scholarly journals Harvey Cushing and pituitary Case Number 3 (Mary D.): the origin of this most baffling problem in neurosurgery

2016 ◽  
Vol 41 (1) ◽  
pp. E6 ◽  
Author(s):  
José María Pascual ◽  
Ruth Prieto
Keyword(s):  
Great Influence ◽  
Pituitary Surgery ◽  
Multiple Sources ◽  
Tumor Registry ◽  
Neurosurgical Procedure ◽  
Harvey Cushing ◽  
History Of ◽  
Seminal Article ◽  
Adamantinomatous Craniopharyngioma ◽  
Case Number

From the very beginning of his career, Harvey Williams Cushing (1869–1939) harbored a deep interest in a complex group of neoplasms that usually developed at the infundibulum. These were initially known as “interpeduncular” or “suprasellar” cysts. Cushing introduced the term “craniopharyngioma” for these lesions, which he believed represented one of the most baffling problems faced by neurosurgeons. The patient who most influenced Cushing's thinking was a 16-year-old seamstress named “Mary D.,” whom he attended in December 1901, exactly the same month that Alfred Fröhlich published his seminal article describing an adiposogenital syndrome in a young boy with a pituitary cyst. Both Cushing's and Fröhlich's patients showed similar symptoms caused by the same type of tumor. Notably, Cushing and Fröhlich had met one another and became good friends in Liverpool the summer before these events took place. Their fortunate relationship led Cushing to realize that Fröhlich's syndrome represented a state of hypopituitarism and provided a useful method of diagnosing interpeduncular cysts. It is noteworthy that Cushing's very first neurosurgical procedure on a pituitary tumor was performed in the case of Mary D.'s “interpeduncular cyst,” on February 21, 1902. Cushing failed to remove this lesion, which was later found during the patient's autopsy. This case was documented as Pituitary Case Number 3 in Cushing's masterpiece, The Pituitary Body and Its Disorders, published in 1912. This tumor was considered “a teratoma”; however, multiple sources of evidence suggest that this lesion actually corresponded to an adamantinomatous craniopharyngioma. Unfortunately, the pathological specimens of this lesion were misplaced, and this prompted Cushing's decision to retain all specimens and documents of the cases he would operate on throughout his career. Accordingly, Mary D.'s case crystallized the genesis of the Cushing Brain Tumor Registry, one of Cushing's major legacies to neurosurgery. In this paper the authors analyze the case of Mary D. and the great influence it had on Cushing's conceptions of the pituitary gland and its afflictions, and on the history of pituitary surgery.

The history of pituitary surgery for Cushing disease

2012 ◽  
Vol 116 (2) ◽  
pp. 261-268 ◽  
Author(s):  
Gautam U. Mehta ◽  
Russell R. Lonser ◽  
Edward H. Oldfield
Keyword(s):  
Cushing Syndrome ◽  
Pituitary Surgery ◽  
Selective Removal ◽  
Cushing Disease ◽  
Historical Texts ◽  
Harvey Cushing ◽  
Transient Improvement ◽  
History Of ◽  
Unclear Etiology ◽  
Acth Secreting

Although he never performed a pituitary operation for the disease, Harvey Cushing was the first to describe and treat patients with Cushing disease (CD). Other surgeons at the time were reluctant to operate on the pituitary due to the normal sella on skull radiographs in CD and the unclear etiology of the disorder. To better define and understand factors influencing the history of pituitary surgery for CD, the authors analyzed historical texts related to CD biology, diagnosis, and treatment. Cushing's monograph on basophilic pituitary adenomas and cortisol excess appeared in 1932. One year later in 1933, Alfred Pattison performed the first successful pituitary operation for CD by implanting radon seeds in the sella. Resection of a pituitary adenoma for CD was attempted 1 month later in 1933 by Howard Naffziger, resulting in only transient improvement that corresponded to the lack of tumor in the resected tissue. Soon thereafter, Susman in 1935 and Costello in 1936 described pituitary basophilic adenomas at autopsy in patients without premorbid endocrinopathy. They concluded that the adrenal gland was the cause of CD, which resulted in a 3-decade abandonment of pituitary surgery for CD. Jules Hardy in 1963 used the operating microscope to perform the first selective removal of an adrenocorticotropic hormone (ACTH)–secreting microadenoma, which established a pituitary cause and defined the modern treatment of CD. Subsequent reports by Hardy, Laws, and Wilson resulted in widespread acceptance of pituitary surgery for CD. Initial reluctance to operate on the pituitary for CD was multifaceted and included general uncertainty surrounding the etiology of Cushing syndrome as well as a lack of early surgical success, both due to the small size of ACTH-secreting adenomas. Selective removal of ACTH-secreting adenomas identified the source of CD and ended the delay in acceptance of pituitary surgery for CD.

Epidemics and History: Multiple Approaches to the Subject

2021 ◽  
pp. 5
Author(s):  
Dmitriy Mikhel
Keyword(s):  
20Th Century ◽  
Great Influence ◽  
Medical Knowledge ◽  
Public Attention ◽  
Medical Texts ◽  
Quarter Century ◽  
History Of ◽  
The Media ◽  
New Generation ◽  
The 19Th Century

The problems of epidemics have increasingly attracted the attention of researchers in recent years. The history of epidemics has its own historiography, which dates to the physician Hippocrates and the historian Thucydides. Up to the 19th century, historians followed their ideas, but due to the progress in medical knowledge that began at that time, they almost lost interest in the problems of epidemics. In the early 20th century, due to the development of microbiology and epidemiology, a new form of the historiography of epidemics emerged: the natural history of diseases which was developed by microbiologists. At the same time, medical history was reborn, and its representatives saw their task as proving to physicians the usefulness of studying ancient medical texts. Among the representatives of the new generation of medical historians, authors who contributed to the development of the historiography of epidemics eventually emerged. By the end of the 20th century, they included many physician-enthusiasts. Since the 1970s, influenced by many factors, more and more professional historians, for whom the history of epidemics is an integral part of the history of society. The last quarter-century has also seen rapid growth in popular historiography of epidemics, made possible by the activation of various humanities researchers and journalists trying to make the history of epidemics more lively and emotional. A great influence on the spread of new approaches to the study of the history of epidemics is now being exerted by the media, focusing public attention on the new threats to human civilization in the form of modern epidemics.

Sources of auxiliation in the perfects of Europe

2013 ◽  
Vol 37 (3) ◽  
pp. 599-644 ◽  
Author(s):  
Bridget Drinka
Keyword(s):  
Language Contact ◽  
Western Europe ◽  
Language Change ◽  
Multiple Sources ◽  
Ancient Greek ◽  
12Th Century ◽  
History Of ◽  
Peripheral Areas ◽  
Explanatory Mechanism ◽  
Scribal Tradition

This paper explores the complex role of language contact in the development of be and have auxiliation in the periphrastic perfects of Europe. Beginning with the influence of Ancient Greek on Latin, it traces the spread of the category across western Europe and identifies the Carolingian scribal tradition as largely responsible for extending the use of the be perfect alongside the have perfect across Charlemagne’s realm. Outside that territory, by contrast, in “peripheral” areas like Iberia, Southern Italy, and England, have came to be used as the only perfect auxiliary. Within the innovating core area, a further innovation began in Paris in the 12th century and spread to contiguous areas in France, Southern Germany, and northern Italy: the semantic shift in the perfects from anterior to preterital meaning. What can be concluded from these three successive instances of diffusion in the history of the perfect is that contact should be regarded as one of the essential “multiple sources” of innovation, and as a fundamental explanatory mechanism for language change.

scholarly journals PENGARUH MODEL PEMBELAJARAN TWO STAY TWO STRAY TERHADAP HASIL BELAJAR SEJARAH DI SMA NEGERI 7 MEDAN

2019 ◽  
Vol 1 (2) ◽  
pp. 85
Author(s):  
Marcho Alex Samuel Silitonga
Keyword(s):  
Student Learning ◽  
Learning Outcomes ◽  
Great Influence ◽  
Student Learning Outcomes ◽  
Learning Model ◽  
T Test ◽  
Average Value ◽  
Post Test ◽  
Quasi Experimental ◽  
History Of

This study aims to determine the effect of the application of the Two Stay Two Stray learning model (TSTS) to the history of student learning outcomes at SMA Negeri 7 Medan. The research method used is quasi-experimental. The study population was students of class X IPS with a sample of 65 students consisting of 34 students of class X IPS 2 as an experimental class and 31 students of class X IPS 1 as a control class. Data collection techniques using observation and tests. The data obtained were analyzed using the t-test. The observation results showed that 91% of the experimental class students who took part in learning with the TSTS model got very good average scores. The average post-test value of the experimental class was 80.3, while the average value of the post-test of the control class that followed the learning with the conventional model was 63.70. T-test results for the post-test scores were obtained tcount > ttable (7,004 > 1,670).These results indicate that the TSTS learning model has a great influence in improving the history of student learning outcomes in class XI IPS 2 SMA Negeri 7 Medan.

scholarly journals KONTRIBUSI POSITIF ORIENTALISME: KAJIAN ATAS REINHART DOZY (1820-1883 M)

2020 ◽  
Vol 20 (1) ◽  
pp. 85
Author(s):  
Ghulam Falach
Keyword(s):  
Qualitative Research ◽  
Islamic Law ◽  
Great Influence ◽  
Literary Work ◽  
Comprehensive Understanding ◽  
Islamic History ◽  
Library Research ◽  
History Of ◽  
And Function ◽  
Islamic Civilization

The main focus of Orientalist thought is nothing but to reconstruct and influence Islamic civilization. Their enthusiasm to activate orientalism is increasingly challenged by the presence of Islam as a religion that has followers of most of the world's population. One of the actions of orientalism towards the Islamic world is to start a research movement on the Qur'an and al-Hadith which are the basis of the law and guidelines of Muslims. Not far from the critics of the Qur'an and al-Hadith, they also deconstructed aspects of the development of science, Islamic law, and even the originality of Islamic history. Some famous orientalism figures, one of them is Reinhart Dozy, a famous orientelism from the Netherlands with the concept of literacy in the history of Islamic civilization in Spain. Even though he received a lot of criticism and appreciation from both orientalists and Muslim thinkers, his literary work has had a great influence on Islamic civilization. The discussion steps of this study are entirely carried out using qualitative research that is library research. To be more useful and function properly, this paper is equipped with an explanation using the method of description, interpretation and analysis of data in each discussion. This is done, none other than to focus the discussion to produce a consistent and comprehensive understanding.

scholarly journals Polish Notes on Moscow Documents of the Time of Troubles: Historical and Linguistic Analysis

2019 ◽  
pp. 55-61
Author(s):  
Natalia Eilbart
Keyword(s):  
Great Influence ◽  
Linguistic Analysis ◽  
Russian Language ◽  
Petersburg Institute ◽  
System Method ◽  
History Of ◽  
Polish Language ◽  
Time Of Troubles ◽  
State Archives ◽  
Academy Of Sciences

Introduction. The article analyzes Polish markings made on documents of Moscow origin during the Time of Troubles. Materials. For analysis we took documents stored in the archives of St. Petersburg Institute of History of the Russian Academy of Sciences (petitions of nobles, merchants and peasants to Moscow princes, King Sigismund III and Prince Vladislav), as well as documents from the Smolensk archive, which are located in the State Archives of Sweden (Riksarkivet). Two categories of documents stand out: petitions of Moscow nobles addressed to King Sigismund III and Prince Vladislav, as well as other documents that fell into the hands of the Poles after the fall of Smolensk in 1611. We included in the last category the documents of Smolensk Provincial Prikaz and the personal archive of voevoda M.B. Shein as well. After a long stay in the territory of the Polish- Lithuanian Commonwealth, a part of The Smolensk Archive came to Sweden during the Polish-Swedish war (the “Flood”), a part settled in the continental Europe, later re-entered the territory of Russia due to the activities of the Archaeographic Commission. Methods. We used the methods of comparative linguistic analysis, the method of comparison, the system method, as well as the narrative and historical-genetic methods. Results. Polish inscriptions on documents of Moscow origin testify to the great influence of the Russian language on Polish and the appearance of numerous Russisms in the Polish language.

scholarly journals New data towards the development of a comprehensive taphonomic framework for the Late Jurassic Cleveland-Lloyd Dinosaur Quarry, Central Utah

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3368 ◽  
Author(s):  
Joseph E. Peterson ◽  
Jonathan P. Warnock ◽  
Shawn L. Eberhart ◽  
Steven R. Clawson ◽  
Christopher R. Noto
Keyword(s):  
Late Jurassic ◽  
Data Sets ◽  
Morrison Formation ◽  
Multiple Sources ◽  
Theropod Dinosaurs ◽  
The Matrix ◽  
Significant Step ◽  
Primary Driver ◽  
History Of ◽  
Bone Fragments

The Cleveland-Lloyd Dinosaur Quarry (CLDQ) is the densest deposit of Jurassic theropod dinosaurs discovered to date. Unlike typical Jurassic bone deposits, it is dominated by the presence ofAllosaurus fragilis. Since excavation began in the 1920s, numerous hypotheses have been put forward to explain the taphonomy of CLDQ, including a predator trap, a drought assemblage, and a poison spring. In an effort to reconcile the various interpretations of the quarry and reach a consensus on the depositional history of CLDQ, new data is required to develop a robust taphonomic framework congruent with all available data. Here we present two new data sets that aid in the development of such a robust taphonomic framework for CLDQ. First, x-ray fluorescence of CLDQ sediments indicate elevated barite and sulfide minerals relative to other sediments from the Morrison Formation in the region, suggesting an ephemeral environment dominated by periods of hypereutrophic conditions during bone accumulation. Second, the degree of abrasion and hydraulic equivalency of small bone fragments dispersed throughout the matrix were analyzed from CLDQ. Results of these analyses suggest that bone fragments are autochthonous or parautochthonous and are derived from bones deposited in the assemblage rather than transported. The variability in abrasion exhibited by the fragments is most parsimoniously explained by local periodic re-working and re-deposition during seasonal fluctuations throughout the duration of the quarry assemblage. Collectively, these data support previous interpretations that the CLDQ represents an attritional assemblage in a poorly-drained overbank deposit where vertebrate remains were introduced post-mortem to an ephemeral pond during flood conditions. Furthermore, while the elevated heavy metals detected at the Cleveland-Lloyd Dinosaur Quarry are not likely the primary driver for the accumulation of carcasses, they are likely the result of multiple sources; some metals may be derived from post-depositional and diagenetic processes, and others are potentially produced from an abundance of decomposing vertebrate carcasses. These new data help to support the inferred depositional environment of the quarry as an ephemeral pond, and represent a significant step in understanding the taphonomy of the bonebed and Late Jurassic paleoecology in this region.

Responding to organizational identity change: ethnographic insights from multinational hotel subsidiaries

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sandra Sun-Ah Ponting
Keyword(s):  
Organizational Identity ◽  
Participant Observation ◽  
Internal Communication ◽  
Hospitality Management ◽  
Organizational Memory ◽  
Multiple Sources ◽  
Content Type ◽  
Emotional Challenges ◽  
Organizational Ethnography ◽  
History Of

Purpose This paper aims to use an organizational ethnography perspective to explore how subsidiary hotel properties of a multinational hotel corporation experience planned organizational identity (OI) change instituted by headquarters. Design/methodology/approach This study uses a multi-site approach to collect ethnographic data on organizational change from six hotel subsidiaries in California, USA. Over three years, multiple sources of data were collected including: 31 interviews with hotel subsidiary leaders; more than 100 participant observation hours including job shadows, conferences and meetings; and photographs and internal communication materials. Findings Multinational hospitality companies face struggles between corporate standardization and subsidiary localization. This paper reveals that when headquarters plan changes focused on employees at their subsidiaries, the ways the latter initially accept and resist change are significantly impacted by the organizational memory and history of subsidiary leaders. However, as time progressed, properties with strong financial performance continued to operationalize new identity initiatives while properties with poorer profit margins played a balancing act between headquarters’ visionary identity and subsidiary ownership’s revenue expectations. Additionally, the situational realities caused by the COVID-19 pandemic put a halt to all properties which amplified practical and emotional challenges of organizational ethnography in hospitality research. Originality/value This paper contributes to hospitality literature by introducing an under-researched concept, OI change and advances understanding of the struggles in managing multinational company change. More importantly, this paper is a stepping stone for future hospitality management to embark on organizational ethnography.

The Case

2016 ◽  
Vol 25 (4) ◽  
pp. 749-749
Keyword(s):  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Pharmacological Therapy ◽  
The Other ◽  
Research Protocol ◽  
Neurosurgical Procedure ◽  
Therapeutic Outcomes ◽  
Cooking Shows ◽  
History Of ◽  
Deep Brain

Ms. L. is a 31-year-old female who presents to Dr. Impf, a neurosurgeon. Ms. L. has a more than 25-year history of iteratively worsening Tourette syndrome, characterized by severe motoric and postural tics and respiratory expression (grunting). Ms. L. is a rather shy, somewhat introverted woman who spends her time with her husband and a small group of friends, mostly watching cooking shows. Although she has been, and is generally, a good student, she describes her academic performance as “not stellar.” Following years of unsuccessful attempts at pharmacological therapy, Ms. L. was evaluated and accepted into an investigator-initiated research protocol (with provision for humanitarian care exemption) that Dr. Impf and her team were running for deep brain stimulation (DBS). During the neurosurgical procedure, electrodes were satisfactorily placed at bilateral subcortical targets (within the basal ganglia/striatum), and Ms. L. reported a reduced “urge to tic” and decreased frequency and severity of tics intraoperatively, immediately following surgery, during her recovery, and for 15 weeks following surgery. Then, however, the tics began to return and increased in frequency and progression, although not to the full preoperative extent. Attempts at altering DBS current parameters were not successful in reducing the severity and frequency of tics. Decreasing or terminating DBS current resulted in full rebound tics and respiratory expression, and Ms. L. finds this to be even more problematic than before (stating: “It’s like I’ve felt a new way and don’t want to go back to the other way”). Per definition, DBS did not achieve the desired medical/therapeutic outcomes.

A History of Some of the International Fisheries Commissions

1972 ◽  
Vol 73 ◽  
pp. 361-390 ◽  
Author(s):  
D. H. Cushing
Keyword(s):  
World War Ii ◽  
Great Influence ◽  
World War ◽  
International Council ◽  
North West ◽  
North East ◽  
The North ◽  
Foreign Office ◽  
History Of ◽  
International Fisheries

This paper is an account of the development of the International Fisheries Commissions. Excluded are the commissions under the aegis of FAO: an earlier group, for example the Indo-Pacific Fisheries Commission, are only advisory, and later ones, like the Atlantic Tuna Commission, have not been in existence for long enough to discern characteristics in their activity. The activities of the Russo-Japanese commissions in the north-west Pacific are also excluded, because their actions do not have great influence on the older commissions or upon the newer ones established in the last five years or so. Although the International Council for the Exploration of the Sea has now only an advisory function in the North-East Atlantic Fisheries Commission, during its earlier history before World War II it was always able to act through the Danish Foreign Office. But a much more important point is that the International Council played a historically dominant part in the early development of many of the commissions, except of course those which originated in the north-east Pacific.

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