Interactions Between Handgrip Strength and Serum Folate and Homocysteine Levels on Cognitive Function in the Elderly Chinese Population

2021 ◽  
pp. 1-11
Author(s):  
Yongjie Chen ◽  
Yue Du ◽  
Zhuoyu Sun ◽  
Qian Liu ◽  
Changqing Sun ◽  
...  

Background: Handgrip strength (HGS) and serum folate and homocysteine (Hcy) levels were associated with cognitive function. However, little was known whether there were interactions between HGS and serum folate and Hcy levels on cognitive function. Objective: To examine the interactions between HGS and serum folate and Hcy levels on cognitive function. Methods: This study analyzed the baseline data of the Tianjin Elderly Nutrition and Cognition Cohort study. All participants aged ≥60 years were potential eligible. HGS was measured using a grip strength dynamometer. Serum folate and Hcy levels were assayed using standard laboratory protocol. A Mini-Mental State Examination was used to assess cognitive function. Linear regressions were employed to examine the interactions between HGS and serum folate and Hcy levels on cognitive function. Results: 4,484 participants were included in this study. There were interactions between HGS and serum folate and Hcy levels on cognitive function. Furthermore, subjects with strong HGS and sufficient folate level had the best cognitive function (β= 2.018), sequentially followed by those with strong HGS and insufficient folate level (β= 1.698) and with poor HGS and sufficient folate level (β= 0.873). Similarly, cognitive function was ranked in the descending order of subjects with strong HGS and normal Hcy level (β= 1.971), strong HGS and high Hcy level (β= 1.467), and poor HGS and normal Hcy level (β= 0.657). Conclusion: There were interactions between HGS and serum folate and Hcy levels on cognitive function. However, the temporal associations cannot be examined in a cross-sectional study. Further cohort study should be conducted to confirm these associations in the future.

2019 ◽  
Vol 13 ◽  
Author(s):  
Mônica Neris de Lima ◽  
Marielle Maria Oliveira Barros ◽  
Ana Maria Ribeiro dos Santos ◽  
Adélia Dalva Da Silva Oliveira ◽  
Francisca Cecilia Viana Rocha

Objetivo: avaliar o desempenho cognitivo de idosos atendidos por acidente de trânsito. Método: trata-se de um estudo quantitativo, descritivo, observacional, transversal, em um hospital público. Compôs-se a amostra por 250 idosos. Utilizou-se a variável dependente do estudo a função cognitiva definida por meio do Mini Exame do Estado Mental e um formulário sociodemográfico elaborado pelos pesquisadores do estudo e processado estatisticamente. Resultados: caracterizou-se que a maioria dos idosos era do sexo masculino; com idades de 60 a 79 anos; estado civil casado; renda abaixo de um salário mínimo e natural de Teresina. Evidenciou-se, que a maioria dos idosos era apta cognitivamente, observando-se relação estatisticamente significativa entre a função cognitiva, faixa etária, escolaridade, estado civil e renda mensal. Revela-se que o tipo de acidente de trânsito que mais acometeu os idosos foi o atropelamento. Conclusão: manteve-se o desempenho cognitivo dos idosos acidentados preservado, no entanto, observaram-se fatores que mostraram relação como a idade mais avançada, a ausência de alfabetização, a viuvez e o nível econômico mais baixo. Descritores: Idoso; Acidentes de Trânsito; Enfermagem Geriátrica; Prevenção de Acidentes; Saúde do Idoso; Causas Externas.AbstractObjective: to evaluate the cognitive performance of elderly people treated by traffic accident. Method: this is a quantitative, descriptive, observational, cross-sectional study in a public hospital. The sample was composed by 250 elderly. The dependent variable of the study was the cognitive function defined through the Mini Mental State Examination and a sociodemographic form elaborated by the study researchers and processed statistically. Results: it was characterized that most of the elderly were male; aged 60 to 79 years; married marital status; income below a minimum wage and Teresina natural. Most of the elderly were cognitively fit, with a statistically significant relationship between cognitive function, age, education, marital status and monthly income. It is revealed that the type of traffic accident that most affected the elderly was being run over. Conclusion: the cognitive performance of the injured elderly was preserved, however, there were factors that showed a relationship such as older age, lack of literacy, widowhood and lower economic level. Descriptors: Aged Accidents; Traffic; Geriatric Nursing; Accident Prevention; Health of the Elderly; External Causes.ResumenObjetivo: evaluar el desempeño cognitivo de ancianos atendidos por accidente de tránsito. Método: se trata de un estudio cuantitativo, descriptivo, observacional, transversal en un hospital público. La muestra estuvo compuesta por 250 ancianos. La variable dependiente del estudio fue la función cognitiva definida a través del Mini Examen del Estado Mental y una forma sociodemográfica elaborada por los investigadores del estudio y procesada estadísticamente. Resultados: se caracterizó que la mayoría de los ancianos eran varones; de 60 a 79 años de edad; estado civil: Casado; ingresos inferiores a un salario mínimo y natural de la ciudad de Teresina. La mayoría de los ancianos tenían un estado cognitivo adecuado, con una relación estadísticamente significativa entre la función cognitiva, la edad, la educación, el estado civil y el ingreso mensual. Se revela que el tipo de accidente de tránsito que más afectó a los ancianos fue atropellamiento. Conclusión: se conservó el rendimiento cognitivo de los ancianos lesionados, sin embargo, hubo factores que mostraron una relación como la edad avanzada, la falta de alfabetización, la viudez y el bajo nivel económico. Descriptores: Anciano; Accidentes de Tránsito; Enfermería Geriátrica; Prevención de Accidentes; Salud del Anciano; Causas Externas.


2021 ◽  
pp. 1-8
Author(s):  
Xiao Liu ◽  
Ayiguli Abudukeremu ◽  
Yuan Jiang ◽  
Zhengyu Cao ◽  
Maoxiong Wu ◽  
...  

Background: Several kinds of motor dysfunction can predict future cognitive impairment in elderly individuals. However, the ability of the fine motor index (FINEA) and gross motor index (GROSSA) to predict the risk of cognitive impairment has not been assessed. Objective: We investigated the associations between FINEA/GROSSA and cognitive impairment. Methods: The data of 4,745 participants from The Irish Longitudinal Study on Ageing (TILDA) were analyzed. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). We first assessed the correlation between the FINEA GROSSA and MMSE in a cross-sectional study. Then, we further investigated the predictive role of the incidence of cognitive impairment in a prospective cohort study. Results: We found that both FINEA and GROSSA were negatively correlated with MMSE in both the unadjusted (FINEA: B = –1.00, 95%confidence intervals (CI): –1.17, –0.83, t = –11.53, p <  0.001; GROSSA: B = –0.85, 95%CI: –0.94, –0.76, t = –18.29, p <  0.001) and adjusted (FINEA: B = –0.63, 95%CI: –0.79, –0.47, t = –7.77, p <  0.001; GROSSA: B = –0.57, 95%CI: –0.66, –0.48, t = –12.61, p <  0.001) analyses in a cross-sectional study. In a prospective cohort study, both high FINEA and high GROSSA were associated with an increased incidence of cognitive function impairment (FINEA: adjusted odds ratios (OR) = 2.35, 95%CI: 1.05, 5.23, p = 0.036; GROSSA adjusted OR = 3.00, 95%CI: 1.49, 6.03, p = 0.002) after 2 years of follow-up. Conclusion: Higher FINEA and GROSSA scores were both associated with an increased incidence of cognitive impairment. FINEA or GROSSA might be a simple tool for identifying patients with cognitive impairment.


2019 ◽  
Author(s):  
Hongmei Wu ◽  
Mingyue Liu ◽  
Qing Zhang ◽  
Li Liu ◽  
Ge Meng ◽  
...  

Abstract Background although handgrip strength (HGS) is considered an excellent predictor of morbidity and mortality, there are few reference data available, especially across life from young to old populations. Objective to investigate the reference values and determinants for HGS in a large Chinese adult population. Design this cross-sectional study used data from the Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study ranging from 2013 to 2017. Setting and subjects in total, 37,707 Chinese adults aged 18–93 years with measures of HGS were included. Methods HGS was measured using a handheld digital dynamometer. The percentile distribution of HGS, as well as mean (standard deviation) values of HGS, was calculated according to sex and age categories. The Pearson’s or Spearman’s correlation coefficient and multiple linear regression were also used. Results the peak mean value of HGS was 45.2 ± 6.88 kg in men and 26.8 ± 4.65 kg in women. Different reference values for each sex and age category are present. The prevalence of low HGS was 7.69% in men and 6.46% in women. Multiple regression analysis showed that almost 72.5% of HGS variability can be explained by sex, age, height and weight. Conclusions the HGS reached peak at 40 years old, maintained or slightly lowered between ages 40 and50 and then start an accelerated decline after 50 years old. Reference values of HGS should be stratified by sex and age group. HGS variability can be largely explained by sex, age, height and weight.


2008 ◽  
Vol 66 (4) ◽  
pp. 809-813 ◽  
Author(s):  
Keithlen Cruz Moreira de Castro ◽  
Ricardo Oliveira Guerra

Functional incapacity and cognitive impairment are conditions related to the process of human aging. Cognitive impairment is considered an important predicitve factor for functional impairment in elderly populations. This cross-sectional study analyzes the association between cognitive performance and functional capacity in an elderly population sample in Natal, Brazil. A total of 213 elderly persons were assessed by the BOAS Multidimensional Questionnaire (Brazil Old Age Schedule) and the Mini-Mental State Examination (MMSE). The results of multivariate analysis and linear regression showed that age and schooling level are factors associated with cognitive performance in the elderly of this study. The final explicative model, elaborated by logistic regression, found that cognitive performance was the only predicitve variable of functional incapacity for the activities of daily living even when adjusted for sociodemographic variables.


2021 ◽  
Author(s):  
Sohyae Lee ◽  
Jin-Young Min ◽  
Kyoung-Bok Min

Abstract Background Chloroform is a water disinfection by-product associated with hepatic, renal and neurotoxicity. High concentrations of chloroform are known to cause central nervous system depression; however, the association between blood chloroform levels and cognitive function in the general elderly population is unknown. In this study, we investigated the association between blood chloroform levels and cognitive function in the elderly US population (n=782). Methods We analyzed blood chloroform levels and cognitive function, as measured by the digit symbol substitution test (DSST), from the 2011-2012 and 2013-2014 National Health and Nutrition Examination Surveys (NHANES) for participants aged 60 years and older. Blood chloroform levels were measured using capillary gas chromatography and mass spectrometry with selected-ion monitoring detection and istotope-dilution. Results After adjusting for all covariates, increases in log-transformed blood chloroform levels were significantly associated with decreased DSST scores (β = -1.56, SE = 0.57, p-value 0.010). Compared with individuals in the lowest quartile of blood chloroform, the regression coefficients were significantly lower among those in the second and third tertile (tertile 2 β = -3.00 (SE = 1.25, p-value 0.022); tertile 3 β = -4.05 (SE = 1.22, p-value 0.002)). After stratification by obesity status, increases in log-transformed chloroform levels showed borderline significant associations with decreased DSST scores among the obese (β = -1.71, SE = 0.85, p-value 0.052). Conclusions Our finding suggest a possible link between blood chloroform levels and cognitive function in the US elderly population.


2020 ◽  
Author(s):  
Zhi jian Wu ◽  
Zhu ying Wang ◽  
Bing qian Hu ◽  
Xu hui Zhang ◽  
Fan Zhang ◽  
...  

Abstract Background: This study explored the effects of physical activity and sedentary behaviour on the decline of cognitive ability among the elderly. To compensate for the limitations of self-reported physical activity, objective measures were used. Methods: A cross-sectional survey of 308 aged people mean 68.66±5.377 years, in Nanjing, China, was conducted. Physical activity was measured using the ActiGraph GT3X+, and cognitive function was measured using the Montreal Cognitive Assessment. Results: The overall participant model, adjusted for age, BMI, education, and monthly average income, found that light physical activity (β=0.006, p<0.01), moderate-vigorous physical activity (β=0.068, p<0.001), and total physical activity (β=0.006, p<0.01) had a significant linear relationship with cognitive ability, while sedentary time did not (β=-0.020, p>0.05). Further, light physical activity only affects the cognitive ability of elderly females (β=0.006, p<0.05). There was an inverted ‘U’ association between moderate-vigorous physical activity and cognitive ability. The association models found that moderate-vigorous physical activity in the 22.13 min·day–1~38.79 min·day–1 range affected cognitive ability most beneficially, with the highest beta coefficient among all groups (β=0.091, p<0.05). Conclusions: While physical activity can significantly improve cognitive ability among the elderly, sedentary behaviour is associated with decreased cognitive function across genders.


2020 ◽  
Author(s):  
Zhi jian Wu ◽  
Zhu ying Wang ◽  
Bing qian Hu ◽  
Xu hui Zhang ◽  
Fan Zhang ◽  
...  

Abstract This study explored the effects of physical activity and sedentary behaviour on the decline of cognitive ability among the elderly. To compensate for the limitations of self-reported physical activity, objective measures were used. A cross-sectional survey of 308 aged people mean 68.66±5.377 years, in Nanjing, China, was conducted. Physical activity was measured using the ActiGraph GT3X+, and cognitive function was measured using the Montreal Cognitive Assessment. The overall participant model, adjusted for age, BMI, education, and monthly average income, found that light physical activity (β=0.006, p<0.01), moderate-vigorous physical activity (β=0.068, p<0.001), and total physical activity (β=0.006, p<0.01) had a significant linear relationship with cognitive ability, while sedentary time did not (β=-0.020, p>0.05). Further, light physical activity only affects the cognitive ability of elderly females (β=0.006, p<0.05). There was an inverted ‘U’ association between moderate-vigorous physical activity and cognitive ability. The association models found that moderate-vigorous physical activity in the 22.13 min·day –1 ~38.79 min·day –1 range affected cognitive ability most beneficially, with the highest beta coefficient among all groups (β=0.091, p<0.05). In conclusion, while physical activity can significantly improve cognitive ability among the elderly, sedentary behaviour is associated with decreased cognitive function across genders.


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