On the advisability of using antioxidants in the treatment of acute salpingooophoritis

2021 ◽  
Author(s):  
Т.А. Марзиева ◽  
И.Е. Рогожина ◽  
Т.Н. Глухова
Keyword(s):  
Lipid Peroxidation ◽  
Treatment Time ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
The State ◽  
Antioxidant Therapy ◽  
Long Term Results ◽  
Lipid Hydroperoxides ◽  
Complex Treatment ◽  
Peroxidation Processes

В работе проведено изучение состояния процессов перекисного окисления липидов в крови больных с острым сальпингооофоритом, а также обоснование использования антиоксидантной терапии в комплексном лечении пациенток с указанной патологией. В группе из 50 пациенток с острым сальпингооофоритом проведено традиционное лечение, включающее антибактериальные средства в соответствии с клиническим протоколом диагностики и лечения воспалительных заболеваний органов малого таза (2015), противовоспалительную, дезинтоксикационную терапию (группа сравнения). У 50 пациенток с острым сальпингооофоритом аналогичная комплексная терапия была дополнена назначением препаратов со свойствами антиоксидантов (основная группа). При поступлении больных в стационар и после проведения терапии выполнена оценка состояния процессов перекисного окисления липидов в крови по содержанию продуктов липопероксидации в плазме крови и в эритроцитах, а также состоянию антиоксидантной системы крови. Результаты проведенных исследований свидетельствуют об активации перекисного окисления липидов и дестабилизации биологических мембран у больных с острым сальпингооофоритом. Показано, что использование антиоксидантной терапии в комплексном лечении больных с острым сальпингооофоритом способствует сокращению сроков лечения в стационаре и улучшает отдаленные результаты лечения пациенток с указанной патологией. The study of the state of lipid peroxidation processes in patients with acute salpingo-oophoritis, as well as the rationale for the use of antioxidant therapy in the complex treatment of patients with this pathology, was carried out. In a group of 50 patients with acute salpingo-oophoritis, traditional treatment was performed, including antibacterial agents in accordance with the clinical protocol for the diagnosis and treatment of pelvic inflammatory diseases (2015), anti-inflammatory, detoxification therapy (comparison group). In 50 patients with acute salpingo-oophoritis, similar complex therapy was supplemented by the appointment of drugs with antioxidant properties (main group). When patients were admitted to the hospital and after therapy, the state of lipid peroxidation processes in the blood was assessed by the content of lipid hydroperoxides and malondialdehyde in blood plasma and in red blood cells, as well as the state of the antioxidant blood system. The results of the studies indicate the activation of lipid peroxidation and the destabilization of biological membranes in patients with acute salpingo-oophoritis. It is shown that the use of antioxidant therapy in the complex treatment of patients with acute salpingo-oophoritis helps to reduce the treatment time in the hospital and improves the long-term results of treatment for patients with this pathology.

scholarly journals Influence of Marmix premix on the state of lipid peroxidation and indices of non-specific resistance of the organism of pregnant mares with microelementosis

2019 ◽  
Vol 10 (1) ◽  
pp. 87-91
Author(s):  
A. R. Shcherbatyy ◽  
L. G. Slivinska ◽  
B. V. Gutyj ◽  
V. L. Fedorovych ◽  
B. O. Lukashchuk
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Immune Complexes ◽  
Positive Influence ◽  
Lysozyme Activity ◽  
The State ◽  
Circulating Immune Complexes ◽  
Lipid Hydroperoxides ◽  
Diene Conjugates ◽  
Lipid Peroxidation Products

We observed the processes of lipid peroxidation, characterized by increased content of intermediate and its end products (diene conjugates, lipid hydroperoxides, malonic dialdehyde), in the blood of the pregnant mares. The changes of the data of indicators in the organism of the mares at the 9–11 months of pregnancy were established. The level of diene conjugates in the blood of animals was 3.6 ± 0.12 μmol/l, 33.3 and 44.0%, which was higher compared to non-pregnant mares and mares at 4th month of pregnancy. The concentration of lipid hydroperoxides in the blood of mares increased by 100% and by 42.9% in the blood of non-pregnant mares and mares at 4th month of pregnancy. The concentration of malondialdehyde in the blood of mares increased by 75.0%, 51.2% and 25.0% compared to non-pregnant mares and mares at 4th and 7th month of pregnancy, respectively. The results of our research showed that the mineral-vitamin premix Marmix had a positive influence on the state of lipid peroxidation products, contributed to their lowering in the blood of pregnant mares, which demonstrated antioxidant action and stimulated the function of the immune system. It was established that the bactericidal and lysozyme activity of the blood serum and the concentration of circulating immune complexes increases in the mares with lack of trace elements. It was shown that feeding mares during the 9–11 months of pregnancy with the mineral-vitamin premix Marmix had a positive influence on the state of humoral factors of nonspecific resistance. In particular, the concentration of bactericidal activity of serum increased by 31.0%, lysozyme activity of blood serum – 45.4% and contributed to the decrease of the concentration of circulating immune complexes in serum by 3.8 times. The use of mineral-vitamin premix Marmix during 60 days in feeding pregnant mares caused a restoration of the clinical status, a decrease in the content of lipid peroxidation products.

scholarly journals Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

2020 ◽  
Vol 33 (3) ◽  
pp. 125-131
Author(s):  
Nataliya Harasym ◽  
Svitlana Mandzynets ◽  
Dmytro Sanahursky
Keyword(s):  
Lipid Peroxidation ◽  
Sodium Hypochlorite ◽  
Structural Changes ◽  
Sialic Acids ◽  
Simultaneous Action ◽  
Lipid Hydroperoxides ◽  
Rehabilitation Period ◽  
Peroxidation Processes ◽  
Structural Changes In Membranes ◽  
Positive Effect

AbstractWe studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in membranes (via the content of sialic acid) in rat erythrocytes. We established that histamine affects lipid peroxidation processes with the formation of lipid hydroperoxides, damages proteins and reduces the content of sialic acids, which leads to changes in the surface charge of red blood cells. However, the simultaneous action of histamine and low SH concentration has a positive effect in that it corrects the pro-oxidant state of erythrocytes. Hence, the content of lipid hydroperoxides, TBA-active products, carbonyl groups of proteins and sialic acids were mainly reduced after the simultaneous action of histamine and SH at all studied concentrations during the rehabilitation period.

scholarly journals Chemiluminescence Studies of Lipoperoxidation Processes in Arterial Hypertension and Stress

2019 ◽  
Vol 4 (1) ◽  
pp. 133-137
Author(s):  
Anastasiya S. Brichagina ◽  
Mariya I. Dolgikh ◽  
Larisa R. Kolesnikova ◽  
Larisa V. Natyaganova
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Oxidation ◽  
The State ◽  
Male Rats ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Biochemical Methods ◽  
Peroxidation Processes

Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.

scholarly journals CORRECTION OF PROCESSES OF LIPID PEROXIDATION AND ENDOGENIC TOXICITY WITH EXTRACT OF GERANIUM PALUSTRE HERB AS A DENTAL FILM IN CONDITIONS OF EXPERIMENTAL STOMATITIS

2018 ◽  
pp. 17-20
Author(s):  
M.Yu. Khavrona ◽  
I.L. Benzel ◽  
R.M. Fedin ◽  
O.R. Pinyazhko ◽  
O.P. Khavrona
Keyword(s):  
Lipid Peroxidation ◽  
Therapeutic Effect ◽  
Oral Mucosa ◽  
Biologically Active ◽  
Control Group ◽  
Lipid Hydroperoxides ◽  
Experimental Animals ◽  
Middle Molecules ◽  
Peroxidation Processes ◽  
Ulcerative Stomatitis

The development of stomatitis is characterized by the appearance of oxidative stress, which is marked by an increase in the intensity of peroxide lipid oxidation processes, resulting in metabolic disturbance in oral mucosa. As a result, toxic substances accumulate and endogenic toxicity develops. Thus, correction of pathological processes in the oral mucosa with antioxidant medication enables to optimize the intensity of inflammation, shorten the period of catabolic phase and accelerate the regeneration. Extract of Geranium palustre herb as a dental film was used to reduce the intensity of processes of lipid peroxidation and endogenous intoxication. This treatment method enables to release an active substance from the drug locally and to provide optimal therapeutic effect. The efficacy of the experimental medication was studied in the dynamics of experimental ulcerative stomatitis development in rabbits. The experimental model of ulcerative stomatitis in animals was induced with a burn method. For the experiment, the animals were divided into 2 groups: control group, where treatment was not performed, and experimental group, where animals were treated by applying a dental film with Geranium palustre extract. The monitoring was conducted on the 3rd, 5th, 7th and 10th days of the experiment, which are key stages of healing. During these periods, blood was taken under anesthesia from the auricular vein of each experimental animal. Dynamics of prooxidant processes was detected by the level of lipid hydroperoxides and malondialdehyde, and the level of endogenic toxicity by the content of middle molecules. Statistic processing of the obtained results of investigation was performed using personal computer with installed proper software package StatSoft Statistica 10. Reliable difference was considered р<0.05. It has been shown that extract of Geranium palustre herb, as a dental film, has antioxidant properties, which are effectively reducing the intensity of lipid peroxidation processes. It should be mentioned that the content of lipid hydroperoxides and final product of lipid peroxidation processes – malondialdehyde – in experimental animals’ blood was statistically lower in all periods of investigation than in control group, where treatment was not performed. The obtained results show that higher inhibiting effect of experimental medication is marked during the final stage of lipid peroxide oxidation than during the initial stage. As the result showed, the development of endogenic toxicity was observed in both groups and the highest indices were recorded at the peak of the inflammatory process on the third day of the experiment. Dynamics of middle molecules content shows that application of Geranium palustre extract, as a dental film, decreases this index during all investigated periods and reduces intoxication level in experimental animals. Thus, application of dental film in stomatitis treatment enables to release medication directly into the damaged area, which significantly increases therapeutic effect of biologically active substances of Geranium palustre phytocomplex, and rapid absorption of the film in the oral cavity provides easy use. Considering efficacy, non-toxicity and availability of the investigated medication, the expediency of its application in dental practice for the treatment of stomatitis and other inflammatory diseases of the oral mucosa may be considered.

The state of lipid peroxidation processes and the antioxidant defense system in obstructive sleep breathing disorders

Therapy ◽  
2020 ◽  
Vol 5_2020 ◽  
pp. 102-106
Author(s):  
Miroshnichenko A.I. Miroshnichenko ◽  
Petrova A.A. Petrova ◽  
Ivanov K.M. Ivanov ◽  
Krasikov S.I. Krasikov ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
The State ◽  
Defense System ◽  
Sleep Breathing Disorders ◽  
Breathing Disorders ◽  
Obstructive Sleep ◽  
Peroxidation Processes

NEW HORIZONS IMPROVING THE SOMATIC STATUS OF YOUNG CHILDREN

2020 ◽  
Vol 2 (1) ◽  
pp. 54-57
Author(s):  
Rustam Sharipov ◽  
◽  
Nadira Rasulova ◽  
Zebo Maxmudova
Keyword(s):  
Lipid Peroxidation ◽  
Nervous System ◽  
Young Children ◽  
Neurological Disorders ◽  
The State ◽  
Healthy Children ◽  
New Horizons ◽  
Somatic Status ◽  
Peroxidation Processes

In the work, the features of the state of lipid peroxidation in healthy children and with perinatal damage to the nervous system were studied.A scientifically based approach to the administration of oxybral to children with perinatal injuries under the control of changes in lipid peroxidation processes was carried out.Studies have shown that the use of oxybral for children, along with the normalization of most of the LP indicators, contributes to a faster normalization of neurological symptoms.The possibility of oxybral correction of neurological disorders opens up the prospect of rehabilitation and contributes to a significant reduction in the percentage of often ill children

scholarly journals Studying the processes of lipid peroxidal oxidation in the organism of fresh cows under the antioxidant impact

2020 ◽  
Vol 176 ◽  
pp. 02001
Author(s):  
Lidiya Kashirina ◽  
Konstantin Ivanischev ◽  
Kirill Romanov
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Properties ◽  
The Body ◽  
Control Group ◽  
Lactation Period ◽  
Black And White ◽  
Inhibiting Effect ◽  
Peroxidation Processes ◽  
Quality Of Milk

The article contains information on the state of the processes of lipid peroxidation (LPO) in fresh cows under the influence of stress reaction caused by labor and the beginning of the lactation period. To reduce oxidative stress in the body of fresh cows, antioxidants were used in the form of preparations “E-selenium” and “Butofan”. The aim of the research was to determine the effect of vitamin-containing preparations “E-selenium” and “Butofan” on the productivity of fresh cows, the quality of milk and butter, made from it. The studies were carried out during the winter-stall period on one of the farms of Ryazan district of Ryazan region and involved 12 fresh black-and-white cows aged 4 years. The control group of animals was intact. As a result of the investigations, it was found that due to the action of the above preparations, which have antioxidant properties, the productivity parameters in the experimental groups of animals were higher compared to the control group, because they had an inhibiting effect on lipid peroxidation processes in the organism and activated the work of its own antioxidant system.

scholarly journals The quality of dairy products made from the milk of cows consuming vitamin-containing preparations

2020 ◽  
Vol 17 ◽  
pp. 00096
Author(s):  
Lydia G. Kashirina ◽  
Konstantin A. Ivanishchev ◽  
Kirill I. Romanov
Keyword(s):  
Lipid Peroxidation ◽  
Dairy Products ◽  
Antioxidant Properties ◽  
The Body ◽  
Control Group ◽  
Lactation Period ◽  
Black And White ◽  
Peroxidation Processes ◽  
Quality Of Milk

The article contains information on the state of the processes of lipid peroxidation (LPO) in fresh cows under the influence of stress reaction caused by labor and the beginning of the lactation period. To reduce oxidative stress in the body of fresh cows, antioxidants were used in the form of preparations “E-selenium” and “Butofan”. The aim of the research was to determine the effect of vitamin-containing preparations “E-selenium” and “Butofan” on the productivity of fresh cows, the quality of milk and butter, made from it. The studies were carried out during the winter-stall period on one of the farms of Ryazan district of Ryazan region and involved 12 fresh black-and-white cows aged 4 years. The control group of animals was intact. As a result of the investigations, it was found that due to the action of the above preparations, which have antioxidant properties, the productivity parameters in the experimental groups of animals were higher compared to the control group, because they had an inhibiting effect on lipid peroxidation processes in the organism and activated the work of its own antioxidant system.

scholarly journals The state of the oxidation-reduction system in patients with primary open angle glaucoma

2012 ◽  
Vol 93 (3) ◽  
pp. 488-490
Author(s):  
I R Gazizova
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Thiobarbituric Acid ◽  
The State ◽  
Open Angle ◽  
Reduction System ◽  
Oxidation Reduction ◽  
Peroxidation Processes

Aim. To study the state of the oxidation-reduction system in patients with primary open-angle glaucoma. Methods. Conducted were biochemical studies of the state of the oxidation-reduction system in 30 patients with primary open-angle glaucoma. The level of lipid peroxidation of cell membranes was determined in blood serum by the method of accumulation of malondialdehyde based on its interaction with thiobarbituric acid. The state of the antioxidant system was assessed according to the activity of superoxide dismutase, catalase, glutathione reductase and the content of thiol disulfide groups in the blood. The concentration of lactate in the blood serum was determined using an automated analyzer. Results. In patients with a chronic course of glaucoma elevated levels of oxidized thiol groups of proteins, increased activity of antioxidant enzymes, activation of lipid peroxidation processes, increased lactate content have been identified. Conclusion. Changes in the oxidation-reduction system in patients with primary open-angle glaucoma may be a sign of mitochondrial dysfunction.

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