Parkinson’s Disease and the COVID-19 Pandemic

Studies focusing on the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19), and Parkinson’s disease (PD) have provided conflicting results. We review the literature to investigate: 1) Are PD patients at higher risk for contracting COVID-19 and are there specific contributing factors to that risk? 2) How does COVID-19 affect PD symptoms? 3) How does COVID-19 present in PD patients? 4) What are the outcomes in PD patients who contract COVID-19? 5) What is the impact of COVID-19 on PD care? 6) Does COVID-19 increase the risk of developing PD? A literature search was performed from 1979 to 2020 using the terms: ‘Parkinson’s disease’ and ‘parkinsonism’ combined with: ‘COVID-19’; ‘SARS-CoV-2’ and ‘coronavirus’. It does not appear that PD is a specific risk factor for COVID-19. There is evidence for direct/indirect effects of SARS-CoV-2 on motor/non-motor symptoms of PD. Although many PD patients present with typical COVID-19 symptoms, some present atypically with isolated worsening of parkinsonian symptoms, requiring increased anti-PD therapy and having worse outcomes. Mortality data on PD patients with COVID-19 is inconclusive (ranging from 5.2%to 100%). Patients with advanced PD appear to be particularly vulnerable. Single cases of acute hypokinetic-rigid syndrome have been described but no other convincing data has been reported. The rapidity with which COVID-19 has swept across the globe has favored the proliferation of studies which lack scientific rigor and the PD literature has not been immune. A coordinated effort is required to assimilate data and answer these questions in larger PD cohorts.

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Effort-Based Decision-Making for Exercise in People with Parkinson’s Disease

Journal of Parkinson s Disease ◽

10.3233/jpd-202353 ◽

2021 ◽

pp. 1-11

Author(s):

Cristina Colón-Semenza ◽

Daniel Fulford ◽

Terry Ellis

Keyword(s):

Parkinson’S Disease ◽

Decision Making ◽

Parkinson's Disease ◽

Motor Task ◽

Healthy Controls ◽

Physical Effort ◽

Dopaminergic Pathway ◽

The Impact ◽

The Relationship ◽

Non Motor Symptoms

Background: People with Parkinson’s disease (PwPD) are less active than their age-matched peers. Non-motor symptoms, specifically, deficient motivation, may influence decision-making for exercise due to the impaired mesolimbic dopaminergic pathway. Objective: The purpose of this study was to determine if effort-based decision-making for physical effort was different in PwPD compared to healthy controls. We sought to determine the relationship between effort-based decision making for exercise and a discrete motor task as well as the impact of components of motivation on decision-making for physical effort in PwPD. Methods: An effort-based decision-making paradigm using a discrete motor task (button pressing) and a continuous exercise task (cycling) was implemented in 32 PwPD and 23 healthy controls. Components of motivation were measured using the Apathy Scale and the Temporal Experience of Pleasure Scale- Anticipatory Pleasure scale. Results: The presence of Parkinson’s disease (PD) did not moderate decisions for either physical effort task. There was a moderate correlation between decisions for both tasks, within each group. The anticipation of pleasure and apathy were predictors of decisions for both physical effort tasks in PwPD, but not in healthy controls. Conclusion: PwPD responded similarly to effort and reward valuations compared to those without PD. Individuals were consistent in their decisions, regardless of the physical effort task. The anticipation of pleasure and apathy were significant predictors of decisions for exercise in PwPD only. Increased anticipation of pleasure, reduction of apathy, and the use of rewards may enhance engagement in high effort exercise among PwPD.

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Appendectomy Does Not Increase the Risk of Future Emergence of Parkinson’s Disease: A Meta-analysis

The American Surgeon ◽

10.1177/0003134821989034 ◽

2021 ◽

pp. 000313482198903

Author(s):

Mitsuru Ishizuka ◽

Norisuke Shibuya ◽

Kazutoshi Takagi ◽

Hiroyuki Hachiya ◽

Kazuma Tago ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Meta Analysis ◽

Cochrane Library ◽

Random Effects Models ◽

Significant Difference ◽

The Cochrane Library ◽

The Impact ◽

The Relationship ◽

Observation Period

Objective To explore the impact of appendectomy history on emergence of Parkinson’s disease (PD). Background Although there are several studies to investigate the relationship between appendectomy history and emergence of PD, the results are still controversial. Methods We performed a comprehensive electronic search of the literature (the Cochrane Library, PubMed, and the Web of Science) up to April 2020 to identify studies that had employed databases allowing comparison of emergence of PD between patients with and those without appendectomy history. To integrate the impact of appendectomy history on emergence of PD, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI) for the selected studies, and heterogeneity was analyzed using I2 statistics. Results Four studies involving a total of 6 080 710 patients were included in this meta-analysis. Among 1 470 613 patients with appendectomy history, 1845 (.13%) had emergences of PD during the observation period, whereas among 4 610 097 patients without appendectomy history, 6743 (.15%) had emergences of PD during the observation period. These results revealed that patients with appendectomy history and without appendectomy had almost the same emergence of PD (RR, 1.02; 95% CI, .87-1.20; P = .83; I2 = 87%). Conclusion This meta-analysis has demonstrated that there was no significant difference in emergence of PD between patients with and those without appendectomy history.

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1.066 INVESTIGATION ON THE RELATIONSHIP BETWEEN ANXIETY AND THE MOTOR SYMPTOMS OR NON-MOTOR SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE

Parkinsonism & Related Disorders ◽

10.1016/s1353-8020(11)70180-8 ◽

2012 ◽

Vol 18 ◽

pp. S26

Author(s):

Z. Liu ◽

X. Huang ◽

L. Sun ◽

C. Cao ◽

S. Yu ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Symptoms ◽

The Relationship ◽

Non Motor Symptoms

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Effects of deep brain stimulation on sleep-wake disturbances in patients with Parkinson's disease: A narrative review

Current Neuropharmacology ◽

10.2174/1570159x19666210215115718 ◽

2021 ◽

Vol 19 ◽

Author(s):

Yu Jin Jung ◽

Han-Joon Kim ◽

Sun Ha Paek ◽

Beomseok Jeon

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Brain Stimulation ◽

Brain Stimulation ◽

Early Stage ◽

Motor Symptoms ◽

Specific Effects ◽

The Impact ◽

Non Motor Symptoms ◽

Deep Brain

: Sleep-wake disturbances (SWD) are one of the most common non-motor symptoms in Parkinson's disease (PD) and can appear in the early stage even before the onset of motor symptoms. Deep brain stimulation (DBS) is an established treatment for the motor symptoms in patients with advanced PD. However, the effect of DBS on SWD and its specific mechanisms are not widely understood and remain controversial. In addition to the circuit-mediated direct effect, DBS may improve SWD by an indirect effect such as the resolution of nocturnal motor complications and a reduction of dopaminergic medication. Here, the authors review the recent literatures regarding the impact of DBS on SWD in patients with PD. Furthermore, the selection of the DBS targets and the specific effects of applying DBS to each target on SWD in PD are also discussed.

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Frequency of non-motor symptoms in Peruvian patients with Parkinson's disease

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130005 ◽

2013 ◽

Vol 71 (4) ◽

pp. 216-219 ◽

Cited By ~ 14

Author(s):

Carlos Cosentino ◽

Yesenia Nuñez ◽

Luis Torres

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Progressive Increase ◽

Motor Symptoms ◽

Number Of Patients ◽

Progression Of Disease ◽

The Mean ◽

Relationship Of ◽

The Relationship ◽

Non Motor Symptoms

Introduction: Non-motor symptoms in Parkinson's disease are often not well recognized in clinical practice. Non-motor symptoms questionnaire (NMSQuest) is a simple instrument that allows patients or caregivers to report non-motor symptoms in a practical manner. Objective: We attempted to determine the prevalence of non-motor symptoms in three hundred Parkinson's disease outpatients. Results: The mean total non-motor symptoms was 12.41, ranging from 0 to 27 of a maximum of 30. At least one was present in 99.3% of patients. A progressive increase in mean total score was observed across each 5-year interval. Depression domain scored the most “positive” answers while urinary and anxiety /memory were secondly and thirdly most prevalent respectively. Conclusion: The large number of patients included in this study allowed evaluation of the occurrence of non-motor symptoms in early and advanced disease in addition to the relationship of these kinds of symptoms with progression of disease.

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An Update of the Impact of Deep Brain Stimulation on Non Motor Symptoms in Parkinson's Disease

Journal of Parkinson s Disease ◽

10.3233/jpd-130273 ◽

2014 ◽

Vol 4 (2) ◽

pp. 289-300 ◽

Cited By ~ 16

Author(s):

Lisa Klingelhoefer ◽

Michael Samuel ◽

K. Ray Chaudhuri ◽

Keyoumars Ashkan

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Brain Stimulation ◽

Brain Stimulation ◽

Motor Symptoms ◽

The Impact ◽

Non Motor Symptoms ◽

Deep Brain

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Biomechanical Perspectives on the Relationship between Gait Dysfunction and Non-motor Symptoms in Parkinson’s Disease

Journal of The Korean Society of Living Environmental System ◽

10.21086/ksles.2020.10.27.5.673 ◽

2020 ◽

Vol 27 (5) ◽

pp. 673-679

Author(s):

Hyokeun Lee

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Symptoms ◽

Gait Dysfunction ◽

The Relationship ◽

Non Motor Symptoms

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The impact of subthalamic deep brain stimulation on sleep and other non-motor symptoms in Parkinson's disease

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2019.04.001 ◽

2019 ◽

Vol 64 ◽

pp. 138-144 ◽

Cited By ~ 7

Author(s):

Jarosław Dulski ◽

Michał Schinwelski ◽

Agnieszka Konkel ◽

Karol Grabowski ◽

Witold Libionka ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Brain Stimulation ◽

Brain Stimulation ◽

Motor Symptoms ◽

The Impact ◽

Non Motor Symptoms ◽

Deep Brain

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Impact of Progression of Parkinson's Disease and Various Other Factors on Generalized Anxiety Disorder

Journal of Neurosciences in Rural Practice ◽

10.4103/jnrp.jnrp_52_18 ◽

2018 ◽

Vol 09 (03) ◽

pp. 287-290 ◽

Cited By ~ 2

Author(s):

Abdul Qayyum Rana ◽

Hamza Ansari ◽

Abdul Rehman M. Qureshi ◽

Eraad Rahman

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Ethnically Diverse ◽

Influential Factors ◽

Generalized Anxiety ◽

Increased Risk ◽

The Impact ◽

The Relationship

ABSTRACT Objective: While much research has been conducted toward understanding the relationship between prevalence of Parkinson's disease (PD) and generalized anxiety, little has been done considering additional influential factors in the relationship by means of a large ethnically diverse sample. Our study strives to fulfill these deficits in the literature as we set out to determine the impact of progression of PD, age, gender, and Hoehn and Yahr (H and Y) staging of PD on generalized anxiety. Methods: A retrospective chart review analysis was performed on PD patients who were regularly examined in a community-based PD and movement disorders center from 2005 to 2010. Results: This study consisted of 310 patients with PD among whom 12% had generalized anxiety. Neither age nor gender was significant onset predictors at P = 0.05. The impact of progression of H and Y Stages 2–3 and 2–4 increased the odds of generalized anxiety disorder (GAD) prevalence though it was statistically insignificant at P = 0.05. Conclusions: Clinicians should not expect the risk of developing anxiety to depend on gender nor change as a function of age though it may increase with symptomatic progression of PD as outlined by H and Y. To the best of our knowledge, this is the largest and most ethnically diverse prevalence study with a focus on generalized anxiety and PD. Significant Outcomes and Limitations: The symptomatic progression of PD, but not age or gender, may be associated with an increased risk for GAD. This study lacked adjustment for potential confounders such as depression and PD medications.

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