scholarly journals Sex-dependent modulation of treatment response

2004 ◽  
Vol 6 (1) ◽  
pp. 39-51 ◽  
Keyword(s):  
Treatment Response ◽  
Psychotropic Medication ◽  
Individual Characteristic ◽  
Tissue Response ◽  
Sexual Differences ◽  
Blood Levels ◽  
Clinical Interventions ◽  
The Individual

The response to a psychotropic medication reflects characteristics of both the medication and the substrate, ie, the individual receiving the medication. Sex is an individual characteristic that influences all elements of the pharmacokinetic process - absorption, distribution, metabolism, and elimination. The effects of sex on these components of the pharmacokinetic process often counterbalance one another to yield minimal or varying sexual differences in blood levels achieved. However, sex also appears to influence pharmacodynamics, the tissue response to a given level of medication. Consideration by the practitioner of sex as a possible contributing factor to treatment nonresponse will enhance the efficacy and precision of clinical interventions.

scholarly journals Association between serum biomarkers and postoperative delirium after cardiac surgery

2019 ◽  
Vol 26 (1) ◽  
pp. 8-10 ◽  
Author(s):  
Mindaugas Gailiušas ◽  
Judita Andrejaitienė ◽  
Edmundas Širvinskas ◽  
Darijus Krasauskas ◽  
Milda Švagždienė ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Delirium ◽  
Neuronal Damage ◽  
Artery Bypass ◽  
Neuron Specific Enolase ◽  
Perioperative Period ◽  
Early Postoperative Period ◽  
Blood Levels ◽  
Increased Risk ◽  
The Individual

Background. In cardiac surgery, patients face an increased risk of developing postoperative delirium (POD) that is associated with poor outcomes. Neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP) have shown some promising results as potential tools for POD risk stratification, diagnosis, monitoring, and prognosis. Methods. Prospective single-centre study enrolled 44 patients undergoing elective coronary artery bypass grafting (CABG) and/ or valve procedures using cardiopulmonary bypass (CPB). The patients were assessed and monitored preoperatively, during surgery, and in the early postoperative period. The blood levels of NSE and GFAP were measured before and after surgery. The early POD was assessed by CAM-ICU criteria and patients were assigned to the POD group (with POD) or to the NPOD group (without POD) retrospectively. Results. The incidence of POD was 18.2%. After surgery, NSE significantly increased in the whole sample (p = 0.002). Comparing between groups, NSE significantly increased in the POD group after surgery (p = 0.042). ΔGFAP (before/after operation) for the whole sample was statistically significant (p = 0.022). There was a significant correlation between ΔGFAP and the lowest MAP during surgery in the POD group (p = 0.033). Conclusions. Our study demonstrated that NSE and GFAP are associated with early POD. An increase in NSE level during the perioperative period may be associated with subclinical neuronal damage. Serum GFAP levels show the damage of glial cells. Further studies are needed to find the factors influencing the individual limits of optimal MAP during surgery.

scholarly journals Abstract : stomp in HPFT

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S220-S220
Author(s):  
Anu Sharma ◽  
Kamalika Mukherji ◽  
Chetan Shah
Keyword(s):  
Data Collection ◽  
Learning Disability ◽  
Psychotropic Medication ◽  
Clinical Sample ◽  
Challenging Behaviour ◽  
Psychological Therapies ◽  
Nice Guidance ◽  
The Individual ◽  
Community Team ◽  
The Impact

AimsAnalyse the pattern of psychotropic drug use and deprescribing (in the context of STOMP) in people with Intellectual disability and Challenging behaviour in Hertfordshire community team(s) during 2016-17. STOMP stands for Stopping Over Medication in People with Learning Disability, Autism or both.BackgroundPublic Health England in 2015 estimated that on an average day in England, between 30,000 and 35,000 adults with a learning disability, autism or both were taking prescribed psychotropics without appropriate clinical indications . HPFT signed up to the STOMP pledge in 2017 to actively review psychotropic prescribing in line with NICE guidance alongside patients, carers and professional partnerships. This audit provides the outcomes of applying the STOMP Pledge to clinical practice.MethodData collection for the current audit occurred over Q1-5 in 2016–2017. All patients with Intellectual Disabilities on psychotropic medication were reviewed in psychiatric clinics. Awareness was raised about STOMP in teams. A semi-structured tool was developed based on the Self assessment framework published by the ID faculty RCPsych and prospective data were collected after each outpatient visit.Result347 patients were prescribed psychotropic medication and reviewed quarterly between 2016-2017. 96 patients were prescribed antipsychotics for challenging behaviour. Other prescribed medications included mood stabilisers, anticonvulsants, anti-depressants and benzodiazepines. Common antipsychotics used: Risperidone (63), Aripiprazole (14), Quetiapine (9), Olanzapine (4); Chlorpromazine (2). Four patients were maintained on two antipsychotics in varying combinations. The data collection tool noted that alternatives to medication were tried in 32 cases. Deprescribing occurred in 41 casesConclusionThis study represents an attempt to capture the impact of the STOMP principles in a clinical sample. Various alternatives to medications were pursued in the sample such as positive behaviour support, sensory integration, psychological therapies, social support. Younger adults (under 30 years) represented the largest proportion of cases where medication was increased. Adults over 30 years represented the largest proportion of cases where a STOMP reduction occurred. This may reflect the individual factors at play. Younger people with ID and /or Autism are more likely to experience changes in support and structure at transition, whilst older adults may have more physical comorbidities that may influence this decision.zcvv

scholarly journals PENGARUH KARAKTERISTIK INDIVIDU DAN LINGKUNGAN KERJA NON FISIK TERHADAP KINERJA KARYAWAN DEPARTEMEN PARTS PT TRAKINDO UTAMA CABANG SAMARINDA

2020 ◽  
Vol 8 (4) ◽  
pp. 345
Author(s):  
Juliana Juliana
Keyword(s):  
Work Environment ◽  
Employee Performance ◽  
Secondary Data ◽  
Individual Characteristics ◽  
Individual Characteristic ◽  
Primary Data ◽  
Physical Work ◽  
Observation Data ◽  
Physical Work Environment ◽  
The Individual

Individual characteristics and work environment are considered as crucial aspects for companies that want to improve their employees’ performance. PT Trakindo Utama specifically Samarinda branch is one of many branches of PT Trakindo Utama in Indonesia, which become the sole agent of Caterpillar products in Indonesia. Caterpillar itself is the world's leading manufacturer of heavy equipment originally from USA. This research aims to determine the influence of characteristics and non-physical work environment of the employee performance in parts Department at PT Trakindo Utama Samarinda branch. The individual characteristics (x1) and non-physical work environment (x2) are used as independent variables while the performance of employees (Y) as dependent variable. Primary data is obtained by conducting interviews to 34 respondents by using questionnaires while secondary data is obtained by conducting field observation. Data analysis uses a double linear regression technique by using SPSS 22 software. The results show that the individual characteristic variables does not have any partial effect toward the performance of the employees of Parts Department PT Trakindo Utama Cabang Samarinda branch and individual characteristic variables (X1) and non-physical work environment (x2) are simultaneously influential in the performance of the Employees (Y) Parts Department at PT trakindo Utama, Samarinda branch.  Suggestions for PT Trakindo Utama Samarinda Branch, the company should hold a family gathering in order to improve not only for each employees relations but also with bosses to stay awake, provide suggestions and evaluate employee work which can effectively improve employee performance, manage the best possible time so that the job can be completed on time.

The optical imagery of curved surfaces

1957 ◽  
Vol 240 (1223) ◽  
pp. 458-461
Keyword(s):  
Characteristic Function ◽  
Functional Equations ◽  
Individual Characteristic ◽  
Optical Systems ◽  
Characteristic Functions ◽  
Curved Surfaces ◽  
Angular Characteristic ◽  
Optical Imagery ◽  
The Individual ◽  
Angular Characteristic Function

The form of Hamilton’s angular characteristic function for the aberrationless imagery of one surface of rotation on another, and the connexions between the coefficients of the surface and functional equations, are found. When several optical systems of the type considered are arranged in succession the relations between the coefficients of the individual characteristic functions and those of the combination are obtained. These connexions enable all aberrations to be computed without resorting to ray tracing.

Phase I study of a combination of recombinant interferon-alpha and recombinant interferon-gamma in cancer patients.

1986 ◽  
Vol 4 (11) ◽  
pp. 1677-1683 ◽  
Author(s):  
R Kurzrock ◽  
M G Rosenblum ◽  
J R Quesada ◽  
S A Sherwin ◽  
L M Itri ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Interferon Alpha ◽  
Maximum Tolerated Dose ◽  
Blood Levels ◽  
Recombinant Interferon ◽  
Starting Dose ◽  
The Individual ◽  
Dose Levels ◽  
Recombinant Interferon Alpha

Combinations of interferon-alpha and interferon-gamma demonstrate synergistic antiviral and anti-proliferative activity in vitro. Therefore, we initiated a clinical study of combination interferon therapy in humans. Eighteen patients with metastatic solid tumors received daily intramuscular (IM) injections of recombinant interferon-alpha-A (IFN alfa-2a, Roferon-A; Hoffman-LaRoche, Nutley, NJ) and recombinant IFN-gamma (rIFN-gamma) for 6 weeks. The dose levels were 0.5, 1.0, 2.0, and 5.0 X 10(6) U/m2/d of each interferon. A minimum of two patients were entered sequentially at each dose level. Fever, chills, fatigue, and a greater than or equal to 50% drop in granulocyte counts were observed at all doses. Severity of symptoms corresponded to increasing dose levels. In contrast to the tachyphylaxis to these symptoms that usually develops in patients treated with the individual interferons, many patients on this study experienced persistent fever and worsening fatigue over 6 weeks. The maximum tolerated dose was 1 X 10(6) U/m2/d of each interferon. One patient with renal-cell carcinoma achieved a partial remission (duration, 3 months). Enzyme-linked immunoassay analysis in all four patients for whom complete data were available revealed that peak blood levels of IFN alfa-2a on day 22 were about tenfold higher than on day 1. Because of the possibility of cumulative toxicity, the recommended starting dose for further studies is 0.5 X 10(6) U/m2/d of each interferon, with escalation to 1.0 X 10(6) U/m2/d after 1 month if tolerance is acceptable. Phase II investigations to explore the antitumor efficacy of this regimen are planned.

scholarly journals Three decades of antidepressant, anxiolytic and hypnotic use in a national population birth cohort

2006 ◽  
Vol 189 (2) ◽  
pp. 156-160 ◽  
Author(s):  
Ian Colman ◽  
Michael E. J. Wadsworth ◽  
Tim J. Croudace ◽  
Peter B. Jones
Keyword(s):  
Mental Disorder ◽  
Birth Cohort ◽  
Psychotropic Medication ◽  
Common Mental Disorder ◽  
Strong Predictor ◽  
Medication Use ◽  
Multiple Time ◽  
Individual Level ◽  
Multiple Time Points ◽  
The Individual

BackgroundPsychotropic medication use is common and increasing. Use of such drugs at the individual level over long periods has not been reported.AimsTo describe antidepressant, anxiolytic and hypnotic drug use, and associations between such medication use and common mental disorder, over a 22-year period.MethodQuestions about psychotropic medication use and symptoms of common mental disorder were asked of more than 3000 members of the 1946 British birth cohort at multiple time points between ages 31 and 53 years.ResultsPrevalence of any antidepressant, anxiolytic or hypnotic use increased significantly from 1977 (30.6 per 1000) to 1999 (59.1 per 1000) as the cohort aged. Less than 30% with mental disorder used antidepressants, anxiolytics or hypnotics. Previous use of antidepressant, anxiolytic or hypnotic was a strong predictor of future use during an episode of mental disorder (odds ratios 3.0–8.4); this association became weaker over time.ConclusionsPharmacotherapy is infrequently used by individuals with common mental disorder in Britain; this has not changed in the past three decades.

scholarly journals Characteristic Curves of Iridium-Rhodium Sensing Elements in High-Temperature Transducer Applications

2021 ◽  
Vol 7 (1) ◽  
pp. 62-67
Author(s):  
Vasyl Fedynets ◽  
◽  
Yaroslav Yusyk ◽  
Ihor Vasylkivskyi
Keyword(s):  
High Temperature ◽  
Gas Turbines ◽  
Internal Combustion Engines ◽  
High Reliability ◽  
Characteristic Curve ◽  
Individual Characteristic ◽  
General View ◽  
Temperature Transducer ◽  
Oxidizing Atmosphere ◽  
The Individual

In order to increase the capacity and efficiency factor of gas turbines and internal combustion engines while preserving their high reliability, the gas temperature and its distribution need to be measured in combustion chambers. Values of these temperatures can exceed 1800°С in an oxidizing atmosphere. Therefore, designing temperature transducers for measurements in such severe environments, special attention should be paid to the selection of thermometric materials. The requirements of the necessary accuracy and temperature range over 1800°С in an oxidizing atmosphere are fulfilled only by the temperature transducer based on iridium-rhodium alloys. The characteristic curve of such sensing elements is individual and each temperature transducer is to be calibrated. The paper discusses a technique of determining the individual characteristic curve of iridium-rhodium sensing elements of high-temperature transducers. The preparation steps to be taken prior to the calibration and the main stages of determining the characteristic curve are described. The general view of the experimental set for calibrating the sensing elements is presented. Based on the calibration results, the form of approximating polynomial of the individual characteristic curve is proposed.

scholarly journals Treatment Response Prediction and Individualized Identification of Short-Term Abstinence Methamphetamine Dependence Using Brain Graph Metrics

2021 ◽  
Vol 12 ◽  
Author(s):  
Cui Yan ◽  
Xuefei Yang ◽  
Ru Yang ◽  
Wenhan Yang ◽  
Jing Luo ◽  
...  
Keyword(s):  
Treatment Response ◽  
Response Prediction ◽  
Middle Temporal Gyrus ◽  
Precentral Gyrus ◽  
Middle Temporal ◽  
Individual Level ◽  
Graph Metrics ◽  
The Individual ◽  
The Right ◽  
Orbital Part

Background: The abuse of methamphetamine (MA) worldwide has gained international attention as the most rapidly growing illicit drug problem. The classification and treatment response prediction of MA addicts are thereby paramount, in order for effective treatments to be more targeted to individuals. However, there has been limited progress.Methods: In the present study, 43 MA-dependent participants and 38 age- and gender-matched healthy controls were enrolled, and their resting-state functional magnetic resonance imaging data were collected. MA-dependent participants who showed 50% reduction in craving were defined as responders to treatment. The present study used the machine learning method, which is a support vector machine (SVM), to detect the most relevant features for discriminating and predicting the treatment response for MA-dependent participants based on the features extracted from the functional graph metrics.Results: A classifier was able to differentiate MA-dependent subjects from normal controls, with a cross-validated prediction accuracy, sensitivity, and specificity of 73.2% [95% confidence interval (CI) = 71.23–74.17%), 66.05% (95% CI = 63.06–69.04%), and 80.35% (95% CI = 77.77–82.93%), respectively, at the individual level. The most accurate combination of classifier features included the nodal efficiency in the right middle temporal gyrus and the community index in the left precentral gyrus and cuneus. Between these two, the community index in the left precentral gyrus had the highest importance. In addition, the classification performance of the other classifier used to predict the treatment response of MA-dependent subjects had an accuracy, sensitivity, and specificity of 71.2% (95% CI = 69.28–73.12%), 86.75% (95% CI = 84.48–88.92%), and 55.65% (95% CI = 52.61–58.79%), respectively, at the individual level. Furthermore, the most accurate combination of classifier features included the nodal clustering coefficient in the right orbital part of the superior frontal gyrus, the nodal local efficiency in the right orbital part of the superior frontal gyrus, and the right triangular part of the inferior frontal gyrus and right temporal pole of middle temporal gyrus. Among these, the nodal local efficiency in the right temporal pole of the middle temporal gyrus had the highest feature importance.Conclusion: The present study identified the most relevant features of MA addiction and treatment based on SVMs and the features extracted from the graph metrics and provided possible biomarkers to differentiate and predict the treatment response for MA-dependent patients. The brain regions involved in the best combinations should be given close attention during the treatment of MA.

scholarly journals ‘Prescribing’ psychotropic medication to our rivers and estuaries

2018 ◽  
Vol 43 (4) ◽  
pp. 147-150
Author(s):  
Alex T. Ford ◽  
Helena Herrera
Keyword(s):  
Mental Health ◽  
Psychotropic Medication ◽  
Aquatic Ecosystems ◽  
Mental Health Problems ◽  
Health Problems ◽  
High Income ◽  
Benefit Ratio ◽  
The Individual

SummaryThe influence of pharmaceuticals on the environment is an increasing concern among environmental toxicologists. It is known that their growing use is leading to detectable levels in wastewater, conceivably causing harm to aquatic ecosystems. Psychotropic medication is one such group of substances, particularly affecting high-income countries. While these drugs have a clear place in therapy, there is debate around the risk/benefit ratio in patients with mild mental health problems. Therefore, it is necessary to evaluate the wider implications as risks could extend beyond the individual to non-target organisms, particularly those in rivers and estuaries.Declaration of interestNone.

Tumor necrosis as prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 722-722
Author(s):  
Ji Han Jung ◽  
Hyung Jin Kim ◽  
Ho Jung An ◽  
Sung Whan Kim ◽  
Hyun Min Cho ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Treatment Response ◽  
Tumor Necrosis ◽  
Cox Regression ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Tissue Response ◽  
Response Factor ◽  
Pathologic Stage

722 Background: Association between treatment response on the basis of pathologic stage evaluated after radical tumor resection and patient prognosis was well established. The object of this study is that tumor necrosis factor after CRT is also important as treatment response. Methods: A total of 243 patients with locally advanced rectal cancer that underwent neoadjuvant CRT was included. Three treatment response groups were classified by their pathologic stage results: complete treatment response (CTR), intermediate treatment response (ITR), and poor treatment response (PTR). Three tissue necrosis groups were classified by tissue pathologic results: complete necrosis response (CNR), intermediate necrosis response (INR), and poor necrosis response (PNR). Results: Overall survival (OS) and recurrence free survival (RFS) rate at 3 years were 74.5% and 61.3%, respectively. The 3-year OS rates of the CTR, ITR, and PTR were 83.7%, 75.9%, and 69.7%, respectively (p<0.001); the 3-year RFS rates were 76.7%, 69.0%, and 52.1%, respectively (p<0.001). The 3-year OS rates of the CNR, INR, and PNR were 83.7%, 80.6%, and 61.8%, respectively (p<0.001); the 3-year RFS rates were 76.7%, 68.9%, and 44.3%, respectively (p<0.001). When compared to CTR / CNR, PTR / PNR was strongly related to an increased risk of recurrence (hazard ratio, 5.53; 95% CI, 2.01 to 15.23 / 6.37; 95% CI, 2.29 to 17.74) respectively in the univariate Cox regression. Therefore in the two models using multivariate Cox regression, both PTR and PNR were strongly associated to RFS and OS compared with CTR and CNR. Conclusions: The tissue response factor to neoadjuvant CRT is one surrogate marker for recurrence and oncologic outcomes and almost as important as the treatment response factor in rectal cancer patients treated with neo-adjuvant CRT.

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