period lengths. Holstein–Friesian dairy cows were assigned to one of three dry period lengths (0-, 30-, or 60-d) and one of two early lactation rations (glucogenic or lipogenic ration). Cows were fed either a glucogenic or lipogenic ration from 10-d before the expected calving date. Part of the cows which were planned for a 0-d dry period dried themselves off and were attributed to a new group (0 → 30-d dry period), which resulted in total in four dry period groups. Blood was collected (N = 110 cows) in weeks −3, −2, −1, 1, 2, and 4 relative to calving to determine biomarkers for inflammation, liver function, and oxidative stress. Uterine health status (UHS) was monitored by scoring vaginal discharge (VD) based on a 4-point scoring system (0, 1, 2, or 3) in weeks 2 and 3 after calving. Cows were classified as having a healthy uterine environment (HU, VD score = 0 or 1 in both weeks 2 and 3), nonrecovering uterine environment (NRU, VD score = 2 or 3 in week 3), or a recovering uterine environment (RU, VD score = 2 or 3 in week 2 and VD score= 0 or 1 in week 3). Independent of dry period length, cows with NRU had higher plasma haptoglobin (P = 0.05) and lower paraoxonase levels (P < 0.01) in the first 4 weeks after calving and lower liver functionality index (P < 0.01) compared with cows with HU. Cows with NRU had lower plasma albumin (P = 0.02) and creatinine (P = 0.02) compared with cows with a RU, but not compared with cows with HU. Independent of UHS, cows with a 0 → 30-d dry period had higher bilirubin levels compared with cows with 0-, 30-, or 60-d dry period (P < 0.01). Cows with RU and fed a lipogenic ration had higher levels of albumin in plasma compared with cows with NRU and fed a lipogenic ration (P < 0.01). In conclusion, uterine health was related to biomarkers for inflammation (haptoglobin and albumin) and paraoxonase in dairy cows in early lactation. Cows which were planned for a 0-d dry period, but dried themselves off (0 → 30-d dry period group) had higher bilirubin levels, which was possibly related to a more severe NEB in these cows. Inflammatory biomarkers in dairy cows in early lactation were related to uterine health in this period.

Metabolic factors affecting the inflammatory response of periparturient dairy cows

2009 ◽  
Vol 10 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Lorraine M. Sordillo ◽  
G. A. Contreras ◽  
Stacey L. Aitken
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Lipid Metabolism ◽  
Dairy Cows ◽  
Systemic Inflammation ◽  
Dominant Factor ◽  
The Metabolic Syndrome ◽  
Periparturient Period ◽  
Health Disorders ◽  
And Oxidative Stress

AbstractDairy cattle are susceptible to increased incidence and severity of disease during the periparturient period. Increased health disorders have been associated with alterations in bovine immune mechanisms. Many different aspects of the bovine immune system change during the periparturient period, but uncontrolled inflammation is a dominant factor in several economically important disorders such as metritis and mastitis. In human medicine, the metabolic syndrome is known to trigger several key events that can initiate and promote uncontrolled systemic inflammation. Altered lipid metabolism, increased circulating concentrations of non-esterified fatty acids and oxidative stress are significant contributing factors to systemic inflammation and the development of inflammatory-based diseases in humans. Dairy cows undergo similar metabolic adaptations during the onset of lactation, and it was postulated that some of these physiological events may negatively impact the magnitude and duration of inflammation. This review will discuss how certain types of fatty acids may promote uncontrolled inflammation either directly or through metabolism into potent lipid mediators. The relationship of increased lipid metabolism and oxidative stress to inflammatory dysfunction will be reviewed as well. Understanding more about the underlying cause of periparturient health disorders may facilitate the design of nutritional regimens that will meet the energy requirements of cows during early lactation and reduce the susceptibility to disease as a function of compromised inflammatory responses.

scholarly journals Efficacy of Herbal Powder in Reducing Oxidative Stress during Periparturient Period in Crossbred Dairy Cows

2016 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Herbal Product ◽  
Therapeutic Trial ◽  
Lactation Period ◽  
Early Lactation ◽  
Milk Fever ◽  
Periparturient Period ◽  
Group I ◽  
Increased Risk

Background: Periparturient period is very important and critical period in dairy cows because during this period dairy cows are at increased risk of developing various metabolic and production diseases such as ketosis, milk fever, mastitis, retained placenta etc. due to the increased stress imposed upon the animal by the developing fetus and also due to the initiation of lactation after parturition. Now a days, use of herbal medicine as an alternative medicine is under constant debate due to the associated toxicity and side effects of allopathic medicines. Objectives: A therapeutic trial was conducted to check the efficacy of Herbal product “Stress check” on various metabolic and oxidative stress parameters during periparturient period. Methodology: A total of 16 crossbred cows divided into two groups, Group I was kept as control and Group II given herbal powder stress check @ 15 grams per day starting 15 days of expected parturition upto 15 days after parturition. Results: A significant decrease was recorded in the lipid peroxidation (LPO) levels during the fresh period in comparison to control cows, and a non-significant increase was also noticed in both the SOD and GSH levels during the early lactation period, suggesting its role in reducing stress and improving metabolism during early lactation period. Also a non-significant increase was noticed in plasma glucose levels and lower protein, urea, levels during the fresh period, whereas, no effect was observed on other metabolic parameters after the feeding of Stress Check powder. Conclusion: Herbal powder “Stress Check” was effective in controlling the oxidative stress in supplemented cows in comparison to control cows as evidenced by the lower LPO levels and higher SOD and GSH levels.

scholarly journals An Exploration of the Effects of an Early Postpartum Intravenous Infusion with Carnosic Acid on Physiological Responses of Transition Dairy Cows

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1478
Author(s):  
Tainara Cristina Michelotti ◽  
Erminio Trevisi ◽  
Johan S. Osorio
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Intravenous Infusion ◽  
Transition Period ◽  
Carnosic Acid ◽  
Lactation Performance ◽  
Oxidative Stress Biomarkers ◽  
Blood Concentrations ◽  
Beneficial Effects ◽  
And Oxidative Stress

The objective of the present study was to evaluate the effects of an antioxidant and anti-inflammatory compound found in rosemary plants (Salvia rosmarinus) named carnosic acid during the transition period of dairy cows. From day 1 to 3 after calving, 16 multiparous Holstein cows received a daily intravenous infusion of either 500 mL of saline (NaCl 0.9%; Saline; n = 8) or carnosic acid at a rate of 0.3 mg/kg of BW supplied in 500 mL of saline (CA; n = 8). Blood samples were taken at –7, 2, 5, 7, 14, and 21 d relative to parturition, then analyzed for metabolites related to energy metabolism, muscle mass catabolism, liver function, inflammation, and oxidative stress. CA infusion tended to improve milk performance; however, DMI was unaffected by treatment. At 2 d relative to parturition, CA cows had lower blood concentrations of haptoglobin, paraoxonase, FRAP, and NO2– than saline cows. After treatment infusions, haptoglobin remained lower in CA cows than saline at 5 d relative to parturition. Our results demonstrate that carnosic acid promoted positive responses on inflammation and oxidative stress biomarkers and may promote beneficial effects on lactation performance in peripartal dairy cows.

scholarly journals PSI-18 Adiponectin serum concentrations in late pregnancy and early lactation in primiparous and multiparous Holstein dairy cows.

2018 ◽  
Vol 96 (suppl_3) ◽  
pp. 65-65
Author(s):  
C Urh ◽  
J Denißen ◽  
I Harder ◽  
C Koch ◽  
E Stamer ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Late Pregnancy ◽  
Early Lactation ◽  
Serum Concentrations ◽  
Holstein Dairy Cows

Rumen-protected methionine supplementation during the peripartal period alters the expression of galectin genes associated with inflammation in peripheral neutrophils and secretion in plasma of Holstein cows

2019 ◽  
Vol 86 (4) ◽  
pp. 394-398
Author(s):  
Emmanuel K. Asiamah ◽  
Mario Vailati-Riboni ◽  
Zheng Zhou ◽  
Tianle Xu ◽  
Juan J. Loor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Dietary Intervention ◽  
Innate Immune ◽  
Signaling Cascades ◽  
Surface Receptors ◽  
Il Interleukin ◽  
Periparturient Period ◽  
Methionine Supplementation ◽  
And Oxidative Stress

AbstractThe work described in this research communication aimed to investigate whether rumen-protected methionine (Met) supplementation during the periparturient period would affect the expression of galectins in blood-derived neutrophils, and secretion of galectins, IL (interleukin)-1β, IL-6, myeloperoxidase (MPO), and glucose in plasma. Because supplementation of rumen-protected Met would alleviate inflammation and oxidative stress during the peripartal period, we hypothesized that enhancing Met supply would benefit the innate immune response at least in part by altering the expression of galectin genes associated with neutrophil activity and inflammation. Galectins (Gal) have an immuno-modulating effect acting like cell-surface receptors whose activation often results in signaling cascades stimulating cells such as neutrophils. This study revealed an association between Met supplementation and galectin expression and secretion. This implies that galectin expression and secretion can be modulated by Met supplementation. Further studies are needed to evaluate the regulation of galectin gene expression for therapeutic and dietary intervention in the peripartal cow.

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