Proton magnetic resonance spectroscopy to evaluate spinal cord axonal injury in cervical spondylotic myelopathy

2009 ◽  
Vol 10 (3) ◽  
pp. 194-200 ◽  
Author(s):  
Langston T. Holly ◽  
Bonnie Freitas ◽  
David L. McArthur ◽  
Noriko Salamon
Keyword(s):  
Spinal Cord ◽  
Cervical Spine ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mr Spectroscopy ◽  
Cervical Spondylotic Myelopathy ◽  
Neuronal Loss ◽  
Control Group ◽  
Resonance Spectroscopy ◽  
Cellular Biochemistry

Object Magnetic resonance spectroscopy is commonly used to provide cellular and metabolic information in the management of a variety of pathological processes that affect the brain, and its application recently has been expanded to the cervical spine. The majority of radiographic investigations into the pathophysiology of cervical spondylotic myelopathy (CSM) have been focused on the spinal cord macrostructure. The authors sought to determine the feasibility of using MR spectroscopy to analyze spinal cord biochemical function in patients with CSM. Methods Twenty-one patients with clinical and radiographic evidence of CSM were prospectively enrolled in this study. The patients underwent preoperative neurological examination, functional assessment, and cervical spine MR spectroscopy. Voxels were placed at the C-2 level, and the MR spectroscopy spectra peaks for N-acetylaspartate (NAA), choline, lactate (Lac), and creatine (Cr) were measured. Thirteen age-matched healthy volunteers served as controls. Results The NAA/Cr ratio was significantly lower in patients with CSM than in controls (1.27 vs 1.83, respectively, p < 0.0001). The choline/Cr ratio was not significantly different between the 2 groups. Seven of the patients with CSM had a Lac peak, whereas no peaks were noted in the control group (p < 0.05). There was no correlation between the severity of myelopathy and the NAA/Cr ratio in the CSM cohort. Conclusions Data in this study demonstrated the feasibility of using MR spectroscopy to evaluate the cellular biochemistry of the spinal cord in patients with CSM. Patients with CSM had a significantly lower NAA/Cr ratio than healthy controls, likely because of axonal and neuronal loss. The presence of Lac peaks in one-third of the patients in the CSM cohort further supports the role of ischemia in the pathophysiology of CSM.

Cardiac energetics alteration in chronic hypoxia rat model: a non invasive in vivo 31P magnetic resonance spectroscopy experimental study

2021 ◽  
Author(s):  
Xiaohan Yuan ◽  
Xiaomei Zhu ◽  
Yang Chen ◽  
Wangyan Liu ◽  
Wen Qian ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Right Ventricular ◽  
Myocardial Injury ◽  
Chronic Hypoxia ◽  
Volume Index ◽  
Control Group ◽  
Resonance Spectroscopy ◽  
Cardiac Energetics

Abstract Background: Energetics alteration plays a key role in the process of myocardial injury in chronic hypoxic diseases (CHD). 31P magnetic resonance spectroscopy (MRS) can investigate alterations in cardiac energetics in vivo. This study was aimed to characterize the potential value of 31P MRS in evaluating cardiac energetics alteration of chronic hypoxia rats (CHR).Methods: Twenty-four CHRs were induced by SU5416 combined with hypoxia, and six rats were raised as control group. 31P MRS was performed weekly and the ratio of concentrations of phosphocreatine (PCr) to adenosine triphosphate (ATP) (PCr/ATP) was obtained. The index of cardiac structure and systolic function parameters, including the right ventricular function (RVEF), right ventricular end-diastolic volume index (RVEDVi), right ventricular end-systolic volume index (RVESVi), the left ventricular function parameters were also measured.Results: The declension of resting cardiac PCr/ATP ratio in CHR was observed at the 1st week, compared to control group (2.90±0.35 vs. 3.31±0.45, p =0.045), while the RVEF，RVEDVi and RVESVi decreased at the 2nd week (p＜0.05). The PCr/ATP ratio displayed a significant correlation with RVEF(r = 0.605, p = 0.001)，RVEDVi and RVESVi (r = -0.661, r = -0.703; p＜0.001).Conclusions: 31P MRS can early detect the cardiac energetics alteration in CHR model before the onset of ventricular dysfunction. The decrease of PCr/ATP ratio likely revealed myocardial injury and cardiac dysfunction.

In vivo 1 H-magnetic resonance spectroscopy of the spinal cord in humans

2000 ◽  
Vol 42 (7) ◽  
pp. 515-517 ◽  
Author(s):  
B. Gómez-Ansón ◽  
D. G. MacManus ◽  
G. J. M. Parker ◽  
C. A. Davie ◽  
G. J. Barker ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

scholarly journals The Role of Magnetic Resonance Spectroscopy in Evaluating the Rate of Brain Metabolic Variations in Chemical Veterans with Respiratory Problem In Comparison To Control Group

2018 ◽  
Vol 6 (12) ◽  
pp. 2348-2353
Author(s):  
Seyyed Arash Mahdawy ◽  
Babak Shekarchi ◽  
Mahshid Zaman
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Injuries ◽  
Sulfur Mustard ◽  
Complete Information ◽  
Brain Dysfunction ◽  
Control Group ◽  
Resonance Spectroscopy ◽  
Metabolic Properties ◽  
The Brain

BACKGROUND:  During the eight years of the imposed war, Iraq used various chemical agents such as sulfur mustard and nerve agents (mainly tabun and sometimes soman) on Iran's soldiers. Using information obtained from specialist sequences and analysing information obtained from magnetic resonance imaging (MRI) in a susceptibility weighted imaging (SWI) sequence and magnetic resonance spectroscopy (MRS) provides valuable information on continuation of treatment and identifying functional disorders. AIM: The objective of this research was to evaluate the rate of metabolic variations in chemically injured veterans based on chemical neuromarkers using the chemical sequence MRS, which would help patients and physicians in terms of time, economics, and selection of appropriate therapeutic methods, so if the can physician can get complete information about the metabolic properties of the brain through paraclinical (especially MRI) tools before treatment, he might change his treatment program to reduce the complications caused by it. METHODOLOGY: In this research, 40 chemically injured veterans with brain dysfunction admitted to the screening centre for MRI with specialized MRS sequence participated. Accordingly, we examined the rate of brain metabolic variations about the level of neuromarkers and evaluated the relationship between the level of neuromarkers and brain damages. RESULTS: The results of this research revealed that while the demographic characteristics such as age of the two groups of chemically injured veterans and control was similar, only the median of the NAA/Cr (N-acetylaspartate to creatine ratio) ratio in PONS of chemically injured patients was significantly lower than that of the control group, and this ratio was similar in other parts of the brain in two groups. The results also showed that the ratio of NAA to total choline and Cr was similar in all parts of the brain in two groups. CONCLUSION: Based on the research results, using the MR (Magnetic Resonance) spectroscopy device and determination of the value and ratio of markers such as creatinine and N-acetylaspartate and choline, the brain injuries of chemically injured veterans can be examined. By conducting further studies and larger sample size, the brain damages in veterans can be diagnosed early, which would be a great contribution in their treatment.

Application of CT Energy Spectrum Combined with MR Spectroscopy in the Classification of Meningiomas

2020 ◽  
Vol 10 (8) ◽  
pp. 1949-1954
Author(s):  
Ruiping Chai ◽  
Hong Zhang ◽  
Hongcan Ma ◽  
Ximi Xu ◽  
Hamris Andrew
Keyword(s):  
Energy Spectrum ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mr Spectroscopy ◽  
Low Energy ◽  
Resonance Spectroscopy ◽  
Who Grade ◽  
Quantitative Parameters ◽  
Cr Concentration

Objective: To study the application value of CT spectroscopy combined with MR spectroscopy in the classification and classification of meningioma, in order to provide more information for the classification and classification of meningioma from the perspective of imaging, and to improve the intraoperative tumor resection. Provide reference for selection and evaluation of prognosis, judgment of efficacy, and prediction of recurrence. Methods: A total of 102 patients who underwent preoperative energy spectroscopy and 3.0T magnetic resonance spectroscopy were enrolled in our hospital from March 2017 to March 2018. There were 48 patients with spectral CT scan, 43 patients with MR spectroscopy, and 11 patients with energy spectrum CT and MR spectroscopy. Correlation between grading and typing of meningiomas was performed using quantitative parameters of energy spectrum CT and magnetic resonance spectroscopy. Study and evaluate the diagnostic efficacy of quantitative parameters. Results: The results of CT spectra combined with MR spectroscopy in the pathological grading of meningiomas showed significant differences in CT values at low energy (40–70 KeV) (P < 0.05), which showed that the CT values of WHOI-level single energy were less than WHO II grade; WHO grade I meningioma curve slope was significantly smaller than WHO II grade (P < 0.05), statistically significant; also found that WHO grade I meningioma Cho concentration, Cr concentration, Cho/Cr ratio and WHO II grade There was a significant difference (P < 0.05). Conclusion: CT spectroscopy combined with MR spectroscopy imaging in the diagnosis of meningioma, the single-energy CT value and slope of the low-energy (40–70 KeV) level of WHO grade I meningioma, the Cho concentration is significantly lower than the WHO II-level meninges. Tumor, and the Cr concentration is significantly higher than the WHO I level, the combination of the two can more accurately diagnose the meningioma.

Phosphorus-31 Magnetic Resonance Spectroscopy Studies of Pig Spinal Cord Injury

1997 ◽  
Vol 32 (7) ◽  
pp. 382-388 ◽  
Author(s):  
MINORU AKINO ◽  
J. MICHAEL O'DONNELL ◽  
PIERRE-MARIE L. ROBITAILLE ◽  
BRADFORD T. STOKES
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Cord Injury ◽  
Spectroscopy Studies

scholarly journals Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy

2016 ◽  
Vol 77 (4) ◽  
pp. 1639-1649 ◽  
Author(s):  
Nathan P. Skinner ◽  
Shekar N. Kurpad ◽  
Brian D. Schmit ◽  
L. Tugan Muftuler ◽  
Matthew D. Budde
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Double Diffusion ◽  
Resonance Spectroscopy ◽  
Rat Spinal Cord ◽  
In Vivo Detection ◽  
Cord Injury

Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery

2007 ◽  
Vol 107 (4) ◽  
pp. 873-877 ◽  
Author(s):  
Takaaki Beppu ◽  
Takashi Inoue ◽  
Hideaki Nishimoto ◽  
Shinichi Nakamura ◽  
Yoichi Nakazato ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fractional Anisotropy ◽  
Mr Spectroscopy ◽  
Diffusion Tensor ◽  
Resonance Spectroscopy ◽  
Granulomatous Angiitis ◽  
The Central Nervous System

✓Primary granulomatous angiitis of the central nervous system (CNS) is extremely rare. Its preoperative diagnosis is difficult as the condition displays nonspecific features on routine neuroimaging investigations. In this paper, the authors report findings of magnetic resonance (MR) spectroscopy and fractional anisotropy (FA) with diffusion tensor MR imaging in a case of granulomatous angiitis of the CNS. A 30-year-old man presented with morning headaches and grand mal seizures. An MR image revealed a mass resembling glioblastoma in the right temporal lobe. Magnetic resonance spectroscopy showed a high choline/creatine (Cho/Cr) ratio indicative of a malignant neoplasm, accompanied by a slight elevation of glutamate and glutamine. The FA value was very low, which is inconsistent with malignant glioma. The mass was totally removed surgically. Histologically, the peripheral lesion of the mass consisted of a rough accumulation of fat granule cells, infiltration of inflammatory cells, and distribution of capillary vessels. Some vessels within the lesion were replaced by granulomas. The histological diagnosis was granulomatous angiitis of the CNS. The MIB-1–positive rate of the granuloma was approximately 5%. Both MR spectroscopy and FA were unable to accurately diagnose granulomatous angiitis of the CNS prior to surgery; however, elevated Cho/Cr and glutamate and glutamine shown by MR spectroscopy may indicate the moderate proliferation potential of the granuloma and the inflammatory process, respectively, in this condition. Although the low FA value in the present case enabled the authors to rule out a diagnosis of glioblastoma, FA values in inflammatory lesions require careful interpretation.

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