Primary intracranial plasma-cell granuloma

1988 ◽  
Vol 69 (5) ◽  
pp. 785-788 ◽  
Author(s):  
Dominic M. Cannella ◽  
Anthony P. Prezyna ◽  
John P. Kapp
Keyword(s):  
Differential Diagnosis ◽  
Radiation Therapy ◽  
Plasma Cell ◽  
Surgical Excision ◽  
Steroid Treatment ◽  
Plasma Cell Granuloma ◽  
Clinical Feature ◽  
Content Type ◽  
Affected Area ◽  
Fine Print

✓ The authors report the fourth case of primary intracranial plasma-cell granuloma. The patient was a 16-year-old girl who presented with loss of vision as the major clinical feature. The tumor resembled a meningioma both preoperatively and grossly at surgery. Because the tumor did not respond to steroid treatment following subtotal surgical excision, radiation therapy was administered to the affected area. Major considerations in the differential diagnosis of this neoplasm are discussed.

Results of surgical treatment for growth hormone-secreting pituitary adenomas

1993 ◽  
Vol 79 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Dudley H. Davis ◽  
Edward R. Laws ◽  
Duane M. Ilstrup ◽  
James K. Speed ◽  
Michela Caruso ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Radiation Therapy ◽  
Hormone Level ◽  
Growth Hormone Level ◽  
Surgical Excision ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Content Type ◽  
Prior Surgery ◽  
Fine Print

✓ The results of surgical therapy for acromegaly were reviewed in a series of 175 patients treated between 1972 and 1983. Patients with prior surgery or radiation therapy were excluded from the study. Postoperative radiation therapy was given to 54 patients. The criterion of achieving a postoperative basal or glucose-suppressed growth hormone level of 2 ng/ml or less was used to indicate remission. Utilizing the most recently available growth hormone determinations, 90 (51.7%) of 174 patients were in remission. The actuarial probability of remission at 1 and 5 years after surgery was 48.8% and 62.7%, respectively. Tumor size and the preoperative basal growth hormone level were correlated with outcome. Surgical excision of a pituitary adenoma is the most effective therapy currently available for acromegaly.

Intramedullary plasma cell granuloma in the cervicothoracic spine

2002 ◽  
Vol 97 (2) ◽  
pp. 235-238 ◽  
Author(s):  
Toshimi Aizawa ◽  
Tetsuro Sato ◽  
Yasuhisa Tanaka ◽  
Koshi Kishimoto ◽  
Mika Watanabe ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Plasma Cell ◽  
Bladder Dysfunction ◽  
Imaging Modality ◽  
Plasma Cell Granuloma ◽  
Mr Images ◽  
Content Type ◽  
First Case ◽  
Fine Print

✓ Intraspinal plasma cell granuloma, which is a nonneoplastic entity, is extremely rare. To date, only four cases have been documented in the spinal meninges. The authors report the first case of a C7—T1 intramedullary plasma cell granuloma. After excision of the lesion, the patient's gait and bladder dysfunction improved. This plasma cell granuloma initially showed no delineated mass on T1-weighted magnetic resonance (MR) images, low signal intensity on T2-weighted images, and was well enhanced after administration of gadolinium diethylenetriamine pentaacetic acid. The latter MR imaging modality should help to detect this tumorous lesion. Histologically, the granuloma needs to be distinguished from lymphoplasmacyte-rich meningioma and plasmacytoma.

Atypical monoclonal plasma cell hyperplasia: its identity and treatment

1996 ◽  
Vol 85 (4) ◽  
pp. 697-700 ◽  
Author(s):  
John N. K. Hsiang ◽  
Ho-Keung Ng ◽  
Wai-Sang Poon
Keyword(s):  
Plasma Cell ◽  
Complete Resolution ◽  
Inflammatory Pseudotumor ◽  
Plasma Cell Granuloma ◽  
Disease Entity ◽  
Cell Hyperplasia ◽  
Content Type ◽  
Fractionated Radiotherapy ◽  
The Central Nervous System ◽  
Fine Print

✓ Atypical monoclonal plasma cell hyperplasia, like plasma cell granuloma, is an inflammatory pseudotumor. Both are extremely rare in the central nervous system. Atypical monoclonal plasma cell hyperplasia is a recently identified neuropathological entity described by Weidenheim, et al., in 1989. A second case of this disease entity is now reported. The histological findings that differentiate this lesion from plasma cell granuloma, plasmacytoma, and meningioma are discussed. The present case clearly demonstrates the complete resolution of the disease after a course of fractionated radiotherapy.

Choroid plexus papillomas: long-term follow-up results in a surgically treated series

1988 ◽  
Vol 69 (6) ◽  
pp. 843-849 ◽  
Author(s):  
Stephen J. McGirr ◽  
Michael J. Ebersold ◽  
Bernd W. Scheithauer ◽  
Lynn M. Quast ◽  
Edward G. Shaw
Keyword(s):  
Radiation Therapy ◽  
Choroid Plexus ◽  
Surgical Excision ◽  
Perioperative Period ◽  
Content Type ◽  
Long Term Follow Up ◽  
Subtotal Removal ◽  
Choroid Plexus Papillomas ◽  
Fine Print

✓ The medical records and histological specimens from 26 patients with choroid plexus papillomas operated on at one institution were reviewed retrospectively. Four patients died perioperatively, and 21 of the remaining 22 patients were followed through March, 1986; the patient lost to follow-up review was last seen 14 years postoperatively. Of the 14 patients who underwent gross total removal of their tumor, one had a recurrence at 11 years postoperatively and two died in the perioperative period. Of the 12 patients who underwent subtotal removal of their tumor, two died in the perioperative period. The two patients who did not have radiation therapy postoperatively are free of apparent disease at 6 and 8 years after their operation. Eight patients underwent radiation therapy after subtotal removal of their tumor; four of these remain alive and well, and four have died of progressive disease. The role of irradiation in the treatment of subtotally resected lesion remains controversial, but this therapy is thought to be indicated for recurrent disease after a surgical excision that is as complete as possible. Histopathologically, the presence of occasional mitotic figures, microscopic infiltration, ependymal differentiation, or mild to moderate atypia was not correlated with likelihood of complete resectability or tendency to recurrence.

Recurrences of cerebellar astrocytomas: a violation of Collins' Law

1988 ◽  
Vol 68 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Everett J. Austin ◽  
Ellsworth C. Alvord
Keyword(s):  
Radiation Therapy ◽  
Surgical Treatment ◽  
Brain Stem ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Review Of The Literature ◽  
Content Type ◽  
Cerebellar Astrocytoma ◽  
Incomplete Excision ◽  
Fine Print

✓ Cerebellar astrocytomas generally carry an excellent prognosis when managed with surgical treatment alone. However, these tumors may violate Collins' Law in two opposite ways: by recurring late or by being “cured” with incomplete excision. In a study of 41 cases of cerebellar astrocytoma and a review of the literature, no gross or microscopic factors that correlated with either of these two outcomes could be identified other than brain-stem involvement. The effect of radiation therapy in the treatment of primary or recurrent cerebellar astrocytomas was not detectable when analyzed the same way. Malignant recurrence of cerebellar astrocytoma and primary malignant tumors of the cerebellum are so rare that the possibility should not be taken as a reason to substitute radiation therapy for surgical excision repeated as necessary.

Plasma-cell granuloma of the fourth ventricle

1984 ◽  
Vol 60 (6) ◽  
pp. 1291-1296 ◽  
Author(s):  
Yukio Maeda ◽  
Eiichi Tani ◽  
Masaru Nakano ◽  
Tsuyoshi Matsumoto
Keyword(s):  
Cell Proliferation ◽  
Plasma Cell ◽  
Microscopic Examination ◽  
Fourth Ventricle ◽  
Plasma Cells ◽  
Plasma Cell Granuloma ◽  
Mixed Cell ◽  
Content Type ◽  
Mixed Cell Population ◽  
Fine Print

✓ The case is presented of a 36-year-old woman with a plasma-cell granuloma arising in the fourth ventricle. The mass appeared on computerized tomography as a well circumscribed area of slightly high density that was markedly enhanced with contrast medium. Microscopic examination showed a mixed-cell population with a predominance of plasma cells, and the tumor was characterized immunohistochemically by polyclonal plasma-cell proliferation.

Combined stereotactic split-course fractionated gamma knife radiosurgery and conventional radiation therapy for unfavorable gliomas: a phase I study

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 37-41 ◽  
Author(s):  
William F. Regine ◽  
Roy A. Patchell ◽  
James M. Strottmann ◽  
Ali Meigooni ◽  
Michael Sanders ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Disease Progression ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
External Beam Radiation ◽  
Low Grade ◽  
Beam Radiation ◽  
Content Type ◽  
Group B ◽  
Fine Print

Object. This investigation was performed to determine the tolerance and toxicities of split-course fractionated gamma knife radiosurgery (FSRS) given in combination with conventional external-beam radiation therapy (CEBRT). Methods. Eighteen patients with previously unirradiated, gliomas treated between March 1995 and January 2000 form the substrate of this report. These included 11 patients with malignant gliomas, six with low-grade gliomas, and one with a recurrent glioma. They were stratified into three groups according to tumor volume (TV). Fifteen were treated using the initial FSRS dose schedule and form the subject of this report. Group A (four patients), had TV of 5 cm3 or less (7 Gy twice pre- and twice post-CEBRT); Group B (six patients), TV greater than 5 cm3 but less than or equal to 15 cm3 (7 Gy twice pre-CEBRT and once post-CEBRT); and Group C (five patients), TV greater than 15 cm3 but less than or equal to 30 cm3 (7 Gy once pre- and once post-CEBRT). All patients received CEBRT to 59.4 Gy in 1.8-Gy fractions. Dose escalation was planned, provided the level of toxicity was acceptable. All patients were able to complete CEBRT without interruption or experiencing disease progression. Unacceptable toxicity was observed in two Grade 4/Group B patients and two Grade 4/Group C patients. Eight patients required reoperation. In three (38%) there was necrosis without evidence of tumor. Neuroimaging studies were available for evaluation in 14 patients. Two had a partial (≥ 50%) reduction in volume and nine had a minor (> 20%) reduction in size. The median follow-up period was 15 months (range 9–60 months). Six patients remained alive for 3 to 60 months. Conclusions. The imaging responses and the ability of these patients with intracranial gliomas to complete therapy without interruption or experiencing disease progression is encouraging. Excessive toxicity derived from combined FSRS and CEBRT treatment, as evaluated thus far in this study, was seen in patients with Group B and C lesions at the 7-Gy dose level. Evaluation of this novel treatment strategy with dose modification is ongoing.

Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 32-36 ◽  
Author(s):  
Toru Serizawa ◽  
Toshihiko Iuchi ◽  
Junichi Ono ◽  
Naokatsu Saeki ◽  
Katsunobu Osato ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Cerebral Metastases ◽  
Whole Brain Radiation Therapy ◽  
Whole Brain ◽  
Content Type ◽  
Whole Brain Radiation ◽  
Brain Radiation ◽  
Fine Print

Object. The purpose of this retrospective study was to compare the effectiveness of gamma knife radiosurgery (GKS) for multiple cerebral metastases with that of whole-brain radiation therapy (WBRT). Methods. Ninety-six consecutive patients with cerebral metastases from nonsmall cell lung cancer were treated between 1990 and 1999. The entry criteria were the presence of between one and 10 multiple brain lesions at initial diagnosis, no surgically inaccessible tumors with more than a 30-mm diameter, no carcinomatous meningitis, and more than 2 months of life expectancy. The patients were divided into two groups: the GKS group (62 patients) and the WBRT group (34 patients). In the GKS group, large lesions (> 30 mm) were removed surgically and all other small lesions (≤ 30 mm) were treated by GKS. New distant lesions were treated by repeated GKS without prophylactic WBRT. In the WBRT group, the patients were treated by the traditional combined therapy of WBRT and surgery. In both groups, chemotherapy was administered according to the primary physician's protocol. The two groups did not differ in terms of age, sex, initial Karnofsky Performance Scale (KPS) score, type, lesion number, and size of lesion, systemic control, and chemotherapy. Neurological survival and qualitative survival of the GKS group were longer than those of the WBRT group. In multivariate analysis, significant poor prognostic factors were systemically uncontrolled patients, WBRT group, and poor initial KPS score. Conclusions. Gamma knife radiosurgery without prophylactic WBRT could be a primary choice of treatment for patients with as many as 10 cerebral metastases from nonsmall cell cancer.

Hemangiopericytoma of the spinal canal

1978 ◽  
Vol 49 (6) ◽  
pp. 914-920 ◽  
Author(s):  
Darrell J. Harris ◽  
Victor L. Fornasier ◽  
Kenneth E. Livingston
Keyword(s):  
Endothelial Cells ◽  
Differential Diagnosis ◽  
High Risk ◽  
Spinal Canal ◽  
Vertebral Column ◽  
Soft Tissues ◽  
Surgical Removal ◽  
Vascular Neoplasm ◽  
Content Type ◽  
Fine Print

✓ Hemangiopericytoma is a vascular neoplasm consisting of capillaries outlined by an intact basement membrane that separates the endothelial cells of the capillaries from the spindle-shaped tumor cells in the extravascular area. These neoplasms are found in soft tissues but have rarely been shown to involve the spinal canal. This is a report of three such cases. Surgical removal of the tumor from the spinal canal was technically difficult. A high risk of recurrence has been reported but in these three cases adjunctive radiotherapy appeared to be of benefit in controlling the progression of the disease. These cases, added to the six cases in the literature, confirm the existence of hemangiopericytoma involving the vertebral column with extension into the spinal canal. This entity should be included in the differential diagnosis of lesions of the spinal canal. The risk of intraoperative hemorrhage should be anticipated.

Primary eosinophilic granuloma of the oculomotor nerve

1994 ◽  
Vol 81 (5) ◽  
pp. 784-787 ◽  
Author(s):  
Markus Hardenack ◽  
Anje Völker ◽  
J. Michael Schröder ◽  
Joachim M. Gilsbach ◽  
Albrecht G. Harders
Keyword(s):  
Differential Diagnosis ◽  
Eosinophilic Granuloma ◽  
Cranial Nerves ◽  
Oculomotor Nerve ◽  
Content Type ◽  
Osseous Involvement ◽  
Fine Print

The authors report the occurrence of primary eosinophilic granuloma of the oculomotor nerve without osseous involvement in a 68-year-old man. Histopathological and neuroradiological findings are discussed. This case demonstrates that eosinophilic granuloma should be included in the differential diagnosis of tumor in which cranial nerves are involved.

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