scholarly journals EFFICIENCY OF ANTIOXIDANTS IN INTEGRATED THERAPY OF ACUTE ODONTOGENIC OSTEOMYELITIS IN CHILDREN

2020 ◽  
Vol 20 (3) ◽  
pp. 76-80
Author(s):  
P.I. Tkachenko ◽  
S.O. Bilokon ◽  
N.M. Lokhmatova ◽  
O.B. Dolenko ◽  
Yu.V. Popelo
Keyword(s):  
Lipid Peroxidation ◽  
Inflammatory Diseases ◽  
Natural Antioxidants ◽  
Antioxidant Protection ◽  
Clinical Recovery ◽  
Integrated Therapy ◽  
Fluid Fraction ◽  
Treatment Measures ◽  
Biological Substrates ◽  
Peroxidation Processes

This paper presents the comparative generalization of the results obtained by studying the activation of the processes of lipid peroxidation and the state of antioxidant protection factors in the peripheral blood and unstimulated oral fluid fraction in patients having a complicated course of odontogenic mandibular osteomyelitis. To determine the effectiveness of natural antioxidants, which were additionally included in the therapy protocol for patients with this the disease, we created two similar groups of participants (22 and 23 people in each) aged 7 to 15 years. Based on our previous reports, on admission to the hospital, these patients demonstrated the activation of the lipid peroxidation processes and the reduction of antioxidant protection factors in biological substrates. The scope of the treatment measures described in the protocol did not allow us to normalize their components for the time of clinical recovery. This prompted us to prescribe tocopherol acetate and ascorbic acid as components of the integrated complex therapeutic measures. This helped to stabilize the levels of all indicators up to the time of clinical recovery in this group of patients and supported the feasibility of these pharmaceuticals as important components in the therapy of odontogenic inflammatory diseases.

scholarly journals PROCESSES OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION IN ACUTE ODONOGIC OSTEOMYELITIS IN CHILDREN

2020 ◽  
Vol 20 (1) ◽  
pp. 67-71
Author(s):  
P.I. Tkachenko ◽  
N.M. Lokhmatova ◽  
O.B. Dolenko ◽  
Yu.V. Popelo ◽  
N.M. Korotych
Keyword(s):  
Lipid Peroxidation ◽  
Clinical Examination ◽  
Peripheral Blood ◽  
Oral Fluid ◽  
Antioxidant Protection ◽  
Significant Deterioration ◽  
Diene Conjugates ◽  
Fluid Fraction ◽  
Therapeutic Measures ◽  
Peroxidation Processes

The paper presented summarizes the results on the parameters of free radical lipid oxidation and antioxidant protection factors in 24 children aged from 3 to 15 years with acute odontogenic mandible osteomyelitis. In addition to standard clinical examination, peripheral blood and unstimulated oral fluid fractions were collected from all patients for 10 min at hospital admission and discharge. The samples were used to determine the components of lipid peroxidation: diene conjugates; malondialdehyde, its initial level, in 1.5 hours of incubation and its growth; antioxidant protection factors as superoxide dismutase, and catalase. It has been found out at the time of hospitalization, clinical examination showed a significant deterioration of the general condition, which was accompanied by widespread infiltrative changes and collateral oedema in the projection of the involved region of the mandible. In 12 people (50%) osteomyelitis spread from temporary molars. In other cases, permanent first and second molars were regarded as the causes. The patients demonstrated the activation of lipid peroxidation processes and reduction of antioxidant protection factors found out in peripheral blood and unstimulated oral fluid fraction. Repeated studies over the clinical recovery following the treatment conducted in accordance with the protocol of medical care enables to estimate the absence of infiltrative changes, but despite the elimination of acute inflammation, not all the studied parameters reached the level of control values. This makes it necessary to address the issue on making corrections towards the complex of therapeutic measures by including antioxidants that seems to be quiet promising and requires further in-depth investigation.

scholarly journals Parameters of Lipid Peroxidation and Antioxidant Protection in Men with Pathological Spermogram Variants

2019 ◽  
Vol 4 (1) ◽  
pp. 14-18
Author(s):  
Nadezhda A. Kurashova ◽  
Ekaterina A. Kudeyarova ◽  
Ekaterina O. Kuznetsova
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Total Antioxidant Activity ◽  
Antioxidant Protection ◽  
Defense System ◽  
Total Antioxidant ◽  
Peroxidation Processes

Background.Today infertile marriage is not only a serious medical, but also a socio-demographic and economic problem. Male factor contributes averagely to half of the cases of the disease in couples. Such factors as high levels of reactive oxygen species and oxidative stress have been reported to compromise the process of spermatogenesis and sperm function in men. Oxidative stress is a significant risk factor for male infertility. A pro-oxidant testicular environment may alter the expression profile of functional sperm proteins and result in poor sperm quality.Aims.To study the characteristics of the intensity of the processes of lipoperoxidation and antioxidant status in the ejaculate of men with different variants of spermograms.Materials and methods.We examined 69 men with primary infertility and 155 fertile men. The content of lipid peroxidation components and antioxidant protection was determined by spectrophotometric method.Results.The results of the study in men with infertility and asthenozoospermia showed decreased total antioxidant activity of sperm by 50 % and α-tocopherol by 52 %, and in men with infertility and oligozoospermia, decreased total antioxidant activity of sperm by 47 % and α-tocopherol by 41 %.Conclusions.The analysis indicates a change in the parameters of the system of lipid peroxidation – antioxidant defense system and confirms the development of oxidative stress in them. Depending on the pathological state of the ejaculate in men of reproductive age, lipid peroxidation processes have their own characteristics. In men with oligozoospermia, peroxidation processes occur more intensively. Activation of lipid peroxidation – antioxidant defense system processes can be both a consequence and a cause of various metabolic changes in the human body.

scholarly journals Chemiluminescence Studies of Lipoperoxidation Processes in Arterial Hypertension and Stress

2019 ◽  
Vol 4 (1) ◽  
pp. 133-137
Author(s):  
Anastasiya S. Brichagina ◽  
Mariya I. Dolgikh ◽  
Larisa R. Kolesnikova ◽  
Larisa V. Natyaganova
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Oxidation ◽  
The State ◽  
Male Rats ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Biochemical Methods ◽  
Peroxidation Processes

Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.

CHARACTERISTICS OF THE DYNAMICS OF LIPID PEROXIDATION, ANTIOXIDANT PROTECTION, AND PHAGOCYTIC ACTIVITY OF NEUTROPHILS IN THE TREATMENT OF ACUTE ODONTOGENIC OSTEOMYELITIS OF THE JAW

2020 ◽  
pp. 26-30
Author(s):  
Aliev K.I. ◽  
Toboev G.V.
Keyword(s):  
Lipid Peroxidation ◽  
Phagocytic Activity ◽  
Antioxidant Defense ◽  
Standard Treatment ◽  
Maxillofacial Surgery ◽  
Antioxidant Protection ◽  
Seeking Help ◽  
The Common ◽  
Peroxidation Processes ◽  
Standard Treatment Regimen

At the present stage, odontogenic osteomyelitis is one of the common purulent-inflammatory pathologies of the maxillofacial region. There is a tendency to change the nature of the clinical course of the disease: there is a predominance of a sluggish process with a tendency to chronicity and the development of complications. An unexpressed picture of the diagnosis of acute odontogenic osteomyelitis is difficult, which explains the delay in seeking help. The aim of the study was to determine and compare indicators of lipid peroxidation, antioxidant defense and phagocytic activity of neutrophils in patients with acute odontogenic osteomyelitis who received standard and combination treatment with Melaxen. The study was conducted on 30 patients with an established diagnosis of the Department of Maxillofacial Surgery of the Republican Clinical Hospital in Vladikavkaz. The indicators of lipid peroxidation, antioxidant protection, and phagocytic activity of neutrophils in patients with acute odontogenic osteomyelitis who received standard treatment and combined with the use of the drug “Melaxen” were evaluated. It was found that the disease can cause an increase in the concentration of malondialdehyde and hydroperoxides and a decrease in catalase activity. Under the influence of pathology, the absorption and digestion functions of neutrophils are inhibited. The efficacy of the use of the drug "Melaxen" in the treatment of acute odontogenic osteomyelitis due to its ability to suppress lipid peroxidation processes, restore antioxidant defense and phagocytic activity of neutrophils has been proven. the inclusion of Melaxen in the standard treatment regimen allows for faster reduction of oxidative stress and restoration of antioxidant protection, and also helps to normalize the phagocytic activity of neutrophils in a shorter time.

On the advisability of using antioxidants in the treatment of acute salpingooophoritis

2021 ◽  
Author(s):  
Т.А. Марзиева ◽  
И.Е. Рогожина ◽  
Т.Н. Глухова
Keyword(s):  
Lipid Peroxidation ◽  
Treatment Time ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
The State ◽  
Antioxidant Therapy ◽  
Long Term Results ◽  
Lipid Hydroperoxides ◽  
Complex Treatment ◽  
Peroxidation Processes

В работе проведено изучение состояния процессов перекисного окисления липидов в крови больных с острым сальпингооофоритом, а также обоснование использования антиоксидантной терапии в комплексном лечении пациенток с указанной патологией. В группе из 50 пациенток с острым сальпингооофоритом проведено традиционное лечение, включающее антибактериальные средства в соответствии с клиническим протоколом диагностики и лечения воспалительных заболеваний органов малого таза (2015), противовоспалительную, дезинтоксикационную терапию (группа сравнения). У 50 пациенток с острым сальпингооофоритом аналогичная комплексная терапия была дополнена назначением препаратов со свойствами антиоксидантов (основная группа). При поступлении больных в стационар и после проведения терапии выполнена оценка состояния процессов перекисного окисления липидов в крови по содержанию продуктов липопероксидации в плазме крови и в эритроцитах, а также состоянию антиоксидантной системы крови. Результаты проведенных исследований свидетельствуют об активации перекисного окисления липидов и дестабилизации биологических мембран у больных с острым сальпингооофоритом. Показано, что использование антиоксидантной терапии в комплексном лечении больных с острым сальпингооофоритом способствует сокращению сроков лечения в стационаре и улучшает отдаленные результаты лечения пациенток с указанной патологией. The study of the state of lipid peroxidation processes in patients with acute salpingo-oophoritis, as well as the rationale for the use of antioxidant therapy in the complex treatment of patients with this pathology, was carried out. In a group of 50 patients with acute salpingo-oophoritis, traditional treatment was performed, including antibacterial agents in accordance with the clinical protocol for the diagnosis and treatment of pelvic inflammatory diseases (2015), anti-inflammatory, detoxification therapy (comparison group). In 50 patients with acute salpingo-oophoritis, similar complex therapy was supplemented by the appointment of drugs with antioxidant properties (main group). When patients were admitted to the hospital and after therapy, the state of lipid peroxidation processes in the blood was assessed by the content of lipid hydroperoxides and malondialdehyde in blood plasma and in red blood cells, as well as the state of the antioxidant blood system. The results of the studies indicate the activation of lipid peroxidation and the destabilization of biological membranes in patients with acute salpingo-oophoritis. It is shown that the use of antioxidant therapy in the complex treatment of patients with acute salpingo-oophoritis helps to reduce the treatment time in the hospital and improves the long-term results of treatment for patients with this pathology.

scholarly journals Influence of parasitic invasions on the values of malondialdehyde and ceruloplasmin in horses

2020 ◽  
Vol 63 (8) ◽  
pp. 105-109
Author(s):  
Larisa V. Pilip ◽  
◽  
Olga V. Byakova ◽  
Maria E. Kazakova ◽  
◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Negative Impact ◽  
Free Radical Oxidation ◽  
Moderate Degree ◽  
Antioxidant Protection ◽  
Membrane Phospholipids ◽  
Radical Oxidation ◽  
Peroxidation Processes ◽  
And Performance

Parasitic invasions in horses often cause metabolic disorders and have a negative impact on their health and performance. The purpose of this research was to study the processes of lipid peroxidation and antioxidant protection in horse helminthiases, as well as following the deworming with a drug containing the antioxidant santoquine. The intensity of lipid peroxidation and antioxidant protection was determined in horses with different degrees of invasion by concentrations of malondialdehyde and ceruloplasmin accumulated in the blood. The studies have revealed that the concentration of malondialdehyde, the end product of free radical oxidation of cell membrane phospholipids, depends on the intensity of infestation with intestinal nematodes. In horses infested with paraskaris and intestinal strongylata, a significant accumulation of malondialdehyde was by 18.2% higher as compared to uninfected animals. The level of ceruloplasmin was significantly lower – by 21.8% in animals with a moderate degree of invasion as compared to clinically healthy animals. To neutralize free radicals the antioxidant santoquine was used. Effective deworming by means of using santoquine reduced the intensity of lipid peroxidation processes, which resulted in a significant decrease in the concentration of malondialdehyde by 22.1% and an increase in the level of ceruloplasmin against the background of the lower rate of free radical oxidation by 25.8%.

scholarly journals Complex Therapy of Oral Mucosa Inflammatory Diseases in Children

2019 ◽  
Vol 5 (5) ◽  
pp. 96-104
Author(s):  
E. Suerkulov ◽  
I. Yuldashev ◽  
A. Mamyraliev ◽  
N. Zhumashova ◽  
G. Yuldasheva
Keyword(s):  
Lipid Peroxidation ◽  
Laser Irradiation ◽  
Oral Mucosa ◽  
Inflammatory Diseases ◽  
Toxic Action ◽  
Antioxidant Protection ◽  
Complex Therapy

The article presents the results of the parameters of the lipid peroxidation system and antioxidant protection against the background of complex therapy in children with oral mucosa inflammatory diseases using Laser irradiation of blood and Lizak. Studies have shown that the treatment leads to a decrease in the toxic action of peroxide radicals.

scholarly journals CORRECTION OF LIPID PEROXIDATION PROCESSES OF BIOMEMBRANES BY NATURAL ANTIOXIDANTS

2016 ◽  
pp. 104-106
Author(s):  
N.V. Simonova ◽  
◽  
V.A. Dorovskikh ◽  
R.A. Anokhina ◽  
M.A. Shtarberg ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Natural Antioxidants ◽  
Peroxidation Processes

scholarly journals Age features of lipid peroxidation and antioxidant protection processes in girls and women tofalar ethnic groups

2010 ◽  
Vol 9 (5) ◽  
pp. 55-59 ◽  
Author(s):  
L. I. Kolesnikova ◽  
M. A. Darenskaya ◽  
V. V. Dolgikh ◽  
V. A. Shenin ◽  
S. V. Dutova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Ethnic Groups ◽  
Age Groups ◽  
Antioxidant Protection ◽  
Lipid Peroxidation Products ◽  
Peroxidation Processes ◽  
Age Features

Research objective: studying lipid peroxidation and antioxidant protection processes in girls and women of 3 age groups living in Tofalariya (ethnic tofalars). Spectrophotometric, fluorometric and statistic methods (Student’s parametrical criterion and Fisher's coefficient) were used. It was determined that decrease of lipid peroxidation and antioxidant protection processes activity takes place in puberty period. We marked increase concentration of lipid peroxidation products and retinol. The elder age period is characterized by the raised intensity of peroxidation processes.

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