Intraoperative electrostimulation for awake brain mapping: how many positive interference responses are required for reliability?

2020 ◽  
Vol 133 (4) ◽  
pp. 1191-1201 ◽  
Author(s):  
Franck-Emmanuel Roux ◽  
Imène Djidjeli ◽  
Romain Quéhan ◽  
Emilie Réhault ◽  
Carlo Giussani ◽  
...  
Keyword(s):  
Brain Mapping ◽  
Naming Task ◽  
Error Rates ◽  
Specific Protocol ◽  
Second Resection ◽  
Baseline Testing ◽  
Current Threshold ◽  
Highly Correlated ◽  
The Individual ◽  
Baseline Error

OBJECTIVEThe purpose of this study was to characterize the reproducibility of language trials within and between brain mapping sessions.METHODSBrain mapping and baseline testing data from 200 adult patients who underwent resection of left-hemisphere tumors were evaluated. Data from 11 additional patients who underwent a second resection for recurrence were analyzed separately to investigate reproducibility over time. In all cases, a specific protocol of electrostimulation brain mapping with a controlled naming task was used to detect language areas, and the results were statistically compared with preoperative and intraoperative baseline naming error rates. All patients had normal preoperative error rates, controlled for educational level and age (mean 8.92%, range 0%–16.25%). Intraoperative baseline error rates within the normal range were highly correlated with preoperative ones (r = 0.74, p < 10−10), although intraoperative rates were usually higher (mean 13.30%, range 0%–26.67%). Initially, 3 electrostimulation trials were performed in each cortical area. If 2 of 3 trials showed language interference, 1 or 2 additional trials were performed (depending on results).RESULTSIn the main group of 200 patients, there were 82 single interferences (i.e., positive results in 1 of 3 trials), 227 double interferences (2/3), and 312 full interferences (3/3). Binomial statistics revealed that full interferences were statistically significant (vs intraoperative baseline) in 92.7% of patients, while double interferences were significant only in 38.5% of patients, those with the lowest error rates. On further testing, one-third of the 2/3 trials became 2/4 trials, which was significant in only one-quarter of patients. Double interference could be considered significant for most patients (> 90%) when confirmed by 2 subsequent positive trials (4/5). In the 11 patients who were operated on twice, only 26% of areas that tested positive in the initial operation tested positive in the second and showed the same type of interference and the same current threshold (i.e., met all 3 criteria).CONCLUSIONSElectrostimulation trials in awake brain mapping produced graded patterns of positive reproducibility levels, and their significance varied with the baseline error rates. The results suggest that caution is warranted when 2 of 3 trials are positive, although the need for additional trials depends on the individual patients’ baseline error rates. Reproducibility issues should be considered in the interpretation of data from awake brain mapping.

Syllable weight in monolingual and heritage Spanish

2018 ◽  
Vol 11 (2) ◽  
pp. 395-427
Author(s):  
Michael Shelton ◽  
Hannah Grant
Keyword(s):  
Reading Proficiency ◽  
Naming Task ◽  
Error Rates ◽  
General Effect ◽  
Heritage Speakers ◽  
Stress Assignment ◽  
Syllable Weight ◽  
Bilingual Speakers ◽  
Quantity Sensitivity ◽  
Analysis Of Error

AbstractThis study presents two experiments employing a naming task that test the modulation of stress assignment by syllable structure in Spanish. The first replicates the findings of a previous study in which words containing arguably heavy penultimate diphthongs provoke higher error rates than putatively light monophthong controls when marked for antepenultimate stress. This result is interpreted as support for quantity sensitivity in the language. This experiment also replicates a subtler finding of differential patterning between rising and falling diphthong in their interaction with Spanish stress, suggesting gradient sensitivity to patterns in the lexicon. The second experiment presents the results of an identical task with Spanish-English heritage speakers in which the general effect of syllable weight is replicated, while the effect of diphthong type does not emerge. An analysis of error types suggests that varying levels of reading proficiency among heritage speakers may have led to the lack of the latter result, while still revealing sensitivity to frequencies in the lexicon. The combined results are offered as further evidence of quantity sensitivity among both monolingual and bilingual speakers of Spanish and provide further data in the understudied subfield of heritage phonotactics.

Elemental content of mast cell granules measured by X-ray microanalysis of rat thymic tissue sections

1986 ◽  
Vol 83 (1) ◽  
pp. 77-87 ◽  
Author(s):  
M.D. Kendall ◽  
A. Warley
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Elemental Content ◽  
Thymic Tissue ◽  
X Ray ◽  
Tissue Sections ◽  
Freeze Dried ◽  
The Mean ◽  
Highly Correlated ◽  
The Individual

Mast cell granules were examined by fully quantitative X-ray microanalysis of 20 cells in freeze-dried cryosections. The mast cells were situated mainly in the connective tissue of the thymic capsule of five adult male Carworth Sprague Europe rats. In addition 30 red blood cells were analysed from the same sections. Nineteen of the mast cells had granules rich in S and K. One cell had smaller granules, and in this cell the granules contained high [Ca] and [P] instead of high [S] and [K]. In the majority of cells (13) the S:K ratio was highly correlated and less than 2.2, whereas in the remaining six cells the individual granule ratios were very variable in any one cell and much higher. The mean granule [K] (994 +/− 57 mmol kg-1 dry wt) was about four times the mean cytoplasmic level of 227 +/− 81 mmol kg-1 dry wt. The existence of this difference in concentration between the granules and the cytoplasm suggests that the K in the granules must be bound. The relationship between the [K] and [S] is discussed with regard to the possible binding of heparin and amines in the granules.

scholarly journals FBSEM: A Novel Feature-Based Stacked Ensemble Method for Sentiment Analysis

2020 ◽  
Vol 12 (6) ◽  
pp. 11-22
Author(s):  
Yasin Görmez ◽  
◽  
Yunus E. Işık ◽  
Mustafa Temiz ◽  
Zafer Aydın
Keyword(s):  
Sentiment Analysis ◽  
Cross Validation ◽  
Emotional State ◽  
Ensemble Methods ◽  
Extraction Methods ◽  
Error Rates ◽  
Ensemble Method ◽  
Learning Tasks ◽  
Feature Based ◽  
The Individual

Sentiment analysis is the process of determining the attitude or the emotional state of a text automatically. Many algorithms are proposed for this task including ensemble methods, which have the potential to decrease error rates of the individual base learners considerably. In many machine learning tasks and especially in sentiment analysis, extracting informative features is as important as developing sophisticated classifiers. In this study, a stacked ensemble method is proposed for sentiment analysis, which systematically combines six feature extraction methods and three classifiers. The proposed method obtains cross-validation accuracies of 89.6%, 90.7% and 67.2% on large movie, Turkish movie and SemEval-2017 datasets, respectively, outperforming the other classifiers. The accuracy improvements are shown to be statistically significant at the 99% confidence level by performing a Z-test.

scholarly journals Snowpack variability and trends at long-term stations in northern Colorado, USA

2015 ◽  
Vol 371 ◽  
pp. 131-136 ◽  
Author(s):  
S. R. Fassnacht ◽  
M. Hultstrand
Keyword(s):  
Snow Depth ◽  
Snow Water Equivalent ◽  
Entire Period ◽  
Northern Colorado ◽  
Snow Water ◽  
Highly Correlated ◽  
The Individual

Abstract. The individual measurements from snowcourse stations were digitized for six stations across northern Colorado that had up to 79 years of record (1936 to 2014). These manual measurements are collected at the first of the month from February through May, with additional measurements in January and June. This dataset was used to evaluate the variability in snow depth and snow water equivalent (SWE) across a snowcourse, as well as trends in snowpack patterns across the entire period of record and over two halves of the record (up to 1975 and from 1976). Snowpack variability is correlated to depth and SWE. The snow depth variability is shown to be highly correlated with average April snow depth and day of year. Depth and SWE were found to be significantly decreasing over the entire period of record at two stations, while at another station the significant trends were an increase over the first half of the record and a decrease over the second half. Variability tended to decrease with time, when significant.

Can an automated sleep detection algorithm for waist-worn accelerometry replace sleep logs?

2018 ◽  
Vol 43 (10) ◽  
pp. 1027-1032
Author(s):  
Tiago V. Barreira ◽  
Jessica G. Redmond ◽  
Tom D. Brutsaert ◽  
John M. Schuna ◽  
Emily F. Mire ◽  
...  
Keyword(s):  
Detection Algorithm ◽  
Good Evidence ◽  
Mean Difference ◽  
Absolute Difference ◽  
Individual Level ◽  
Wake Time ◽  
Highly Correlated ◽  
Mean Differences ◽  
Dependent Sample ◽  
The Individual

The purpose of this study was to test whether estimates of bedtime, wake time, and sleep period time (SPT) were comparable between an automated algorithm (ALG) applied to waist-worn accelerometry data and a sleep log (LOG) in an adult sample. A total of 104 participants were asked to log evening bedtime and morning wake time and wear an ActiGraph wGT3X-BT accelerometer at their waist for 24 h/day for 7 consecutive days. Mean difference and mean absolute difference (MAD) were computed. Pearson correlations and dependent-sample t tests were used to compare LOG-based and ALG-based sleep variables. Effect sizes were calculated for variables with significant mean differences. A total of 84 participants provided 2+ days of valid accelerometer and LOG data for a total of 368 days. There was no mean difference (p = 0.47) between LOG 472 ± 59 min and ALG SPT 475 ± 66 min (MAD = 31 ± 23 min, r = 0.81). There was no significant mean difference between bedtime (2348 h and 2353 h for LOG and ALG, respectively; p = 0.14, MAD = 25 ± 21 min, r = 0.92). However, there was a significant mean difference between LOG (0741 h) and ALG (0749 h) wake times (p = 0.01, d = 0.11, MAD = 24 ± 21 min, r = 0.92). The LOG and ALG data were highly correlated and relatively small differences were present. The significant mean difference in wake time might not be practically meaningful (Cohen’s d = 0.11), making the ALG useful for sample estimates. MAD, which gives a better estimate of the expected differences at the individual level, also demonstrated good evidence supporting ALG individual estimates.

Internal and external factors contributing to variability in consonant accuracy of Arabic–French simultaneous bilingual children

2021 ◽  
pp. 1-23
Author(s):  
Rabia Sabah MEZIANE ◽  
Andrea A.N. MACLEOD
Keyword(s):  
Naming Task ◽  
Arabic Language ◽  
External Factors ◽  
Receptive Vocabulary ◽  
Bilingual Children ◽  
Expressive Vocabulary ◽  
Word Repetition ◽  
Language Exposure ◽  
The Individual ◽  
Internal And External Factors

Abstract This study aims to describe the relationships between child-internal and child-external factors and the consonant accuracy of bilingual children. More specifically, the study looks at internal factors: expressive and receptive vocabulary, and external factors: language exposure and language status, of a group of 4-year-old bilingual Arabic–French children. We measured the consonant accuracy of the children by the percentage of correct consonants in a Picture-Naming Task and a Non-Word Repetition Task in each language. The results suggest a significant relationship between vocabulary and consonant accuracy. A cross-language correlation was observed between the expressive vocabulary level of the majority language (French) and the consonant accuracy of the minority language (Arabic). Also, a significant correlation was found between Arabic language exposure and Arabic consonant accuracy. Finally, consonant accuracy was significantly higher in French tasks than in Arabic, despite the individual differences of the children.

Deception Detection Tests: A Subdued Investigating Tool

2021 ◽  
Vol 8 (11) ◽  
pp. 419-422
Author(s):  
Senthil Kumaran M ◽  
Bedanta Sarma ◽  
Arun Kumar S
Keyword(s):  
Brain Mapping ◽  
Deception Detection ◽  
Science And Technology ◽  
Fundamental Rights ◽  
Personal Liberty ◽  
The Past ◽  
Medical Issues ◽  
Increasing Demand ◽  
The Individual ◽  
Extract Information

The increasing demand to dispose of the cases swiftly, police often resort to third-degree methods to extract information from the individual; and in the process violate the fundamental rights to life and personal liberty stated under article 21 of the constitution of India. With the development of science and technology quickly eliciting the information is possible by adopting methods of polygraph, brain mapping, and narco analysis. In the past various experts, committees and judgements in courts have recommended these technologies to be used. Though there is a demand, it also raises serious legal, ethical and medical issues. Through this article we attempted to analyze the issues from various angles, and should take steps in the future to implement them. Keywords: Deception Detection Test (DDT), polygraph, brain mapping, narco analysis.

scholarly journals Validation of a digitally displayed photographic food portion-size estimation aid among women in urban and rural Malawi

2019 ◽  
Vol 22 (17) ◽  
pp. 3140-3150 ◽  
Author(s):  
Valerie L Flax ◽  
Chrissie Thakwalakwa ◽  
Courtney H Schnefke ◽  
Heather Stobaugh ◽  
John C Phuka ◽  
...  
Keyword(s):  
Rural Communities ◽  
Low Income ◽  
Portion Size ◽  
Size Estimation ◽  
Individual Level ◽  
Low Income Country ◽  
Urban Rural ◽  
Highly Correlated ◽  
The Individual ◽  
Portion Size Estimation

AbstractObjective:To validate digitally displayed photographic portion-size estimation aids (PSEA) against a weighed meal record and compare findings with an atlas of printed photographic PSEA and actual prepared-food PSEA in a low-income country.Design:Participants served themselves water and five prepared foods, which were weighed separately before the meal and again after the meal to measure any leftovers. Participants returned the following day and completed a meal recall. They estimated the quantities of foods consumed three times using the different PSEA in a randomized order.Setting:Two urban and two rural communities in southern Malawi.Participants:Women (n 300) aged 18–45 years, equally divided by urban/rural residence and years of education (≤4 years and ≥5 years).Results:Responses for digital and printed PSEA were highly correlated (>91 % agreement for all foods, Cohen’s κw = 0·78–0·93). Overall, at the individual level, digital and actual-food PSEA had a similar level of agreement with the weighed meal record. At the group level, the proportion of participants who estimated within 20 % of the weighed grams of food consumed ranged by type of food from 30 to 45 % for digital PSEA and 40–56 % for actual-food PSEA. Digital PSEA consistently underestimated grams and nutrients across foods, whereas actual-food PSEA provided a mix of under- and overestimates that balanced each other to produce accurate mean energy and nutrient intake estimates. Results did not differ by urban and rural location or participant education level.Conclusions:Digital PSEA require further testing in low-income settings to improve accuracy of estimations.

scholarly journals Pharmacodynamic Analysis of the Activity of Quinupristin-Dalfopristin against Vancomycin-ResistantEnterococcus faecium with Differing MBCs via Time-Kill-Curve and Postantibiotic Effect Methods

1998 ◽  
Vol 42 (9) ◽  
pp. 2188-2192 ◽  
Author(s):  
Jeffrey R. Aeschlimann ◽  
Michael J. Rybak
Keyword(s):  
Antibacterial Activities ◽  
Water Soluble ◽  
Postantibiotic Effect ◽  
Curve Method ◽  
Highly Correlated ◽  
Kill Curve ◽  
The Individual ◽  
Time Kill

ABSTRACT Quinupristin-dalfopristin (Q-D) is a new water-soluble, semisynthetic antibiotic that is derived from natural streptogramins and that is combined in a 30:70 ratio. A number of studies have described the pharmacodynamic properties of this drug, but most have investigated only staphylococci or streptococci. We evaluated the relationship between Q-D, quinupristin (Q), and/or dalfopristin (D) susceptibility parameters and antibacterial activities against 22 clinical isolates of vancomycin-resistant Enterococcus faecium (VREF) by using the concentration-time-kill-curve method and by measuring postantibiotic effects. Q-D, Q, and D MICs and minimum bactericidal concentrations (MBCs) ranged from 0.125 to 1 and 0.25 to 64, 8 to 512 and >512, and 2 to 8 and 8 to 512 μg/ml, respectively. There were no significant relationships between susceptibilities to the individual components and the susceptibilities to the Q-D combination product. In the time-kill-curves studies, Q-D at a concentration of 6 μg/ml was at least bacteriostatic against all VREF tested. There was increased activity against more susceptible isolates when the isolates were grouped either by Q-D MBCs or by Q MICs. By multivariate regression analyses, the percent change in the inoculum from that at the baseline was significantly correlated with the Q MIC (R = 0.74; P = 0.008) and the Q-D concentration-to-MBC ratio (R = 0.58;P = 0.02) and was inversely correlated with the Q-D MBC-to-MIC ratio (R = 0.68; P = 0.003). A strong correlation existed between the killing rate and the Q-D concentration-to-MBC ratio (R = 0.99;P < 0.0001). Time to 99.9% killing was best correlated with the Q-D MBC (R = 0.96;P < 0.0001). The postantibiotic effect ranged from 0.2 to 3.2 h and was highly correlated with the Q-D concentration-to-MBC ratio (R = 0.96;P < 0.0001) and was less highly correlated with the Q MIC (R = 0.42; P = 0.04). Further study of these relationships with in vitro or in vivo infection models that simulate Q-D pharmacokinetics should further define the utility of these pharmacodynamic parameters in the prediction of Q-D activity for the treatment of VREF infections in humans.

scholarly journals Measuring Language Dominance in Early Spanish/English Bilinguals

Languages ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 62
Author(s):  
Cecilia Solís-Barroso ◽  
Sara Stefanich
Keyword(s):  
Research Question ◽  
Language Dominance ◽  
Highly Correlated ◽  
The Individual ◽  
Repetition Task

This paper analyzes the comparability of language dominance assessments with the purpose of determining whether they yield similar results. Language dominance is an important construct in the field of bilingualism as it allows for a more thorough classification of bilinguals and is thought to play a role in both bilingual production and perception. Yet, there is no unified methodology for assessing language dominance. To that end, we ask the following research question: Do different language dominance measures predict the results of one another? Twenty-nine Spanish/English early bilinguals completed four language dominance assessments. Results indicate that three of the four assessments are highly correlated with each other while the fourth, a repetition task, is not significantly correlated with any of the assessments. Further, twenty of the participants were categorized differently across the individual measures; the more “balanced” a bilingual was, the greater likelihood of being categorized differently. These results indicate that certain language dominance assessments are not comparable with one another and suggest that it could be the case they do not even measure the same variable.

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